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6323366 |
Arylamine synthesis
The present invention provides a method for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated...
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6287778 |
Allele detection using primer extension with sequence-coded identity tags
A method for determining the genotype of one or more individuals at a polymorphic locus employs amplification of a region of DNA, labeling of allele-specific extension primers containing tags, and...
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6284459 |
Solid support matrices with memories and combinatorial libraries therefrom
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
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6265228 |
Process for preparing combinatorial amide alcohol libraries
Combinatorial chemical libraries of the Formula [S]--C(O)--L'--Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and --L'--Z is a...
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6261776 |
Nucleic acid arrays
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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6255120 |
Combinatorial library of substituted statine esters and amides via a novel acid-catalyzed rearrangement
A combinatorial chemical library comprising a plurality of members of the Formula [S]--C(O)--L'-Z containing hydroxyamides is disclosed, in which [S] represents a solid support and L'-Z is a...
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6235871 |
Synthesis of oligoarylamines, and uses and reagents related thereto
The transition metal-catalyzed amination of aryl halides, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. The oligoaniline...
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6228986 |
Solid-phase synthesis of novel 14-membered macroycles for high throughput screening
The preparation of 14-membered macrocycles from a resin-bound orthogonally protected lysine residue is described. Reductive alkylation of the a-nitrogen followed by acylation with an Fmoc-aminoacid...
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6228645 |
Promoter elements conferring root-preferred gene expression
This invention relates generally to mechanisms of gene expression in plants and more specifically to regulation of expression of genes in plants in a "tissue-preferred" manner. A method for...
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6204326 |
PNA combinatorial libraries and improved methods of synthesis
New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid...
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6194544 |
Cyclic semi-random peptide libraries
Cyclic penta- and hexa-peptide libraries containing one or more known amino acids, one or more randomized amino acids and a conformationally constraining element are disclosed. These peptide...
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6190875 |
Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe
Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a...
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6177572 |
Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
Methods for preparing benzoxazoles and benzothiazoles on solid supports. Substituted benzothiazoles and benzoxazoles, libraries of the compounds, and methods of using the compounds are also disclosed.
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6168914 |
System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
The invention provides a system and method for synthesizing chemicals onto supports in a parallel manner to produce a combinatorial collection of compounds. The system includes a plurality of...
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6153743 |
Lithographic mask design and synthesis of diverse probes on a substrate
Systems and methods of synthesizing probes on a substrate are provided. One or more shift reticles are utilized to uniformly add monomers to the substrate at specified locations. The shift reticles...
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6133436 |
Beads bound to a solid support and to nucleic acids
Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are...
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6127191 |
Aminobenzenedicarboxylic acid-based combinatorial libraries
The present invention provides a library of compounds, each comprised of a common aminobenzenedicarboxylic acid core structure (scaffold) that serves as a template for synthesizing approximately 10...
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6127489 |
Silyl linker for solid phase organic synthesis of aryl-containing molecules
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6121048 |
Method of conducting a plurality of reactions
An apparatus and method is provided for preparing and using a very large and diverse array of compounds on a substrate having rapidly accessible locations. The substrate contains cells in which the...
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6121054 |
Method for separation of liquid and solid phases for solid phase organic syntheses
A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic...
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6093799 |
Universal linker for combinatorial synthesis
A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates...
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6083727 |
Methods and compositions for producing 5' enriched cDNA libraries
Methods are provided for preparing a double-stranded cDNA corresponding to the 5' end of an mRNA. In the subject methods, an mRNA is first contacted with an oligo dT primer under first strand cDNA...
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6083761 |
Method and apparatus for transferring and combining reagents
The invention provides exemplary systems, methods, and apparatus for distinctly allocating liquids containing chemical compositions or compounds to known locations in an organized manner so that...
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6051439 |
Methods for parallel synthesis of organic compounds
The invention provides a method for synthesizing various chemicals onto solid supports, cleaving the synthesized compounds and preparing samples for analysis. In one exemplary embodiment, the...
