|
Match
|
Document |
Document Title |
|
|
6787524 |
CpG oligonucleotides and related compounds for enhancing ADCC induced by anti-IgE antibodies
The invention relates to a method of stimulating antibody-dependent cellular cytotoxicity to enhance the elimination of IgE-bearing B-cells comprising administering to a mammal an anti-IgE...
|
|
|
6777000 |
In-situ gel formation of pectin
In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically...
|
|
|
6770303 |
Use of antifungal and/or antibacterial and/or antiviral compounds
Phosphorus acid derivatives and the like are used as an amplifier (potentiator) of plant defense responses induced by other materials (elicitors).
|
|
|
6753309 |
Nucleosides for imaging and treatment applications
Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic...
|
|
|
6750195 |
Use of 5-HT4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
A compound which acts as an antagonist at 5-HT 4 receptors is of potential use in the treatment of conditions associated with bladder hypersensitivity, such as urinary incontinence, which is often...
|
|
|
6747004 |
Method for inducing growth and enhancing survival of nervous tissue
The present invention provides a method of inducing growth or enhancing survival of nervous tissue comprising contacting the nervous tissue with an amount of ebaf effective to induce the growth or...
|
|
|
6740306 |
Imidazotriazinone-containing compositions for nasal administration
The present invention relates to imidazotriazinone-containing compositions for nasal administration which, besides the cGMP PDE inhibitor, contain a small amount of a local anaesthetic.
|
|
|
6736972 |
Method and system for providing therapeutic agents with hemofiltration for reducing inflammatory mediator related diseases
The present invention relates to a method and system for providing hemofiltration for reducing inflammatory mediator related diseases. In one form, a hemofiltration system for treating inflammatory...
|
|
|
6713461 |
Pharmaceutical complex
This invention relates to a complex of eletriptan and a sulphobutylether-beta-cyclodextrin, or a pharmaceutically acceptable salt thereof, and to processes for the preparation of, pharmaceutical...
|
|
|
6699832 |
Methods of treating obesity using a neurotensin receptor ligand
The present invention relates to methods of treating obesity, diabetes, sexual dysfunction, atherosclerosis, insulin resistance, impaired glucose tolerance, hypercholesterolemia or...
|
|
|
6699836 |
Vancomycin analogs
Compounds that are vancomycin analogs bearing terminal carboxyl group modifications as well as modifications to the vancosamine nitrogen and, optionally, modifications to the C6 position of the...
|
|
|
6696407 |
Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
The present invention provides methods of modulating neurotrophic factor-associated activity, especially CNTF-associated levels and activity, using aldose reductase inhibitors. These methods are...
|
|
|
6696064 |
Methods of protecting vasculature from damage by diphtheria toxin-and pseudomonas toxin-based immunotoxins during therapy
Vascular damage has proven to be dose limiting in administering immunotoxins into the brain to treat brain tumors. Vascular toxicity of immunotoxins which rely in part on exposure to lowered pH in...
|
|
|
6696089 |
Nanogel networks including polyion polymer fragments and biological agent compositions thereof
The present invention relates to nanogel networks having at least one cross-linked polyionic polymer fragment and at least one nonionic water-soluble polymer fragment, and compositions thereof,...
|
|
|
6693135 |
Prostaglandin compositions and methods of treatment for male erectile dysfunction
The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E...
|
|
|
6689741 |
Biocompatible polymers, process for their preparation and compositions containing them
A biocompatible polymer constituted by a sequence of identical or different components of the general formula (I): A a X x Y y , in which A represents a monomer, X represents a carboxyl group fixed...
|
|
|
6680068 |
Drug delivery formulations and targeting
The invention is based on the discovery that angiogenic vessels have heterogeneous surface charge and that cationic liposomes actually target human tumor blood vessels only in irregularly shaped...
|
|
|
6676950 |
Neurokinin receptor antagonists and methods of use thereof for inhibiting HIV infection
Compositions and methods are provided which may be used to advantage for the treatment of HIV infection. More specifically, neurokinin receptor antagonists and methods for administration to inhibit...
|
|
|
6677298 |
Regulators of PPAR&dgr (β) and their use in the treatment of obesity and insulin resistance
Obesity is a common clinical problem in most developed nations and is also rapidly becoming a major health concern in developing nations. Overweight individuals frequently suffer from several...
|
|
|
6677317 |
Disaccharide derivatives for treating hyperglycaemia
The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or...
|
|
|
6673558 |
Drug compositions to prevent desensitization of cellular receptors
Drug compositions combining antagonists with agonists to prevent desensitization of cellular receptors. An agonist is a substance or drug that produces a maximal or nearly maximal response, whereas...
|
|
|
6673777 |
Guanylhydrazones useful for treating diseases associated with T cell activation
There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target...
|
|
|
6670332 |
Complex cationic lipids having quarternary nitrogens therein
Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.
|
|
|
6660720 |
Targeted oligonucleotide conjugates
The present invention provides improved ingress of therapeutic and other moieties into cellular targets. In accordance with preferred embodiments, complexes are provided which carry primary...
|
|
|
6660268 |
Proteasome regulation of NF-KB activity
Disclosed herein is a method for regulating the activity of NF-κB in an animal comprising contacting cells of the animal with certain proteasome inhibitors.
