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8119407 |
Hemoglobin based bilirubin reference material
What is described is a single reference material and method of making useful for calibrating or qualifying instruments that are diagnostic spectroscopically for bilirubin, hemoglobin, and...
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8062902 |
Mammalian disease detection system
A mammalian disease detecting system used to provide a visual indication of a possible disease state includes particles made of a material that is substantially clear or transparent to permit the...
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7951606 |
Bilirubin sensor
A bilirubin sensor has a working electrode with a first chemical matrix disposed thereon that contains a binder, a substrate electrode with a second chemical matrix dispose thereon that contains a...
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7939333 |
Metal enhanced fluorescence-based sensing methods
The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background...
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7846383 |
Lateral flow assay device and absorbent article containing same
A lateral flow assay device for testing a bodily fluid, such as urine, blood, mucous, saliva, etc., is provided. The lateral flow assay device includes a chromatographic medium (e.g., porous...
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7749766 |
Bilirubin sensor
A bilirubin sensor has a working electrode with a first chemical matrix disposed thereon that contains a binder, a substrate electrode with a second chemical matrix dispose thereon that contains a...
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7524681 |
Rapid assay for biological substances using FTIR
The present invention relates to a method for determining the condition of a biological fluid by recording the IR spectrum of a sample of the biological fluid. To this end, the biological fluid can...
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7416896 |
Determination of plasma total and unbound bilirubin using zone fluidics
A method for determining total and bound plasma bilirubin. The method utilizes zone fluidics to enable accurate determination of the bilirubin using small volumes of sample and reagents, and...
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7407626 |
Composition and method of use of medical test kit
A medical test kit includes a glucose testing composition, a protein testing composition, a bilirubin testing composition, a bilinogen testing composition, an amylase testing composition, a blood...
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7255835 |
Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity
Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a...
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7198955 |
Method and apparatus for measurement of blood substitutes
A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method...
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7109038 |
Occult blood detection in biological samples by laser desorption and matrix-assisted laser desorption/ionization mass spectrometry for biomedical applications
Methods are described for detecting and quantifying occult blood in a biological sample using laser desorption mass spectrometry (LD MS). Biological samples that can be analyzed using various...
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6905880 |
Bilirubin tests as risk predictors for systemic lupus erythematosus and psoriatic arthritis
A new method for predicting the risk of cancer morality, rheumatoid arthritis; systemic lupus erythematosus, psoriatic arthritis, and all-cause mortality is disclosed. The method uses serum...
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6869802 |
Combined cholesterol and bilirubin tests as risk predictors for coronary artery disease
A new method for predicting the risk of coronary artery disease (CAD) is disclosed. The method uses a ratio made up of the levels of an individuals LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C)...
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6773922 |
Reagentless analysis of biological samples
Apparatus and method for determining at least one parameter, e.g., concentration, of at least one analyte, e.g., urea, of a biological sample, e.g., urine. A biological sample particularly suitable...
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6720189 |
Bilirubin tests as risk predictors for cancer mortality, rheumatoid arthritis, Gilbert's syndrome and all-cause mortality
A new method for predicting the risk of future cancer mortality, rheumatoid arthritis and all-cause mortality is disclosed. The method uses serum bilirubin levels as indicator for such risks, lower...
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6696297 |
Non-oxidizable bilirubin substitutes and uses therefor
Compositions and methods are disclosed for use in the analysis and quantitation of conjugated and unconjugated bilirubin in patient or other samples. The compositions have the general formula:...
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6326208 |
Assay for total and direct bilirubin
Methods for assay of both total bilirubin and direct bilirubin in a sample. The inventive methods enable the amounts of total and direct (conjugated) bilirubin to be colorimetrically measured in...
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6030841 |
Liver function test
A method for the determination of liver function, comprises the steps of: (i)introducing an effective amount of a coloured or fluorescent bile acid derivative intravenously into a patient,...
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5955374 |
Method of detection of bilirubin in urine on an automated analyzer
Method for detecting total bilirubin in urine using a chemical detection means with an indicator that will produce a detectable quantitative response in the presence of bilirubin in urine on an...
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5939327 |
Measurement of bile pigments in serum or plasma
A method which provides a quick simple means of assessing plasma or serum specimen integrity with respect to bile pigments is described. Application of the method simultaneously screens serum or...
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5935861 |
Diazonium ion assay reagents and methods for their use
Diazonium ions which are useful as reagents for the assay of bilirubin content in a sample, such as a body fluid sample, are provided. In one preferred embodiment, 2-methyl-3-nitroaniline diazonium...
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5935805 |
Measurement of bilirubin albumin binding
The present invention is directed to the determination of unconjugated and unbound bilirubin in a sample.
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5872009 |
Method for measuring bilirubin
Total bilirubin or direct bilirubin is measured by allowing nitrous acid as an oxidizing agent to act on a sample of living body fluid, and measuring optical changes of the sample. For measuring...
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5854073 |
Stabilization of bilirubin in control sera and calibrators
The invention concerns a stable control serum or calibration serum containing bilirubin to analytically examine the methodical accuracy of individual parameters in human sera or patients. The...
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5804405 |
Bilirubin detection
A method is taught by which a sample can be analyzed for the selective determination of the total concentration of bilirubin (Bt), the concentration of conjugated bilirubin (Bc), the concentration...
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5798267 |
Method for determining alcohol consumption rates
A method for assessing or determining alcohol consumption rates including using a blood specimen from a human subject to develop an individual blood constituent panel; comparing the individual...
