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Document Title |
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7611900 |
High throughput screening methods for lubricating oil compositions
Method for determining deposit formation tendencies for a plurality of fluid samples of different compositions is provided. Each sample includes one or more lubricating oil compositions containing...
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7592440 |
Methods of obtaining active antisense compounds
Methods for obtaining antisense oligonucleotides with activity against a desired target are provided. Methods of identifying oligonucleotide sequence motifs which are predictive of antisense...
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7557070 |
Multiplexed cell analysis system
Systems including apparatus, methods, compositions, and kits for multiplexed analysis of biological systems using nonpositional and/or positional arrays of coded carriers.
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7534742 |
Isoprenoid biosynthesis
The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More...
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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7485855 |
On-probe sample cleanup system and method for MALDI analysis
A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least...
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7468279 |
Selection of polymerization catalysts and apparatus for carrying this out
In a method of selecting polymerization catalysts, in particular Phillips catalysts for the polymerization of olefins, from a multiplicity of catalysts on the basis of their catalytic properties, a...
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7429238 |
Systems and methods for the generation of crystalline polymorphs
The present invention relates to systems and methods for generating polymorphs of compounds. In particular, the present invention provides high throughput systems and methods for generating and...
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7413536 |
Substrates and screening methods for transport proteins
A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided....
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7384387 |
High throughput mass spectrometry
Apparatus and methods for high throughput mass spectrometry are provided. The methods involve sample preparation in an off-line parallel purification system. Such methods include but are not...
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7377894 |
Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for...
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7354704 |
High throughout screening method and apparatus
High-throughput screening method and apparatus arm described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about...
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6914279 |
Multifunctional biosensor based on ZnO nanostructures
The present invention provides the multifunctional biological and biochemical sensor technology based on ZnO nanostructures. The ZnO nanotips serve as strong DNA or protein molecule binding sites...
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6901334 |
Methods and systems for high throughput analysis
Methods of analyzing processes for making catalysts and/or certain properties of catalysts using a plurality of reaction zones are provided. The methods of the present invention have the capability...
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6866786 |
Rapid characterization of polymers
Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography...
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6864201 |
Preparation and screening of crystalline zeolite and hydrothermally-synthesized materials
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
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6855258 |
Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography...
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6836326 |
Rheo-optical indexer and method of screening and characterizing arrays of materials
A method and apparatus for characterizing and screening an array of material samples is disclosed. The apparatus includes a sample block having a plurality of regions for containing the material...
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6833921 |
Optical systems and methods for rapid screening of libraries of different materials
Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or...
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6813958 |
Method for combinatorially measuring adhesion strength
A method of measuring the adhesive strength of polymer materials that are arranged in a combinatorial library which involves providing a lens array having a plurality of individual lens elements on...
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6813567 |
System, method, and product for dynamic noise reduction in scanning of biological materials
Systems and methods are described for processing an emission signal, such as a fluorescent signal, to compensate for noise in an excitation beam, such as a laser beam. As one example, a scanning...
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6808934 |
High-throughput biomolecular crystallization and biomolecular crystal screening
The present invention provides a method for the acoustic ejection of fluid droplets from fluid-containing reservoirs to form arrays suitable for high-throughput combinatorial crystallization...
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6791690 |
Reading dry chemical arrays
Array units and methods are provided which have constructions to reduce or take advantage of Fresnel reflection. The array units may have a subtantially unreflective substrate. In one arrangement a...
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6772642 |
High throughput mechanical property and bulge testing of materials libraries
A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.
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6769292 |
High throughput rheological testing of materials
A library of materials is screened for viscosity. A library of materials is provided. The library is contacted with at least one capillary for applying a force through the materials. The relative...
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6764858 |
Methods for creating a compound library
A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for...
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6730228 |
Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling
Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography...
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6690179 |
High throughput mechanical property testing of materials libraries using capacitance
One aspect of the present invention provides instruments for measuring mechanical properties of a combinatorial library of materials. The instruments include at least one capacitor to which a...
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6686205 |
Screening combinatorial arrays of inorganic materials with spectroscopy or microscopy
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
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6671631 |
Systems and methods for analyzing viscoelastic properties of combinatorial libraries of materials
Systems and methods for analyzing a viscoelastic property of a combinatorial library of materials including a plurality of full bridge devices operable for measuring a temperature-modulated...
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6656700 |
Isoforms of human pregnancy-associated protein-E
The invention provides isolated nucleic acids that encode three novel isoforms of human pregnancy associated plasma protein E, hPAPP-E, and fragments thereof, vectors for propagating and expressing...
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6653138 |
Apparatus and method of research for creating and testing novel catalysts, reactions and polymers
A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand...
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6650411 |
System, method, and product for pixel clocking in scanning of biological materials
Systems and methods are described that may be applied to scanning biological materials in or on probe arrays. For example, a system is described that includes a scanner that has one or more...
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6649413 |
Synthesis and screening combinatorial arrays of zeolites
Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is...
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6635452 |
Releasable nonvolatile mass label molecules
Using nonvolatile, releasable, mass-labels, the present invention provides for the synthesis and use of mass-labeled compounds to specifically interact with biomolecular targets. Following binding...
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6625546 |
Structure identification methods using mass measurements
Methods of identifying predicted or actual structures of members of a chemical or physical library are provided. The methods provide for the direct identification of compound structure following...
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6623935 |
Deconvolution method and apparatus for analyzing compounds
A mass spectrometer system analyzes a sample with the aid an associated computer system or processor which utilizes a relatively small compound deconvolution data library. The deconvolution library...
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6605258 |
High throughput screening method, array assembly and system
A liquid chemical stripping or cleaning solution is selected by combinatorial high throughput screening. A high throughput screening well array assembly includes (A) a metal substrate and (B) a...
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6597000 |
Systems and methods for detection of labeled materials
Labeled targets on a support synthesized with polymer sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, can be detected by...
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6584832 |
High-temperature characterization of polymer libraries
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems...
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6577392 |
Characterization of non-biological polymers using flow-injection analysis with light-scattering detection
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems...
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6569631 |
Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
The present invention provides a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of unfolding due to a thermal change. The...
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6566079 |
Methods for analyzing protein binding events
The present invention provides a variety of methods of analyzing protein binding events using a system capable of directly detecting protein/ligand complexes based upon the dielectric properties of...
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6551784 |
Method of comparing nucleic acid sequences
The present invention provides methods for comparing and identifying differences in nucleic acid sequences using a plurality of sequence specific recognition reagents (i.e., probes comprising a...
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6541271 |
Infrared spectroscopic imaging of libraries
Methods and apparatus for screening diverse arrays of materials using infrared imaging techniques are provided. Typically, each of the individual materials on the array will be screened or...
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6536944 |
Parallel screen for rapid thermal characterization of materials
A method and apparatus for high-throughput determination of phase change points of combinatorial libraries of metal alloys uses an infrared camera to monitor temperature-dependent changes in...
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6524863 |
High throughput HPLC method for determining Log P values
Methods for calculating Log P values for organic compounds are disclosed. The methods allow identification of compounds in a library with a desired Log P value. The method can be used to minimize...
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6511802 |
Solid phase selection of differentially expressed genes
The invention provides a method and materials for monitoring and isolating differentially expressed genes. In accordance with the method of the invention, differently labeled populations of DNAs...
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6509454 |
Free solution ligand interaction molecular separation method
The present invention is directed to novel methods for enhancing the ability to separate a species of interest from other different species present in a free solution mixture thereof which takes...
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6508984 |
System for creating and testing novel catalysts, reactions and polymers
A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand...
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