|
Match
|
Document |
Document Title |
|
|
7960313 |
Combinatorial processing including stirring
Combinatorial processing including stirring is described, including defining multiple regions of a substrate, processing the multiple regions of the substrate in a combinatorial manner, introducing...
|
|
|
7795182 |
Method for making biochips
A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.
|
|
|
7687043 |
Heat block assembly and organic compound synthesizing apparatus using the heat block assembly
A heat block assembly and an organic compound synthesizing apparatus using the heat block assembly are provided. The heat block assembly includes one or more heat blocks provided with grooves in...
|
|
|
7468280 |
High throughput preparation of lubricating oil compositions for combinatorial libraries
A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided....
|
|
|
7465545 |
Microfluidic chip and manipulating apparatus having the same
Provided are a microfluidic chip and a microfluidic manipulating apparatus including the same. The microfluidic chip includes at least one microfluidic manipulating unit formed in a substrate. The...
|
|
|
7390622 |
Apparatus and methods for detecting nucleic acid in biological samples
There are disclosed apparatus and methods for the field-assisted acceleration of biological processes involving charged entities, including in particular the detection of target DNA in a biological...
|
|
|
7358051 |
Liquid flow actuation and suspension manipulation using surface tension gradients
Disclosed herein is a method of collecting suspensions in a liquid film including the steps of developing a variation in surface tension at a gas-liquid interface of the liquid film to generate a...
|
|
|
7195872 |
High surface area substrates for microarrays and methods to make same
The present invention is directed to a substrate having a plurality of microfeatures that provide a high surface area and are open to provide ready access to fluids and components therein. Methods...
|
|
|
6998230 |
Array fabrication with drop detection
A drop deposition apparatus, and a method and computer program products using the drop deposition apparatus, for fabricating at least one addressable array of biopolymers on a substrate. The drop...
|
|
|
6936474 |
Method and apparatus for manufacturing biochip
A method and apparatus for manufacturing biochips. The apparatus includes a conveying device and a series of dispensers positioned at a series of dispensing positions above the conveying device. At...
|
|
|
6902704 |
Injection pump assembly for a combinatorial reactor and related method
An injection pump assembly 10 in a chemical delivery system for simultaneously delivering reagents into a combinatorial reactor system having multiple injectors. The assembly 10 has a plurality of...
|
|
|
6900047 |
Apparatus for coating a substrate quickly and uniformly with a small volume of fluid
A method is provided for applying a fluid onto a surface of a solid substrate. The method employs a distribution member having an upper surface and a lower surface, and including a permeable...
|
|
|
6893613 |
Parallel chemistry reactor with interchangeable vessel carrying inserts
The base of the modular reactor includes a frame which defines an opening into which one of a plurality of interchangeable reaction vessel carrying inserts can be removeably received. Each insert...
|
|
|
6872535 |
Three-dimensional array of supports for solid-phase parallel synthesis and method of use
A three-dimensional (3D) array of solid-phase supports is adapted to provide parallel synthesis of a library of molecules with 3D diversity. Individual locations in the 3D array may be assigned to...
|
|
|
6872359 |
Pressure variation in array fabrication
A method, apparatus and computer program product, for fabricating an array of biopolymers on a substrate. The method uses a biopolymer or biomonomer fluid and a drop dispenser having a chamber into...
|
|
|
6866825 |
Micro-dispenser for biochemical analysis
A micro-dispenser for dispensing predetermined amounts of fluids under the control of a controller. The micro-dispenser comprises a base and a high-density array of tube assemblies. The base,...
|
|
|
6867050 |
Apparatus and methods for chemical synthesis
Apparatuses and methods are described for parallel oligonucleotide synthesis of hundreds of different sequences and lengths at a time. Standard phosphoramidite chemistry is employed. The syntheses...
|
|
|
6855538 |
High-efficiency microarray printing device
This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing dev...
|
|
|
6846454 |
Fluid exit in reaction chambers
Apparatus and methods are disclosed for controlling flow of fluid inside a chamber. A device comprises a chamber comprising at least one wall, a first opening for introducing a fluid into the...
|
|
|
6827113 |
Massively parallel fluid dispensing systems and methods
The present invention provides highly automated fluid delivery systems and related methods with significantly improved throughput relative to preexisting technologies. In particular, the invention...
|
|
|
6828143 |
Nanoscale chemical synthesis
A modular reactor system and method for synthesizing nanoscale quantities of chemical compounds characterized by a continuous flow reactor under high pressure having uniform temperature throughout...
|
|
|
6825048 |
Combinational method for microgram-scale production and characterization of crystalline and amorphous libraries of materials
The present invention relates to a method for the wet chemical preparation of materials libraries consisting of a large number of solids, the solids being deposited from reaction mixtures in...
|
|
|
6815015 |
Jetting behavior in the laser forward transfer of rheological systems
A method for laser transfer and deposition of a rheological fluid wherein laser energy strikes a target substrate comprising a rheological fluid, causing a portion of the rheological fluid to...
