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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7485855 |
On-probe sample cleanup system and method for MALDI analysis
A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least...
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7282491 |
Prokaryotic proteasomal proteases of Mycobacterium tuberculosis (MTB) as targets for antibiotic therapy
The present invention relates to methods of treating Mycobacterium pathogen infection in a subject that involve: inhibiting proteasomal activity in a pathogen under conditions effective to make...
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6623922 |
Methods for identifying, characterizing, and evolving cell-type specific CIS regulatory elements
The invention provides methods for efficient and rapid identification of cis-acting nucleic acid sequences that act in a cell-type specific manner to stimulate or repress the expression of linked...
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6607885 |
Method for high-density microarray medicated gene expression profiling
The global effect on genes under different environmental conditions can be determined by a comprehensive gene expression profile. The present invention provides a method to monitor the changes in...
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6605430 |
DNA shuffling of monooxygenase genes for production of industrial chemicals
This invention provides improved monoxygenases, dehydrogenases, and transferases that are useful for the biocatalytic synthesis of compounds such as α-hydroxycarboxylic acids, and aryl- and...
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6605258 |
High throughput screening method, array assembly and system
A liquid chemical stripping or cleaning solution is selected by combinatorial high throughput screening. A high throughput screening well array assembly includes (A) a metal substrate and (B) a...
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6492184 |
Automated sampling methods with integral serial sample preparation for rapid characterization of polymers
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems...
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6472150 |
Sifter screening to identify biologically active molecules
A novel single-insect feeding, testing and recovery (SIFTER) strategy is described for screening and isolating biomolecules that exert a desired biological activity in arthropods, preferably...
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6410248 |
General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
The present invention provides methods for making zinc finger proteins with high affinity for their targets, by sequentially selecting each finger of the protein.
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6221597 |
Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferative drugs
The present invention relates to genes in Saccharomyces cerevisiae which are essential for germination and proliferation of S. cerevisiae and using the identified genes or their encoded proteins as...
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6083695 |
Optimized primer library for gene sequencing and method of using same
A novel method of primer walking using octamer oligonucleotides to prime DNA sequencing reactions is described. Octamer sequencing is compatible with isotopic and fluorescent sequencing chemistry,...
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6022691 |
Determination of oligonucleotides for therapeutics, diagnostics and research reagents
Oligonucleotides which selectively bind to target biomolecules are determined by in vitro assay of a pool of random oligonucleotides for activity against the biomolecules, followed by recovery and...
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5968740 |
Method of Identifying a Base in a Nucleic Acid
Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution,...
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5928868 |
Three hybrid screening assay
Methods and a kit are provided for characterizing small molecules from a library of small molecules or alternatively identifying protein targets to which known small molecules bind. The methods...
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5866334 |
Determination and identification of active compounds in a compound library
Libraries of compounds such as nucleic acids or peptides are contacted with a target molecule and libraries that have at least one compound that bind with at least a minimum activity are determined...
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5853991 |
PCR-based cDNA subtractive cloning method
A process is described in which PCR-based cDNA libraries with anchored ends are made, a PCR-based cDNA subtracted (PCSUB) library is produced therefrom, and the ends of a cDNA clone are isolated,...
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5792613 |
Method for obtaining RNA aptamers based on shape selection
RNA molecules are selected from a random sequence library for their ability to bind to a selecting nucleic acid structural element. Selection of RNA aptamers with extensive Watson-Crick...
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5672472 |
Synthetic unrandomization of oligomer fragments
Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled subunits are provided. The disclosed methods involve...
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5670312 |
Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease
Antibodies are recovered and isolated from the sera of a number "n" of patients each of which have or have had the same given disease so that each of the "n" patients has, within a large number of...
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5574656 |
System and method of automatically generating chemical compounds with desired properties
A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity...
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5565325 |
Iterative methods for screening peptide libraries
Peptides which bind to selected ligands are identified by screening peptide libraries which encode a random or controlled collection of amino acid sequences. A rapid and convenient iterative...
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5556762 |
Scanning synthetic peptide combinatorial libraries: oligopeptide mixture sets having a one predetermined residue at a single, predetermined position, methods of making and using the same
Synthetic peptide combinatorial libraries (sets) having a single, predetermined amino acid residue at a single, predetermined oligopeptide chain position and mixtures of amino acid residues at the...
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