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6008058 |
Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
A method of preparing cyclic peptide mixtures via side chain or backbone and solid phase synthesis. The cyclic peptide mixtures form libraries that are useful for screening purposes featuring the...
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6004823 |
Compounds
The present invention relates to libraries of compounds based upon a N-(4-alkoxyphenyl)-N-acyl-benzylamine, N-(4-alkoxyphenylmethyl)-N-acyl-benzylamine and...
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6001311 |
Apparatus for diverse chemical synthesis using two-dimensional array
A chemical synthesis apparatus (20) for building chemical compounds includes a head assembly (21) having an array of nozzles (22) with each nozzle or plurality of nozzles coupled to a reservoir...
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5976813 |
Continuous format high throughput screening
Continuous format high throughput screening (CF-HTS) using at least one porous matrix allows the pharmaceutical industry to simultaneously screen large numbers of chemical entities for a wide range...
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5976894 |
Combinatorial amide alcohol libraries
Combinatorial chemical libraries of the Formula [S]-C(O)-L'-Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and -L'-Z is a...
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5965719 |
Combinatorial synthesis of carbohydrate libraries
Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide...
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5962337 |
Combinatorial 1,4-benzodiazepin-2,5-dione library
A method has now been found of synthesizing a combinatorial library of 1,4-benzodiazepin-2,5-diones on solid supports via an aza-Wittig ring closure, said compounds optionally encoded with tags,...
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5942387 |
Combinatorial process for preparing substituted thiophene libraries
This invention relates to a novel solid phase process for the preparation of thiophene combinatorial libraries. These libraries have use for drug discovery and are used to form wellplate components...
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5932743 |
Methods for the solid phase synthesis of substituted indole compounds
The present invention relates to novel substituted indole compounds of formula (I) ##STR1## having pharmacological activity, to processes for their preparation, to solid phase methods for preparing...
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5916899 |
Isoquinoline derivatives and isoquinoline combinatorial libraries
The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries...
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5900481 |
Bead linkers for immobilizing nucleic acids to solid supports
Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are...
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5889165 |
Photolabile nucleoside protecting groups
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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5859190 |
Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by...
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5851494 |
Solid phase synthesis reaction vessel and method of using the same
A solid phase synthesis reaction vessel includes a vessel with a first inlet, a second inlet, and an outlet. A first stopcock is disposed within the first inlet and a second stopcock is disposed...
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5817751 |
Method for synthesis of diketopiperazine and diketomorpholine derivatives
The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of...
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5811241 |
Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones
The invention provides a method of synthesizing N-substituted 1,4-piperazines and N-substituted 1,4-piperazinediones. The invention also provides a method for synthesing combinatorial libraries of...
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5789162 |
Methods of synthesizing diverse collections of oligomers
A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate...
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5770358 |
Tagged synthetic oligomer libraries
A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates...
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5759779 |
Polynucleotide-array assay and methods
A method of analyzing the sequence of a polynucleotide analyte. The method includes contacting the analyte with a position-addressable array of oligonucleotides, each anchored to a solid support...
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5744305 |
Arrays of materials attached to a substrate
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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5684130 |
Process for synthesis of organic compounds using magnetic particles
This invention provides a process for the synthesis of a defined chemical entity, i.e., any desired chemical compound, in high yield using a solid support comprising a magnetic particle, in organic...
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5679773 |
Reagants and methods for immobilized polymer synthesis and display
Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, β-turn mimetics, and prostaglandins. The present invention provides new...
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5591646 |
Method and apparatus for peptide synthesis and screening
Method and apparatus for simple and rapid preparation of reusable, addressable surface-immobilized arrays of biomolecules (libraries) used for screening for interaction with any biologically...
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5550215 |
Polymer reversal on solid surfaces
A method for cyclization and reversal of the polarity of polymers on a substrate. The method provides for the formation of a polymer on a substrate (2) with a tether molecule (4). Through unmasking...
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5545568 |
Solid phase and combinatorial synthesis of compounds on a solid support
Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is...
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5545531 |
Methods for making a device for concurrently processing multiple biological chip assays
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a...
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