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7586089 Feedback fragmentation in ion trap mass spectrometers  
In an RF ion trap mass spectrometer, selected parent ions are fragmented by collisions or electrons and a spectrum of the ion fragments is measured. The measured fragment ion spectrum is then...
7550558 Antimicrobial peptides and methods for identifying and using such peptides  
This invention relates to a method for identifying peptides having antimicrobial activity and to the antimicrobial peptides identified thereby and methods for their use.
7547662 Target recognizing binding agents  
The invention is directed to binding agents having binding loops and a stable beta barrel conformation. The binding loops of these agents can easily be altered so that the binding agent can bind...
7473671 Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same  
A glycopeptide of the formula A 1 -A 2 -A 3 -A 4 -A 5 -A 6 -A 7 , in which each dash represents a covalent bond; wherein A 1 comprises a modified or unmodified α-amino acid residue, alkyl, aryl,...
7442773 Universal peptide-binding scaffolds and protein chips  
The present invention provides a universal peptide-binding scaffold. This scaffold is used to bind a target. The target can be a peptide or peptides of interest (for example, peptides associated...
7413538 Epitopes formed by non-covalent association of conjugates  
A composition for interacting with a ligand, which composition comprises a non-covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group,...
7393318 Methods and compositions for interaction trap assays  
The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the...
7294472 Method for identifying modulators of G protein coupled receptor signaling  
This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which...
7252954 Sets of digital antibodies directed against short epitopes, and methods using same  
The present invention relates generally to sets of digital antibodies directed against short epitopes, and use thereof in methods for protein analysis.
7244572 One-dimensional arrays on optical fibers  
Linear arrays of chemosensors or chemical compounds are supported by an optical fiber that allows one to rapidly assay the entire array using changes in optical properties such as fluorescence. The...
7229777 Hairpin peptides with a novel structural motif and methods relating thereto  
The invention is directed to a model system for structure-activity relationship analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are...
7132243 Clonal expansion of T cells of unknown specificity and identification of ligand recognized by the clonally expanded T cells  
A process for clonally expanding T cells of unknown specificity and a process for identifying a peptide ligand recognized by said T cells are provided. A process for clonally expanding T cells of...
7063949 Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes  
Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic...
7033766 Construction and screening of lantibody display libraries  
A sublancin peptide variant (lantibody) having a spacer region and a subtilin leader peptide fused to the C-terminal end of the mature sublancin peptide provide an anchoring means for inserting and...
6919211 Polypeptide arrays  
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
6916541 Modified substrates for the attachment of biomolecules  
The present invention relates to a substrate for attachment of biomolecules. The substrate is coated with a multiamino organosilane. If desired, the substrate can be further modified prior to...
6897029 MCK-10 a novel receptor tyrosine kinase  
The present invention relates to the novel family of receptor tyrosine kinases, herein referred to as MCK-10, to nucleotide sequences and expression vectors encoding MCK-10, and to methods of...
6897028 Identification of molecular targets  
Identification of the molecular targets of a drug or toxin is the first step in understanding how the drug or toxin works, an important advance in learning how to improve a drug or assess the risks...
6897017 Vivo library-versus-library selection of optimized protein-protein interactions  
The present invention describes a rapid and efficient in vivo library-versus-library screening strategy for identifying optimally interacting pairs of heterodimerizing polypeptides. It allows for...
6887665 Methods of array synthesis  
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of...
6872536 Chemotactic peptide antagonists for imaging sites of inflammation  
Radiopharmaceuticals comprising molecules that target to N-formyl-methionyl-leucy-phenylalanine (fMLF) receptor on leukocytes in order to target sites of inflammation for diagnostic imaging are...
6858713 Chemically modified biological molecules and methods for coupling biological molecules to solid support  
The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid...
6846634 Method to screen phage display libraries with different ligands  
The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in...
6844161 Modular protein libraries and methods of preparation  
Novel proteins and protein libraries are disclosed. The proteins possess one or more functional protein modules from different parent protein molecules. The proteins and protein libraries are...
6815078 Substrate for protein microarray containing functionalized polymer  
A gelatin-based substrate for fabricating protein arrays, the substrate comprising: gelatin having at least one surface; a polymer scaffold affixed to the gelatin surface; wherein the polymer in...
6811969 Retentate chromatography—profiling with biospecific interaction adsorbents  
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
6794168 Process for oxidising aromatic compounds  
Process of oxidising a substrate which is a halo aromatic compound, which process comprises oxidizing said substrate with a monooxygenase enzyme. The enzyme may be P450cam. The process may be...
6790672 Encoded molecular sieve particle-based sensors  
A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into...
6777190 Crosstalk inhibitors and their uses  
Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample....
6756199 Peptide nucleic acid combinatorial libraries and improved methods of synthesis  
New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid...
6733977 Hybridization device and method  
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO...
6733975 DNA chip and its preparation  
An analytical element (typically DNA chip) composed of a solid carrier and a group of nucleotide derivatives or their analogues fixed to the solid carrier can be produced by bringing nucleotide...
6733894 High-density functional slide and preparation method thereof  
The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an...
6727062 Identification of target structures E.G. in vivo selection method for a phage library  
The invention relates to a selection method and the products identified using the selection method which includes the steps of identifying one or more binding structures to a target structure using...
6716395 Integrated protein affinity capture centrifugation device  
A method and apparatus are described for screening a proteome. The method and apparatus include an array of affinity elements, such that a proteome is directed through the array and those...
6696620 Immunoglobulin binding protein arrays in eukaryotic cells  
Arrays of immunoglobulin binding proteins in plants or plant cells are provided. Such arrays comprise plants or plant cells transformed with polynucleotides encoding multiple different...
6696245 Methods for selecting functional polypeptides  
The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in...
6686164 Low allergenic protein variants  
The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein. This method includes the steps of screening a random...
6677163 Functionalized silicon surfaces, and method for their production  
Provided is a method for modifying silicon with an organic molecule, under mild conditions. If the attached molecule is bi-functional, it may be subsequently reacted with a bio-molecule, to form a...
6673543 Solid phase synthesis of LXR ligands  
The invention provides solid support synthetic methods for producing combinatorial libraries of modulators of LXRs. The combinatorial libraries thus produced are useful both as diagnostic...
6670142 Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells  
The invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of...
6664282 Synthesis of &lsqb 3,5,7&rsqb -1H-imidazo &lsqb 1,5-a&rsqb imidazol-2 (3H)- one compounds  
Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and...
6653151 Dry deposition of materials for microarrays using matrix displacement  
A method is disclosed which relates to the placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive...
6632655 Manipulation of microparticles in microfluidic systems  
Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets...
6632641 Method and apparatus for performing large numbers of reactions using array assembly with releasable primers  
The present invention relates to a method and apparatus for performing a large number of reactions using array assembly. In particular, the present invention features a method and apparatus for...
6630358 Arrays of proteins and methods of use thereof  
Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins,...
6627400 Multiplexed measurement of membrane protein populations  
Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound...
6620587 Ribosome complexes as selection particles for in vitro display and evolution of proteins  
The invention provides a method of displaying nascent proteins or peptides as complexes with eukaryotic ribosomes and the mRNA encoding the protein or peptide following transcription and...
6617114 Identification of drug complementary combinatorial libraries  
The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which...
6613876 β-polypeptide foldamers of well-defined secondary structure  
Disclosed are β-peptides containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone. The β-peptides adopt stable helical and...
Matches 1 - 50 out of 121 1 2 3 >