Patents in Class 506/14

Matches 1 - 50 out of 92

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Match	Document	Document Title
1	7612019	Polypeptide display libraries and methods of making and using thereof Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of...
2	7550558	Antimicrobial peptides and methods for identifying and using such peptides This invention relates to a method for identifying peptides having antimicrobial activity and to the antimicrobial peptides identified thereby and methods for their use.
3	7442773	Universal peptide-binding scaffolds and protein chips The present invention provides a universal peptide-binding scaffold. This scaffold is used to bind a target. The target can be a peptide or peptides of interest (for example, peptides associated...
4	7442159	Selection system The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising...
5	7413537	Directed evolution of disulfide-bonded micro-proteins The invention relates, in part, to a library of chimeric proteins, each chimeric protein including a mini-protein between about eight and about forty amino acids long, wherein the mini-protein has...
6	7309577	Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste Binding assays for identifying compounds that induce or modulate the T1R1/T1R3 (umami) receptor-associated taste are provided. These binding assays detect the specific binding of a compound to a...
7	7303886	Functional assays for identifying compounds that modulate T1R1/T1R3 (umami) taste Functional assays for identifying compounds that activate or modulate the activation of the T1R1/T1R3 (umami) taste receptor are provided. These assays detect the effect of one or more compounds on...
8	7303885	Screening method for candidate drugs The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
9	7300759	Use of tramdorins in diagnostic and therapeutic methods A family of transmembrane domain proteins, the tramdorins, has been identified in human, mouse and rat. A variety of uses for these proteins is contemplated, including but not limited to peripheral...
10	7258986	Intrabodies with defined framework that is stable in a reducing environment and applications thereof A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined...
11	7258985	Intrabodies with defined framework that is stable in a reducing environment and applications thereof A method for the isolation of CDRs in a defined framework that is stable and soluble in reducing environment is described as well as thus obtainable scFv. Starting from such scFv with defined...
12	7252952	In vivo production of cyclic peptides for inhibiting protein—protein interaction The present invention relates to methods and compositions utilizing inteins to generate libraries of cyclic peptides in vivo. The prevent invention also relates to methods for inhibiting...
13	7223547	Polypeptides having a functional domain of interest and methods of identifying and using same Novel polypeptides having functional domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent...
14	7056679	Target specific screening and its use for identifying target binders The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a...
15	7033769	Method for discovering one or more peptides adapted for specific binding to a microorganism of interest A method for discovering one or more peptides adapted for specific binding to a microorganism of interest. The method comprises (i) identifying an antimicrobial peptide having antimicrobial...
16	7033766	Construction and screening of lantibody display libraries A sublancin peptide variant (lantibody) having a spacer region and a subtilin leader peptide fused to the C-terminal end of the mature sublancin peptide provide an anchoring means for inserting and...
17	7018803	Inhibitors of collagen assembly The invention relates to peptides and peptidomimetics which inhibit assembly of human type I collagen. Methods of identifying such peptides and peptidomimetics are also included in the invention.
18	7018801	Selection of peptides with antibody-like properties The present invention provides a highly sensitive screening assay for the identification of peptide binding partners to virtually any peptide or polypeptide ligand. Utilizing an...
19	6972178	Drug screening using a proline-rich nuclear receptor co-regulatory protein/nuclear receptor co-expression system Assays are presented for screening for chemicals which affect the binding between proteins comprising an SH3 binding motif and nuclear receptor proteins. PNRC (Proline-rich Nuclear Receptor...
20	6893845	Surface expression libraries of heteromeric receptors The invention is directed to a composition of matter consisiting of a plurality of procaryotic cells. The plurality of procaryotic cells contain diverse combinations of first and second DNA...
21	6887362	Dielectrophoretic separation and immunoassay methods on active electronic matrix devices This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates...
22	6875578	System for cell-based screening The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently...
23	6872518	Methods for selecting polynucleotides encoding T cell epitopes The present invention relates to methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of such...
24	6861229	Method of identifying a gene product The present invention provides a method of identifying a gene product. The method comprises providing a multiplicity of cells comprising a first gene product. Preferably, the first gene product is...
25	6833245	Methods for screening for transdominant effector peptides and RNA molecules Methods and compositions for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
26	6818410	Methods of isolating RNA-binding proteins and compositions related to the same The present invention discloses a general in vitro method for isolating proteins that bind to specific RNA regulatory elements. The method employs a lyt-lys bacteriophage display library and a host...
