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8168568 |
Combinatorial therapy for protein signaling diseases
A method for selecting combinations of drugs for treatment of diseases that arise from deranged signaling pathways is disclosed. The method involves measuring the activity states for signaling...
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8119572 |
Methods for determining protein binding specificity using peptide libraries
A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase...
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8105982 |
Aptamers and methods for their in vitro selection and uses thereof
The present method is an improved in vitro selection protocol that relies on magnetic separations for DNA aptamer production that is relatively easy and scalable without the need for expensive...
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8101553 |
Antibody library
An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because...
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8088715 |
Detection of circulating tumor cells in peripheral blood with an automated scanning fluorescence microscope
An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
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8084399 |
Process for screening of a binding amphiphilic peptides specific for hairpin RNA
The present invention relates to a screening method of an amphiphilic peptide specifically binding to hairpin RNA, more precisely a screening method of an amphiphilic peptide having specificity and...
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8076083 |
Screening methods involving the detection of short-lived proteins
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter...
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8071289 |
Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
A method to make libraries of hybrid polynucleotide molecules of two parental polynucleotide molecules utilizing single-stranded DNA was invented. Example of the method comprises several steps: (i)...
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8067339 |
Surface display of whole antibodies in eukaryotes
Methods for display of recombinant whole immunoglobulins or immunoglobulin libraries on the surface of eukaryote host cells, including yeast and filamentous fungi, are described. The methods are...
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8058072 |
Microanalysis measuring apparatus and microanalysis measuring method using the same
This invention provides a measuring apparatus for microanalysis, which can be simply manufactured and can realize a number of analyses and measurements in a small analyte amount and particularly...
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8058022 |
Diagnosis and monitoring of mycobacterium tuberculosis infection
Disclosed are methods for detecting protein complexes of sigma factors and interacting proteins in a sample containing Mycobacterium tuberculosis. Such methods are useful for the diagnosis and/or...
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8053195 |
Isolated genomic nucleic acid molecules obtainable from chromosome 1p21-p13 that encode human RhoC
The invention is directed to an isolated genomic nucleic acid molecule fragment that encodes human RhoC, vectors and hosts containing the fragment and fragments hybridizing to noncoding regions as...
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8034571 |
Microbial polynucleotides expressed during infection of a host
Disclosed are methods for obtaining antigens that are expressed by pathogenic microorganism during an infection process, as well as the antigens so obtained. Also disclosed are isolated...
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8026110 |
Combinatorial rosamine library and uses thereof
The present invention relates to a rosamine derivative compound, as described herein, having the following structure: Also disclosed are methods of making such compounds and for using them for...
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7999070 |
Process for screening of a binding peptide specific for specific RNA and RNA binding peptides therefrom
The present invention relates to a screening method for RNA specific binding peptide using alpha-helical peptides. The screening method for RNA specific binding peptide of the present invention...
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7994096 |
Method for antigen-specific stimulation of T lymphocytes with synthetic peptide libraries
The invention relates to a method for the antigen-specific stimulation of T-lymphocytes with a synthetic peptide library, by preparing a plurality of peptides, each of said peptides comprising a...
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7985546 |
Genomic library construction
Compositions and methods for amplifying nucleic acid sequences from a single cell are provided. Compositions and methods for constructing a genomic library from a single cell are also provided.
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7985550 |
Methods of isolating methylated CpG islands
Provided is a method for isolating methylated CpG islands. The method includes identifying an imprinted gene adjacent to the methylated CpG island, and identifying a disease which is preferentially...
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7981601 |
Method of preparing polyepitope chimeric gene vaccine
The invention relates to a method for preparing polyepitope chimeric gene vaccines, designated as Epitopes Assemble Library Immunization (EALI). It involves the construction of expression libraries...
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7981614 |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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7981843 |
Antibody specificity transfer using minimal essential binding determinants
The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal...
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7981842 |
Method for detecting transcription factor-protein interactions
A method is provided for identifying complexes between a transcription factor and another protein, such as another different transcription factor. The method includes the steps of isolating from a...
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7977279 |
Differential phage capture proteomics
Disclosed herein are methods for identifying, isolating and comparing proteins and other biomolecules differing between two complex biological samples using affinity chromatography and phage...
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7968287 |
In vitro evolution in microfluidic systems
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into...
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7964534 |
Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes
The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds...
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7951959 |
Hydrophilic labels for biomolecules
Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labeling biomolecules such as protein and deoxyribonucleic acid for their detection and...
