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7560417 |
Method and apparatus for parallel synthesis of chain molecules such as DNA
Synthesis of chain molecules such as DNA is carried out in a conduit having an interior channel with an inlet end and an outlet end. At least one wall of the conduit is substantially transparent to...
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7557069 |
Combinatorial synthesis on arrays
The present invention provides methods for synthesizing arrays of polymers. A barrier to a reaction is applied to select features of the array thereby limiting the reaction to the remaining features.
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7504365 |
Combinatorial artificial receptors including tether building blocks
The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of...
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7504364 |
Methods of making arrays and artificial receptors
The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building...
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7479472 |
DNA-templated combinatorial library chemistry
The present invention describes templated combinatorial chemical libraries comprised of a plurality of bifunctional molecules having both a chemical compound and a nucleic acid tag that defines the...
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7427260 |
Efficient methods for solid phase synthesis using trityl chloride resins
Disclosed are efficient methods for loading amino derivatives onto trityl chloride resins and for cleaving chemically modified amino derivatives from trityl chloride resins. Methods for making a...
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7387865 |
Composition containing a photoacid generator monomer, substrate coated with the composition, method for synthesizing a compound on a substrate using the composition, and microarray produced according to the method
A composition containing a photoacid generator monomer and surfactant, and a method for synthesizing a compound on a substrate using the composition are provided. The method includes bonding a...
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7384388 |
Styryl dyes with linker
A combinatorial library of solid-state fluorescent dyes is prepared by reacting an aldehyde with a solid-supported pyridinium salt having a linker.
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6929944 |
Analysis using a distributed sample
The present invention is directed to the production of a sample microarray for use in detecting one or more target biopolymers in the sample. The sample microarray of this invention is formed by...
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6919211 |
Polypeptide arrays
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6893823 |
Polynucleotide separation method and apparatus therefor
Different probes each having a specific base sequence are immobilized to each of independent areas formed on the surface of a substrate, complementary polynucleotides in a sample solution are...
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6833921 |
Optical systems and methods for rapid screening of libraries of different materials
Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or...
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6828435 |
Combinatorial protecting group strategy for multifunctional molecules
The use of protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or...
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6828143 |
Nanoscale chemical synthesis
A modular reactor system and method for synthesizing nanoscale quantities of chemical compounds characterized by a continuous flow reactor under high pressure having uniform temperature throughout...
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6794052 |
Polymer arrays from the combinatorial synthesis of novel materials
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
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6746104 |
Method for generating molecular arrays on porous surfaces
The present invention provides a unique and highly accurate method for generating molecular arrays of very high density on porous surfaces. The method involves the application of focused acoustic...
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6699719 |
Biosensor arrays and methods
A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface...
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6696605 |
Process for preparing α-hydroxyamides and α-ketoamides on a solid phase support
The present invention relates to a process for preparing a α-hydroxyamide or α-ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide...
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6667406 |
Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries
Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels...
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6664372 |
Azatide peptidomimetics
Peptidomimetic azatides and combinatorial oligoazitide libraries are produced by means of a stepwise synthesis. Combinatorial library construction of this new biomimetic polymer provides a means to...
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6649413 |
Synthesis and screening combinatorial arrays of zeolites
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
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6632641 |
Method and apparatus for performing large numbers of reactions using array assembly with releasable primers
The present invention relates to a method and apparatus for performing a large number of reactions using array assembly. In particular, the present invention features a method and apparatus for...
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6627400 |
Multiplexed measurement of membrane protein populations
Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound...
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6610504 |
Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase
The present invention relates to compositions and methods for assaying the activity of methyltransferases, such as S-adenosylmethionine (SAM)-dependent methyltransferases. The methods can be used...
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6605438 |
Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
The disclosure relates to the stabilization of a fluid drop comprising a liquid solvent and solute, so that upon drying of the solvent, the solute is not preferentially concentrated at the edges of...
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6590092 |
Process for preparing a “universal support” and the reagents used for generating such support
Universal solid supports suitable for use synthesizing of oligonucleotides. The solid supports may be used irrespective of the first RNA or DNA nucleotide to be synthesized, and irrespective of the...
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6589726 |
Method and apparatus for in situ synthesis on a solid support
The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for...
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6586211 |
Method for producing polymers
The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) provision of a support having a...
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6583318 |
Method for synthesis of α-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives
A method of synthesizing α-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or...
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6582908 |
Oligonucleotides
The present invention provides a number of oligonucleotide sequences which can be used for a wide variety of analyses applicable to the diverse fields impacted by the nature of molecular...
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6566494 |
Support material for solid phase organic synthesis
A support material for solid phase synthesis is provided having an amine-containing organic group attached to it through a linker. The support material is of the following general formula (Formula I):
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6558904 |
Method for producing structured, self-organized molecular monolayers of individual molecular species, in particular substance libraries
The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded...
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6541276 |
Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a...
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6541211 |
Apparatus and method for synthesizing combinational libraries
An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library...
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6528324 |
Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports
A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers...
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6492096 |
Patterned molecular self-assembly
A patterned molecular self-assembly is provided. The patterned molecular self-assembly comprises a support having an exposed patterned surface and a non-patterned surface. A compound is selectively...
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6485913 |
Systems and methods for performing reactions in an unsealed environment
Open systems for performing submicroliter reactions are provided. The systems can include a support for performing the reaction; a liquid dispensing system for dispensing a submicroliter amount of...
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6482591 |
Conformationally-restricted peptide probe libraries
Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific...
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6468740 |
Cyclic and substituted immobilized molecular synthesis
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6458583 |
Method and apparatus for making nucleic acid arrays
Methods and devices for depositing a nucleic acid on a substrate surface are provided. In the subject methods, a thermal inkjet head loaded with nucleic acid fluid composition is positioned in...
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6448443 |
Synthesis of combinatorial libraries of compounds reminiscent of natural products
The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds...
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6420123 |
Spatially defined synthesis
In accordance with the method of the invention and within the framework of the split synthesis technique, compounds are synthesized on macroscopic solid support units which are spatially organized...
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6413724 |
Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The...
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6395491 |
Method of information storage and recovery
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6387273 |
Sample preparation for high throughput purification
An HPLC method for purifying and/or characterizing large numbers of related compounds, for example, combinatorial and lead generation libraries, is disclosed. The compounds are purified on a...
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6376256 |
Rapid process for arraying and synthesizing bead-based combinatorial libraries
A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive...
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6362009 |
Solid phase synthesis of heterocycles
Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones,...
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6350609 |
Electrospraying for mass fabrication of chips and libraries
A method of fabricating deposits of non-volatile substances, including biomacromolecules, in the form of spots and filing on a substrate surface by electrospray, where the deposits are used to...
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6346413 |
Polymer arrays
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6329139 |
Automated sorting system for matrices with memory
Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of...
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