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9029165 System and method for the analysis of DNA sequences in biological fluids  
A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an...
9023655 Sample processing units, systems, and related methods  
Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample...
9023650 DNA tagged microparticles  
A simulant that includes a carrier and DNA encapsulated in the carrier. Also a method of making a simulant including the steps of providing a carrier and encapsulating DNA in the carrier to...
9017970 RNA polyphosphatase compositions, kits, and uses thereof  
The present invention relates to the discovery of RNA 5′ polyphosphatase enzymes not previously described in the art, methods for discovery of said enzymes, compositions of said enzymes, methods...
9012229 Capillary electrophoresis method for fine structural analysis of enoxaparin sodium  
A capillary electrophoresis method for quantitatively analyzing characteristic oligosaccharide present in enoxaparin sodium is provided in this invention. The method may be used for quantitatively...
9012838 Covalently functionalized nanodiamond-based MALDI matrices and methods of use thereof  
The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure...
9005892 Labelling strategies for the sensitive detection of analytes  
The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological...
9005985 Optical reporter compositions  
This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to...
8999720 Aqueous radiation protecting formulations and methods for making and using them  
Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages...
8999719 Quality control marker and its use in herbs authentication  
The present invention relates to a quality control marker and method of using such marker in qualitative and quantitative authentication of Dendrobium officinale Kimura et Migo, which is known as...
8993335 Methods for detection and analysis of polynucleotide-binding protein interactions  
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
8993345 Method of producing functional molecule-containing silica nanoparticles on which biomolecules are bonded  
A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule...
8975017 Process for concentrating nucleic acid molecules  
A process concentrates nucleic acid molecules to be detected of a sample on a surface, with capture molecules that specifically bind the nucleic acid molecules. A support material has a capture...
8969090 DNA sequencing methods and detectors and systems for carrying out the same  
In some embodiments, an analyte detection system is provided that includes a nanochannel, an electrode arrangement, and a plurality of nanoFET devices disposed in the nanochannel. A plurality of...
8969091 Study of polymer molecules and conformations with a nanopore  
The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or...
8969095 Method and system for explosive detection  
The present invention is directed to methods and systems for detecting the presence of explosive elements. A sample element may be used to swipe an object for a test sample. The sample element may...
8969092 Gel particle measurement reagent and measurement method using same  
Provided is a gel particle measurement reagent effective in quickly measuring a time point of initiation of production of gel particles. A gel particle measurement reagent R is a gel particle...
8956876 Method for quantitatively detecting 8-OXO 2′-deoxyguanosine in aqueous sample solution with high sensitivity  
There is provided a method for quantitatively detecting 8-oxo 2′-deoxyguanosine in an aqueous sample solution with high sensitivity. A method for quantitatively detecting 8-oxo 2′-deoxyguanosine...
8951804 Isolation of RNA-protein complexes using cross-linking reagents and oligonucleotides  
Provided herein is a method of sample analysis. In certain embodiments, the method comprises: a) cross-linking protein of a cell using a first compound to produce a first cross-linked product...
8940541 Device, system and method for storing and sorting cellular samples  
The present invention discloses a sample sorter system adapted to receive and sort samples according to predetermined criteria. The sample sorter system comprises a receptacle that is adapted to...
8940538 Apparatus and method for quantifying binding and dissociation kinetics of molecular interactions  
The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without...
8937171 Nucleic-acid-responsive gel, method for producing same, and use of same  
The present invention provides a nucleic-acid-responsive gel which allows (i) a larger volumetric change through structural design, (ii) adjustment of its recognition ability to recognize a...
8932867 High purity heparin and production method therefor  
The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a...
8932866 Method for inspecting gastroenterological cancer by utilizing N-linked sugar chain  
As a result of collecting blood from pancreatic cancer patients, esophageal cancer patients, and stomach cancer patients, and conducting mass spectrometry on N-linked sugar chains in the plasmas,...
8932868 Biosensor using impedimetric real-time monitoring  
A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which...
