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7601823 |
Nucleic acid inhibitors of glutamate receptors
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of...
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7595157 |
Microarrays utilizing hydrogels
A method of making a microarray by coating a flat substrate with a polymerizable hydrogel layer which contains anchoring moieties dispersed uniformly therethroughout. Following curing, a continuous...
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7579192 |
High throughput screening methods for lubricating oil compositions
A method for determining storage stability for a plurality of fluid lubricant samples of different compositions is provided. Each sample includes one or more lubricating oil additives, or a...
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7557070 |
Multiplexed cell analysis system
Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers.
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7557069 |
Combinatorial synthesis on arrays
The present invention provides methods for synthesizing arrays of polymers. A barrier to a reaction is applied to select features of the array thereby limiting the reaction to the remaining features.
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7550410 |
Method and apparatus for combinatorial chemistry
A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable...
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7544638 |
Device for chemical and biochemical reactions using photo-generated reagents
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the...
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7541314 |
Microarray having a base cleavable sulfonyl linker
The present invention provides a microarray having base cleavable, sulfonyl-containing linkers and a process to make the microarray. Oligonucleotides of any sequence may be synthesized on the...
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7534742 |
Isoprenoid biosynthesis
The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More...
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7504365 |
Combinatorial artificial receptors including tether building blocks
The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of...
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7504364 |
Methods of making arrays and artificial receptors
The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building...
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7468280 |
High throughput preparation of lubricating oil compositions for combinatorial libraries
A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided....
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7462490 |
Combinatorial lubricating oil composition libraries
A combinatorial lubricating oil composition library is provided including at least a plurality of different lubricating oil compositions comprising (a) a major amount of a base oil of lubricating...
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7431685 |
Method and device for investigating substance libraries
The aim of the invention is to investigate the bonding of substances to target molecules. This is achieved by means of a densely packed device wherein various target molecules are bonded in a large...
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7367933 |
Screening of chemical compounds purified from biological sources
A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type...
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7331920 |
Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same
Methods for preparing a glycopeptide are disclosed. The methods comprise the steps of selecting a protected glycopeptide of the formula A 1 -A 2 -A 3 -A 4 -A 5 -A 6 -A 7 , wherein the groups A 1 ...
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6844161 |
Modular protein libraries and methods of preparation
Novel proteins and protein libraries are disclosed. The proteins possess one or more functional protein modules from different parent protein molecules. The proteins and protein libraries are...
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6640191 |
Library design in combinatorial chemistry by Monte Carlo methods
Methods for generating multiple rounds of combinatorial libraries, which use Monte Carlo methods to search the multi-dimensional composition and non-composition space of variables in combinatorial...
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6503452 |
Biosensor arrays and methods
A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface...
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6497820 |
Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
Disclosed is a rapid method for the separation of small organic compounds using gradient reverse phase HPLC. The method achieves a run time of one minute or less and a resolution with a peak...
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6372885 |
Solid-phase technology for the preparation of amides
Method for preparing a combinatorial chemistry library of compounds of the formula R1—C(═O)—NH—R2, wherein R1 and R2 are as defined in the specification, which comprises acylating a...
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6048698 |
Parallel SELEX™
This invention discloses a method for coevolving products from two or more reactants, along with the nucleic acid that can facilitate the reaction for making the products. The invention further...
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5958702 |
Receptor-assisted combinatorial chemistry
This invention provides a method for preparing molecules that bind to a preselected receptor, whereby the receptor itself acts as an agent for either joining two ligand fragments to form a...
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5907047 |
Papyracillic acid, method for preparation and its use as synthon for bioactive substances
This invention relates to a new biologically active compound as shown in formula (I) and its biologically active derivatives; whereas derivatives are produced by the reaction of formula (I) with...
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5863708 |
Partitioned microelectronic device array
A method of making a dielectric substrate array for conducting a plurality of reactions in parallel in a number of wells, the method comprising: forming a first passage and a second passage each...
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5545531 |
Methods for making a device for concurrently processing multiple biological chip assays
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a...
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