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8105982 |
Aptamers and methods for their in vitro selection and uses thereof
The present method is an improved in vitro selection protocol that relies on magnetic separations for DNA aptamer production that is relatively easy and scalable without the need for expensive...
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8097421 |
Method for performing a multiplex immunoassay using label disassociation and an integrated substrate
The application relates to a method, system and device for performing biological assays. The method, system and device allow more accurate and specific detections of biomolecules in multiplex...
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8017559 |
Combinatorial libraries of proteins having the scaffold structure of C-type lectin-like domains
The present invention provides novel polypeptides having the scaffold structure of a C-type lectin-like domain (CTLD) and a randomized loop region for specifically binding a variety of target...
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7998904 |
Evolving new molecular function
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for...
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7964534 |
Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes
The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds...
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7935659 |
Multiplexed assays using encoded solid supports
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The...
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7915201 |
Ligational encoding of small molecules
The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in...
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7902122 |
Method for detecting target biological material using DNA barcodes
A method for detecting a target biological material using DNA barcodes is provided. The method is for detecting a target biological material (e.g., DNA) by using DNA barcodes by which a trace...
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7902121 |
MHC-antigen arrays for detection and characterization of immune responses
T cells are profiled with respect to their expression of antigen receptor. The cells are arrayed on a planar or three-dimensional substrate through binding to immobilized or partially diffused...
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7718575 |
Method of selecting HLA-DP4 ligands and the applications thereof
A method of selecting a test molecule that binds to HLA-DP4 by (i) incubating HLA-DP4 with the test molecule and a labeled peptide of formula (I) Z1X1X2X3X4X5X6X7X8X9Z2 thereby forming respective...
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7713915 |
Cytotoxic heteromeric protein combinatorial libraries
A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit...
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7704925 |
Ligational encoding using building block oligonucleotides
The present invention in one aspect relates to a method for synthesizing a bifunctional complex comprising a molecule and an identifier polynucleotide identifying at least some of the chemical...
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7666817 |
Cellular libraries of peptide sequences (CLiPS) and methods of using the same
The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and...
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7585815 |
High throughput protein production screening
Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic...
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7552013 |
Ratio-based oligonucleotide probe selection
Disclosed herein are methods of selecting probes to target nucleic acid sequences, methods of making oligonucleotide arrays comprising such probes, and methods of using such arrays. Also, described...
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7499806 |
Image processing in microsphere arrays
Described herein are methods for registering analytical images comprising obtaining an image of an array, wherein the image depicts fiducials that can be used to register the sequential images of...
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7473767 |
Methods for detection and quantification of analytes in complex mixtures
The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid....
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7465540 |
Multiple reporter read-out for bioassays
A method for detecting a plurality of reactive sites on an analyte, comprising allowing reactants on an addressable microsphere and the reactive sites to react, forming reactant-reactive site pairs...
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7439419 |
Solanum tuberosum β-solanine/β-chaconine rhamnosyl transferase sequences and uses thereof
Nucleic acid sequences from potato that encode the enzyme β-solanine/β-chaconine rhamnosyltransferase (SGT3) are disclosed. Recombinant DNA molecules containing the sequences, and use thereof, in p...
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7432082 |
Methods and compositions for analyzing AHASL genes
The invention relates to methods and compositions for analyzing plant acetohydroxy acid synthase large subunit (AHASL) genes. In particular, the invention relates to methods for the detection of...
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7425431 |
Polony fluorescent in situ sequencing beads
Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.
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7385043 |
Homogeneous multiplex screening assays and kits
Highly multiplexed homogeneous in vitro screening assays for numerous possible nucleic acid targets, any of which might be present in a sample, utilize fluorescent hybridization probes that are...
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7384737 |
Synthesis of spatially addressed molecular arrays
Methods are disclosed for forming spatially addressable arrays of polynucleotides of known squence, by using blocking groups that prevent the incorporation of multiple nucleotides during each...
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7381810 |
Polyphenol oxidase genes from lettuce
The present invention provides genetic sequences encoding polyphenol oxidase enzymes of lettuce, banana, tobacco and pineapple plants, and recombinant vectors comprising same, and methods of...
