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9028874 Antioxidant nanosphere comprising [1,2]-dithiolane moieties  
The present invention is directed to multiple a-lipoic acid-containing hydrophobic compounds (mALAs) capable of acting as scavengers of free radicals, metals and reactive oxygen species (ROS)....
9012374 Methods for manufacturing molecular arrays  
The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for...
8999897 Protein tag comprising a biotinylation domain and method for increasing solubility and determining folding state  
The use of a tag moiety comprising a biotinylation domain, such as biotin carboxyl carrier protein (BCCP), as a protein folding marker and protein solubility enhancer in the orientated surface...
8987174 Methods for manufacturing molecular arrays  
The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for...
8957039 Methods and compositions for the diagnosis and prognosis of cervical intraepithelial neoplasia and cervical cancer  
The invention provides methods and compositions for the diagnosis and prognosis of cervical intraepithelial neoplasia and cervical cancer. The methods comprise the step of determining the...
8932992 Templated molecules and methods for using such molecules  
The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis...
8932993 Method of testing for endometriosis and treatment therefor  
The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has...
8927464 Assembly and deposition of materials using a superhydrophobic surface structure  
Fluidics-induced localized deposition and assembly of materials using a superhydrophobic surface structure is described. A method of localized deposition of a material includes contacting a...
8921051 Methods and means for typing a sample comprising colorectal cancer cells  
The invention relates to a method of typing colorectal cancer cells by determining the RNA levels of a set of signature genes. Said typing can be use for predicting a risk for recurrence of said...
8906831 Single molecule loading methods and compositions  
Methods for non-random loading of single analyte molecules into array structures are provided. The methods allow for distribution of a population of target molecules into a plurality of size...
8889597 Sequences associated with TDP-43 proteinopathies and methods of using the same  
The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides...
8853134 Microarrays of binary nucleic acid probes for detecting nucleic acid analytes  
Some embodiments of the invention are directed to a microarray of binary nucleic acid probes for the detection of one or a plurality of nucleic acid analytes in a complex sample in a single high...
8835162 Methods of incorporating amino acid analogs into proteins  
The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA,...
8822384 Methods for detecting plasticizers  
Nanoparticles having one or more attached sensing moieties including uridine 5′-triphosphate (UTP) and deoxythymidine 5′-triphosphate (dTTP), are disclosed herein. These nanoparticles can, for...
8802024 Biochip and manufacturing method thereof  
A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first...
8795787 Surface modification  
The invention relates to a carrier comprising at least one substrate, which has a coating in at least certain regions produced from individual modules by plasma polymerization, and the coating has...
8785352 Metal nanoparticle structures for enhancing fluorescence-based assays  
Provided, among other things, is a multiplex assay comprising: conducting a fluorescence-developing assay on microtabs having at least one surface that shows plasmonic enhancement, wherein a...
8778849 Microarray fabrication system and method  
A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the...
8741558 Compositions, methods, and kits for identifying candidate molecules from encoded chemical libraries  
The subject matter relates to relates to a one-bead-one-sequence composition, a library of tagged chemicals comprising a plurality of one-bead-one-sequence compositions, a method for identifying a...
8729245 Recombinant butyrylcholinesterases and truncates thereof  
Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including...
8716191 Method of preparing an adduct  
A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, the molecular structure(s) each including one nucleotide chain onto which is...
8715966 Preparation of templates for nucleic acid sequencing  
The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands...
8697605 Polymer co-location in surface-attached biopolymers and arrays of biopolymers  
Embodiments of the present invention provide substrates having controllably co-located polymers of different sequences. Methods are provided that allow the fabrication of arrays of polymers on a...
8685894 Modified nucleic acid nanoarrays and uses therefor  
The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use.
8673823 Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia  
The present invention relates to a method of identifying a compound involved in pain, the use of Epsti1 nucleic acid or Epsti1 protein for identifying a compound involved in pain as well as...
8673824 Encoded self-assembling chemical libraries (ESACHEL)  
The invention provides a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule, and an oligonucleotide (b) or functional analogue...
8663924 Quantitative PCR-based method to predict the efficiency of target enrichment for next-generation sequencing using repetitive DNA elements (lines/sines) as negative controls  
A method for determining an efficiency of target enrichment from a DNA library, includes: adding a negative control sequence and a positive control sequence to the DNA library, or picking a...