|
|
|
6652885 |
Purification and stabilization of peptide and protein pharmaceutical agents
Methods are provided for purifying peptides and proteins by incorporating the peptide or protein into a diketopiperazine or competitive complexing agent to facilitate removal one or more...
|
|
|
6641811 |
Use of angiotensin II inhibitors to prevent malignancies associated with immunosuppression
The invention provides a method for reducing formation or progression of neoplasms associated with immunosuppressive therapy in a mammal, the method comprising treating the mammal with an effective...
|
|
|
6638913 |
Concentrated injection and infusion solution for intravenous administration
Additives to concentrated injection and infusion solutions that avoid or mitigate acute or delayed hypersensitivity reactions as well as injection and infusion solutions that contain these...
|
|
|
6638915 |
Anti-viral composition
The invention relates to antiviral compositions comprising a mixture comprising zinc oxide, aspartic acid, and high fructose corn syrup, and to methods of making and using such compositions.
|
|
|
6632789 |
Methods for modulating T cell responses by manipulating intracellular signal transduction
Methods for modulating T cell responses by manipulating intracellular signals associated with T cell costimulation are disclosed. The methods involve inhibiting or stimulating the production of at...
|
|
|
6624138 |
Drug-loaded biological material chemically treated with genipin
A method for treating tissue of a patient comprising, in combination, mixing a drug with a solidifiable biological material, chemically treating the drug with the biological material with a...
|
|
|
6617305 |
Stable aqueous dispersion of nutrients
This invention relates to a stable aqueous dispersion of nutrients and more particularly, to an aqueous dispersions of an active nutritional ingredient selected form (a) an isoflavone, (b) lycopene...
|
|
|
6596262 |
Modulated release particles for aerosol delivery
A polymeric construct is disclosed. The construct comprises a polymer selected from silica gel, fumed silica gel, silicic acid, disilicic acid, trisilicic acid, metasilicic acid, and orthosilicic...
|
|
|
6593301 |
Use of steroidal saponins for the prophylaxis or treatment of dementia, and novel steroidal saponin compounds
The invention relates to the steroidal saponin compounds for the propylaxis or treatment dementia, the new steroidal saponin compounds and the pharmaceutical composition containing the same.
|
|
|
6579525 |
Pharmaceutical compositions comprising erythropoietin for treatment of cancer
Pharmaceutical compositions comprising erythropoietin are provided for treatment of cancer, particularly for treatment of multiple myeloma. Erythropoietin was found to be effective for inhibition...
|
|
|
6576676 |
Means for the modulation of processes mediated by retinold receptors and compounds useful therefor
In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In...
|
|
|
6576242 |
Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides and atherosclerosis
This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q 10 , and chromium, with or without inositol hexanicotinate, selenium, and mixed...
|
|
|
6566086 |
Diagnostic kit for detecting creatine levels
Methods for the detection of creatine compound levels in body fluid samples are discussed. Portable kits capable of determining creatine levels using non-invasive and visually detectable methods...
|
|
|
6562347 |
Chemokine-tumor antigen fusion proteins as cancer vaccines
The present invention provides a fusion polypeptide comprising a chemokine and either a tumor or viral antigen which is administered as either a protein or nucleic acid vaccine to elicit an immune...
|
|
|
6551578 |
Modulated release particles for aerosol delivery
A modulated release aerosol formulation is disclosed. The formulation comprises a polysaccharide polymer having a selected medicament associated therewith, a fluid carrier for carrying and...
|
|
|
6551989 |
Preventing airway mucus production by administration of EGF-R antagonists
Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic...
|
|
|
6552007 |
Use of somatostatin analogs for the delivery of anti-tumor drugs to tumor cells
A conjugate of somatostatin-spacer-drug and a method of making the same. The conjugate can be used to enhance an anti-cancer drug's specificity on the targeted tumor cells, thus increasing its...
|
|
|
6544959 |
High affinity nucleic acid ligands to lectins
This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin...
|
|
|
6541005 |
Compositions and methods for reducing or controlling blood cholesterol, lipoproteins, triglycerides and atherosclerosis
This invention provides compositions and methods related to the administration of red yeast rice, coenzyme Q 10 , and chromium, with or without inositol hexanicotinate, selenium, and mixed...
|
|
|
6537964 |
Reversal of multidrug resistance in human colon carcinoma cells
The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects...
|
|
|
6528259 |
Methods for detecting human methylenetetrahydrofolate reductase allelic variants
Provided herein is a heretofore unknown isolated nucleic acid molecule which encodes human methylenetetrahydrofolate reducatase, along with an amino acid sequence of methylenetetrahydrofolate...
|
|
|
6524571 |
Methioninase gene therapy for tumor treatment
A depletion method to inhibit tumor growth includes introducing a viral expression system capable of expressing methioninase or a fusion protein containing methioninase into a tumor contained in a...
|
|
|
6509153 |
Genetic markers of toxicity preparation and uses
The present invention describes new methods for the determination of the potential toxicity of test compounds, as well as the kits and tools for the implementation of these methods. The invention...
|
|
|
6498145 |
Use of purified SDG as a hypotensive (vasodilator) agent
The compound secoisolariciresinol diglucoside (SDG), obtained from flaxseed is used for treating hypertension or for reducing or preventing the development of elevated blood pressure in humans or...
|
|
|
6495523 |
Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration
Anticonvulsant compounds of the general formula I: where X, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as...
|