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7566685 |
Methods and compositions for screening using diphtheria toxin constructs
The invention relates to methods and compositions utilizing diphtheria toxin for screening purposes. The invention is particularly useful in screening for modulators of IgE synthesis, secretion and...
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7442159 |
Selection system
The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising...
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7377894 |
Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for...
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6573110 |
Combinatorial chemistry system and method of use
A combinatorial chemistry system allows for the dual processing of different molecules coated on a library of beads. The system includes beads coated with different molecules on each bead, a bead...
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6562594 |
Saturation mutagenesis in directed evolution
Disclosed is a rapid and facilitated method of producing from a parentlal template polynucleotide, a set of mutagenized progeny polynculeotides whereby at each original codon position there is...
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6558902 |
Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules
Mixtures containing a biological macromolecule, such as a nucleic acid molecule or a polypeptide, and a liquid matrix, which absorbs infrared (IR) radiation, are provided. These mixtures are useful...
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6413431 |
HPLC method for purifying organic compounds
An HPLC method which purifies and/or characterizes large numbers of related compounds, for example, those prepared for use in combinatorial libraries, is disclosed. The compounds are purified on a...
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6387628 |
Mass spectrometric detection of polypeptides
A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for...
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6218118 |
Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
Methods and reagents are disclosed which satisfy the need for more sensitive, more accurate and higher through-put analyses of target nucleic acid sequences. The methods and reagents may be...
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6177280 |
Ricin inhibitors and methods for use thereof
Ricin A-chain is an N-glycosidase that attacks ribosomal RNA at a highly conserved adenine residue. Crystallographic studies show that not only adenine and formycin, but also pterin-based rings can...
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6090280 |
High-throughput apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures
A method and apparatus for high-throughput identity confirmation, quantitation and purity determination of a compound of interest in a mixture of compounds is disclosed. According to the method, a...
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6043024 |
Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
The present invention provides a process for identifying compounds which bind to a specific target molecule. The process comprises the steps of: a) generating a first T 2 - or diffusion-filtered...
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5993662 |
Method of purifying and identifying a large multiplicity of chemical reaction products simultaneously
The invention provides a system utilizing computer databases, high pressure liquid chromatography and mass spectrometry to isolate, purify and identify compounds present in a chemical library of...
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5866430 |
Raman optrode processes and devices for detection of chemicals and microorganisms
A methodology and devices for detecting or monitoring or identifying chemical or microbial analytes are described. The methodology comprises four basic steps: (1) The gas or liquid medium to be...
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5804390 |
Use of nuclear magnetic resonance to identify ligands to target biomolecules
The present invention provides a process for identifying compounds which bind to a specific target molecule. The process includes the steps of a) generating a first two-dimensional 15 N/ 1 H NMR...
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5470753 |
Peptide sequencing using mass spectrometry
The present invention relates to methods for determining the amino acid composition, and more preferably the sequence, of a peptide using mass spectrometric techniques. The method is particularly...
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