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8183178 Iterated branching reaction pathways via nucleic acid-mediated chemistry  
The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and...
8119572 Methods for determining protein binding specificity using peptide libraries  
A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase...
8084400 Methods for discretized processing and process sequence integration of regions of a substrate  
The present invention provides methods and systems for discretized, combinatorial processing of regions of a substrate such as for the discovery, implementation, optimization, and qualification of...
8076467 Nucleic acid inhibitors of glutamate receptors  
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ...
8067340 Methods for discretized processing and process sequence integration of regions of a substrate  
The present invention provides methods and systems for discretized, combinatorial processing of regions of a substrate such as for the discovery, implementation, optimization, and qualification of...
8048826 Methods for combinatorial synthesis on arrays  
The present invention provides methods for synthesizing arrays of polymers. The polymers are synthesized from monomers through a series of synthesis steps at chemically-modified electrodes by the...
8022013 Method of forming and using solid-phase support  
A method of forming a solid-phase support, the method including the steps of providing a substrate having a reaction vessel, dispensing a particle in the reaction vessel, and permanently bonding...
7998904 Evolving new molecular function  
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for...
7994097 Microarray, substrate for microarray and methods of fabricating the same  
A microarray, a substrate for a microarray and more productive methods of fabricating the microarray and the substrate are provided. The microarray includes a substrate divided into a first region...
7989395 Methods for identifying compounds of interest using encoded libraries  
The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
7985598 Biomolecule-immobilized plate and method for fabricating biomolecule-immobilized plate  
There is provided a biomolecule-immobilized plate having a flat part, at least a surface of the flat part comprising a polymer material, wherein the flat part has an arithmetic average roughness of...
7981843 Antibody specificity transfer using minimal essential binding determinants  
The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal...
7977279 Differential phage capture proteomics  
Disclosed herein are methods for identifying, isolating and comparing proteins and other biomolecules differing between two complex biological samples using affinity chromatography and phage...
7972992 Methods for synthesis of encoded libraries  
The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an...
7972993 Identification of protein binding sites  
The invention relates to the field of molecular recognition or detection of discontinuous or conformational binding sites or epitopes corresponding to a binding molecule, in particular, in relation...
7972994 Methods for synthesis of encoded libraries  
The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding...
7964535 Arrays and artificial receptors  
The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building...
7960311 Methods employing combinatorial artificial receptors  
The present invention relates to methods employing artificial receptors, such as combinatorial artificial receptor arrays. The present receptors include heterogeneous and immobilized combinations...
7956011 Materials and methods for the photodirected synthesis of oligonucleotide arrays  
Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator...
7935658 Methods for synthesis of encoded libraries  
The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally...
7915201 Ligational encoding of small molecules  
The invention relates to a method for synthesising a bifunctional complex comprising an encoded molecule and an identifier polynucleotide identifying the chemical entities having participated in...
7893007 Directed evolution of novel binding proteins  
In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal...
7888291 Substrates and assays for β-secretase  
The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage ...
7888292 Nano-chem-FET based biosensors  
Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising...
7884052 Combinatorial artificial receptors including tether building blocks on scaffolds  
The present invention relates to artificial receptors on scaffolds, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building...
7873477 Method and system using systematically varied data libraries  
Methods and systems for providing biological results in the form of systematically varied libraries of sequences or as data representing sequences or physical preparations of systematically varied...
7858375 Air-stable supported lipid bilayer membranes  
The present invention relates to methods for fabricating air-stable supported lipid bilayer membranes. In one embodiment, the present invention relates to methods of producing supported lipid...
7858560 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions  
Capture Collections of capture compounds and collections thereof and methods using the compounds collections for the analysis of biomolecules are provided. In particular, collections, compounds and...
7842649 Quality control method for making a biochip displaying an encoded bead array  
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities...
7838466 Device for chemical and biochemical reactions using photo-generated reagents  
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the...
7829505 Method for construction of oligonucleotide microarrays  
Disclosed herein is a method for the preparation of oligonucleotide microarrays obviating the drawbacks to an extent, such as time consuming complex chemical reactions, preparation of modified...
7825069 Mass labels  
Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalization moiety; and 3) a cleavable linker connecting the mass marker moiety to...
7820413 Incrementally truncated nucleic acids and methods of making same  
A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all...
7816304 Mass labels  
Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to...
7781378 Protective coating for array material deposition  
An array is formed with a protective cover on a substrate. The protective cover is patterned to produce an array of openings to the substrate. Desired material is deposited on the substrate through...
7718578 Method of synthesis and testing of combinatorial libraries using microcapsules  
The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of...
7718579 Electrochemical deblocking using a hydrazine derivative  
A method for electrochemical removal of acid-labile protecting groups on an electrode microarray using an organic solution is disclosed. The solution comprises a hydrazine derivative and a salt in...
7713915 Cytotoxic heteromeric protein combinatorial libraries  
A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit...
7704925 Ligational encoding using building block oligonucleotides  
The present invention in one aspect relates to a method for synthesizing a bifunctional complex comprising a molecule and an identifier polynucleotide identifying at least some of the chemical...
7705136 Synthesis of 3′-, or 5′-, or internal methacrylamido-modified oligonucleotides  
New modifiers were synthesized for incorporation of a methacrylic function in 3′-, 5′- and internal positions of oligonucleotides during solid phase synthesis. A modifier was used for synthesis of ...
7702464 Method and apparatus for codon determining  
Computer processing methods and/or systems for minimizing and/or optimizing data strings in accordance with rules and options. Minimized data strings can represent data sequences important in...
7666819 Integrated micro array system and methods therefor  
Various methods are provided for an integrated micro array system (100) that allows fully automated sample processing and detection/quantification of nucleic acid and protein samples in a single...
7662751 Method and apparatus for detection of microscopic pathogens  
Detection apparatus for use in the detection of the presence of a selected pathogen in a sample are disclosed. Such apparatus include: a substrate with a detection region on a surface thereof, the...
7601823 Nucleic acid inhibitors of glutamate receptors  
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ...
7595157 Microarrays utilizing hydrogels  
A method of making a microarray by coating a flat substrate with a polymerizable hydrogel layer which contains anchoring moieties dispersed uniformly therethroughout. Following curing, a continuous...
7557070 Multiplexed cell analysis system  
Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers.
7557069 Combinatorial synthesis on arrays  
The present invention provides methods for synthesizing arrays of polymers. A barrier to a reaction is applied to select features of the array thereby limiting the reaction to the remaining features.
7550410 Method and apparatus for combinatorial chemistry  
A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable...
7544638 Device for chemical and biochemical reactions using photo-generated reagents  
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the...
7541314 Microarray having a base cleavable sulfonyl linker  
The present invention provides a microarray having base cleavable, sulfonyl-containing linkers and a process to make the microarray. Oligonucleotides of any sequence may be synthesized on the...
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