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7611900 |
High throughput screening methods for lubricating oil compositions
Method for determining deposit formation tendencies for a plurality of fluid samples of different compositions is provided. Each sample includes one or more lubricating oil compositions containing...
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7579192 |
High throughput screening methods for lubricating oil compositions
A method for determining storage stability for a plurality of fluid lubricant samples of different compositions is provided. Each sample includes one or more lubricating oil additives, or a...
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7468280 |
High throughput preparation of lubricating oil compositions for combinatorial libraries
A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided....
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6914279 |
Multifunctional biosensor based on ZnO nanostructures
The present invention provides the multifunctional biological and biochemical sensor technology based on ZnO nanostructures. The ZnO nanotips serve as strong DNA or protein molecule binding sites...
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6890485 |
High throughput chemical handling system
A high throughput chemical handling system includes a chemical storage module, a transport module, and one or more liquid handling modules. The transport module may implement parallel chemical...
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6875578 |
System for cell-based screening
The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently...
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6861251 |
Translucent solid matrix assay device for microarray analysis
The present invention concerns methods and compositions relating to matrix arrays. In certain embodiments, the arrays are translucent. In other embodiments, the arrays are reconfigurable. In...
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6836326 |
Rheo-optical indexer and method of screening and characterizing arrays of materials
A method and apparatus for characterizing and screening an array of material samples is disclosed. The apparatus includes a sample block having a plurality of regions for containing the material...
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6818110 |
Combinatorial electrochemical deposition and testing system
An electrochemical deposition and testing system consisting of individually addressable electrode arrays, a fully automated deposition head, and a parallel screening apparatus is described. The...
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6813958 |
Method for combinatorially measuring adhesion strength
A method of measuring the adhesive strength of polymer materials that are arranged in a combinatorial library which involves providing a lens array having a plurality of individual lens elements on...
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6776902 |
Parallel high-performance liquid chromatography with post-separation treatment
High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine parallel chromatographic separation of a plurality of samples with a detection technique that involves...
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6763309 |
Method and system for the development of materials
A catalyst development engine (CDE) provides a rapid approach to the rational development of scalable heterogeneous catalysts and of high-performance solid materials. The CDE includes three main...
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6723235 |
Apparatus for screening compound libraries
Disclosed are apparatus for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target...
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6716395 |
Integrated protein affinity capture centrifugation device
A method and apparatus are described for screening a proteome. The method and apparatus include an array of affinity elements, such that a proteome is directed through the array and those...
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6713264 |
Process and device for the screening of molecules with regard to their individual binding behaviour towards at least one given ligand
The process is used for the screening of molecules from molecule libraries with regard to their individual binding behavior towards at least one given ligand. For this purpose the ligands labelled...
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6699719 |
Biosensor arrays and methods
A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface...
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6684161 |
Combinatorial experiment design method and system
An experimental space comprising levels of factors is designed according to an incomplete block design and an experimental space comprising levels of factors is designed by random selection....
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6680202 |
Method for concurrent and sequential multi-step reactions for producing a plurality of different chemical compounds
The present invention is a method and an apparatus to provide a dynamic matrix system for synthesizing a plurality of chemical compounds simultaneously, i.e. in parallel, and to synthesize a series...
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6670122 |
Method for detecting transcription templates
Methods are provided for detecting the sense and antisense transcripts and for determining template strand of a genomic DNA. Exemplary methods include reverse transcribing transcripts without...
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6668230 |
Computer readable medium for performing sensor array based materials characterization
A modular materials characterization apparatus includes a sensor array disposed on a substrate, with a standardized array and contact pad format; electronic test and measurement apparatus for...
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6650411 |
System, method, and product for pixel clocking in scanning of biological materials
Systems and methods are described that may be applied to scanning biological materials in or on probe arrays. For example, a system is described that includes a scanner that has one or more...
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6630111 |
Apparatus for testing catalysts using spectroscopy
Apparatus for evaluating catalysts, including a multicell holder, e.g., a honeycomb or plate, or a collection of individual support particles, is treated with solutions/suspensions of catalyst...
