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7612019 |
Polypeptide display libraries and methods of making and using thereof
Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of...
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7592147 |
Modulation of IL-2 production by T-bet
The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that...
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7557070 |
Multiplexed cell analysis system
Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers.
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7550271 |
Detecting phospho-transfer activity
Disclosed are methods and reagents for detecting the presence of and/or activity of one or more phospho-transfer activities such as kinase, phosphatase, nucleotide cyclase, or phosphodiesterase...
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7544477 |
Circularly permutated, interaction-activated proteins
Interaction-activated circularly permutated proteins are disclosed that depend for their functional reassembly into the parent protein on the interaction of heterologous polypeptides or other...
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7534742 |
Isoprenoid biosynthesis
The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More...
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7528093 |
SCN3A locus for idiopathic generalized epilepsy, mutations thereof and method using same
The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome...
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7498409 |
Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
The present invention relates to novel screening methods for identifying agonists and antagonists of toll-like receptor (TLR) 7, TLR8 or TLR9. Methods are disclosed for identifying agonists and...
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7485855 |
On-probe sample cleanup system and method for MALDI analysis
A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least...
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7469036 |
Analysis of macromolecules, ligands and macromolecule-ligand complexes
A method for determining atomic level structures of macromolecule-ligand complexes through high-resolution powder diffraction analysis and a method for providing suitable microcrystalline powder...
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7442773 |
Universal peptide-binding scaffolds and protein chips
The present invention provides a universal peptide-binding scaffold. This scaffold is used to bind a target. The target can be a peptide or peptides of interest (for example, peptides associated...
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7442160 |
Evolving new molecular function
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for...
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7442159 |
Selection system
The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising...
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7413536 |
Substrates and screening methods for transport proteins
A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided....
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7371207 |
Estrogen receptor α regulated gene expression, related assays and therapeutics
A plurality of genes modulated by estrogen or other agents, such as hormones or combinations of hormones, in various types of tissue is described. One embodiment of the disclosure relates to a...
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7322927 |
Hybrid phthalocyanine derivatives and their uses
Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit...
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7297501 |
Method and devices for running reactions on a target plate for MALDI mass spectrometry
A peptide or protein microassay method and apparatus in which a wide variety of chromogenic or fluorogenic peptide or protein substrates of interest are individually suspended or dissolved in a...
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7258986 |
Intrabodies with defined framework that is stable in a reducing environment and applications thereof
A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined...
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7258985 |
Intrabodies with defined framework that is stable in a reducing environment and applications thereof
A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined...
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7252954 |
Sets of digital antibodies directed against short epitopes, and methods using same
The present invention relates generally to sets of digital antibodies directed against short epitopes, and use thereof in methods for protein analysis.
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7208279 |
Method for identifying inhibitors of G protein coupled receptor signaling
This invention relates to methods for identifying peptides and other compounds which block G protein coupled receptor mediated signaling with high affinity and specificity. Assays developed in...
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7118873 |
Polynucleotides encoding cellular transporters and methods of use thereof
This disclosure encompasses the Indy gene, polypeptides encoded by the Indy gene and fragments thereof. This disclosure also encompasses homologs of the Indy gene both from Drosophila and other...
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7063949 |
Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes
Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic...
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7033769 |
Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
A method for discovering one or more peptides adapted for specific binding to a microorganism of interest. The method comprises (i) identifying an antimicrobial peptide having antimicrobial...
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7033766 |
Construction and screening of lantibody display libraries
A sublancin peptide variant (lantibody) having a spacer region and a subtilin leader peptide fused to the C-terminal end of the mature sublancin peptide provide an anchoring means for inserting and...
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7018801 |
Selection of peptides with antibody-like properties
The present invention provides a highly sensitive screening assay for the identification of peptide binding partners to virtually any peptide or polypeptide ligand. Utilizing an...
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6972178 |
Drug screening using a proline-rich nuclear receptor co-regulatory protein/nuclear receptor co-expression system
Assays are presented for screening for chemicals which affect the binding between proteins comprising an SH3 binding motif and nuclear receptor proteins. PNRC (Proline-rich Nuclear Receptor...
