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7592440 |
Methods of obtaining active antisense compounds
Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense...
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7516018 |
Structural unit analysis
A computer implemented method is disclosed for analyzing a large data set of chemical compounds for which there is a measured activity in the same assay for each compound to determine the...
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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7416524 |
System, method and computer program product for fast and efficient searching of large chemical libraries
A system, method, and computer program product for fast and efficient searching of large virtual combinatorial libraries based on a fitness function. According to the method of the present...
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7329222 |
Comparative field analysis (CoMFA) utilizing topomeric alignment of molecular fragments
The static and electrostatic interaction energy fields between probe atoms and the atoms of a topomerically aligned fragment placed in a three-dimensional grid may be used to derive a CoMFA model....
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7169563 |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
Methods for identifying a member of a mass-coded molecular library, which is a ligand for a biomolecule and binds to the biomolecule at the binding site of a known second ligand for the biomolecule...
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6763309 |
Method and system for the development of materials
A catalyst development engine (CDE) provides a rapid approach to the rational development of scalable heterogeneous catalysts and of high-performance solid materials. The CDE includes three main...
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6625546 |
Structure identification methods using mass measurements
Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following...
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6535824 |
Sensor array-based system and method for rapid materials characterization
A modular materials characterization apparatus includes a sensor array disposed on a substrate, with a standardized array and contact pad format; electronic test and measurement apparatus for...
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6245517 |
Ratio-based decisions and the quantitative analysis of cDNA micro-array images
Gene expression can be quantitatively analyzed by hybridizing fluor-tagged mRNA to targets on a cDNA micro-array. Comparison of gene expression levels arising from co-hybridized samples is achieved...
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6240374 |
Further method of creating and rapidly searching a virtual library of potential molecules using validated molecular structural descriptors
The problem of how to select out of a large chemically accessible universe molecules representative of the diversity of that universe is resolved by the discovery of a method to validate molecular...
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6230102 |
Computer system and process for identifying a charge distribution which minimizes electrostatic contribution to binding at binding between a ligand and a molecule in a solvent and uses thereof
The present computer-implemented process involves a methodology for determining properties of ligands which in turn can be used for designing ligands for binding with protein or other molecular...
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6132969 |
Methods for testing biological network models
The present invention provides methods and systems for testing and confirming how well a network model represents a biological pathway in a biological system. The network model comprises a network...
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6068977 |
Method and system for sequencing genomes
The present invention pertains to a method for sequencing genomes. The method comprises the steps of obtaining nucleic acid material from a genome. Then there is the step of constructing a clone...
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6061636 |
Technique for representing combinatorial chemistry libraries resulting from selective combination of synthons
A computer-implemented method and apparatus are provided for the generation and representation of combinatorial chemical libraries produced by a series of chemical reaction stages, each stage...
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5684711 |
System, method, and computer program for at least partially automatically generating chemical compounds having desired properties
A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity...
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