27	6800442	Methods of selecting polynucleotides encoding antigens The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of...
28	6767701	Methods of constructing and screening a DNA library of interest in filamentous fungal cells A method of constructing and screening a library of polynucleotide sequences of interest in filamentous fungal cells by use of an episomal replicating AMA1-based plasmid vector, thus achieving a...
29	6762031	Targeting viral vectors to specific cells Methods for creating viral display libraries for purposes of isolating variants with modified target cell specificity and related methods; also retroviral display libraries.
30	6737241	Methods for screening for transdominant intracellular effector peptides and RNA molecules Methods and compositions for screening for intracellular transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
31	6737240	Methods of screening for a multi-drug resistance conferring peptide The invention relates generally to methods of screening for drugs which bind to and/or regulate cellular proteins involved in drug resistance, particularly resistance of tumor cells to...
32	6723512	METHODS USING GENETIC PACKAGE DISPLAY FOR DETECTING AND IDENTIFYING PROTEIN-PROTEIN INTERACTIONS THAT FACILITATE INTERNALIZATION AND TRANSGENE EXPRESSION AND CELLS OR TISSUES COMPETENT FOR THE SAME AND METHODS FOR EVOLVING GENE DELIVERY VECTORS A genetic package display system and methodology for probing protein-protein interactions that lead to cell transduction, selecting and/or identifying internalizing ligands, target cells and...
33	6667150	Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly) peptide complex The present invention relates to methods for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex by screening for polyphage particles. Furthermore,...
34	6660485	Antibodies to human goose-type lysozyme The invention provides a human goose-type lysozyme (GOLY) and polynucleotides which identify and encode GOLY. The invention also provides expression vectors, host cells, antibodies, agonists, and...
35	6656700	Isoforms of human pregnancy-associated protein-E The invention provides isolated nucleic acids that encode three novel isoforms of human pregnancy associated plasma protein E, hPAPP-E, and fragments thereof, vectors for propagating and expressing...
36	6632655	Manipulation of microparticles in microfluidic systems Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets...
37	6620587	Ribosome complexes as selection particles for in vitro display and evolution of proteins The invention provides a method of displaying nascent proteins or peptides as complexes with eukaryotic ribosomes and the mRNA encoding the protein or peptide following transcription and...
38	6617114	Identification of drug complementary combinatorial libraries The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which...
39	6610495	Method for detecting proteinaceous inhibitors of protein-protein or DNA-protein interactions The present invention relates generally to a method of identifying modulators of biological interactions and agents useful for same. More particularly, the present invention contemplates a method...
40	6589730	Methods for identifying protein-protein interactions by selective transduction A method for identifying specific protein-protein (i.e., ligand/anti-ligand) interactions that internalize and are detected by transgene expression. A ligand displaying genetic package that carries...
41	6586190	Parallel high throughput method and kit A parallel high throughput method and kit for the discovery of small molecule interactors of target proteins, in particular, target proteins expressed from entire genomes or subsets thereof. The...
42	6582915	Production of anti-self bodies from antibody segment repertories and displayed on phage Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species....
43	6579676	Rapid mutational analysis method and compositions A novel rapid mutational analysis method for mapping protein epitopes is disclosed. This method has been used to identify the binding sites for 16 anti-CD2 and anti-CD4 monoclonal antibodies. The...
44	6576467	Methods for producing recombined antibodies A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
45	6562617	Fusions of scaffold proteins with random peptide libraries The invention relates to the use of scaffold proteins, particularly green fluorescent protein (GFP), in fusion constructs with random and defined peptides and peptide libraries, to increase the...
46	6555313	Production of anti-self antibodies from antibody segment repertoires and displayed on phage Methods are disclosed for the production of human self-antibodies and antibody fragments, which bind human antigens. Methods comprise providing a library of replicable genetic display packages...
47	6555310	Polyclonal libraries The invention is directed to inter alia two related but self-sufficient improvements in conventional display methods. The first improvement provides methods of enriching conventional display...
48	6541210	Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations:...
49	6503712	Methods and compositions for preparing a genomic library for knockout targeting vectors The present invention is directed to methods for producing gene targeting constructs by homologous recombination using mouse genomic libraries arrayed in yeast shuttle vectors. The invention is...
50	6500639	DNA shuffling to produce nucleic acids for mycotoxin detoxification Methods of shuffling nucleic acids to acquire or enhance mycotoxin detoxification activity, libraries of shuffled mycotoxin detoxification nucleic acids, transgenic cells, plants and DNA shuffling...

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