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6929944 |
Analysis using a distributed sample
The present invention is directed to the production of a sample microarray for use in detecting one or more target biopolymers in the sample. The sample microarray of this invention is formed by...
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6924113 |
Method and kit for isolating DNA probes that bind to activated transcription factors
Methods, arrays and kits are provided for rapidly and efficiently identifying and quantifying multiple different activated transcription factors in a biological sample at the same time. In one...
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6924112 |
Cloning method by multiple-digestion, vectors for implementing same and applications
The present invention pertains to a process for isolating an intact clone of one target nucleic acid fragment having a known characteristic, from a group of fragments by preparing an initial...
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6924111 |
Microarray substrate comprising patterned photoresist film with spot regions, microarray, and method of detecting target material
Provided is a microarray substrate. The microarray substrate includes a patterned photoresist film having one or more spot regions therein. The photoresist film can be detached from the substrate.
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6924109 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6913882 |
Methods of screening for B cell activity modulators
The invention provides for the identification of all genes, whether known or novel, which are differentially expressed within and among B cells, making possible the characterization of their...
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6897029 |
MCK-10 a novel receptor tyrosine kinase
The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of...
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6893827 |
Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation
Methods for detecting G-protein coupled receptor (GPCR) activity; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G-protein-coupled receptor kinase (GRK) activity, and...
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6878524 |
Reagents and methods for detection and characterization of protein-protein interactions, nuclear export and localization sequences and inducible Gal4p-mediated gene expression in yeast
This invention provides methods for cytoplasmic detection of protein—protein interactions, nuclear export/localization sequences, and galactose-independent inducible Gal4 p -mediated gene...
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6875619 |
Microfluidic devices comprising biochannels
The present invention is directed to a variety of microfluidic devices with configurations including the use of biochannels or microchannels comprising arrays of capture binding ligands to capture...
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6861229 |
Method of identifying a gene product
The present invention provides a method of identifying a gene product. The method comprises providing a multiplicity of cells comprising a first gene product. Preferably, the first gene product is...
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6846634 |
Method to screen phage display libraries with different ligands
The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in...
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6821737 |
Method for screening for drug candidates for modulating transcription factor activity
Method and kits are provided for screening for transcription factor modulators efficiently. In one aspect, the method can be employed to profile multiple, different transcription factors activated...
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6818410 |
Methods of isolating RNA-binding proteins and compositions related to the same
The present invention discloses a general in vitro method for isolating proteins that bind to specific RNA regulatory elements. The method employs a lyt-lys bacteriophage display library and a host...
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6811969 |
Retentate chromatography—profiling with biospecific interaction adsorbents
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6797480 |
Purification of heat shock/stress protein cell surface receptors and their use as immunotherapeutic agents
The present invention relates to receptors for heat shock proteins (HSPs), such as gp96, Hsp70 and Hsp90. The heat shock receptor is associated with the cell membranes of a subset of antigen...
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6794144 |
Methods and materials for generating SH3 domains with tailored binding properties
The present invention relates to controlled modification of Src homology region 3 (SH3) domains by using random manipulation of the non-conserved region of SH3 RT-loop. Consequently, the invention...
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6777190 |
Crosstalk inhibitors and their uses
Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample....
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6756224 |
Device for receiving a chip shaped carrier and process for assembling a plurality of such devices
A device for receiving a chip shaped carrier having an active surface, e.g. a surface which carries an array of DNA oligonucleids and which is adapted to be read by an electro-optical reading...
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6737241 |
Methods for screening for transdominant intracellular effector peptides and RNA molecules
Methods and compositions for screening for intracellular transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
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6733977 |
Hybridization device and method
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO...
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6723517 |
Use of self-assembled monolayers to probe the structure of a target molecule
Weak binding motifs were transformed into a high affinity ligand surface by using a heterologous self-assembled monolayer (SAM) as a rigid scaffold to present discrete binding moieties, in a...
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6723235 |
Apparatus for screening compound libraries
Disclosed are apparatus for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target...
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