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7579192 |
High throughput screening methods for lubricating oil compositions
A method for determining storage stability for a plurality of fluid lubricant samples of different compositions is provided. Each sample includes one or more lubricating oil additives, or a...
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7468280 |
High throughput preparation of lubricating oil compositions for combinatorial libraries
A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided....
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6936474 |
Method and apparatus for manufacturing biochip
A method and apparatus for manufacturing biochips. The apparatus includes a conveying device and a series of dispensers positioned at a series of dispensing positions above the conveying device. At...
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6935727 |
Pulse jet print head assembly having multiple reservoirs and methods for use in the manufacture of biopolymeric arrays
Pulse jet printhead assemblies having multiple reservoirs and multiple printhead dies, as well as methods for their use in the deposition of fluids, typically fluids containing a biopolymer or...
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6902704 |
Injection pump assembly for a combinatorial reactor and related method
An injection pump assembly 10 in a chemical delivery system for simultaneously delivering reagents into a combinatorial reactor system having multiple injectors. The assembly 10 has a plurality...
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6900047 |
Apparatus for coating a substrate quickly and uniformly with a small volume of fluid
A method is provided for applying a fluid onto a surface of a solid substrate. The method employs a distribution member having an upper surface and a lower surface, and including a permeable...
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6893613 |
Parallel chemistry reactor with interchangeable vessel carrying inserts
The base of the modular reactor includes a frame which defines an opening into which one of a plurality of interchangeable reaction vessel carrying inserts can be removeably received. Each insert...
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6872535 |
Three-dimensional array of supports for solid-phase parallel synthesis and method of use
A three-dimensional (3D) array of solid-phase supports is adapted to provide parallel synthesis of a library of molecules with 3D diversity. Individual locations in the 3D array may be assigned to...
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6872359 |
Pressure variation in array fabrication
A method, apparatus and computer program product, for fabricating an array of biopolymers on a substrate. The method uses a biopolymer or biomonomer fluid and a drop dispenser having a chamber into...
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6867050 |
Apparatus and methods for chemical synthesis
Apparatuses and methods are described for parallel oligonucleotide synthesis of hundreds of different sequences and lengths at a time. Standard phosphoramidite chemistry is employed. The syntheses...
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6866825 |
Micro-dispenser for biochemical analysis
A micro-dispenser for dispensing predetermined amounts of fluids under the control of a controller. The micro-dispenser comprises a base and a high-density array of tube assemblies. The base,...
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6855538 |
High-efficiency microarray printing device
This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing...
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6846454 |
Fluid exit in reaction chambers
Apparatus and methods are disclosed for controlling flow of fluid inside a chamber. A device comprises a chamber comprising at least one wall, a first opening for introducing a fluid into the...
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6828143 |
Nanoscale chemical synthesis
A modular reactor system and method for synthesizing nanoscale quantities of chemical compounds characterized by a continuous flow reactor under high pressure having uniform temperature throughout...
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6827113 |
Massively parallel fluid dispensing systems and methods
The present invention provides highly automated fluid delivery systems and related methods with significantly improved throughput relative to preexisting technologies. In particular, the invention...
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6825048 |
Combinational method for microgram-scale production and characterization of crystalline and amorphous libraries of materials
The present invention relates to a method for the wet chemical preparation of materials libraries consisting of a large number of solids, the solids being deposited from reaction mixtures in...
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6815015 |
Jetting behavior in the laser forward transfer of rheological systems
A method for laser transfer and deposition of a rheological fluid wherein laser energy strikes a target substrate comprising a rheological fluid, causing a portion of the rheological fluid to...
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6808934 |
High-throughput biomolecular crystallization and biomolecular crystal screening
The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization...
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6776963 |
Multiple parallel catalytic reactor assembly
A multiple parallel catalytic reactor assembly has been developed. The assembly has (1) a plurality of vessels for containing catalyst, each vessel having an open end and a fluid permeable end; (2)...
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6770245 |
Multiple parallel processing assembly
A multiple parallel processing assembly has been developed. The assembly has (1) a plurality of vessels for containing material, each vessel having an open end and a fluid permeable end (2) a...
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6758951 |
Synthesis and characterization of materials for electrochemical cells
An apparatus including a basis that has a plurality of wells associated therewith for defining a plurality of electrochemical cells; at least two electrodes sealingly disposed in each...
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6753449 |
Cleavable linker for solid phase synthesis
Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of...
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6723555 |
Multi-sample fermentor and method of using same
A fermentation apparatus is constructed to produce a known and repeatable amount of untainted fermentation product using multiple fermentation vessels. To facilitate further processing compatible...
