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7612020 |
Composite arrays utilizing microspheres with a hybridization chamber
The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods...
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7601823 |
Nucleic acid inhibitors of glutamate receptors
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of...
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7592440 |
Methods of obtaining active antisense compounds
Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense...
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7585957 |
Site specific system for generating diversity protein sequences
This invention relates to the diversification of nucleic acid sequences by use of a nucleic acid molecule containing a region of sequence that acts as a template for diversification. The invention...
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7541314 |
Microarray having a base cleavable sulfonyl linker
The present invention provides a microarray having base cleavable, sulfonyl-containing linkers and a process to make the microarray. Oligonucleotides of any sequence may be synthesized on the...
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7393318 |
Methods and compositions for interaction trap assays
The present invention provides methods and compositions for interaction trap assays for detecting protein-protein, protein-DNA, or protein-RNA interactions. The methods and compositions of the...
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6936461 |
Method for immobilizing multistranded nucleic acid molecules by modifying more than one strand thereof, and binding each strand to a solid support
Various methodologies for the immobilization of molecules such, as multistranded nucleic acid molecules, are described. The methodologies include activation of solid supports, as well as treatment...
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6924113 |
Method and kit for isolating DNA probes that bind to activated transcription factors
Methods, arrays and kits are provided for rapidly and efficiently identifying and quantifying multiple different activated transcription factors in a biological sample at the same time. In one...
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6916541 |
Modified substrates for the attachment of biomolecules
The present invention relates to a substrate for attachment of biomolecules. The substrate is coated with a multiamino organosilane. If desired, the substrate can be further modified prior to...
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6893823 |
Polynucleotide separation method and apparatus therefor
Different probes each having a specific base sequence are immobilized to each of independent areas formed on the surface of a substrate, complementary polynucleotides in a sample solution are...
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6887665 |
Methods of array synthesis
Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of...
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6858713 |
Chemically modified biological molecules and methods for coupling biological molecules to solid support
The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid...
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6830890 |
Nucleic acid probe libraries
Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific...
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6813567 |
System, method, and product for dynamic noise reduction in scanning of biological materials
Systems and methods are described for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning...
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6794144 |
Methods and materials for generating SH3 domains with tailored binding properties
The present invention relates to controlled modification of Src homology region 3 (SH3) domains by using random manipulation of the non-conserved region of SH3 RT-loop. Consequently, the invention...
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6790672 |
Encoded molecular sieve particle-based sensors
A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into...
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6756224 |
Device for receiving a chip shaped carrier and process for assembling a plurality of such devices
A device for receiving a chip shaped carrier having an active surface, e.g. a surface which carries an array of DNA oligonucleids and which is adapted to be read by an electro-optical reading...
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6756199 |
Peptide nucleic acid combinatorial libraries and improved methods of synthesis
New sub-monomer synthetic methods for the preparation of peptide nucleic acid oligomeric structures are disclosed that provide for the synthesis of both predefined sequence peptide nucleic acid...
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6733977 |
Hybridization device and method
A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO...
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6733975 |
DNA chip and its preparation
An analytical element (typically DNA chip) composed of a solid carrier and a group of nucleotide derivatives or their analogues fixed to the solid carrier can be produced by bringing nucleotide...
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6733894 |
High-density functional slide and preparation method thereof
The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an...
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6720149 |
Methods for concurrently processing multiple biological chip assays
Methods for concurrently processing multiple biological chip assays by providing a biological chip plate comprising a plurality of test wells, each test well having a biological chip having a...
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6696256 |
Method, array and kit for detecting activated transcription factors by hybridization array
Methods, arrays and kits are provided for rapidly and efficiently identifying and quantifying multiple different activated transcription factors in a biological sample at the same time. In one...
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6696246 |
Assays using crosslinkable immobilized nucleic acids
Improved methods for in situ hybridization assays of cellular and subcellular systems and tissue sections, and immobilization-based assay techniques such as Northern blotting, Southern blotting,...
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6689563 |
System and methods for sequencing by hybridization
The systems and methods described herein relate to nucleic acid probes comprising a a pattern of universal and designate nucleotides, or ‘gapped’ probes, and the use of sets of gapped probes in...