8653007 Compositions, methods and related uses for cleaving modified DNA  
Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at...
8648017 Methods of using small RNA from bodily fluids for diagnosis and monitoring of neurodegenerative diseases  
Described are methods for detection of neuronal pathologies using quantitative analysis in bodily fluids of synapse and/or neurite small RNAs and application of these methods to early diagnosis...
8642514 Encoded self-assembling chemical libraries (ESACHEL)  
The invention provides a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule, and an oligonucleotide (b) or functional analogue...
8642513 Method for preparing immunoglobulin libraries  
The invention relates to the generation of immunoglobulin libraries and the identification and production of immunoglobulins having a specific functionality of interest.
8642515 Genetic determinants of prostate cancer risk  
Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa).
8637436 Integrated semiconductor bioarray  
A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are...
8603948 Panel for the detection and differentiation of renal cortical neoplasms  
The present invention provides a novel, highly sensitive and specific probe panel which detects the type of renal cortical neoplasm present in a biopsy sample. As such, the invention permits...
8597938 System for providing control reactions for real time RT-PCR  
Provided are methods and oligonucleotides useful as primers and templates for internal controls designed for use in Real Time Reverse Transcriptase Polymerase Chain Reactions. Use of the present...
8598089 Methods for synthesis of encoded libraries  
The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
8569574 Methods and compositions for improved fertilization and embryonic survival  
Single nucleotide polymorphic sites at positions 3117, 12195, 13244, 13319, and 13516 of the bovine STAT5 gene are associated with improved fertilization rate and/or improved embryo survival rate....
8563477 Modified molecular arrays  
A composition including (a) a solid support having a surface; (b) a first plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the first plurality each include the...
8557747 Tool for diagnosis and prognosis of mature B-cell neoplasms  
The present invention provides a microarray useful as a tool in the diagnosis and/or prognosis of certain types of cancers, particularly mature B-cell neoplasms. The microarray can include a...
8545772 Nanoliter array loading  
An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of...
8541345 Compositions and methods for the identification and use of epigenetic markers useful in the study of normal and abnormal mammalian gametogenesis  
The invention includes compositions comprising a S. cerevisiae yeast library, and methods of identifying an epigenetic marker for the diagnosis of infertility or a disorder associated with...
8481699 Multiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing  
Multiplex barcoded Paired-End Ditag (mbPED) library construction for ultra high throughput sequencing is disclosed. The mbPED library comprises multiple types of barcoded Paired-End Ditag (bPED)...
8475998 Compound synthesis method, microarray, acid-transfer composition, and biochip composition  
A compound synthesis method includes bonding a first compound to a substrate to form a first film. A second film is formed on the first film using an acid-transfer composition including (A) a...
8455401 Methods and devices for making arrays  
The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a...
8445412 Separation of pyrophosphate release and pyrophosphate detection  
The present technology relates to methods and systems for detection of pyrophosphate. As such, disclosed herein are methods and systems that permit improved pyrophosphate detection. Also disclosed...
8435740 Method for HLA typing  
A method for the identification of DNA sequence elements in complex and highly variable sequences is described. The method consists of identifying a short sequence element of several DNA bases...
8425845 Genetic analysis LOC with hybridization array with calibration chamber containing probe that lacks a reporter  
A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, hybridization chambers containing probes that each have a...
8410027 Density modification in arrays of surface-attached nucleic acid molecules  
Substrates having nucleic acid polymers attached at varying surface densities and methods for creating substrates having nucleic acid polymers attached at varying surface densities are provided....
8398938 Microfluidic thermal bend actuated pressure pulse valve  
A microfluidic thermal bend actuated pressure pulse valve having an inlet for receiving a flow of liquid, an outlet for outputting the flow of liquid, a meniscus anchor between the inlet and the...
8394339 LOC device with on-chip semiconductor controlled incubation section  
A lab-on-a-chip (LOC) device having a supporting substrate, a sample inlet for receiving a fluid sample, an incubation section in fluid communication with the sample inlet, the incubation section...

Matches 1 - 50 out of 229 1 2 3 4 5 >