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7566685 |
Methods and compositions for screening using diphtheria toxin constructs
The invention relates to methods and compositions utilizing diphtheria toxin for screening purposes. The invention is particularly useful in screening for modulators of IgE synthesis, secretion and...
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7550558 |
Antimicrobial peptides and methods for identifying and using such peptides
This invention relates to a method for identifying peptides having antimicrobial activity and to the antimicrobial peptides identified thereby and methods for their use.
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7528093 |
SCN3A locus for idiopathic generalized epilepsy, mutations thereof and method using same
The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome...
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7504230 |
Method of identifying a useful set of signal transduction proteins from a multiplicity of potentially useful proteins
The present invention is a cell-based method of identifying a set of signal transduction proteins having an intracellular localization pattern responsive to toxic compounds. The method requires...
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7354704 |
High throughout screening method and apparatus
High-throughput screening method and apparatus arm described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about...
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7270969 |
Methods of constructing and screening diverse expression libraries
The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic...
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6913882 |
Methods of screening for B cell activity modulators
The invention provides for the identification of all genes, whether known or novel, which are differentially expressed within and among B cells, making possible the characterization of their...
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6897017 |
Vivo library-versus-library selection of optimized protein-protein interactions
The present invention describes a rapid and efficient in vivo library-versus-library screening strategy for identifying optimally interacting pairs of heterodimerizing polypeptides. It allows for...
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6875578 |
System for cell-based screening
The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently...
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6872518 |
Methods for selecting polynucleotides encoding T cell epitopes
The present invention relates to methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of such...
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6861220 |
Genetic screening methods
A method for screening molecule which have a synthetic lethal property when in combination with a gene of interest carrying a non-lethal mutation, said method comprising the steps of: transfecting...
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6841352 |
Mating-based method for detecting protein—protein interaction
The present invention provides a mating-based yeast two-hybrid system for determining whether a test polypeptide interacts with another test polypeptide in the presence or absence of one or more...
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6841351 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6833245 |
Methods for screening for transdominant effector peptides and RNA molecules
Methods and compositions for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
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6800442 |
Methods of selecting polynucleotides encoding antigens
The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of...
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6767701 |
Methods of constructing and screening a DNA library of interest in filamentous fungal cells
A method of constructing and screening a library of polynucleotide sequences of interest in filamentous fungal cells by use of an episomal replicating AMA1-based plasmid vector, thus achieving a...
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6762031 |
Targeting viral vectors to specific cells
Methods for creating viral display libraries for purposes of isolating variants with modified target cell specificity and related methods; also retroviral display libraries.
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6737240 |
Methods of screening for a multi-drug resistance conferring peptide
The invention relates generally to methods of screening for drugs which bind to and/or regulate cellular proteins involved in drug resistance, particularly resistance of tumor cells to...
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6723512 |
METHODS USING GENETIC PACKAGE DISPLAY FOR DETECTING AND IDENTIFYING PROTEIN-PROTEIN INTERACTIONS THAT FACILITATE INTERNALIZATION AND TRANSGENE EXPRESSION AND CELLS OR TISSUES COMPETENT FOR THE SAME AND METHODS FOR EVOLVING GENE DELIVERY VECTORS
A genetic package display system and methodology for probing protein-protein interactions that lead to cell transduction, selecting and/or identifying internalizing ligands, target cells and...
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6670142 |
Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells
The invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of...
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6617114 |
Identification of drug complementary combinatorial libraries
The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which...
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6613555 |
32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense...
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6610495 |
Method for detecting proteinaceous inhibitors of protein-protein or DNA-protein interactions
The present invention relates generally to a method of identifying modulators of biological interactions and agents useful for same. More particularly, the present invention contemplates a method...
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6610483 |
Methods for identifying cellular responses attributable to signaling molecule inhibition and inhibitors thereof
The present invention provides a method for the identification of a pattern of changes in cellular responses induced by the selective inhibition of a signaling molecule, by determining the specific...
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6582915 |
Production of anti-self bodies from antibody segment repertories and displayed on phage
Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species....
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6573057 |
Methods of using transporter-like molecules to treat pain and pain-related disorders
The invention relates to OCT-3 polypeptides, nucleic acid molecules encoding OCT-3, and uses thereof. OCT-3 is a protein that is expressed in the plasma membrane of biological cells, across which...
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6573044 |
Methods of using chemical libraries to search for new kinase inhibitors
The generation of selective inhibitors for specific protein kinases would provide new tools for analyzing signal transduction pathways and possibly new therapeutic agents. We have invented an...
