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7557069 |
Combinatorial synthesis on arrays
The present invention provides methods for synthesizing arrays of polymers. A barrier to a reaction is applied to select features of the array thereby limiting the reaction to the remaining features.
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7387865 |
Composition containing a photoacid generator monomer, substrate coated with the composition, method for synthesizing a compound on a substrate using the composition, and microarray produced according to the method
A composition containing a photoacid generator monomer and surfactant, and a method for synthesizing a compound on a substrate using the composition are provided. The method includes bonding a...
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6936461 |
Method for immobilizing multistranded nucleic acid molecules by modifying more than one strand thereof, and binding each strand to a solid support
Various methodologies for the immobilization of molecules such, as multistranded nucleic acid molecules, are described. The methodologies include activation of solid supports, as well as treatment...
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6935727 |
Pulse jet print head assembly having multiple reservoirs and methods for use in the manufacture of biopolymeric arrays
Pulse jet printhead assemblies having multiple reservoirs and multiple printhead dies, as well as methods for their use in the deposition of fluids, typically fluids containing a biopolymer or...
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6916541 |
Modified substrates for the attachment of biomolecules
The present invention relates to a substrate for attachment of biomolecules. The substrate is coated with a multiamino organosilane. If desired, the substrate can be further modified prior to...
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6908678 |
Plastic slides for the fabrication of biochips
The present invention discloses a chemically surface-treated plastic slide that is useful for the immobilization of proteins, peptides or small molecules to its surface for the fabrication of...
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6900047 |
Apparatus for coating a substrate quickly and uniformly with a small volume of fluid
A method is provided for applying a fluid onto a surface of a solid substrate. The method employs a distribution member having an upper surface and a lower surface, and including a permeable...
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6890723 |
Method of shielding biosynthesis reactions from the ambient environment on an array
A method of fabricating an array of biopolymers provides a shield for biochemical reactions and biochemical reactants and is particularly useful for those reactions and reactants that are...
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6887665 |
Methods of array synthesis
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of...
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6887362 |
Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates...
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6872359 |
Pressure variation in array fabrication
A method, apparatus and computer program product, for fabricating an array of biopolymers on a substrate. The method uses a biopolymer or biomonomer fluid and a drop dispenser having a chamber into...
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6858713 |
Chemically modified biological molecules and methods for coupling biological molecules to solid support
The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid...
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6855538 |
High-efficiency microarray printing device
This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing...
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6830890 |
Nucleic acid probe libraries
Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific...
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6824987 |
Small molecule printing
The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a...
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6815078 |
Substrate for protein microarray containing functionalized polymer
A gelatin-based substrate for fabricating protein arrays, the substrate comprising: gelatin having at least one surface; a polymer scaffold affixed to the gelatin surface; wherein the polymer in...
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6800439 |
Methods for improved array preparation
Improved nucleic acid arrays are provided which have been prepared in a non-oxidizing atmosphere.
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6780582 |
Arrays of protein-capture agents and methods of use thereof
Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an...
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6758951 |
Synthesis and characterization of materials for electrochemical cells
An apparatus including a basis that has a plurality of wells associated therewith for defining a plurality of electrochemical cells; at least two electrodes sealingly disposed in each...
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6756074 |
Methods for the deposition and curing of coating compositions
Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating...
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6733975 |
DNA chip and its preparation
An analytical element (typically DNA chip) composed of a solid carrier and a group of nucleotide derivatives or their analogues fixed to the solid carrier can be produced by bringing nucleotide...
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6689478 |
Polyanion/polycation multilayer film for DNA immobilization
A substrate with a charged surface coated with one or more bilayers of oppositely charged polyelectrolytes. Subsequent optional bilayers of polyelectrolytes must bear alternating opposite charges....
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6677163 |
Functionalized silicon surfaces, and method for their production
Provided is a method for modifying silicon with an organic molecule, under mild conditions. If the attached molecule is bi-functional, it may be subsequently reacted with a bio-molecule, to form a...
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6673543 |
Solid phase synthesis of LXR ligands
The invention provides solid support synthetic methods for producing combinatorial libraries of modulators of LXRs. The combinatorial libraries thus produced are useful both as diagnostic...
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6670298 |
Combinatorial synthesis and analysis of organometallic compounds and catalysts
The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of...
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6660234 |
Apparatus for polymer synthesis
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6660192 |
Molded waveguides
Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically...
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6656725 |
Method of fabrication of microarray of gel-immobilized compounds on a chip by copolymerization
A method for making polymerized molecules is provided whereby a solution containing monomer is contacted to a solid substrate so as to form discrete accumulations of the monomer on the substrate;...
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6653468 |
Universal support media for synthesis of oligomeric compounds
Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first...
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6653151 |
Dry deposition of materials for microarrays using matrix displacement
A method is disclosed which relates to the placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive...
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6646243 |
Nucleic acid reading and analysis system
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6630358 |
Arrays of proteins and methods of use thereof
Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins,...
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6630308 |
Methods of synthesizing a plurality of different polymers on a surface of a substrate
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6613876 |
β-polypeptide foldamers of well-defined secondary structure
Disclosed are β-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone. The β-peptides adopt stable helical and...
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6610482 |
Support bound probes and methods of analysis using the same
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6600031 |
Methods of making nucleic acid or oligonucleotide arrays
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6589739 |
Biopolymer array inspection
A method of fabricating a biopolymer array, and an apparatus which can execute the method, droplets of fluid carrying the biopolymer or a biomonomer are deposited onto a front side of a transparent...
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6586187 |
Methods for solid phase combinatorial synthesis of integrin inhibitors
Compounds of the formula are useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer,...
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6566495 |
Very large scale immobilized polymer synthesis
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6558907 |
Methods and compositions for arraying nucleic acids onto a solid support
The present invention provides a method for depositing a nucleic acid on a solid support. The method comprises contacting a solid support with a solution of nucleic acid, the solution comprising...
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6544334 |
Systems and methods for the deposition and curing of coating compositions
Systems and methods for creating a combinatorial coating library including a coating system operatively coupled to at least one of a plurality of materials suitable for forming at least one coating...
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6531278 |
Ligand-DNA composition for capture and detection of contaminants on a solid surface
Compositions and methods of use thereof for capture and detection of selected molecules are described. In one embodiment, a first composition includes a ligand component, such as an antibody...
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6528291 |
Activated inorganic slide having aldehyde groups deposited by plasma deposition
A method is provided for preparing an active slide, including introducing a monomer containing an aldehyde group, or a mixture of a monomer containing an aldehyde group and an acidic functional...
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6528264 |
Polymer support for DNA immobilization
This invention relates to substrates for use in immobilizing biomolecules. More particularly, the invention relates to substrates (e.g. glass slides) having a coating of polylysine covalently...
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6515039 |
Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material
The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous...
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6496250 |
Combinatorial method foe development of optical ceramics
A method of preparing and testing an array of ceramics for optical properties, comprising: providing a host material that is capable of being made optically transparent or translucent upon...
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6489466 |
C-3′ protected monomeric nucleotides and synthesis of oligonucleotides on solid support
Immobilized nucleotide primers of this invention include a modified nucleotide tethered to a support substrate through a linking group. In particular, the modified nucleotide is constructed such...
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6440669 |
Methods for applying small volumes of reagents
Methods, devices and apparatus are disclosed for carrying out multiple chemical reactions, such as in situ synthesis of polynucleotides, on a surface comprising an array of discrete sites....
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6403957 |
Nucleic acid reading and analysis system
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6403320 |
Support bound probes and methods of analysis using the same
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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