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8999897 Protein tag comprising a biotinylation domain and method for increasing solubility and determining folding state  
The use of a tag moiety comprising a biotinylation domain, such as biotin carboxyl carrier protein (BCCP), as a protein folding marker and protein solubility enhancer in the orientated surface...
8975379 Identification of cancer protein biomarkers using proteomic techniques  
The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to...
8969256 Solution microarrays and uses thereof  
The present invention relates to solution microarrays. In particular, the present invention relates to an aqueous 2-phase system for solution microarrays and uses thereof. The present invention...
8962550 Identification of inhibitors of a bacterial stress response  
A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response....
8927464 Assembly and deposition of materials using a superhydrophobic surface structure  
Fluidics-induced localized deposition and assembly of materials using a superhydrophobic surface structure is described. A method of localized deposition of a material includes contacting a...
8883692 Method for cell surface displaying of target proteins using Bacillus anthracis exosporium  
The present invention relates to a method for expressing a target protein on the surface of a microorganism using Bacillus anthracis exosporium protein. More particularly, to an expression vector...
8871688 Method for absolute quantification of polypeptides  
The present invention relates to a method for absolute quantification of polypeptides.
8859469 Protein chip and production method thereof  
A protein chip including at least a substrate having a plurality of steps which are regularly arranged on one surface thereof; a plurality of metallic microstructures arranged in the steps; and a...
8841238 Methods for producing active scFv antibodies and libraries therefor  
The present disclosure describes scFv antibody libraries, antibodies isolated from the libraries, and methods of producing and using the same.
8835162 Methods of incorporating amino acid analogs into proteins  
The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA,...
8808999 Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof  
The present invention relates to methods of identifying IGF-IR modulators and hybrid-R modulators comprising contacting IGF-IR with a humanized anti-IGF-IR antibody and contacting hybrid-R with a...
8802024 Biochip and manufacturing method thereof  
A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first...
8796003 Label free kinase assays and reagents  
This disclosure describes methods and compositions for measuring the binding specificity, kinetics and affinity of kinase inhibitors indirectly using mass sensing analytical techniques, such as...
8796184 Detection assay devices and methods of making and using the same  
An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c)...
8785352 Metal nanoparticle structures for enhancing fluorescence-based assays  
Provided, among other things, is a multiplex assay comprising: conducting a fluorescence-developing assay on microtabs having at least one surface that shows plasmonic enhancement, wherein a...
8778847 Immunogenic peptides of influenza virus  
Peptides and polypeptides that elicit immunogenic responses in a mammal; especially neutralizing antibodies, against human and avian influenza strains H1N1, H3N2, H5N1 and H7N7 are disclosed...
8759259 Compositions and methods for producing cyclic peptoid libraries  
Embodiments of the invention are directed to a one-bead-two-compound method for the creation of encoded cyclic peptoid libraries. This scheme is useful for the creation of cyclic peptoid...
8759007 Method to produce a receptor chip using biotinylated protein  
The present invention provides a method for detecting modified LDL, abnormal cells or bacteria using an intermolecular interaction analysis method, in which a region involved in ligand recognition...
8753822 Neoepitope detection of disease using protein arrays  
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of...
8748351 Method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands  
The present invention refers to a method for identifying hetero-multimeric ubiquitins with binding capability to a ligand. Furthermore, the invention provides DNA libraries encoding for a...
8748356 Methods for use in human-adapting monoclonal antibodies  
Methods useful for human adapting non-human monoclonal antibodies are disclosed. The methods select candidate human antibody framework sequences from a database of human germline genes or human...
8741814 T cell receptor display  
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native...
8735331 Display library for antibody selection  
Synthetic antibody display library containing human germline antibody molecules with variation in VH CDR3 and VL CDR3 and at position 52 of VH CDR2, for screening and selection of antibody...
8728985 Display of disulfide linked dimeric proteins in filamentous phage  
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion...
