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7704924 Library of compounds comprising pyrrolobenzodiazepine moieties  
A compound of formula (IV): O is a solid support; L is a linking group or a single bond; X′ is selected from CO, NH, S, or O; A is O, S, NH, or a single bond; R2 and R3 are independently selected...
7655602 Peptides comprising aromatic D-amino acids and methods of use  
Disclosed are D-peptides and libraries of D-peptides comprising aromatic D-amino acids. Also disclosed are methods for identifying small D-peptides comprising aromatic D-amino acids that bind to...
7560417 Method and apparatus for parallel synthesis of chain molecules such as DNA  
Synthesis of chain molecules such as DNA is carried out in a conduit having an interior channel with an inlet end and an outlet end. At least one wall of the conduit is substantially transparent...
7557069 Combinatorial synthesis on arrays  
The present invention provides methods for synthesizing arrays of polymers. A barrier to a reaction is applied to select features of the array thereby limiting the reaction to the remaining features.
7504364 Methods of making arrays and artificial receptors  
The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building...
7504365 Combinatorial artificial receptors including tether building blocks  
The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of...
7479472 DNA-templated combinatorial library chemistry  
The present invention describes templated combinatorial chemical libraries comprised of a plurality of bifunctional molecules having both a chemical compound and a nucleic acid tag that defines...
7427260 Efficient methods for solid phase synthesis using trityl chloride resins  
Disclosed are efficient methods for loading amino derivatives onto trityl chloride resins and for cleaving chemically modified amino derivatives from trityl chloride resins. Methods for making a...
7387865 Composition containing a photoacid generator monomer, substrate coated with the composition, method for synthesizing a compound on a substrate using the composition, and microarray produced according to the method  
A composition containing a photoacid generator monomer and surfactant, and a method for synthesizing a compound on a substrate using the composition are provided. The method includes bonding a...
7384388 Styryl dyes with linker  
A combinatorial library of solid-state fluorescent dyes is prepared by reacting an aldehyde with a solid-supported pyridinium salt having a linker.
6929944 Analysis using a distributed sample  
The present invention is directed to the production of a sample microarray for use in detecting one or more target biopolymers in the sample. The sample microarray of this invention is formed by...
6919211 Polypeptide arrays  
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
6893823 Polynucleotide separation method and apparatus therefor  
Different probes each having a specific base sequence are immobilized to each of independent areas formed on the surface of a substrate, complementary polynucleotides in a sample solution are...
6833921 Optical systems and methods for rapid screening of libraries of different materials  
Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or...
6828435 Combinatorial protecting group strategy for multifunctional molecules  
The use of protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or...
6828143 Nanoscale chemical synthesis  
A modular reactor system and method for synthesizing nanoscale quantities of chemical compounds characterized by a continuous flow reactor under high pressure having uniform temperature throughout...
6794052 Polymer arrays from the combinatorial synthesis of novel materials  
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
6746104 Method for generating molecular arrays on porous surfaces  
The present invention provides a unique and highly accurate method for generating molecular arrays of very high density on porous surfaces. The method involves the application of focused acoustic...
6699719 Biosensor arrays and methods  
A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface...
6696605 Process for preparing α-hydroxyamides and α-ketoamides on a solid phase support  
The present invention relates to a process for preparing a α-hydroxyamide or α-ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide...
6667406 Methods for the synthesis of complex reduced isoindole, isooxyindole and isooxyquinoline libraries  
Disclosed are methods of synthesizing libraries of diverse complex hexahydroisoindole, hexahydroisooxyindole and octahydroisooxyquinoline compounds through the use of a facile intramolecular Diels...
6664372 Azatide peptidomimetics  
Peptidomimetic azatides and combinatorial oligoazitide libraries are produced by means of a stepwise synthesis. Combinatorial library construction of this new biomimetic polymer provides a means...
6649413 Synthesis and screening combinatorial arrays of zeolites  
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
6632641 Method and apparatus for performing large numbers of reactions using array assembly with releasable primers  
The present invention relates to a method and apparatus for performing a large number of reactions using array assembly. In particular, the present invention features a method and apparatus for...
6627400 Multiplexed measurement of membrane protein populations  
Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound...
6610504 Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase  
The present invention relates to compositions and methods for assaying the activity of methyltransferases, such as S-adenosylmethionine (SAM)-dependent methyltransferases. The methods can be used...
6605438 Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents  
The disclosure relates to the stabilization of a fluid drop comprising a liquid solvent and solute, so that upon drying of the solvent, the solute is not preferentially concentrated at the edges...
6590092 Process for preparing a “universal support” and the reagents used for generating such support  
Universal solid supports suitable for use synthesizing of oligonucleotides. The solid supports may be used irrespective of the first RNA or DNA nucleotide to be synthesized, and irrespective of...
6589726 Method and apparatus for in situ synthesis on a solid support  
The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for...
6586211 Method for producing polymers  
The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) provision of a support having a...
6583318 Method for synthesis of α-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives  
A method of synthesizing α-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or...
6582908 Oligonucleotides  
The present invention provides a number of oligonucleotide sequences which can be used for a wide variety of analyses applicable to the diverse fields impacted by the nature of molecular...
6566494 Support material for solid phase organic synthesis  
A support material for solid phase synthesis is provided having an amine-containing organic group attached to it through a linker. The support material is of the following general formula (Formula I):
6558904 Method for producing structured, self-organized molecular monolayers of individual molecular species, in particular substance libraries  
The invention relates to a method for producing structured, self-organized molecular monolayers of individual molecular species. The invention is preferably used to create solid-phase bonded...
6541211 Apparatus and method for synthesizing combinational libraries  
An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library...
6541276 Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof  
A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a...
6528324 Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports  
A system for producing a library of oligomer comprising at least two monomers in a positionally determined array comprise a plurality of synthesis supports, a first plurality of support carriers...
6492096 Patterned molecular self-assembly  
A patterned molecular self-assembly is provided. The patterned molecular self-assembly comprises a support having an exposed patterned surface and a non-patterned surface. A compound is...
6485913 Systems and methods for performing reactions in an unsealed environment  
Open systems for performing submicroliter reactions are provided. The systems can include a support for performing the reaction; a liquid dispensing system for dispensing a submicroliter amount of...
6482591 Conformationally-restricted peptide probe libraries  
Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific...
6468740 Cyclic and substituted immobilized molecular synthesis  
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
6458583 Method and apparatus for making nucleic acid arrays  
Methods and devices for depositing a nucleic acid on a substrate surface are provided. In the subject methods, a thermal inkjet head loaded with nucleic acid fluid composition is positioned in...
6420123 Spatially defined synthesis  
In accordance with the method of the invention and within the framework of the split synthesis technique, compounds are synthesized on macroscopic solid support units which are spatially organized...
6413724 Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones  
The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The...
6395491 Method of information storage and recovery  
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
6387273 Sample preparation for high throughput purification  
An HPLC method for purifying and/or characterizing large numbers of related compounds, for example, combinatorial and lead generation libraries, is disclosed. The compounds are purified on a...
6376256 Rapid process for arraying and synthesizing bead-based combinatorial libraries  
A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive...
6362009 Solid phase synthesis of heterocycles  
Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones,...
6350609 Electrospraying for mass fabrication of chips and libraries  
A method of fabricating deposits of non-volatile substances, including biomacromolecules, in the form of spots and filing on a substrate surface by electrospray, where the deposits are used to...
6346413 Polymer arrays  
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
Matches 51 - 100 out of 154 < 1 2 3 4 >