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6555325 |
System for detection of a functional interaction between a compound and a cellular signal transduction component
The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the...
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6555313 |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
Methods are disclosed for the production of human self-antibodies and antibody fragments, which bind human antigens. Methods comprise providing a library of replicable genetic display packages...
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6551812 |
Compositions and methods relating to the peroxisomal proliferator activated receptor-α mediated pathway
The present invention describes polynucleotides and polypeptides associated with PPARα-mediated pathways that are useful as therapeutic compositions in method for the treatment of peroxisomal...
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6548734 |
Methods relating to modulation of cartilage cell growth and/or differentiation by modulation of NFATp activity
The invention demonstrates that NFATp represses cartilage cell division and represses the chondrogenic program in cells and displays the properties of a tumor suppressor gene. In addition, the...
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6537765 |
GPR10 as a target for identifying weight modulating compounds
Assays for the identification of compounds useful for the modulation of body weight, metabolic rate, or feeding behavior are disclosed. Such compounds are useful for the treatment body weight...
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6534277 |
Method for identifying a compound to be tested for an ability to reduce immune rejection by determining Stat4 and Stat6 proteins
The present invention relates to methods for identifying compounds that can reduce immune rejection, for example, transplant- or autoimmune disorder-related immune rejection. The present invention...
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6506603 |
Shuffling polynucleotides by incomplete extension
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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6500639 |
DNA shuffling to produce nucleic acids for mycotoxin detoxification
Methods of shuffling nucleic acids to acquire or enhance mycotoxin detoxification activity, libraries of shuffled mycotoxin detoxification nucleic acids, transgenic cells, plants and DNA shuffling...
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6500626 |
Cell death regulators
A Bcl-2 associated protein (Bax) and uses thereof.
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6500617 |
Optimization of pest resistance genes using DNA shuffling
This invention provides methods of obtaining pest resistance genes that are improved over naturally occurring genes for use in conferring upon plants resistance to pests. The methods involve the...
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6489145 |
Method of DNA shuffling
Disclosed is a method of producing random polynucleotides by introducing two or more related polynucleotides into a suitable host cell such that a hybrid polynucleotide is generated by...
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6485921 |
UBCLP and uses thereof
The invention concerns ubiquitin-conjugating enzyme-like protein (UBCLP) nucleic acid molecules, polypeptides, antibodies, and modulators. The invention also concerns screening assays which can be...
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6479258 |
Non-stochastic generation of genetic vaccines
This invention provides methods of obtaining vaccines by use of non-stochastic methods of directed evolution (DirectEvolution™). These methods include non-stochastic polynucleotide...
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6472150 |
Sifter screening to identify biologically active molecules
A novel single-insect feeding, testing and recovery (SIFTER) strategy is described for screening and isolating biomolecules that exert a desired biological activity in arthropods, preferably...
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6461813 |
Multiparameter FACS assays to detect alterations in cell cycle regulation
The invention related to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through...
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6444873 |
MSH5 ablated mice and uses therefor
An animal, e.g., transgenic mouse, in which the MSH5 gene is misexpressed. The animal is useful for screening treatments for a number of conditions. Methods for identifying contraceptive agents are...
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6420110 |
Methods and reagents for isolating biologically active peptides
One aspect of the present invention is the synthesis of a binary method that combines variegated peptide display libraries, e.g., in a “display mode”, with soluble secreted peptide libraries,...
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6399855 |
QTL mapping in plant breeding populations
This invention relates to a method for improving the efficacy of a plant breeding program by selectively altering the average of a quantitative phenotypic trait in a plant population. The method...
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6358695 |
Methods of screening for agonists and antagonists of the HNEAA81 receptor
HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and...
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6355473 |
Yeast cells having mutations in stp22 and uses therefor
The invention provides yeast cells which comprise a mutation in an endogenous yeast stp22 gene and which express a heterologous G protein coupled receptor. The instant yeast cells display enhanced...
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6251605 |
Yeast cells having mutations in Cav1 and uses therefor
The invention provides isolated yeast cells which comprise a mutation in an endogenous yeast CAV1 gene, which exhibit increased signaling via the pheromone response pathway. In a preferred...
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6159705 |
Recombinant yeast cells for identifying receptor effectors
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a...
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6132970 |
Methods of shuffling polynucleotides
The invention is directed to methods of shuffling polynucleotide variants. The methods entail conducting a multi-cyclic polynucleotide extension process on partially annealed polynucleotide strands...
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