Patents in Class 506/4

Matches 1 - 50 out of 55

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Match	Document	Document Title
1	7585815	High throughput protein production screening Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic...
2	7566685	Methods and compositions for screening using diphtheria toxin constructs The invention relates to methods and compositions utilizing diphtheria toxin for screening purposes. The invention is particularly useful in screening for modulators of IgE synthesis, secretion and...
3	7306923	Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or...
4	7270969	Methods of constructing and screening diverse expression libraries The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic...
5	7169563	Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation Methods for identifying a member of a mass-coded molecular library, which is a ligand for a biomolecule and binds to the biomolecule at the binding site of a known second ligand for the biomolecule...
6	6924109	High-throughput transcriptome and functional validation analysis Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
7	6897028	Identification of molecular targets Identification of the molecular targets of a drug or toxin is the first step in understanding how the drug or toxin works, an important advance in learning how to improve a drug or assess the risks...
8	6790672	Encoded molecular sieve particle-based sensors A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into...
9	6720149	Methods for concurrently processing multiple biological chip assays Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a...
10	6684161	Combinatorial experiment design method and system An experimental space comprising levels of factors is designed according to an incomplete block design and an experimental space comprising levels of factors is designed by random selection....
11	6664048	Identification and characterization of interacting molecules The present invention relates to an improved method for the identification and optionally the characterization of interacting molecules designed to detect positive clones from the rather large...
12	6638719	Genotyping biallelic markers A method is described for determining the genotype of one or more individuals at a biallelic marker. The method employs amplification of a region of genomic DNA using color tagged, allele-specific...
13	6627400	Multiplexed measurement of membrane protein populations Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound...
14	6623970	Process for testing catalysts using spectroscopy Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst...
15	6610547	Selection of contrast agent drug from a combinatorial library The invention provides a method of contrast agent drug candidate selection which involves: (i) obtaining a combinatorial library comprising an admixture of potential contrast agent drug candidates...
16	6607885	Method for high-density microarray medicated gene expression profiling The global effect on genes under different environmental conditions can be determined by a comprehensive gene expression profile. The present invention provides a method to monitor the changes in...
17	6607878	Collections of uniquely tagged molecules This invention is directed to methods and kits for creating and analyzing molecules using uniquely identifiable tags. The invention is also directed to methods and kits that use uniquely...
18	6605470	Process for testing catalysts using detection agents Methods for evaluating catalysts, in which a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst...
19	6589730	Methods for identifying protein-protein interactions by selective transduction A method for identifying specific protein-protein (i.e., ligand/anti-ligand) interactions that internalize and are detected by transgene expression. A ligand displaying genetic package that carries...
20	6555310	Polyclonal libraries The invention is directed to inter alia two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display...
21	6548734	Methods relating to modulation of cartilage cell growth and/or differentiation by modulation of NFATp activity The invention demonstrates that NFATp represses cartilage cell division and represses the chondrogenic program in cells and displays the properties of a tumor suppressor gene. In addition, the...
22	6544739	Method for marking samples The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
23	6511803	Replica amplification of nucleic acid arrays Disclosed are improved methods of making and using immobilized arrays of nucleic acids, particularly methods for producing replicas of such arrays. Included are methods for producing high density...
24	6480791	Parallel methods for genomic analysis The present invention provides parallel methods for determining nucleotide sequences and physical maps of polynucleotides associated with sample tags. This information can be used to determine the...
25	6479268	7970, a novel ATPase-like molecule and uses thereof Novel ATPase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ATPase-like proteins, the invention further provides isolated ATPase-like...
26	6472146	Methods for identification on internalizing ligands and identification of known and putative ligands A method for identifying target cells and tissues which internalize known or putative ligands is provided. A ligand displaying genetic package that carries a reporter or selectable marker and...
27	6451527	Methods using genetic package display for selecting internalizing ligands for gene delivery A genetic package display system is presented for selecting internalizing ligands for gene delivery. The genetic package carries a reporter, selectable marker, or a specifically detectable nucleic...