8933210 Label-free functional nucleic acid sensors for detecting target agents  
A general methodology to design label-free fluorescent functional nucleic acid sensors using a vacant site approach and an abasic site approach is described. In one example, a method for designing...
8912007 Optical measuring apparatus and method for the analysis of samples contained in liquid drops  
An optical measuring apparatus and method for analysis of samples contained in liquid drops provided by a liquid handling system has a liquid handling tip. A light source irradiates the liquid...
8912317 Ribonucleic acid interference molecules of Arabidopsis thaliana  
Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having...
8906692 Instrument and method for analysis of mannose 6-phosphate  
Disclosed are an apparatus and method for separation analysis of mannose-6-phosphate (M6P) by post-column fluorescence detection method. The apparatus is based on chromatography, and includes a...
8901097 Methods for delivery of siRNA to the spinal cord and therapies arising therefrom  
The present application relates at least in part to methods for the administration of small interfering RNAs (siRNAs) to the spinal cord of a human or animal patient and also to a method of...
8895314 System and method for alkylation process analysis  
A method and apparatus is provided for determining concentration of components in a liquid hydrocarbon mixture including hydrocarbons and water flowing through an alkylation process. A fluid flow...
8877441 Methods and kits for performing in situ hybridization  
The invention relates to methods and kits for performing in situ hybridization on a biological sample on a solid surface using nucleic acid probes that are embedded in or sorbed to a dry, fibrous...
8865078 Apparatus for single-molecule detection  
An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one...
8865077 Apparatus for single-molecule detection  
An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least...
8835178 Bio-threat microparticle simulants  
A bio-threat simulant that includes a carrier and DNA encapsulated in the carrier. Also a method of making a simulant including the steps of providing a carrier and encapsulating DNA in the...
8828732 Method of labeling sugar chain  
The method of labeling a sugar chain from a biological sample employs a single reaction vessel for the sequential performance of the following steps of (a) isolating a sugar chain from a sample...
8822148 Method of performing PCR reaction in continuously flowing microfluidic plugs  
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
8815602 Urinary biomarkers for predicting long-term dialysis  
This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term...
8772467 Methods and apparatus for screening and detecting multiple genetic mutations  
An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a...
8765443 Crystals of human topoisomerase II-DNA binary complex, methods for preparing the same and uses thereof  
Disclosed herein are a crystal of a human TOPII (hTOPII)-DNA binary complex, the method for preparing the same and the use thereof. The hTOPII-DNA binary complex includes an hTOPII portion that...
8765950 Reagents for biomolecular labeling, detection and quantification employing raman spectroscopy  
The present disclosure provides isotopically substituted compounds of the formula (II): wherein T, U, V, W, X, Y, Z, R0, R3, R4, R5 and R6 are as defined in the detailed description. The method...
8765484 Optically encoded particles  
The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film...
8759110 Metal enhanced fluorescence-based sensing methods  
The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background...
8748165 Methods for generating short tandem repeat (STR) profiles  
This invention provides a method for generating short tandem repeat (STR) profiles on each of a plurality of samples comprising, for each sample: a) isolating DNA from the sample; b) amplifying...
8734890 Method for forming a molecularly imprinted polymer biosensor  
A method for forming a molecularly imprinted polymer biosensor includes: (a) preparing a reaction solution including an imprinting molecule, a functional monomer, an initiator, and a crosslinking...
8721969 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Apparatus for single-molecule detection
 
An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least...
8703498 Multi-dimensional chromatographic methods for separating N-glycans  
A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan...
8703497 Nanowire-based system for analysis of nucleic acids  
A system and method for analyzing nucleic acids is presented herein. The system can include a nanowire assembly including a plurality of nanowires. In some embodiments, at least two nanowires can...
8703734 Nanoprobes for detection or modification of molecules  
The disclosure provides probes for one or more target molecules. In particular examples, the probes include a molecular linker and first and second functional groups linked and spaced by the...
8698031 Separation and manipulation of a chiral object  
Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral...