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9012375 Array printing  
The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing...
9012374 Methods for manufacturing molecular arrays  
The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for...
8999726 Microfluidic interface for highly parallel addressing of sensing arrays  
Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or...
8987174 Methods for manufacturing molecular arrays  
The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for...
8975216 Articles having localized molecules disposed thereon and methods of producing same  
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the...
8969258 Methods of localizing nucleic acids to arrays  
Methods are disclosed relating to localizing nucleic acids to arrays such as silane-free arrays, and of sequencing the nucleic acids localized thereby.
8945944 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules  
A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte...
8932994 Method for retaining even coverage of short insert libraries  
The invention relates to a method of preparing a library of template polynucleotides with uniform sequence representation and to use of a library of templates prepared using this method for...
8932879 Methods and compounds for phototransfer  
Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through...
8921283 Method for generating microscopic patterns of protein and other macromolecules  
Methods and apparatuses for generating microscopic patterns of macromolecules such as proteins on a solid surface are described. Pulsed laser light is used to alter surface portions of a solid...
8912130 Methods of forming and using a solid-phase support  
Disclosed herein are methods of method of making a substrate for performing a chemical synthesis reaction.
8901046 Oligonucleotides related to lipid membrane attachment  
A method of forming a lipid membrane attached linker comprises contacting a lipid membrane with an oligonucleotide having a first strand and a second strand of nucleic acid and two or more...
8859469 Protein chip and production method thereof  
A protein chip including at least a substrate having a plurality of steps which are regularly arranged on one surface thereof; a plurality of metallic microstructures arranged in the steps; and a...
8846581 Non-emulsion methods and masked biomolecules  
The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a...
8846580 Diagnostic nanosensor and its use in medicine  
This invention relates generally to biosensor technology, and pertains more particularly to novel multifunctional biosensors based on ordered arrays of metallic, semiconductors and magnetic...
8802600 Articles having localized molecules disposed thereon and methods of producing same  
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the...
8802024 Biochip and manufacturing method thereof  
A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first...
8778849 Microarray fabrication system and method  
A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the...
8772202 Articles having localized molecules disposed thereon and methods of producing same  
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the...
8759259 Compositions and methods for producing cyclic peptoid libraries  
Embodiments of the invention are directed to a one-bead-two-compound method for the creation of encoded cyclic peptoid libraries. This scheme is useful for the creation of cyclic peptoid...
8715930 Loading molecules onto substrates  
Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for...
8680023 Methods for screening and arraying microrganisms such as viruses using subtractive contact printing background  
Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for...
8680024 Methods for screening and arraying microrganisms such as viruses using subtractive contact printing background  
Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for...
8658573 Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies  
The invention relates to novel photo-generated carbohydrate arrays and methods of their use to detect the presence of one or more agents in a sample. The invention also relates to a...
8569046 Microarray with microchannels  
A microarray formed in a planar surface of a moldable slab, the microarray including a plurality of microwell sets comprising a plurality of microwells formed in the planar surface of the moldable...
8492315 Method of providing a pattern of biological-binding areas for biological testing  
The present invention provides a method of forming one or more biological-binding areas on a substrate for biological-testing. The method includes activating at least a portion of a glass-ceramic...
8440518 Method for manufacturing a pattern formed body, method for manufacturing a functional element, and method for manufacturing a semiconductor element  
A manufacturing method of a semiconductor element from a pattern formed body capable of attaining patterning efficiently with a high precision. The method includes a photoresist pattern formation...
8383057 Probe array substrate and method for producing the same, and probe array and method for producing the same  
A probe array substrate suitable for forming a probe array that has high packing density, that can hold sufficient amounts of probe molecules, and that has little variation in the amounts of probe...
8377852 Method of preparing a substrate with a composition including an organoborane initiator  
A method of preparing a substrate with a composition comprising (i) an organoborane initiator and (ii) a radical curable component disposed thereon includes the step of depositing the composition...
8372785 Method for immobilizing self-organizing material or fine particle on substrate, and substrate manufactured by using such method  
A method for immobilizing a self-organizing material or fine particles on a substrate, and a substrate whereupon the self-organizing material or the fine particles are immobilized. More...
8343855 Nanostructured device  
The invention concerns a nanostructured device (100) comprising a substrate (101), an intermediate layer (102), a zone (103) consisting of multiple three-dimensional structured sites (104) made of...
8343778 Microfluidic microarray assemblies and methods of manufacturing and using  
The invention encompasses microfluidic microarray assemblies (MMA) and subassemblies and methods for their manufacture and use. In one embodiment, first and second channel plates are provided and...
8333932 Microarray having bright fiducial mark and method of obtaining optical data from the microarray  
A substrate includes; a fiducial mark disposed on the substrate, an area on the substrate on which a probe material is configured to be immobilized, the area being separated from the fiducial...
8282896 Devices and methods for holding microfluidic devices  
Carriers or holders for holding microfluidic devices are provided. Some of the carriers that are provided include a hydration control device and/or a source of controlled fluid pressure to...
8241509 Capillary-channel probes for liquid pickup, transportation and dispense using stressy metal  
Fluidic conduits, which can be used in microarraying systems, dip pen nanolithography systems, fluidic circuits, and microfluidic systems, are disclosed that use channel spring probes that include...
8242058 Reagents and methods for appending functional groups to proteins  
Methods and reagents for site-selective functionalization of peptides and proteins. The methods most generally involve the reaction of a thioester with hydrazine. Reagents include bifunctional...
8232108 Method of making micro-pixelated fluid-assay structure  
A method for producing an active-matrix, fluid-assay micro-structure including, utilizing low-temperature TFT and Si technology, establishing preferably on a glass or plastic substrate a matrix...
8193123 Articles having localized molecules disposed thereon and methods of producing same  
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the...
8178474 Functionalised solid support for alpha-oxoaldehyde synthesis  
The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in...
8067338 Trichloro silyl alkyl isocyanate molecule and surface modified mineral substrate  
A compound having formula (I): X—E—Si−Cl3 (I) wherein:X represents an isocyanate function;E represents a straight, branched or cyclic alkyl chain comprising from 4 to 30 carbon atoms, and...
8067340 Methods for discretized processing and process sequence integration of regions of a substrate  
The present invention provides methods and systems for discretized, combinatorial processing of regions of a substrate such as for the discovery, implementation, optimization, and qualification of...
7989396 Biomolecule immobilization on biosensors  
A highly specific and versatile surface chemistry for immobilization of amine-terminated probes is disclosed. A bi-layered polymer thin film serves as the platform for coupling the probes, which...
7985715 Combinatorial artificial receptors including peptide building blocks  
The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of...
7976824 Production of 2-18F-2-deoxy-D-glucose via solid-phase synthesis  
The invention relates to a compound of formula (I): wherein P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such...
7960312 Method and agent for immobilizing protein via protein bound to silicon oxide-containing substance  
Disclosed is a method for immobilizing a target protein to the surface of silicon oxide-containing substance such as glass without modifying the surface of silicon oxide-containing substance by...
7956011 Materials and methods for the photodirected synthesis of oligonucleotide arrays  
Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator...
7935659 Multiplexed assays using encoded solid supports  
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The...
7846875 Coupling agents comprising a photolabile protecting group and uses thereof, such as for the functionalisation of solid supports  
The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to...
7825070 Method of two-dimensionally arraying ferritin on substrate  
A novel method for two-dimensionally arraying ferritin on a substrate is provided which obviates the need for a metal ion that permits linking between adjacent two ferritin particles. In a method...
7795182 Method for making biochips  
A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.

Matches 1 - 50 out of 151 1 2 3 4 >