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7585815 |
High throughput protein production screening
Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic...
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7442773 |
Universal peptide-binding scaffolds and protein chips
The present invention provides a universal peptide-binding scaffold. This scaffold is used to bind a target. The target can be a peptide or peptides of interest (for example, peptides associated...
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7399585 |
Biological identification system with integrated sensor chip
The system includes a microfabricated electrochemical biosensor for detecting the presence and/or quantity of the target analyte in the sample reagent. The biosensor includes a substrate and at...
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7335153 |
Arrays of microparticles and methods of preparation thereof
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities...
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6830890 |
Nucleic acid probe libraries
Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific...
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6821737 |
Method for screening for drug candidates for modulating transcription factor activity
Method and kits are provided for screening for transcription factor modulators efficiently. In one aspect, the method can be employed to profile multiple, different transcription factors activated...
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6696256 |
Method, array and kit for detecting activated transcription factors by hybridization array
Methods, arrays and kits are provided for rapidly and efficiently identifying and quantifying multiple different activated transcription factors in a biological sample at the same time. In one...
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6515039 |
Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material
The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous...
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6500609 |
Method and apparatus for synthesizing characterizing and assaying combinatorial libraries
Devices and processes for synthesizing, purifying and analyzing large numbers of compounds for use in combinatorial libraries, are disclosed. The processes involve generating a series of compounds...
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6491967 |
Plasma spray high throughput screening method and system
Combinatorial high throughput screening is used to rapidly investigate and screen a multiplicity of complex thermal barrier coating candidates. In the screening method, a solution of thermal...
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6480791 |
Parallel methods for genomic analysis
The present invention provides parallel methods for determining nucleotide sequences and physical maps of polynucleotides associated with sample tags. This information can be used to determine the...
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6479268 |
7970, a novel ATPase-like molecule and uses thereof
Novel ATPase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ATPase-like proteins, the invention further provides isolated ATPase-like...
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6440667 |
Analysis of target molecules using an encoding system
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6352828 |
Oligonucleotide tags for sorting and identification
The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise...
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6280935 |
Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags
The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise...
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6245517 |
Ratio-based decisions and the quantitative analysis of cDNA micro-array images
Gene expression can be quantitatively analyzed by hybridizing fluor-tagged mRNA to targets on a cDNA micro-array. Comparison of gene expression levels arising from co-hybridized samples is achieved...
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6228589 |
Measurement of gene expression profiles in toxicity determination
A method is provided for assessing the toxicity of a compound in a test organism by measuring gene expression profiles of selected tissues. Gene expression profiles are measured by massively...
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6197506 |
Method of detecting nucleic acids
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6180348 |
Method of isolating target specific oligonucleotide ligands
This invention relates to methods of preparing oligonucleotide libraries, isolating oligonucleotide aptamers to target molecules from the libraries, and using the aptamers to purify target...
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6150516 |
Kits for sorting and identifying polynucleotides
The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise...
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6107021 |
Synthetic peptide vaccines for foot-and-mouth disease
The present invention relates to the use of a peptide composition as an immunogen, with each peptide contained therein comprising a target antigenic site derived from the VP1 capsid protein of...
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5925525 |
Method of identifying nucleotide differences
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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5891630 |
Multi-site detection apparatus
A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site...
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5861242 |
Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
The invention provides an array of oligonucleotide probes immobilized on a solid support for analysis of a target sequence from a human immunodeficiency virus. The array comprises at least four...
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5759779 |
Polynucleotide-array assay and methods
A method of analyzing the sequence of a polynucleotide analyte. The method includes contacting the analyte with a position-addressable array of oligonucleotides, each anchored to a solid support...
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5747253 |
Combinatorial oligomer immunoabsorbant screening assay for transcription factors and other biomolecule binding
Methods useful for the determination of oligomers which have specific activity for a transcription factor or other target molecule from a pool of primarily randomly assembled subunits are provided....
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5670322 |
Multi site molecule detection method
A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site...
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5604097 |
Methods for sorting polynucleotides using oligonucleotide tags
The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention each...
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