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7601301 |
Multiplexed active biologic array
A method and apparatus for addressing and driving an electrode array includes addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect, a value...
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7592468 |
Production of Δ 9 tetrahydrocannabinol
Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent,...
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7575930 |
Method for analyzing oligosaccharides from blood plasma
The present invention relates to a method for analyzing oligosaccharides constituting the heparins of low molecular weight and the heparins of very low molecular weight from blood plasma.
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7494816 |
System and method for determining a temperature during analyte measurement
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC...
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7488601 |
System and method for determining an abused sensor during analyte measurement
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC...
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7465586 |
Oral detection test for cannabinoid use
A method for confirming the active intake of marijuana and its active component Δ 9 -tetrahydrocannabinol (“Δ 9 -THC”) by detecting the amount of 11-nor-Δ 9 -THC carboxylic acid (“THCA”)...
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7407811 |
System and method for analyte measurement using AC excitation
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC...
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7397026 |
Efficient electron transfer dissociation for mass spectrometry
The present invention relates to, inter alia, methods and apparatuses for electron transfer dissociation (ETD) that vary the internal energy of precursor ions for ETD. The methods and apparatuses...
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7385185 |
Molecular activation for tandem mass spectroscopy
In a tandem mass spectrometer means are provided for molecular activation of ions prior to fragmentation. An embodiment of a tandem mass spectrometer comprises a first collision cell receiving...
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7335512 |
Marker for measuring liver cirrhosis
The invention provides methods and kits to detect liver cirrhosis in mammals. The diagnostic test is based on the profiling and identification of diagnostic carbohydrates present in a body fluid...
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7264971 |
Read-head for optical diagnostic device
A readhead for a photometric diagnostic instrument includes a housing adapted for incorporation within the photometric diagnostic instrument, and an elongated sample table operatively engaged with...
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7255835 |
Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity
Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a...
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7244619 |
Serum marker for measuring liver fibrosis
The invention provides methods and kits to detect liver fibrosis or a change in the gradation of liver fibrosis in mammals. The diagnostic marker is based on the profiling and identification of...
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7220553 |
Use of Russell's viper venom-induced plasma factor Xa activity to monitor the activity of factor Xa inhibitors
The invention relates to a method of monitoring the effect of a direct of indirect Factor Xa inhibitors comprising the steps of collecting a plasma sample from a patient, adding a solution of...
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7198955 |
Method and apparatus for measurement of blood substitutes
A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method...
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7169359 |
Bioequivalence test for iron-containing formulations
A rapid method for assessing the bioequivalence of iron in iron-supplement formulations, particularly iron-sucrose formulations is described, which is based upon the kinetics of reduction of iron...
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7150997 |
Multiplexed active biologic array
A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method,...
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7101717 |
Addressable biologic electrode array
An addressable biologic electrode array includes an array of electrodes disposed on a support, the array of electrodes being selectively addressed and driven using a memory associated with each...
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7081347 |
Method for predicting cardiovascular events
A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is...
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7045097 |
Biologic electrode array with integrated optical detector
A biologic electrode array is formed on a semiconductor substrate. A matrix of electrode sites is disposed on the semiconductor substrate. A matrix of optical detectors is disposed beneath the...
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6982336 |
1,2-dioxetane derivatives, luminescent reagents, luminescence methods and measuring methods
A 1,2-dioxetane derivative of the formula (I):
wherein R 1 –R 3 and Ar are defined in the claims is provided.
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6881579 |
Sample processing apparatus and methods
Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An...
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6878552 |
Homogeneous detection and/or determination method for a chemical or physico-chemical interaction
The invention relates to a homogeneous method for detecting and/or determining by fluorescence a chemical or physicochemical interaction in a measuring medium, in which a rare-earth metal cryptate...
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6867048 |
Multiplexed active biologic array
A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method,...
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6844198 |
Adsorptive method for determining a surface property of a solid
A method of determining a surface property of solids in a plurality by contacting the solids with a fluid, measuring the radiation emitted, absorbed, or altered during adsorption of the fluid using...
