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7622453 |
Oligomeric compounds for the modulation of Bcl-2
The present invention provides improved oligomeric compound, in particular oligonucleotide compounds, and methods for modulating the expression of the Bcl-2 gene in humans. In particular, this...
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7622306 |
Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies
The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins...
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7618615 |
Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia
Methods and pharmaceutical compositions for preconditioning and/or providing neuroprotection to the animal central nervous system against the effects of ischemia, trauma, metal poisoning and...
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7611833 |
Yeast genes that affect viral replication
An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus...
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7611729 |
Dosage forms having prolonged active ingredient release
The present invention relates to prolonged-release oral dosage forms of 4-phenylbutyric acid salts, such as sodium 4-phenylbutyrate. The prolonged release oral dosage forms are preferably tablets....
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7608687 |
Releasable linkage and compositions containing same
A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.
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7601368 |
Purified Arabinogalactan-Protein (AGP) composition useful in the treatment psoriasis and other disorders
A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified...
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7592319 |
Uses of DNA-PK
This invention provides a method for increasing the susceptibility of a cell to DNA-damaging agents, comprising introducing into the cell an antisense oligonucleotide that specifically hybridizes...
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7592307 |
Releasable linkage and compositions containing same
A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the...
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7589233 |
L-Threonine derivatives of high therapeutic index
The present invention is directed to a derivative comprised of an L-Threonine bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. The derivative has the...
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7589190 |
Potent LNA oligonucleotides for the inhibition of HIF-1A expression
The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of 5′-( T x )G x G x c s a s a s g s c s a s t s c s c s T x G x T-3′ and...
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7589057 |
Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems
Biocompatible microparticles include an ophthalmically active alpha-2 adrenergic receptor agonist and a biodegradable polymer. The microparticles include oil-in-water emulsified microparticles...
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7589056 |
Agent for the prevention and treatment of sexually transmitted diseases-I
Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted...
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7588901 |
Modulation of angiogenesis through targeting of arginyl transferase (ATE1)
The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of...
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7582317 |
Food supplements comprising, as a health component, sargahydroquinoic acid or derivative thereof
The invention concerns blends of a hydroquinone substituted poly unsaturated fatty acid (as present in Kombo nut oil) or a derivative thereof, which blends comprised:
(i) 0.1-99.9 wt % of the...
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7582300 |
Modulation of gamma delta T cells to regulate airway hyperresponsiveness
Disclosed is a method for regulation of airway hyperresponsiveness by modulating the action of γδ T cells in a patient. Also disclosed are methods for identifying compounds that regulate airway...
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7575767 |
Extraction of palm vitamin E, phytosterols and squalene from palm oil
Phytosterols, squalene and Vitamin E are recovered from phytonutrients concentrate derived from crude palm oil by the disclosed invention via esterification, transesterification, vacuum...
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7569551 |
Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides
Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells...
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7569536 |
Method for controlling SR protein phosphorylation, and antiviral agents whose active ingredients comprise agents that control SR protein activity
The present invention provides: (1) antiviral agents that act by reducing or inhibiting the activity of SR proteins, more specifically, (i) antiviral agents that act by enhancing dephosphorylation...
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7566454 |
Influenza nucleic acids, polypeptides, and uses thereof
Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein.
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7563618 |
Oligonucleotide conjugates
Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component...
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7560229 |
Methods of use of the enzymes of mycothiol synthesis
The present invention utilizes three families of bacterial enzymes, which play a key role in mycothiol biosynthesis. The three families are bacterial cysteine:glucosaminyl inositol ligases (MshC)...
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7550568 |
Monoclonal antibodies to human high molecular weight-melanoma associated antigen
The present invention provides monoclonal antibodies that react against high molecular weight melanoma-associated antigen. These antibodies may be used for diagnostic and/or therapeutic purposes.
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7547673 |
Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising...
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7547441 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
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7534769 |
Compositions and methods for enhancing delivery of therapeutic agents to cells
This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and...
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7534435 |
Glycosylated specificity exchangers
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and...
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7531500 |
Preventing airway mucus production by administration of EGF-R antagonists
Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic...
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7531499 |
Medicinal composition
The present invention provides a medicinal composition comprising (1) a pharmacologically active substance, (2) a drug absorbefacient and (3) a taurine compound or a polyamine. A taurine compound...
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7521414 |
Polyol macrolide antitumor-antibiotics from the marine actinomycete strain CNQ140
A novel family of cyclic polyene natural products isolated from marine actinomycete strain CNQ140 is provided. This novel strain of actinomycetes was obtained from a previously unstudied population...
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7514397 |
Methods for inhibition of membrane-fusion-associated events, including Hepatitis B virus transmission
The present invention relates to peptides which exhibit potent anti-viral activity. In particular, the invention relates to methods of using such peptides as inhibitory of hepatitis B virus...
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7507704 |
Receptor modulated cancer protocols
The present invention discloses that prior art protocols that administer HER receptor blockers concurrently with phase specific cytotoxic chemotherapeutics result in antagonistic function that...
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7507703 |
Method of cancer screening; method of cancer treatment; and method of diabetes treatment
A method of cancer screening comprising the steps of administering the Blood CA 27,29 testing procedure; if the result is positive administering a mammogram; if the result is positive administering...
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7504477 |
Polyalkylene glycol acid additives
A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small...
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7504208 |
Solid-phase fluorination of uracil and cytosine
The invention relates to a process for the production of an 18 F-labelled tracer which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-I + -TRACER (I) Y...
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7494669 |
Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically...
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7465717 |
Process for releasing and extracting phosphatides from a phosphatide-containing matrix
A process for releasing and extracting phosphatides from a phosphatide-containing matrix. The process includes (i) contacting the phosphatide-containing matrix with a solvent and a metal salt to...
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7459443 |
Synthesis of biologically active compounds in cells
This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of...
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7449442 |
EGFR inhibitors promote axon regeneration
Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with...
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7423008 |
Derivatives of mithramycin and methods of making and uses thereof
The invention, in one aspect, generally relates to mithramycin derivatives from mutated Streptomyces argillaceus and their production. The invention also relates using the derivatives for the...
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7419964 |
Treatment of HSV-related pathologies using ssDNA
A composition for treatment of HSV-related pathologies including an expression vector for altering expression of a target sequence in an HSV-infected cell by production of single-stranded cDNA...
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7419683 |
Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules
A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents or emulsifier which contain amphiphilic molecules...
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7411042 |
Tumor associated nucleic acids and uses therefor
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
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7405205 |
Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase
Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include...
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7402725 |
WIP, a WASP-associated protein
Described herein is a novel gene and its product, WIP, which associates with WASP. The subject invention relates to the isolated WIP gene or cDNA and transgenic mammals that have the WIP gene...
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7390780 |
Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification
A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a...
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7390497 |
Poly(ester amide) filler blends for modulation of coating properties
Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the...
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7384907 |
Method of treating infection with ABl tyrosine kinase inhibitors
The present invention relates to a method of preventing or treating a pathogen infection comprising administering to a mammal in need thereof an effective amount of an inhibitor of Abl tyrosine...
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7384558 |
Compositions capable of inhibiting reactive oxygen and carbonyl species
Therapeutic compositions are provided. The compositions include a single molecule that can display both antioxidant and carbonyl trapping properties. This can effectively reduce inflammation,...
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7375073 |
Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
The present invention describes the use of angiotensin-(1-7) peptide as an anti-cancer therapeutic. Thus, in one embodiment, the present invention comprises a composition to inhibit the growth of...
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