|
Match
|
Document |
Document Title |
|
|
8168416 |
Modified lecithin-cholesterol acyltransferase enzymes
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of...
|
|
|
8163699 |
Method for the treatment of valvular disease
A method for treating valvular stenosis. The method involves the administration of a therapeutically effective amount of a reverse lipid (in particular cholesterol) transport agonist to a mammal....
|
|
|
8143265 |
Method of treating atherosclerosis
A method of treating atherosclerosis in a subject is carried out by administering the subject 2-aminopurine or a pharmaceutically salt thereof in a treatment effective amount. Optionally, the...
|
|
|
8133857 |
NOTCH inhibition in the treatment of atherosclerosis
The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling...
|
|
|
8124580 |
Apolipoprotein A1 mimetics and uses thereof
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
|
|
|
8124582 |
Treatment of diabetes
The present invention relates to methods and compounds for regulating glucose metabolism, achieving glucose homeostasis, and decreasing blood glucose levels. Methods and compounds for treating or...
|
|
|
8110543 |
Anti-invasive and anti-angiogenic compositions
A peptide compound having the sequence Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu [SEQ ID NO:2] or a substitution variant, addition variant or other chemical derivative thereof inhibits cell invasion,...
|
|
|
8101565 |
Sustained release of Apo A-I mimetic peptides and methods of treatment
A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and...
|
|
|
8084423 |
Synthetic single domain polypeptides mimicking apolipoprotein E and methods of use
The present invention is directed to a synthetic apolipoprotein-E mimicking polypeptide consisting of a single domain. The invention is also directed to nucleic acid encoding the polypeptide,...
|
|
|
8048015 |
Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles...
|
|
|
8048851 |
Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other...
|
|
|
8030277 |
Polypeptide and gene encoding the same
A polypeptide having the amino acid sequence as set forth in SEQ ID NO: 2, 4, or 6, a DNA encoding the same, and an antibody against said polypeptide, and the use thereof. The above amino acid...
|
|
|
8030464 |
Stabilized bioactive peptides and methods of identification, synthesis, and use
An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system,...
|
|
|
8030281 |
Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles...
|
|
|
8030276 |
Treating cardiovascular disease with TRPC3 channel protein
The invention refers to the use of a TRPC channel, an inactivating mutant thereof, or a nucleotide sequence coding for the TRPC channel or for the inactivating mutant for the production of a...
|
|
|
7985727 |
Apo A-I mimetic peptides and methods of treatment
A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide...
|
|
|
7966746 |
Needle penetrable and laser resealable lyophilization method
A device and related method are provided for lyophilizing a substance within the device and storing therein the lyophilized substance. The device is penetrable by a needle for filling the device...
|
|
|
7919084 |
Methods of diagnosis, prognosis and treatment of cardiovascular disease
The invention provides methods for diagnosis or prognosis of cardiovascular disease involving the detection of an elevated amount of MIC-1 in a test body sample. The invention also provides methods...
|
|
|
7897561 |
Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury
The invention includes a method for the treatment or prophylaxis of atherosclerosis, and/or for the treatment or prophylaxis of reperfusion injury in a subject in need of treatment by administering...
|
|
|
7892556 |
Apoptotically active peptides
Specific amino acid sequences and peptides and/or peptide mimetics deducted therefrom influencing apoptosis, and the use thereof for the production of pharmaceuticals as diagnostic tools are shown.
|
|
|
7883699 |
Methods for enlarging the lumen of an obstructed biological conduit
The invention provides methods to for treating a an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue....
|
|
|
7858577 |
Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2
The use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives is described for the preparation of medicament which inhibits the biological activity of the growth factor FGF-2,...
|
|
|
7851441 |
Water-soluble elastin, process for producing same, and food and medicine containing same
A low-molecular-weight water-soluble elastin having a molecular weight of about 10,000 to 30,000 and a high-molecular-weight water-soluble elastin having a molecular weight of about 30,000 to...
|
|
|
7807640 |
Orally administered peptides synergize statin activity
This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. The peptides are class A amphipathic helical peptides. They are highly stable and readily...
|
|
|
7795213 |
Methods of contacting β amyloid protein with VEGF
The present invention relates to a VEGF polypeptide that binds to Aβ. The present invention also relates to a compound that sequesters Aβ. And conversely, the invention relates to a compound that s...
