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8178343 |
Gene cluster diagnosis apparatus
A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a...
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8138123 |
Gene expressing analysis tool
The present invention provides a tool for analysis of expression of Macaca fascicularis gene expression analysis tool containing a set of nucleic acids containing base sequences the same or...
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8133985 |
Peptide nucleic acids conjugated with multi-amine linkers and nucleic acid detecting device using the same
The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is...
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8062900 |
Optically readable microplate
A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based...
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7993583 |
Passive microfluidic array card and reader
A microfluidic array card and reader system for analyzing a sample. The microfluidic array card includes a sample loading section for loading the sample onto the microfluidic array card, a...
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7879765 |
Method and apparatus for detecting bio-chip by using phase-change
A biochip and a biochip scanning method and apparatus using phase changes are provided, wherein a laser beam is radiated to a biochip having immobilized probes placed thereon to cause a phase...
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7670556 |
Surface plasmon resonance imaging of micro-arrays
Disclosed is a method for fabricating 1-dimensional micro-arrays using parallel micro-fluidic channels on chemically-modified metal, carbon, silicon, and/or germanium surfaces; a μL detection ...
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7521179 |
Thermo-optical analysis system for biological reactions
The invention relates to a reaction device, comprising a sample chamber matrix (1), comprising at least two reaction chambers (2) whose walls are permeable with respect to electromagnetic radiation...
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7501241 |
Method of transcribing biomolecular patterns, method of manufacturing chip boards, and method of manufacturing biochips
A method of mass-producing minute structures such as biochips, protein chips, quantum dots, and quantum chips involves arranging an antigen two-dimensionally on a board and arranging probes...
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7468280 |
High throughput preparation of lubricating oil compositions for combinatorial libraries
A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided....
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7465546 |
Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields
Methods and devices are described for the regulation of Transforming Growth actor (TGF)-β1, β2, and/or β3 protein gene expression in bone cells and other tissues via the capacitive coupling or in...
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7462452 |
Field-switch sequencing
The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for...
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7410762 |
Method for detecting biomolecules
A method for detecting and measuring the concentration of biomolecules in solution, utilizing a conducting electrode in contact with a solution containing target biomolecules, with a film with...
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7390622 |
Apparatus and methods for detecting nucleic acid in biological samples
There are disclosed apparatus and methods for the field-assisted acceleration of biological processes involving charged entities, including in particular the detection of target DNA in a biological...
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7381531 |
Displacement assay for detection of small molecules
Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000...
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7364849 |
Treatment of substrates for immobilizing biomolecules
A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing...
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7364848 |
Integrated microarray analysis
The present invention relates to methods for identifying analyte nucleic acids present in a sample comprising nucleic acid molecules, said method comprising the steps of: (a) providing a porous...
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7358043 |
Proteomic interaction and genomic action determinations in the presence of associated redox state conditions
Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are...
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7335472 |
Method for simultaneously detecting hybridization reactions and immuno-reactions, and its uses in diagnosis
The present invention relates to a method for simultaneously detecting hybridization reactions and immunoreactions in a sample which may contain target analytes consisting of at least one nucleic...
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7329492 |
Methods for real-time single molecule sequence determination
A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a...
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7329496 |
Sequencing of surface immobilized polymers utilizing microflourescence detection
Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine...
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7317820 |
System and method for automatically identifying sub-grids in a microarray
A digital image processing-based system and method for quantitatively processing a plurality of nucleic acid species expressed in a microarray are disclosed. The microarray is a grid of a plurality...
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7316899 |
Portable sensor array system
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
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7297486 |
Production of molecular arrays
The subject invention pertains to a method for the production of an array of molecules immobilised on a substrate, comprising the deposition of the molecules from a micropipette containing them,...
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7291471 |
Cleavable oligonucleotide arrays
Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a...
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7282329 |
Suspended microchannel detectors
An apparatus for detecting an analyte in solution that has a suspended beam containing at least one microfluidic channel containing a capture ligand that bonds to or reacts with an analyte. The...