|
|
|
6808934 |
High-throughput biomolecular crystallization and biomolecular crystal screening
The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization...
|
|
|
6776963 |
Multiple parallel catalytic reactor assembly
A multiple parallel catalytic reactor assembly has been developed. The assembly has (1) a plurality of vessels for containing catalyst, each vessel having an open end and a fluid permeable end; (2)...
|
|
|
6770245 |
Multiple parallel processing assembly
A multiple parallel processing assembly has been developed. The assembly has (1) a plurality of vessels for containing material, each vessel having an open end and a fluid permeable end (2) a...
|
|
|
6758951 |
Synthesis and characterization of materials for electrochemical cells
An apparatus including a basis that has a plurality of wells associated therewith for defining a plurality of electrochemical cells; at least two electrodes sealingly disposed in each...
|
|
|
6753449 |
Cleavable linker for solid phase synthesis
Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of...
|
|
|
6723555 |
Multi-sample fermentor and method of using same
A fermentation apparatus is constructed to produce a known and repeatable amount of untainted fermentation product using multiple fermentation vessels. To facilitate further processing compatible...
|
|
|
6696298 |
Multi-channel reagent dispensing apparatus
Embodiments of the present invention are directed to an improved chemical synthesis apparatus for performing chemical synthesis such as nuclei acid synthesis in a plurality of reaction wells or...
|
|
|
6692701 |
Microarrayer
A device for providing incremental translation in multiple directions, having a base plate (3), a first plate (1), a second plate (2) and means for translation, such as differentially spaced holes...
|
|
|
6689218 |
Systems for the deposition and curing of coating compositions
Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating...
|
|
|
6682703 |
Parallel reaction devices
The present invention relates to parallel reaction devices that include reaction blocks having arrays of reaction wells. Devices of the invention also typically include lids having arrays of...
|
|
|
6672344 |
Robotic system having positionally adjustable multiple probes
An array of probes is provided wherein the probes are maintained in place in bores extending through a housing by a friction force applied to the probes. The friction force can be overcome by...
|
|
|
6632655 |
Manipulation of microparticles in microfluidic systems
Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets...
|
|
|
6612686 |
Focused acoustic energy in the preparation and screening of combinatorial libraries
The present invention provides a method for the acoustic ejection of fluid droplets from each of a plurality of fluid-containing reservoirs to prepare combinatorial libraries in the form of...
|
|
|
6605257 |
Micro array manufacturing apparatus
A present micro array manufacturing apparatus includes a substrate placement portion 11 on which a plurality of substrates can be arranged, a tighter plate 12 for storing a solution including a...
|
|
|
6600031 |
Methods of making nucleic acid or oligonucleotide arrays
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
|
|
|
6599755 |
Method and device for applying small quantities of liquid
The present invention relates to a method of depositing small amounts of liquid on a substrate (13) by using a pipette tip (1), which is connected to a flexible delivery line (2). Liquid is taken...
|
|
|
6600016 |
Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same
Multifunctionalized support resin for the solid phase synthesis of combinatorial libraries is disclosed. The support resin comprises a resin backbone to which is attached a template containing at...
|
|
|
6589739 |
Biopolymer array inspection
A method of fabricating a biopolymer array, and an apparatus which can execute the method, droplets of fluid carrying the biopolymer or a biomonomer are deposited onto a front side of a transparent...
|
|
|
6589726 |
Method and apparatus for in situ synthesis on a solid support
The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for...
|
|
|
6558633 |
Chemical reaction apparatus and methods
Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical...
|
|
|
6544334 |
Systems and methods for the deposition and curing of coating compositions
Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating...
|
|
|
6537504 |
Method and apparatus for concurrent and sequential multi-step reactions for producing a plurality of different chemical compounds
The present invention is a method and an apparatus to provide a dynamic matrix system for synthesizing a plurality of chemical compounds simultaneously, i.e. in parallel, and to synthesize a series...
|
|
|
6534307 |
Frozen tissue microarrayer
A device particularly suited for constructing frozen tissue microarrays. The device comprises: a cooling chamber for receiving at least one frozen material and for maintaining the frozen material...
|
|
|
6479301 |
Methods for fabricating an array for use in multiplexed biochemical analysis
The invention provides devices for preparing a reaction substrate for use as an assay device, and methods of using these devices. The devices prepare reaction substrates comprising arrays of...
|
|
|
6458583 |
Method and apparatus for making nucleic acid arrays
Methods and devices for depositing a nucleic acid on a substrate surface are provided. In the subject methods, a thermal inkjet head loaded with nucleic acid fluid composition is positioned in...
|
|
|
6395559 |
Multiple fluid sample processor with single well addressability
A method for single well addressability in a sample processor with row and column feeds. A sample processor or chip has a matrix of reservoirs or wells arranged in columns and rows. Pressure or...
|
|
|
6376256 |
Rapid process for arraying and synthesizing bead-based combinatorial libraries
A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive...
|