8728984 Acute kidney injury risk testing  
The present invention relates to the method of determining the risk of acute kidney injury comprising determining the amount of one or more marker(s) selected from REN, SLC38A4, IL17RB, TMEM149,...
8728485 Peptide library obtained from multi-clade chimeric immunogens derived from highly conserved regions of the human immunodeficiency virus type 1 (HIV-1) consensus proteome  
The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins....
8716472 Tripodal cyclohexane derivatives and their use as carbohydrate receptors  
A tri-podal compound according to formula (I) wherein, each Z is the same and is a substituted or unsubstituted N-heteroaromatic single-, multiple-, or fused-ring; and each A is the same, and can...
8709981 Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development  
The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are...
8709980 Cell surface display, screening and production of proteins of interest  
Aspects of the invention provide compositions and methods for displaying engineered polypeptides on a cell surface. According to aspects of the invention, immobilized polypeptides can be screened...
8703654 Identifying antigen clusters for monitoring a global state of an immune system  
Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of...
8697376 Synthetic protease substrates, assay methods using such substrates and kits for practicing the assay  
Synthetic protease substrates and methods which facilitate the identification of substrates of a protease, particularly ubiquitin, ubiquitin-like, or proteasome protein are provided.
8685895 Methods for selecting protease resistant polypeptides  
The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is...
8685896 Collection and methods for its use  
The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having...
8685892 Colorimetric bioassay for perchlorate  
The present invention relates to methods, compositions and systems for detecting perchlorate in a sample. Compositions useful for detecting perchlorate in a sample include those comprising a...
8680019 Universal fibronectin Type III binding-domain libraries  
Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a...
8658572 Whole proteome tiling microarrays  
The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100%...
8642513 Method for preparing immunoglobulin libraries  
The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
8609437 Biomarkers for the diagnosis and treatment of pancreatic cancer  
Compositions and methods for use in methods and kits for the detection of an increased risk of pancreatic cancer are provided. Cyst fluid samples isolated from patients that are positive for at...
8603949 Libraries of optimized cytochrome P450 enzymes and the optimized P450 enzymes  
The present disclosure teaches that the recombination of homologous sequences of P450 enzymes, with the aid of SCHEMA to predict a resulting protein structure, is able to generate libraries of...
8569481 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions  
Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for...
8563476 Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders  
A method for detecting an inflammatory disease in a subject is disclosed. The method comprises the steps of (a) detecting a level of expression of one or more inflammatory disease markers in a...
8475766 Dual specificity antibodies and methods of making and using  
Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or...
8475998 Compound synthesis method, microarray, acid-transfer composition, and biochip composition  
A compound synthesis method includes bonding a first compound to a substrate to form a first film. A second film is formed on the first film using an acid-transfer composition including (A) a...
8445413 Linker for constructing mRNA-puromycin-protein conjugate  
The present invention provides a linker preferably used when constructing an mRNA/cDNA-puromycin-protein conjugate used in an in vitro virus method, and an mRNA/cDNA-puromycin-protein conjugate...
8372785 Method for immobilizing self-organizing material or fine particle on substrate, and substrate manufactured by using such method  
A method for immobilizing a self-organizing material or fine particles on a substrate, and a substrate whereupon the self-organizing material or the fine particles are immobilized. More...
8372949 Molecular recognition of materials  
The present invention includes methods for selective binding of inorganic materials and the compositions that made up of the selecting agent and the target materials. One form of the present...
8367586 Collection and methods for its use  
The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties...
8361932 Detection of protease and protease activity using a single nanoscrescent SERS probe  
This invention pertains to the in vitro detection of proteases using a single peptide-conjugate nanocrescent surface enhanced Raman scattering (SERS) probes with at least nanomolar sensitivity....
8357638 Oligonucleotide library encoding randomised peptides  
The invention relates to a method of producing an oligonucleotide library comprising a plurality of oligonucleotides, each oligonucleotide in the library having at least one predetermined...
8329958 Combinatorial synthesis of PEG oligomer libraries  
A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of...

Matches 1 - 50 out of 208 1 2 3 4 5 >