Matches 201 - 250 out of 322 < 1 2 3 4 5 6 7 >
Match Document Document Title
6479231 Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1 (hOAT1)  
Secretion of small molecules from systemic blood circulation into urine is one of the physiologically essential functions of the kidney. Human organic anion transporter (hOAT1) is a key component...
6465425 Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins  
This invention relates to sustained release compositions, and methods of forming and using said compositions, for the sustained release of biologically active acid-stable or free...
6465421 Modulating body/cranial hair growth  
The growth of body and/or head/cranial hair on mammalian organisms, for example humans, is modulated by administering thereto, whether topically and/or systemically, therapeutically effective...
6444638 Combinations of PKC inhibitors and therapeutic agents for treating cancers  
This invention provides methods for screening a modulating agent which when combined with antitumor therapeutic agent increases apoptosis in tumor cells. This invention also provides methods for...
6444419 TMPRSS2 is a tumor suppressor  
The present invention relates to the relation of the TMPRSS2 gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human...
6444648 Leishmaniasis remedy containing glucopyranose derivative as the active ingredient  
A leishmaniasis preventing and/or treating agent having 2-deoxy-2-[(3S)-(9-phenylnonanoyloxy)tetradecanoyl]amino-3-O -(9-phenylnonanoyl)-4-O-sulfo-α-D-glucopyranose represented by a formula (I) or...
6436911 IL-12 production inhibitor  
An IL-12 production inhibitor which comprises, as an active ingredient, a keratan sulfate oligosaccharide or a derivative thereof, for example, a keratan sulfate oligosaccharide comprising at least...
6436371 Oral composition  
Oral composition comprises a wintergreen flavor imparting ingredient and having an alkaline pH, wherein the wintergreen flavor imparting ingredient is 2′-hydroxypropiophenone.
6432913 Polypeptide of protein p140 and DNAs encoding it  
The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the...
6428950 Assay to identify compounds that alter apolipoprotein E expression  
The present invention provides a method of assaying for and arresting, preventing and/or reversing the impairment of central and peripheral nervous system function comprising reducing β-amyloid...
6423335 Modified milk powder composition  
A composition comprising modified milk powder, and glutamine and/or a peptide containing glutamine.
6423314 Tumor derived carbohydrate binding protein  
The active, galactose binding site of proteins associated with metastatic tumor cells has been identified and sequenced. The polypeptide comprising the active site may be used as an...
6420335 Combination of radiotherapy and anti-angiogenic factors  
The present invention relates generally to the fields of angiogenesis and cancer therapy. More particularly, it concerns the use of anti-angiogenic factors in cancer therapy. The present invention...
6416759 Antiproliferative Sgk reagents and methods  
The invention provides methods and compositions relating to activated Sgk and the association of activated Sgk activity with proliferating cells, including methods for inhibiting the growth of an...
6410505 Dimeric non-azo naphthalimides and uses for the same  
A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a...
6406917 Methods and compositions for the use of apurinic/apyrimidinic endonucleases  
Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and...
6399314 Methods of detection of amyloidogenic proteins  
A method/assay for detecting various aggregated forms of amyloid peptide using amyloid-specific spectroscopic probes, such as Congo red and related analogs, is described. Such an assay could be...
6376461 Sustained-release preparation  
According to a first embodiment, there is provided a sustained-release preparation comprising a water-insoluble or slightly water-soluble polyvalent metal salt of a water-soluble physiologically...
6369043 Sodium ion absorption inhibitors, sodium ion excretion accelerators, and preventive and therapeutic agents for diseases resulting from excessive intake of common salt  
An sodium ion absorption inhibitor, a sodium ion excretion accelerator and an agent for preventing and treating a disease caused by excessive common salt ingestion, each of which comprising a metal...
6368831 Treatment of hyperproliferative disorders  
A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a...
6337316 Pharmaceutical compositions thereof, and methods of using same  
The present invention relates to peptidomimetics capable of inhibiting CD28 and/or CTLA-4 interaction with CD80 (B7-1) and CD86 (B7-2) and having a core amino acid sequence,...
6333051 Nanogel networks and biological agent compositions thereof  
Copolymer networks having at least one cross-linked polyamine polymer fragment and at least one nonionic water-soluble polymer fragment, and compositions thereof, having at least one suitable...
6329347 Composition and method for the treatment of bladder cancer  
The present invention relates to a composition and method useful for treating cancer in the urinary bladder. The present invention particularly relates to a composition comprising a Mycobacterium...
6329340 Human Defensin DEF-X  
The present invention relates to a human polypeptide defensin Def-X, homologous to HNP-4, its genomic DNA and cDNA, vectors, cells transformed with said vectors, the use of said polypeptides as...