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6696298 |
Multi-channel reagent dispensing apparatus
Embodiments of the present invention are directed to an improved chemical synthesis apparatus for performing chemical synthesis such as nuclei acid synthesis in a plurality of reaction wells or...
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6692701 |
Microarrayer
A device for providing incremental translation in multiple directions, having a base plate ( 3 ), a first plate ( 1 ), a second plate ( 2 ) and means for translation, such as differentially spaced...
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6689218 |
Systems for the deposition and curing of coating compositions
Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating...
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6682703 |
Parallel reaction devices
The present invention relates to parallel reaction devices that include reaction blocks having arrays of reaction wells. Devices of the invention also typically include lids having arrays of...
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6672344 |
Robotic system having positionally adjustable multiple probes
An array of probes is provided wherein the probes are maintained in place in bores extending through a housing by a friction force applied to the probes. The friction force can be overcome by...
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6632655 |
Manipulation of microparticles in microfluidic systems
Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets...
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6612686 |
Focused acoustic energy in the preparation and screening of combinatorial libraries
The present invention provides a method for the acoustic ejection of fluid droplets from each of a plurality of fluid-containing reservoirs to prepare combinatorial libraries in the form of...
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6605257 |
Micro array manufacturing apparatus
A present micro array manufacturing apparatus includes a substrate placement portion 11 on which a plurality of substrates can be arranged, a tighter plate 12 for storing a solution including a...
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6600031 |
Methods of making nucleic acid or oligonucleotide arrays
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6600016 |
Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same
Multifunctionalized support resin for the solid phase synthesis of combinatorial libraries is disclosed. The support resin comprises a resin backbone to which is attached a template containing at...
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6599755 |
Method and device for applying small quantities of liquid
The present invention relates to a method of depositing small amounts of liquid on a substrate ( 13 ) by using a pipette tip ( 1 ), which is connected to a flexible delivery line ( 2 ). Liquid is...
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6589739 |
Biopolymer array inspection
A method of fabricating a biopolymer array, and an apparatus which can execute the method, droplets of fluid carrying the biopolymer or a biomonomer are deposited onto a front side of a transparent...
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6589726 |
Method and apparatus for in situ synthesis on a solid support
The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for...
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6558633 |
Chemical reaction apparatus and methods
Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical...
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6544334 |
Systems and methods for the deposition and curing of coating compositions
Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating...
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6537504 |
Method and apparatus for concurrent and sequential multi-step reactions for producing a plurality of different chemical compounds
The present invention is a method and an apparatus to provide a dynamic matrix system for synthesizing a plurality of chemical compounds simultaneously, i.e. in parallel, and to synthesize a series...
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6534307 |
Frozen tissue microarrayer
A device particularly suited for constructing frozen tissue microarrays. The device comprises: a cooling chamber for receiving at least one frozen material and for maintaining the frozen material...
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6479301 |
Methods for fabricating an array for use in multiplexed biochemical analysis
The invention provides devices for preparing a reaction substrate for use as an assay device, and methods of using these devices. The devices prepare reaction substrates comprising arrays of...
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6458583 |
Method and apparatus for making nucleic acid arrays
Methods and devices for depositing a nucleic acid on a substrate surface are provided. In the subject methods, a thermal inkjet head loaded with nucleic acid fluid composition is positioned in...
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6395559 |
Multiple fluid sample processor with single well addressability
A method for single well addressability in a sample processor with row and column feeds. A sample processor or chip has a matrix of reservoirs or wells arranged in columns and rows. Pressure or...
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6376256 |
Rapid process for arraying and synthesizing bead-based combinatorial libraries
A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive...
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6329139 |
Automated sorting system for matrices with memory
Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of...
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6309608 |
Method and apparatus for organic synthesis
Methods and apparatus for the semi-automated synthesis of libraries of organic compounds are disclosed. More specifically, the present invention comprises multi-vessel reaction blocks, accessory...
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6258323 |
Apparatus and method used in multiple, simultaneous synthesis of general compounds
The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring...
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6251595 |
Methods and devices for carrying out chemical reactions
Methods and devices are disclosed for carrying out multiple chemical reactions. A plurality of electrodes supported by a semiconductor substrate is brought into proximity with a reaction medium,...
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6224832 |
Multi-reactor synthesizer and method for combinatorial chemistry
Solid phase combinatorial synthesis is carried out in a multi-reactor synthesizer comprising an array of separate reactor cells (1-9) containing a solid reaction support medium (26). Subsets of the...
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6197551 |
Spoil-1 protein and nucleic acid molecules and uses therefor
Novel SPOIL-1 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length SPOIL-1 proteins, the invention further provides isolated SPOIL-1 fusion...
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