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7943303 |
Method for engineering strand-specific nicking endonucleases from restriction endonucleases
Methods are provided for engineering novel strand-specific nicking endonucleases by means of an in vivo enrichment of a plasmid library containing a randomly mutagenized restriction endonuclease...
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7932022 |
Dual-labeled molecular constructs for detection of biochemical reactions
The present invention relates to molecular constructs and methods of their use in detecting biochemical reactions. In particular, the invention relates to a molecular construct having a capture...
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7932212 |
Inhibition of placenta growth factor (PlGF) mediated metastasis and/or angiogenesis
The present invention concerns methods and compositions for inhibiting angiogenesis and/or tumor growth, survival and/or metastasis. In particular embodiments, the methods and compositions may...
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7932213 |
Small molecule printing
The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. A composition is...
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7919259 |
Methods for identification, and compounds useful for the treatment of degenerative and inflammatory diseases
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or...
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7919436 |
Sequences for differential diagnostic of Ehrlichia ruminantium and use thereof
The invention provides genes that are unique either to Ehrlichia ruminantium strain Gardel or to Ehrlichia ruminantium strain Welgevonden, or allelic couples which are present in both strains but...
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7893008 |
Oligonucleotides, arrays thereof for detecting microorganisms, and an apparatus, a method and a kit for detecting microorganisms
The present invention relates to an instrument, a method and a kit for detecting a microorganism contaminating a subject test sample, which enables one to quickly and accurately identify the...
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7893007 |
Directed evolution of novel binding proteins
In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal...
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7879765 |
Method and apparatus for detecting bio-chip by using phase-change
A biochip and a biochip scanning method and apparatus using phase changes are provided, wherein a laser beam is radiated to a biochip having immobilized probes placed thereon to cause a phase...
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7858559 |
In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy...
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7833942 |
Methods for simplifying microbial nucleic acids by chemical modification of cytosines
A method for simplification of a microbial genome or microbial nucleic acid comprising treating microbial genome or nucleic acid with an agent that modifies cytosine to form derivative microbial...
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7829502 |
Systems and methods for nuclease-assisted selection and acquisition of single stranded DNA oligomer/polymer aptamers/ligands
A method for identifying aptamers that bind to target molecules may include contacting an oligonucleotide library with target molecule and digesting unbound oligonucleotides with one or more...
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7824895 |
Phytases, nucleic acids encoding them and methods for making and using them
The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from...
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7820413 |
Incrementally truncated nucleic acids and methods of making same
A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all...
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7790378 |
Screening methods involving the detection of short-lived proteins
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter...
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7790367 |
Method for screening a library of VHH polypeptides
There are provided methods for screening a library of VHH polypeptides for VHH polypeptides that bind to an antigen including subjecting a library of VHH polypeptides to antigen-affinity selection...
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7772388 |
Inhibition of metallo-β-lactamase
A method to identify a high affinity nucleic acid ligand to inhibit the activity of a lactamase enzyme. The method comprises several steps that initially involve preparing a candidate mixture of...
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7749957 |
Clay-binding peptides and methods of use
Combinatorially generated peptides are provided that have binding affinity for clay. The peptides may be used to deliver benefit agents to various clay surfaces.
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7732377 |
Methods for producing members of specific binding pairs
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are...
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7723269 |
Process for selecting anti-angiogenesis antibody fragments, anti-angiogenesis antibody fragments thus obtained and their use
The invention describes a process for filter selection of anti-angiogenesis antibody fragments from a large combinatorial repertoire; the invention further relates to the anti-angiogenesis antibody...
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7718578 |
Method of synthesis and testing of combinatorial libraries using microcapsules
The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of...
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7718575 |
Method of selecting HLA-DP4 ligands and the applications thereof
A method of selecting a test molecule that binds to HLA-DP4 by (i) incubating HLA-DP4 with the test molecule and a labeled peptide of formula (I) Z1X1X2X3X4X5X6X7X8X9Z2 thereby forming respective...
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7713915 |
Cytotoxic heteromeric protein combinatorial libraries
A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit...
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7700273 |
Peptidomimetics that mimic a conformational-dependent neutralizing epitope of the human immunodeficiency virus (HIV) CCR5 coreceptor
The present invention relates, e.g., to an isolated peptide comprising a sequence of contiguous amino acids that is at least about 60% identical (e.g., at least about 60%, 65%, 70%, 75%, 80%, 85%,...
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