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7442160 |
Evolving new molecular function
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for...
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7361133 |
Methods of detection utilizing modified bacteriophage
Viruses expressing ligands on their surfaces are used as a detection means for the related polypeptide which binds the ligand. Multiple copies of the ligand can be expressed on the viral surface....
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6808882 |
Optical sorting method
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into...
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6773900 |
End selection in directed evolution
This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by the use of non-stochastic methods of directed evolution (DirectEvolution™). A particular advantage...
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6727062 |
Identification of target structures E.G. in vivo selection method for a phage library
The invention relates to a selection method and the products identified using the selection method which includes the steps of identifying one or more binding structures to a target structure using...
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6696245 |
Methods for selecting functional polypeptides
The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in...
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6686164 |
Low allergenic protein variants
The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein. This method includes the steps of screening a random...
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6635453 |
Methods for the enzymatic assembly of polynucleotides and identification of polynucleotides having desired characteristics
The present invention provides methods of preparing large polynucleotides of arbitrary sequence and in a manner that will readily lend itself to automation. The present invention provides methods...
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6576467 |
Methods for producing recombined antibodies
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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6573072 |
Ribozymes having 2′-O substituted nucleotides in the flanking sequences
The present invention provides methods for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme having a flanking...
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6506603 |
Shuffling polynucleotides by incomplete extension
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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6500639 |
DNA shuffling to produce nucleic acids for mycotoxin detoxification
Methods of shuffling nucleic acids to acquire or enhance mycotoxin detoxification activity, libraries of shuffled mycotoxin detoxification nucleic acids, transgenic cells, plants and DNA shuffling...
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6500617 |
Optimization of pest resistance genes using DNA shuffling
This invention provides methods of obtaining pest resistance genes that are improved over naturally occurring genes for use in conferring upon plants resistance to pests. The methods involve the...
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6489145 |
Method of DNA shuffling
Disclosed is a method of producing random polynucleotides by introducing two or more related polynucleotides into a suitable host cell such that a hybrid polynucleotide is generated by...
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6479258 |
Non-stochastic generation of genetic vaccines
This invention provides methods of obtaining vaccines by use of non-stochastic methods of directed evolution (DirectEvolution™). These methods include non-stochastic polynucleotide...
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6465192 |
Compounds and methods for the inhibition of protein-protein interactions
Compounds having molecular weights of less than 1500 daltons that non-covalently interact with target proteins and covalently bond to target proteins at amino acid side chains that are not part of...
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6440668 |
Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
Disclosed is a process of performing Sexual PCR which includes generating random polynucleotides by interrupting or blocking synthesis or amplification process to slow or halt synthesis or...
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6365408 |
Methods of evolving a polynucleotides by mutagenesis and recombination
A method of mutating a polynucleotide such that it has a desired or improved functional property is disclosed.
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6361949 |
Nucleic acid amplification with direct sequencing
This invention provides methods of amplifying a sequence of interest present within a nucleic acid molecule. In addition, this invention provides a method of determining the nucleotide sequence of...
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6352842 |
Exonucease-mediated gene assembly in directed evolution
A directed evolution process comprising novel methods for generating improved progeny molecules having desirable properties, including, for example, a method for rapid and facilitated production...
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6344356 |
Methods for recombining nucleic acids
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for...
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6132970 |
Methods of shuffling polynucleotides
The invention is directed to methods of shuffling polynucleotide variants. The methods entail conducting a multi-cyclic polynucleotide extension process on partially annealed polynucleotide strands...
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6022691 |
Determination of oligonucleotides for therapeutics, diagnostics and research reagents
Oligonucleotides which selectively bind to target biomolecules are determined by in vitro assay of a pool of random oligonucleotides for activity against the biomolecules, followed by recovery and...
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5856085 |
Compositions and methods of developing oligonucleotides and oligonucleotide analogs having antiviral activity
Methods of identifying and preparing anti-infectious agent compounds comprising the steps of incubating single stranded nucleic acids or nucleic acid analogs in the presence of infectious agents,...
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5773598 |
Systematic evolution of ligands by exponential enrichment: chimeric selex
Methods are disclosed for producing chimeric nucleic acid molecules with two or more functionalities. A chimeric library is generated in which individual chimeric molecules combine the functions or...
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5759817 |
Heterodimeric receptor libraries using phagemids
Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor...
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5698391 |
Methods for synthetic unrandomization of oligomer fragments
Methods useful for the determination of oligomers which have specific activity for a target molecule from a pool of primarily randomly assembled oligomers are provided. The disclosed methods...
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5684711 |
System, method, and computer program for at least partially automatically generating chemical compounds having desired properties
A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity...
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