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7267948 |
SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips
A Raman integrated sensor system for the detection of targets including biotargets includes at least one sampling platform, at least one receptor probe disposed on the sampling platform, and an...
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7250253 |
Immobilization of molecules on surfaces via polymer brushes
The invention relates to polyfunctional polymer monolayers (polymer brushes) comprising a multitude of polymer chains attached to a surface, with each polymer chain comprising a multitude of units...
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7244570 |
Methods and compositions for modulating “marginally indiscriminant” hybridizations
The invention relates to the field of molecular biology, nucleic acid chemistry and medical diagnostics. More specifically, it relates to methods and compositions for promoting the hybridization of...
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7238477 |
Methods to increase nucleotide signals by Raman scattering
The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman...
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7223544 |
Nucleic acid-engineered materials
The present invention relates to the design and use of nucleic acid molecules to create novel materials. The present invention further relates to the use of DNA as a bulding block for DNA-materials...
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7205112 |
Materials and methods for detection of enterovirus and norovirus
The invention provides polynucleotides and methods for detecting and quantifying RNA viruses, such as enteroviruses and noroviruses. In one aspect, the invention provides amplification primers and...
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7195908 |
Supports treated with triamine for immobilizing biomolecules
Supports for immobilizing molecules, particularly biomolecules, methods of making such supports, kits, and biomolecular hybridization assay devices are disclosed. The methods, supports and devices...
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7192703 |
Biomolecule analysis by rolling circle amplification and SERS detection
The present methods, compositions and systems are concerned with biomolecule 130 detection, identification and/or quantification by rolling circle amplification (RCA) and Raman detection. In...
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7160678 |
Compositions for the electronic detection of analytes utilizing monolayers
The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
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7157229 |
Prepatterned substrate for optical synthesis of DNA probes
An optical alignment system for a device for synthesizing DNA polymers provides for a patterned substrate for simple alignment of the system. The substrate may also be used for synthesis allowing...
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7157232 |
Method to detect the end-point for PCR DNA amplification using an ionically labeled probe and measuring impedance change
Impedance measurements are used to detect the end-point for PCR DNA amplification. A pair of spaced electrodes are located on a surface of a microfluidic channel and an AC or DC voltage is applied...
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7157230 |
Electron induced fluorescent method for nucleic acid sequencing
An apparatus, compositions and related methods for sequencing a target nucleic acid are described. In certain embodiments, the apparatus is a microfluidic apparatus comprising an input chamber,...
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7153651 |
Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the...
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7153658 |
Methods and compositions for detecting targets
The present invention relates to methods and kits for detecting the presence or absence of (or quantitating) target nucleic acid sequences using ligation and amplification. The invention also...
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7105301 |
Detecting molecular binding by monitoring feedback controlled cantilever deflections
The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached...
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7105300 |
Sequencing by incorporation
Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible c...
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7101661 |
Apparatus for active programmable matrix devices
A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out...
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7097973 |
Method for monitoring molecular species within a medium
Apparatus and methods for monitoring, analyzing, and/or discriminating molecular species, preferably a biomolecule, within a medium using a multisensor array (MSA) and multivariate processing....
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7090973 |
Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Bacteroides fragilis that are useful in diagnosis and therapy of pathological conditions; antibodies against the...
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7056666 |
Analysis of surface immobilized polymers utilizing microfluorescence detection
Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine...
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7052841 |
Systems, tools and methods of assaying biological materials using spatially-addressable arrays
Systems, tools and methods of assaying biological material are used to perform complex sandwich hybridization assays. The tools used comprise biological solution probes that are customized for each...
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7033758 |
Highly sensitive gene detection and localization using in situ branched-DNA hybridization
Methods are provided for highly sensitive and rapid in situ detection of a nucleic acid analyte of a known sequence. The method employs oligonucleotide probes in a series of optimized steps to...
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7022473 |
Substrates for immobilizing and amplifying DNA and DNA-immobilized chips
Substrates for producing a DNA library are produced by immobilizing DNA onto a suitable substrate having excellent thermal conductivity. A surface of the substrate is chemically modified with a...
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7014992 |
Conductive oligomers attached to electrodes and nucleoside analogs
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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