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6620592 |
18036, a novel calpain-like protease and uses thereof
Novel calpain-like protease polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length calpain-like protease proteins, the invention further provides...
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6597000 |
Systems and methods for detection of labeled materials
Labeled targets on a support synthesized with polymer sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, can be detected by...
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6572828 |
Method and apparatus for high-throughput chemical screening
The present invention is directed to a method and apparatus for rapid screening of potential reactants, catalysts, or associated process conditions. In one embodiment, the method includes the steps...
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6495363 |
In-line complete spectral fluorescent imaging of nucleic acid molecules
The present invention provides a hyperspectral imaging apparatus and methods for employing such an apparatus for multi-dye/base detection of a nucleic acid molecule coupled to a solid surface.
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6426226 |
Method and apparatus for screening catalyst libraries
Rapid screening for activities and selectivities of catalyst libraries having addressable test sites is achieved by contacting potential catalysts at the test sites with reactant streams forming...
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6416714 |
Remotely programmable matrices with memories
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The...
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6403957 |
Nucleic acid reading and analysis system
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6401519 |
Systems and methods for characterization of materials and combinatorial libraries with mechanical oscillators
Methods and apparatus for screening diverse arrays of materials are provided. In one aspect, systems and methods are provided for imaging a library of materials using ultrasonic imaging techniques....
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6403320 |
Support bound probes and methods of analysis using the same
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6342349 |
Optical disk-based assay devices and methods
Optical disk-based assay devices and methods are described, in which analyte-specific signal elements are disposed on an optical disk substrate. In preferred embodiments, the analyte-specific...
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6228326 |
Arrays of independently-addressable supported fluid bilayer membranes
A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface...
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6207960 |
System and methods for detection of labeled materials
Labeled targets on a support synthesized with polymer sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, can be detected by...
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6136592 |
Multiple micro-arrays
A method and device are provided for simultaneously creating a plurality of identical micro-arrays of biological samples. The invention utilizes a plurality of substrates, each of which having a...
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6103479 |
Miniaturized cell array methods and apparatus for cell-based screening
The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining...
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6087181 |
Sampling and detection of trace gas species by optical spectroscopy
The present invention discloses a method for improving the speed and sensitivity of optical spectroscopic techniques for remote detection of trace chemical species in a carrier gas. The disclosed...
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6046003 |
Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders
A method is described for determining the sequence of nucleic acids. The method employs small solid phase particles having transponders, with a primary layer of an oligonucleotide of known sequence...
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6027695 |
Apparatus for holding small volumes of liquids
An apparatus for holding liquid, such as a microtiter plate, in which a plurality of wells are formed. Each of the wells have side walls that intersect in an edge that defines the boundary between...
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5959297 |
Mass spectrometers and methods for rapid screening of libraries of different materials
Methods and apparatus for screening diverse arrays of materials are provided. Techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering...
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5945679 |
Apparatus for scanning a chemical array
A technique for analyzing analytes in a chemical array having a plurality of pixels is provided. The apparatus of the technique contains a light source for irradiating a light beam at the pixels...
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5859190 |
Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by...
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5846708 |
Optical and electrical methods and apparatus for molecule detection
A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is...
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5812272 |
Apparatus and method with tiled light source array for integrated assay sensing
A technique for analyzing target chemicals is provided. The apparatus of the technique contains an array of two or more light sources. Each of the array elements includes a light source. The light...
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5632957 |
Molecular biological diagnostic systems including electrodes
A system for performing molecular biological diagnosis, analysis and multi-step and multiplex reactions utilizes a self-addressable, self-assembling microelectronic system for actively carrying out...
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5545531 |
Methods for making a device for concurrently processing multiple biological chip assays
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a...
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5340474 |
Panels of analyte-binding ligands
The invention provides methods to obtain panels of low molecular weight polymers resulting from varying constituent monomers, which panels are systematically diverse with respect to two or more...
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