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7375259 |
Solanum tuberosum sterol alkaloid glycosyltransferase (SGT) a novel solanidine glucosyltransferase SGT2 and uses thereof
Nucleic acid sequences from potato that encode the enzyme UDP-glucose:solanidine glucosyltransferase (SGT2) are disclosed. Recombinant DNA molecules containing the sequences, and use thereof, in...
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7351536 |
Revolver-2: a novel transposon-like element from rye
The object of the present invention is to obtain a novel transposon-like element specifically present in the genome of rye and the like. According to the present invention, a DNA sequence of a...
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7348147 |
Method and system for nucleic acid detection
The present invention relates to a method of detecting nucleic acids comprising suspending at least one recognizable target nucleic acid in a suspending solution containing polymeric particles...
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7348181 |
Self-encoding sensor with microspheres
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed...
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7323309 |
Bio-barcodes based on oligonucleotide-modified particles
The present invention relates to a screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. proteins such as antibodies, in a sample....
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7306923 |
Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or...
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7285384 |
Parallel genotyping of multiple patient samples
The present invention relates to parallel genotyping (or other sample analysis) of multiple patients by direct sample immobilization onto microspheres of an array. The patient beads can then be...
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7270969 |
Methods of constructing and screening diverse expression libraries
The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic...
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7270950 |
Nucleic acid-protein fusions and methods of making and selecting fusions
Described herein are RNA-protein fusion production methods which involve a high salt post-translational incubation step.
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7238485 |
Methods and apparatus for characterizing polynucleotides
Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure...
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7198900 |
Multiplex detection compositions, methods, and kits
The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence...
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7193136 |
Root-preferred, nematode-inducible soybean promoter and its use
The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a...
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7179796 |
Antisense modulation of PTP1B expression
Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic...
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7169563 |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
Methods for identifying a member of a mass-coded molecular library, which is a ligand for a biomolecule and binds to the biomolecule at the binding site of a known second ligand for the biomolecule...
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7154026 |
Manipulation of cellulose and/or β-1,4,-glucan
The present invention relates generally to isolated genes which encode polypeptides involved in cellulose biosynthesis in plants and transgenic plants expressing same in sense or antisense...
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7150967 |
Fluorescent tags for amino acid and nucleic acid analysis
Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are...
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7148052 |
Nucleic acid encoding β-1,3-glucanase from lily
The present invention relates to a novel nucleic acid encoding a β-1,3-glucanase polypeptide of lily, and an expression vector, host cell and transgenic plant comprising the nucleic acid of the ...
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7138273 |
Method of identifying non-host plant disease resistance genes
The invention describes a new method to isolate disease resistance genes in plants. The method teaches to transiently express in susceptible plants large numbers of R-gene homologs or non-host...
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7125669 |
Solid-phase immobilization of proteins and peptides
Disclosed herein are methods for immobilizing a peptide or protein on a solid support. The method generally includes the following steps: (a) providing one or more templates attached to a solid...
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7094537 |
Micro arrays with structured and unstructured probes
The invention provides an apparatus and method for determining a signal produced by a micro array device. The apparatus provides an unstructured probe and structured probe. The unstructured probe...
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7087433 |
7SK RNA regulated transcription
A method for altering transcription in a cell comprising an amount of active CDK9/cyclin, comprises the steps of: (a) introducing in the cell an agent which modulates the amount of active...
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7087380 |
Forensic identification
The invention provides allelic ladder mixtures and individual alleles suitable for use in such mixtures. The allelic ladder mixtures give improved identification and distinguishing capabilities,...
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7070922 |
Surface treatment
Described is a process for producing a biomolecular monolayer on a biosensor surface comprising the steps of: reacting a biosensor surface with a solution of heterobifunctional reagent having a...
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7026123 |
UTR tag assay for gene function discovery
The methods of the invention provide a means for rapid analysis of gene function in a variety of systems. The invention allows screening of large libraries of nucleotide sequences for involvement...
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6998274 |
Composite arrays utilizing microspheres
The invention relates to compositions and methods for decoding microsphere array sensors.
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6951716 |
Anti-platelet immunoglobulin bead positive control
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one...
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