Patents in Class 506/15

Matches 1 - 50 out of 93

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Match	Document	Document Title
1	7498292	Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In...
2	7432263	Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed;...
3	7413538	Epitopes formed by non-covalent association of conjugates A composition for interacting with a ligand, which composition comprises a non-covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group,...
4	7338428	Combinatorial fluorescent library based on the styryl scaffold A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.
5	6858713	Chemically modified biological molecules and methods for coupling biological molecules to solid support The invention relates to novel chemically modified biological molecules with enhanced lability towards solid supports, such as glass. These modified molecules can be readily affixed to solid...
6	6828143	Nanoscale chemical synthesis A modular reactor system and method for synthesizing nanoscale quantities of chemical compounds characterized by a continuous flow reactor under high pressure having uniform temperature throughout...
7	6800444	Complex chemical libraries Compositions comprising novel chemical libraries are prepared. The compositions of the present invention are useful as antibacterial and other pharmaceutical agents and as intermediates for...
8	6790672	Encoded molecular sieve particle-based sensors A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into...
9	6747144	Collections of compounds A compound of formula (I), wherein: R 2 and R 3 are independently selected from H, R, OH, OR, ═O, ═CH—R, ═CH 2 , CH 2 —CO 2 R, CH 2 —CO 2 H, CH 2 —SO 2 R, O—SO 2 R, CO 2 R, COR...
10	6723517	Use of self-assembled monolayers to probe the structure of a target molecule Weak binding motifs were transformed into a high affinity ligand surface by using a heterologous self-assembled monolayer (SAM) as a rigid scaffold to present discrete binding moieties, in a...
11	6720190	Methods for screening compound libraries Disclosed are methods for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target...
12	6673543	Solid phase synthesis of LXR ligands The invention provides solid support synthetic methods for producing combinatorial libraries of modulators of LXRs. The combinatorial libraries thus produced are useful both as diagnostic...
13	6670193	Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same The present invention provides fluorescent nucleoside analogs which comprise a fluorescent cyclic compound joined to a carbon of a sugar molecule such as pentose, hexose, ribose or deoxyribose or...
14	6664282	Synthesis of &lsqb 3,5,7&rsqb -1H-imidazo &lsqb 1,5-a&rsqb imidazol-2 (3H)- one compounds Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and...
15	6653151	Dry deposition of materials for microarrays using matrix displacement A method is disclosed which relates to the placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive...
16	6653087	Convergent synthesis of combinatorial library Targeted C2-symmetric and unsymmetric chemical libraries for use in protein and receptor homodimerization and heterodimerization are constructed by solution phase methodologies. Exemplary libraries...
17	6632655	Manipulation of microparticles in microfluidic systems Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets...
18	6627748	Combinatorial fluorescence energy transfer tags and their applications for multiplex genetic analyses This invention provides a combinatorial fluorescence energy transfer tag which comprises a plurality of fluorescent molecules, comprising one or more energy transfer donor and one or more energy...
19	6617114	Identification of drug complementary combinatorial libraries The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which...
20	6610483	Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof The present invention provides a method for the identification of a pattern of changes in cellular responses induced by the selective inhibition of a signaling molecule, by determining the specific...
21	6586187	Methods for solid phase combinatorial synthesis of integrin inhibitors Compounds of the formula are useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer,...
22	6583318	Method for synthesis of α-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives A method of synthesizing α-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or...
23	6579725	Linkers for synthesis of oligosaccharides on solid supports The present invention relates to versatile linkers for tethering a molecule to a solid support, e.g., for tethering a monomer, oligomer or polymer to a solid support, which are stable to a wide...
24	6573044	Methods of using chemical libraries to search for new kinase inhibitors The generation of selective inhibitors for specific protein kinases would provide new tools for analyzing signal transduction pathways and possibly new therapeutic agents. We have invented an...
25	6566495	Very large scale immobilized polymer synthesis A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed...
26	6541276	Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a...
27	6508984	System for creating and testing novel catalysts, reactions and polymers A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand...
28	6507636	Rapid X-ray diffraction screening method of polymorph libraries created in multi-well plates Method and device for rapid characterization of arrays of crystalline, polycrystalline or amorphous materials; in particular for the formation and X-ray diffraction analysis of polymorph libraries...
29	6506701	Rapid purification by polymer supported quench Novel polymer-supported quenching reagents of Formula I, P—L—Q I wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an...
30	6497820	Rapid method for separation of small molecules using reverse phase high performance liquid chromatography Disclosed is a rapid method for the separation of small organic compounds using gradient reverse phase HPLC. The method achieves a run time of one minute or less and a resolution with a peak...
31	6482591	Conformationally-restricted peptide probe libraries Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific...
32	6448443	Synthesis of combinatorial libraries of compounds reminiscent of natural products The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds...
33	6448412	Methods for the preparation and characterization of multi-substituted fullerenes The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a...
34	6417195	Isoquinoline derivatives and isoquinoline combinatorial libraries The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel...
35	6416949	Method of synthesizing diverse collections of oligomers A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates...
36	6413724	Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The...
37	6399785	Multiply-substituted fullerenes The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a...
38	6395724	Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of...
39	6388081	4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries The present invention relates to novel 4-substituted quinoline compounds of the following formula, libraries containing such compounds, and to the generation of such combinatorial libraries...
40	6376670	Quinoline-indole antimicrobial agents, uses and compositions related thereto The present invention provides methods and pharmaceutical preparations that inhibit the growth of bacterial microorganisms, via a non-lytic mechanism. Additionally, the present invention provides...
41	6372885	Solid-phase technology for the preparation of amides Method for preparing a combinatorial chemistry library of compounds of the formula R1—C(═O)—NH—R2, wherein R1 and R2 are as defined in the specification, which comprises acylating a...
42	6369194	Vicinyl tricarbonyl compounds and combinatorial libraries containing same The invention relates to compounds of formula where R is a structural diversity element selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, peptidyl,...
43	6358750	Spiro&lsqb pyrrolidine-2,3′-oxindole&rsqb compounds and method of use The invention provides spiro[pyrrolidine-2,3′-oxindole] compounds and libraries of these compounds produced by the stereo- and regio-selective reaction of variously substituted isatins, α-amino...
44	6331441	Multiplexed molecular analysis apparatus and method A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also...
45	6284459	Solid support matrices with memories and combinatorial libraries therefrom Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
46	6277489	Support for high performance affinity chromatography and other uses Multilayered particulate materials are formed by coating a particulate substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition...
47	6265228	Process for preparing combinatorial amide alcohol libraries Combinatorial chemical libraries of the Formula [S]--C(O)--L'--Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and --L'--Z is a...
48	6255120	Combinatorial library of substituted statine esters and amides via a novel acid-catalyzed rearrangement A combinatorial chemical library comprising a plurality of members of the Formula [S]--C(O)--L'-Z containing hydroxyamides is disclosed, in which [S] represents a solid support and L'-Z is a...
49	6251605	Yeast cells having mutations in Cav1 and uses therefor The invention provides isolated yeast cells which comprise a mutation in an endogenous yeast CAV1 gene, which exhibit increased signaling via the pheromone response pathway. In a preferred...
50	6245937	Liquid phase parallel synthesis of chemical libraries This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries...

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