6326357 Bacterial cell complex composition and method of use  
The present invention relates to a composition and method useful for stimulating the immune system and for inhibiting proliferation of and inducing apoptosis in responsive cells of an animal. The...
6323396 Agrobacterium-mediated transformation of plants  
Agrobacterium strains which have lost the capacity to proliferate vigorously in vitro or in planta, are provided, as well as transformation methods using these Agrobacterium strains.
6316434 Assay for emetic activity  
An assay for emetic activity among inhibitors of type 4 phosphodiesterase (PDE 4) is disclosed. The assay comprises: (A) administering to a test mammal an anesthetic compound in an amount...
6312737 Method of inducing apoptosis in cancer cells using an extract of Melothria indica Lou  
The invention includes a method of inducing apoptosis in cancer cells by administering an extract of Melothria indica Lou to the cancer cells. The invention also includes a method of using an...
6306395 Fas antigen derivatives  
This invention provides a novel Fas antigen derivative which comprises at least a part or entire portion of Fas antigen extracellular region polypeptide in which at least one amino acid residue is...
6294339 Method of diagnosing and treating increased risk of death from community-acquired pneumonia associated with the a allele of the TNFα-238 polymorphism  
This invention relates to diagnostic methods based upon a particular genotype in the Tumor Necrosis Factor (TNFα) gene, more specifically, GA or AA at the -238 site rather than the GG at this...
6277389 Non-toxic aqueous pesticide  
A non-toxic aqueous pesticide and method for application on plants and animals comprising at least one surfactant and at least one high terpene containing natural oil to effectively control insects...
6271195 Aminimide-containing molecules and materials as molecular recognition agents  
The design and synthesis of novel aminimide-based molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and...
6268349 Method for treating B19 parvovirus infections  
The present invention discloses a treatment for patients with the B19 parvovirus associated symptoms or patients carrying or infected by the B19 parvovirus or having antibodies against the B19...
6262036 Method for inhibiting RNA translation using chimeric oligonucleoside compounds  
Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target...
6245734 Physiologically active polyoxypeptin and deoxypolyoxypeptin and anticancer drugs containing the same  
As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following...
6225293 Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations  
The present invention provides improved methods for tracking the biodistribution of macromolecules and carriers in cells. In accordance with one embodiment, oligonucleotides and lipid carriers are...
6187760 Cationic phospholipids for transfection  
A novel class of cationic phospholipids and novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids....
6177401 Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis  
The present invention relates to the use of proteins, peptides and organic molecules capable of modulating Flk-1 receptor signal transduction in order to inhibit or promote angiogenesis and...
6165988 Medicament in particulate form  
The medicament in particulate form has one or more anionic or partially anionic active substances bound to a carrier material. The carrier material includes particulate copolymer or homopolymer of...
6156723 Compositions comprising inhibitors of estrogen response  
The present invention provides novel assay methods for identifying compounds that may have both estrogen agonist and antagonist properties. In particular, the assay use cells comprising promoters...
6153596 Polycationic oligomers  
The present invention relates to improved methods for introducing nucleic acid into cells by first complexing the nucleic acid with a selected polycationic oligomer which neutralizes the negative...
6150325 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical compositions  
This invention relates to novel compounds of general formula (I): ##STR1## and to pharmaceutical compositions containing them.
6136779 Methods of specifically transcriptionally modulating the expression of gene of interest  
The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an...
6127346 Phosphonomonoester nucleic acids process for their preparation and their use  
Novel oligonucleotide analogs of the formula [I] are described, ##STR1## in which A, B, D, G, L, P, Q, Q', R 5 , R 6 , X, Y, Z and n are as defined in the description, which have useful physical,...
6126930 Spray compositions  
The present invention relates to personal care and pharmaceutical compositions comprising an alcohol, a personal care polymer, and an alcohol-masking perfumery component. These compositions can be...
6113939 Pharmaceutical compositions for treating priapism and peyronie's syndrome  
A composition for the treatment of impotence via delivery to the urethra comprises a vasoactive prostaglandin and a polyethylene glycol dispersant having sufficient viscosity to be retained without...
6096718 Tissue specific adenovirus vectors for breast cancer treatment  
Replication defective adenoviral vectors serve as vehicles for genes encoding products that kill cells in which the genes are transferred and activated. The novel vectors include tissue specific...
6096521 Adhesin from Helicobacter pylori  
The present invention concerns an adherence gene from Helicobacter pylori, a polypeptide coded thereby and antibodies against the polypeptide.
6080717 Cysteinyl-tRNA synthetase from Staphylococcus aureus  
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are...
6060456 Chimeric oligonucleoside compounds  
Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target...
Matches 201 - 250 out of 322 < 1 2 3 4 5 6 7 >