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8183046 |
Temperature resistant pH buffers for use at low temperatures
A method for preparing a composition that includes selecting a pH of the composition; selecting a first buffer with a negative temperature coefficient; selecting a second buffer with a positive...
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8182829 |
Drug eluting implantable medical device with hemocompatible and/or prohealing topcoat
The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular...
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8183203 |
Methods for treating pulmonary hypertension and compositions comprising vasoactive intestinal peptide
A method and device for discharging an electrical defibrillation pulse or an electrical demand pacer pulse or delivering at least one pharmaceutical agent to treat conditions such as cardiac...
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8183201 |
Methods of treating αvβ3 integrin-associated diseases by administering polypeptides selective for αvβ3 integrin
The invention provides disintegrin variants, and more specifically to disintegrin variants which are selective αvβ3 integrin antagonists for treatment and prevention of αvβ3 integrin-associated dis...
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8183204 |
Methods and compositions for increasing skin remodeling
Skin remodeling is stimulated at the site of blemished skin using an ionic metal-peptide complex to diminish or remove the skin imperfection. The blemish can be a scar, especially surgical or wound...
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8183339 |
Cell-permeable peptide inhibitors of the JNK signal transduction pathway
The invention provides cell-permeable peptides that bind to JNK proteins and inhibit JNK-mediated effects in JNK-expressing cells.
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8178087 |
Process of production of bacteriophage compositions and methods in phage therapy field
A method for producing bacteriophage stock compositions including (a) incubating a culture medium including at least one bacterial strain, at least one bacteriophage strain that can infect the...
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8178474 |
Functionalised solid support for alpha-oxoaldehyde synthesis
The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in ...
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8178487 |
Method for providing glutamine
A method of providing glutamine to a patient. A nutritional composition which includes whey protein, or a protein mixture which simulates the amino acid profile of whey protein, as a protein source...
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8178489 |
Formulation for aviptadil
The present invention relates to pharmaceutical formulations of Aviptadil and its derivatives. The stability of the Aviptadil formulation was shown to be improved by a formulation having a defined...
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8178486 |
Method for promoting hair growth
A method is provided of promoting hair growth in a subject includes applying to the skin of the subject a composition including lactoferrin in an amount effective for at least one of proliferating...
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8178095 |
Method of treating skin inflammation
Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19,...
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8178488 |
Methods for increasing thermogenic adipocytes
In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an...
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8173148 |
Stabilized polymeric delivery system comprising a water-insoluble polymer and an organic liquid
The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for...
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8173602 |
Detecting CYP24 expression level as a marker for predisposition to cancer
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer...
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8168416 |
Modified lecithin-cholesterol acyltransferase enzymes
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of...
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8168586 |
Cancer targets and uses thereof
Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for...
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8168585 |
Purification of peptides from colostrum
The invention relates to the purification of peptides from colostrum. The method involves the addition of an alcohol such as methanol or ethanol to the mixture in order to form an alcohol phase...
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RE43343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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8168176 |
CBLB for treating endotoxin-mediated disorders
Methods of treating endotoxin-mediated disorders are provided.
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8168593 |
Mutated netrin-4, fragments thereof and their use as medicines
A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate the...
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8168584 |
Methods of treating age-related macular degeneration by compstatin and analogs thereof
The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration and other conditions involving macular...
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8168583 |
2-fluoronucleosides
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and c...
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8168233 |
Treatment of pancreatitis with amylin
The disclosed invention provides for the treatment of pancreatitis, and the alleviation of pain associated therewith, with amylin, amylin agonists and amylin analogs.
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8168587 |
Combination enzyme replacement and small molecule therapy for treatment of lysosomal storage diseases
This invention provides various combinations of enzyme replacement therapy, gene therapy, and small molecule therapy for the treatment of lysosomal storage diseases.
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8163702 |
Treatment of melanoma
An immunomodulatory compound is administered to treat, prevent, inhibit, or reduce melanoma in a subject.
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8163302 |
Methods of making and using surfactant polymers
Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional...
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8163692 |
Protection against and treatment of ionizing radiation
Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and treatment...
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8165819 |
Modeling wound healing
Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue...
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8163691 |
Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.
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8163699 |
Method for the treatment of valvular disease
A method for treating valvular stenosis. The method involves the administration of a therapeutically effective amount of a reverse lipid (in particular cholesterol) transport agonist to a mammal....
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8163701 |
Prodrugs of active agents
Disclosed herein are prodrugs of active agents which contain at least one amine, phenol, carboxylic acid, or thiol functionality. Also disclosed herein are methods of making prodrugs of active...
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8163269 |
Bioactive stents for type II diabetics and methods for use thereof
The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand...
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8158578 |
Methods for treating neurological deficits
The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a...
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8158575 |
Agent for the prevention and treatment of sexually transmitted diseases-I
Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted...
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8158573 |
Therapeutic and diagnostic conjugates for use with multispecific antibodies
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or...
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8158577 |
Modulation of cartilage homeostasis by active domains of cell binding extracellular matrix molecules
A linear or cyclic peptide and the use of said peptide in medicine and especially in the manufacture of a medicament for the treatment and/or prophylaxis of a disease associated with inflammatory...
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8158574 |
Compositions and methods to prevent cancer with cupredoxins
The present invention relates to compositions and methods comprising chemopreventive agents that may be cupredoxin(s) or variants, derivatives and structural equivalents of cupredoxins, and at...
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8158576 |
Viral capsid proteins and any peptides or compositions thereof for the treatment of pathologic disorders
The present invention relates to viral capsid proteins, as a medicament for the treatment of a pathologic disorder. More particularly, the invention relates to the viral capsid proteins VP1, VP2...
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8158415 |
Combined use of cell permeable Nanog and Oct4 for increasing self-renewal and suppressing differentiation of stem cells
The present invention discloses cell permeable Nanog and Oct4 recombinant proteins that comprise a kaposi fibroblast growth factor 4 (kFGF4)-derived macromolecule transduction domain (MTD). Also...
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8158579 |
Fusion protein of an exendin to modified transferrin
The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and...
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8158584 |
Pharmaceutical preparations comprising an ALK1-Fc fusion protein
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may...
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8158110 |
Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease
The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the...
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8153593 |
Transglutaminase inhibitors and methods of use thereof
Transglutaminase inhibitors and methods of use thereof are provided.
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8153597 |
Modulators of the ABC transporter family and methods for their use
An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and...
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8153589 |
JNK3 as a target for the treatment of angiogenesis-related diseases
Provided herein are methods for treating a subject having or at risk for an angiogenesis-related disorder. The methods include administering to the subject a therapeutically effective amount of an...
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8153583 |
Toll like receptor 3 antagonists, methods and uses
Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed.
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8153580 |
Nogo receptor binding protein
The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides...
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8153582 |
Personal-care articles having self-assembling peptides
A personal-care article, for receiving body exudates, having a self-assembling peptide is provided.
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8153581 |
Process for producing an injectable medicament preparation
The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a...
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