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6689478 |
Polyanion/polycation multilayer film for DNA immobilization
A substrate with a charged surface coated with one or more bilayers of oppositely charged polyelectrolytes. Subsequent optional bilayers of polyelectrolytes must bear alternating opposite charges....
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6686188 |
Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
Presented are a novel myosin-like protein particularly expressed in human heart and muscle, isolated nucleic acids encoding the myosin-like protein, compounds and compositions derivable directly or...
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6670122 |
Method for detecting transcription templates
Methods are provided for detecting the sense and antisense transcripts and for determining template strand of a genomic DNA. Exemplary methods include reverse transcribing transcripts without...
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6656700 |
Isoforms of human pregnancy-associated protein-E
The invention provides isolated nucleic acids that encode three novel isoforms of human pregnancy associated plasma protein E, hPAPP-E, and fragments thereof, vectors for propagating and expressing...
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6653151 |
Dry deposition of materials for microarrays using matrix displacement
A method is disclosed which relates to the placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive...
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6635453 |
Methods for the enzymatic assembly of polynucleotides and identification of polynucleotides having desired characteristics
The present invention provides methods of preparing large polynucleotides of arbitrary sequence and in a manner that will readily lend itself to automation. The present invention provides methods...
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6632655 |
Manipulation of microparticles in microfluidic systems
Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets...
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6632641 |
Method and apparatus for performing large numbers of reactions using array assembly with releasable primers
The present invention relates to a method and apparatus for performing a large number of reactions using array assembly. In particular, the present invention features a method and apparatus for...
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6627748 |
Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses
This invention provides a combinatorial fluorescence energy transfer tag which comprises a plurality of fluorescent molecules, comprising one or more energy transfer donor and one or more energy...
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6627400 |
Multiplexed measurement of membrane protein populations
Families of compositions are provided as labels, referred to as eTag reporters for attaching to polymeric compounds and assaying based on release of the eTag reporters from the polymeric compound...
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6610482 |
Support bound probes and methods of analysis using the same
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6607885 |
Method for high-density microarray medicated gene expression profiling
The global effect on genes under different environmental conditions can be determined by a comprehensive gene expression profile. The present invention provides a method to monitor the changes in...
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6605438 |
Lyophilizing of liquid drops having arbitrary edges and application thereof to microarrays of biological reagents
The disclosure relates to the stabilization of a fluid drop comprising a liquid solvent and solute, so that upon drying of the solvent, the solute is not preferentially concentrated at the edges of...
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6602400 |
Method for enhanced bio-conjugation events
The present invention provides an apparatus and methods for efficient, high-throughput electrical or electrochemical detection of biomolecules. More specifically, the invention provides an...
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6600031 |
Methods of making nucleic acid or oligonucleotide arrays
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6590092 |
Process for preparing a “universal support” and the reagents used for generating such support
Universal solid supports suitable for use synthesizing of oligonucleotides. The solid supports may be used irrespective of the first RNA or DNA nucleotide to be synthesized, and irrespective of the...
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6589726 |
Method and apparatus for in situ synthesis on a solid support
The present invention relates to methods for fabricating solid supports. More specifically, the present invention features methods for fabricating solid supports for in situ synthesis and for...
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6586211 |
Method for producing polymers
The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) provision of a support having a...
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6582908 |
Oligonucleotides
The present invention provides a number of oligonucleotide sequences which can be used for a wide variety of analyses applicable to the diverse fields impacted by the nature of molecular...
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6576424 |
Arrays and methods for detecting nucleic acids
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6573098 |
Nucleic acid libraries
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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6573044 |
Methods of using chemical libraries to search for new kinase inhibitors
The generation of selective inhibitors for specific protein kinases would provide new tools for analyzing signal transduction pathways and possibly new therapeutic agents. We have invented an...
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6569667 |
26335, a novel human serine/threonine dehydratase and uses thereof
The invention provides isolated nucleic acid molecules, designated DHY nucleic acid molecules, which encode novel DHY-related dehydratase molecules. The invention also provides antisense nucleic...
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6566495 |
Very large scale immobilized polymer synthesis
A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
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6566057 |
Methods and compositions for peptide libraries displayed on light-emitting scaffolds
Methods and compositions for peptides or protein fragments displayed on scaffolds and libraries of sequences encoding peptides or protein fragments displayed on scaffolds that permit the properties...
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