28	6440667	Analysis of target molecules using an encoding system The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
29	6410248	General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites The present invention provides methods for making zinc finger proteins with high affinity for their targets, by sequentially selecting each finger of the protein.
30	6403324	Affinity labeling libraries with tagged leaving group Methods and compositions are provided for identifying compounds having affinity to a target site. The method provides for the affinity group to be a leaving group from a reactive functionality...
31	6368874	Methods for hard-tagging an encoded synthetic library Disclosed are chemical encryption methods for determining the structure of compounds formed in situ on solid supports by the use of specific amines tags which, after compound synthesis, can be...
32	6333196	Catalyst testing process and apparatus Apparatus for testing catalyst candidates including a multicell holder e.g. a honeycomb or plate, or a collection of individual support particles that have been treated with solutions/suspensions...
33	6287778	Allele detection using primer extension with sequence-coded identity tags A method for determining the genotype of one or more individuals at a polymorphic locus employs amplification of a region of DNA, labeling of allele-specific extension primers containing tags, and...
34	6284460	Hybridization and sequencing of nucleic acids using base pair mismatches Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution,...
35	6277583	Affinity labeling libraries and applications thereof Novel methods and compositions are provided for preferentially bonding an oligomeric molecule to a macromolecular target where the target is a member of a complex mixture and/or there is...
36	6265219	Transponder tagging of constituents used in compound synthesis A synthesis member preferably comprises two elements: a crown and a stem. The stem includes a tag, such as a transponder, that is used to identify the synthesis member and/or the synthetic history...
37	6245517	Ratio-based decisions and the quantitative analysis of cDNA micro-array images Gene expression can be quantitatively analyzed by hybridizing fluor-tagged mRNA to targets on a cDNA micro-array. Comparison of gene expression levels arising from co-hybridized samples is achieved...
38	6242262	Method and apparatus for screening catalyst libraries A method for isolating an active catalyst from a library of compounds that are potential catalysts is disclosed. The method involves providing a library which comprises a plurality of discrete...
39	6232067	Adapter directed expression analysis The present invention relate to methods and compositions for simultaneously analyzing multiple different polynucleotides of a polynucleotide composition comprising multiple diverse polynucleotide...
40	6228645	Promoter elements conferring root-preferred gene expression This invention relates generally to mechanisms of gene expression in plants and more specifically to regulation of expression of genes in plants in a "tissue-preferred" manner. A method for...
41	6228589	Measurement of gene expression profiles in toxicity determination A method is provided for assessing the toxicity of a compound in a test organism by measuring gene expression profiles of selected tissues. Gene expression profiles are measured by massively...
42	6218118	Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry Methods and reagents are disclosed which satisfy the need for more sensitive, more accurate and higher through-put analyses of target nucleic acid sequences. The methods and reagents may be...
43	6087103	Tagged ligand arrays for identifying target-ligand interactions The present invention relates generally to high throughput screening methods. More particularly, the present invention provides screening methods that can readily be used to identify simultaneously...
44	6068977	Method and system for sequencing genomes The present invention pertains to a method for sequencing genomes. The method comprises the steps of obtaining nucleic acid material from a genome. Then there is the step of constructing a clone...
45	6060240	Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom The present invention relates to a method for the comparative assessment of the level of specific nucleic acid sequences in samples derived from different sources. More specifically, the invention...
46	6030782	Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds Methods for the covalent, specific and reversible immobilization of nucleic acid molecules onto solid-phases by means of a reversible disulfide bond for nucleic acid molecule array preparation are...
47	5885794	Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an...
48	5876925	Magnetically activated cell sorting for production of proteins The invention includes methods of isolating DNA and a protein encoded thereby, the protein being capable of binding to an antigen-bearing moiety. The methods comprise generating a DNA library...
49	5855885	Isolation and production of catalytic antibodies using phage technology Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation...
50	5759779	Polynucleotide-array assay and methods A method of analyzing the sequence of a polynucleotide analyte. The method includes contacting the analyte with a position-addressable array of oligonucleotides, each anchored to a solid support...

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