|
|
|
7785567 |
Growth hormone-releasing peptides in the treatment or prevention of atherosclerosis and hypercholesterolemia
According to the invention there is provided a method of treatment or prophylaxis of atherosclerosis, hypercholesterolemia or a cardiovascular disease associated with atherosclerosis, which method...
|
|
|
7785566 |
Pharmaceutical compounds
The invention comprises pharmaceuticals of formula (I) Z-(L)n-V, wherein V denotes a peptide, L denotes an optional linker, Z denotes a group that optionally can carry an imaging moiety M, n...
|
|
|
7785589 |
Antibodies against a peptide epitope of apolipoprotein B
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
|
|
|
7745387 |
Use of erythropoietin
The present invention relates to the use of erythropoietin for stimulating the physiological mobilization, proliferation and differentiation of endothelial progenitor cells, for stimulating...
|
|
|
7741289 |
Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of...
|
|
|
7732410 |
Compositions for inhibiting atherosclerosis
The present invention relates to compositions and methods for the reduction of atherosclerotic plaques and the decrease in the level of total serum cholesterol, triglycerides, serum LDL...
|
|
|
7732413 |
Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of...
|
|
|
7723303 |
Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of atherosclerosis and/or other...
|
|
|
7704499 |
Antibodies against a peptide epitope of apoliporotein B
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including...
|
|
|
7700544 |
Compositions and methods for treating atherosclerosis
Peptides and mimetics of selected domains of mammalian serum amyloid A isoform 2.1 (SAA2.1) and compounds and compositions thereof are provided that enhance the effect on macrophage cholesterol...
|
|
|
7615528 |
Methods for alleviating deleterious effects of 3-deoxyglucosone
Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a recently discovered metabolic pathway....
|
|
|
7585507 |
Nucleic acid molecules and polypeptides for immune modulation
The invention provides gp38 polypeptides, which play a role in immunomodulation, nucleic acid molecules encoding these polypeptides, and therapeutic and diagnostic methods employing these...
|
|
|
7576060 |
Inhibition of adhesion and migration of an endothelial cell to fibronectin by neutrophil alpha-defensins
The present invention relates to the inhibition of angiogenesis by neutrophil alpha-defensins. Further, the present invention relates to methods involving the inhibition of endothelial cell...
|
|
|
7531516 |
Peptidic compounds selectively binding to P-selectin
The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence...
|
|
|
7517857 |
Immune-modulating peptide
Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood...
|
|
|
7511009 |
Retinal pigmented epithelium derived neurotrophic factor
The present invention relates to a purified retinal pigmented epithelium derived neurotrophic factor composition and a method for purifying such a retinal pigmented epithelium neurotrophic factor....
|
|
|
7488717 |
Methods of inhibiting chemokine binding to chemokine receptors
Novel peptides or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed...
|
|
|
7470660 |
Treatment for dark adaptation
The present invention addresses the treatment of age-related macular degeneration, and treatment of individuals with impaired visual function such as impaired dark adaptation, using regulation of...
|
|
|
7459433 |
Homotrimeric extended OBG3 globular head and uses thereof
The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, homotrimer of OBG3 polypeptide fragment comprising...
|
|
|
7459438 |
Specific mechanism for inhibiting platelet adhesion to collagen
The present invention relates to the polypeptide Saratin and its use for the manufacture of a medicament having the capability to significantly decrease platelet adhesion and platelet accumulation...
|
|
|
7439229 |
Cytokine activity regulator molecules from tick salivary glands
The present invention relates to cytokine activity regulator molecules (CARMs) and their use in controlling the action of cytokines, particularly chemokines. In particular, the invention relates to...
|
|
|
7432245 |
Pharmaceutical formulation comprising a peptide angiogenesis inhibitor
Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.
|
|
|
7417030 |
Indazole peptidomimetics as thrombin receptor antagonists
The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
|
|
|
7393825 |
Microdose therapy
Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve...
|
|
|
7390783 |
Charged phospholipid compositions and methods for their use
The invention provides a pharmaceutical composition comprising a synthetic or naturally occurring charged phospholipid, which is formulated into a dosage form for administration to a subject or...
|