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5776779 |
Integral multi-layer element for analyzing bile acid sulfate
An integral multi-layer analytical element for analyzing bile acid sulfate comprising a support member, a reagent layer on said support member and a porous developing layer on said reagent layer,...
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5736408 |
Method for the detection of urobilinogen in urine on an automated analyzer
Method of detecting urobilinogen in urine using a chemical detection means with an indicator that will produce a detectable quantitative response in the presence of, or lack of urobilinogen in...
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5702955 |
Ascorbate resistant detection of hydrogen peroxide
The present invention is a method for the detection of hydrogen peroxide in biological fluids or an aqueous solution which involves contacting the solution with an oxidation-reduction indicator and...
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5624811 |
Bilirubin oxidase from alfalfa and use of the enzyme
Enzyme specific for bilirubin which has a phenol oxidase activity of less than 0.5% and an activity for biliverdin of less than 10%, a broad pH optimum as well as a good thermostability. The enzyme...
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5599661 |
Reagent for measuring direct bilirubin
A reagent system and method are described for optically measuring direct bilirubin by the reaction of a bilirubin oxidase, oxidizing agent or diazonium salt, with the direct bilirubin, wherein a...
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5563072 |
Method for measuring bilirubin
Direct bilirubin can be measured stably with high reliability by using bilirubin oxidase or a chemical oxidizing agent of manganese (III) ions, ferricyanide ions or copper ions, or direct bilirubin...
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5516699 |
Pyridinoline crosslinks as markers of periodontal and peri-implant disease activity
A method of diagnosing severity of periodontal disease or peri-implant disease in a human patient, involving a) obtaining a sample of tissue or gingival crevicular or other fluid from the mouth of...
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5468641 |
Device for validating urobilinogen test devices
The present invention involves the use of certain indole sulfonates in a test control method for the Ehrlich reagent used in diagnostic tests for urobilinogen. The indole sulfonates exhibit unique...
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5401639 |
Stabilized bilirubin calibrator solution and method therefor
A stabilized anoxic diagnostic reagent solution comprising an oxygen labile reagent, glucose oxidase, glucose, a hydrogen donor, sterile membrane fragments derived from bacteria having membranes...
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5380667 |
Serum bilirubin and liver function tests as risk predictors for coronary artery disease
A new series of non-lipid risk factors for predicting coronary artery disease (CAD) are disclosed. The level of serum total bilirubin was found to be a statistically significant independent risk...
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5340714 |
Use of nonmetallic tetrapyrrole molecules and novel signal solutions in chemiluminescent reactions and assays
Nonmetallic tetrapyrrole molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution at a pH from about 10.0 to about 14.0, having an...
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5294403 |
Kit for the determination of bilirubin in urine
A kit including a reagent containing a buffer suitable for maintaining the pH of the reagent between 3-7, sulfanilic acid or sulfanilamide, a cupric soluble salt and an alkaline metal nitrite, for...
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5286450 |
Bilirubin assay using crosslinkable polymers
A colorimetric assay for the determination of conjugated or unconjugated bilirubin in biological fluids can be carried out with an improved analytical element. The element includes a support having...
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5281393 |
Multilayered device containing a polymer-copper complex to control interference of biological substances in colorimetric test systems
A layered device suitable for use in the analysis of blood samples which includes a first layer of a matrix material having dispersed therein a complex of copper and a polymer containing multiple...
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5281536 |
Stable liquid control serum or calibration system for use in clinical diagnostics
A stable liquid control and/or calibration serum for use in clinical diagnostics containing a liquid-stable bilirubin derivative and a known concentration of at least one analyte. The invention...
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5278073 |
Method of bilirubin assay
In the assaying of direct and indirect bilirubin, it is has been found that organic compounds, capable of undergoing diazotization to products having absorption spectrum substantially identically...
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5262304 |
Method for optical measurement of bilirubin and reagent therefor
A method for optical measurement of bilirubin which comprises reacting a bilirubin-containing sample with a zinc compound, a coloring agent and bilirubin oxidase in a buffer, wherein a stable green...
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5229296 |
Use of polymer-copper complex to control interference of biological substances in colorimetric test systems
Disclosed is a method for separating biological substances, particularly hemoglobin or bilirubin, from blood plasma or serum which involves contacting the plasma or serum with a water insoluble...
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5223436 |
Test carrier for the analytical determination of a component of a liquid sample
The present invention provides a test carrier for the analytical determination of a component of a liquid sample, especially of a body fluid, with a carrier layer, which is partly covered by a...
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5183762 |
Copper containing reagent for the detection and determination of bilirubin in the urine
A reagent containing a buffer suitable for maintaining the Ph of the reagent between 3-7, sulfanilic acid or sulfanilamide, a cupric soluble salt and an alkaline metal nitrite, for the detection...
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5149272 |
Assay for total and direct billirubin
Novel reagent compositions and an assay method for the measurement of total and direct bilirubin are disclosed. The reagent compositions comprise an aqueous solution of at least one betaine...
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5112769 |
Stable single liquid reagent for determination of direct bilirubin in sera and method of forming same
There is provided a stable liquid single reagent solution for determination of conjugated bilirubin in biological fluids which comprises an essentially surfactant free aqueous solution containing a...
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5104794 |
Quantitative determination of bilirubin and a reagent therefor
Disclosed is a process for measuring an amount of all bilirubins in a specimen, comprising deconjugating conjugated bilirubins with a reagent comprising an enzyme capable of deconjugation to form...
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