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6825045 |
System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels
A system and method for desorption and ionization of analytes in an ablation medium. In one embodiment, the method includes the steps of preparing a sample having analytes in a medium including at...
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6821784 |
Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy
Two dimensional COSY magnetic resonance spectroscopy of human stool can be used in a non-invasive method of detecting the presence of colorectal cancer. The spectrum of a patient's stool is...
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6790668 |
Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids
The present invention is a method for drug level detection by using a simplified and effective deproteinizing step from body fluids, such as plasma, blood, urine, saliva, tear fluid, followed by...
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6730519 |
Method of preparing delta-9-tetrahydrocannabinol
A method for the isolation of delta-9-tetrahydrocannibinol (THC) from, Cannabis plant material, wherein delta-9-THC Acid and THC are separately obtained including the steps of extracting the...
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6723564 |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
Mass spectrometry of large nucleic acids by infrared Matrix-Assisted Laser Desorption/Ionization (MALDI) using a liquid matrix is reported.
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6703244 |
Method for confirming presence of mycotoxicosis
The present invention is a very significant way to determine exposure to toxic mold, or the disease called mycotoxicosis. Urine samples are extracted for trichothecene mycotoxins to confirm the...
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6682936 |
Addressable biologic electrode array
A biologic electrode array assembly is formed on an integrated circuit chip that includes an array of electrodes. At least one metal oxide semiconductor (MOS) switch is coupled to at least one of...
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6620624 |
Mass spectrometry interface, a mass spectrometer and a mass spectrometry
With rotating and translating a rotation-translation drum installed in a vacuum chamber of a mass spectrometry interface to constitute a mass spectro-meter, a liquid sample incorporating a...
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6605472 |
Microfluidic devices connected to glass capillaries with minimal dead volume
A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the...
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6558956 |
Method and apparatus for detection of a controlled substance
Techniques and devices for detecting and analyzing controlled substances and the like are discussed including highly reactive sensor molecules which are coated on a spectroscopic sample surface ( 4...
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6534316 |
Colorimetric and fluorimetric analysis of carbohydrates
Methods are disclosed for the simple, rapid, and selective colorimetric detection of carbohydrates, including fructose, glucose, sialic acid, and oligosaccharides. There is no need for any prior...
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6417006 |
Assay method for cardiovascular disease
An assay method for detecting potential cardiovascular disease (CVD) in a vascularized subject by assessing the concentration of holo-transcobalamin II (holo-TCII) in a sample from the subject...
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6344360 |
Detection of analytes by fluorescent lanthanide metal chelate complexes containing substituted ligands
Compositions and methods for determining the presence or concentration of an analyte in a sample by exposing the sample to an indicator molecule comprising a fluorescent lanthanide metal chelate...
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6340764 |
Reference compound for use in the analysis of levosimendan batches
A pyridazinyl derivative (I) and its use as a reference compound in the determination of potentially genotoxic impurities in levosimendan samples. An analytic method for the determination of...
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6228653 |
1,2-dioxetane derivative fused to pyran ring and use thereof
A 1,2-dioxetane derivative represented by the general formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 each independently represents hydrogen atom, an alkyl group, or an aryl...
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6190921 |
Ouabain immunoassay and kit and ouabain labeled with 125I or fluorescent label
The invention deals with the use of a reactive compound in immunological analyses. The compound is ouabain or its analog to which another compound, labeled by radioiodine or by a fluorogen, is...
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6153399 |
Determining ascorbic acid using ASOD and LEUCO chromogen
A reagent, kit and method for the quantative determination of ascorbic acid in a sample uses ascorbate oxidase which catalyzes the reaction of reduced ascorbic acid to oxidized ascorbic acid and...
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6121050 |
Analyte detection systems
The present invention is directed to an improved analyte systems which are able to compensate for interfering signals and to provide accurate detection and/or quantification of analytes in a...
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6063637 |
Sensors for sugars and other metal binding analytes
Sensors (20, 50, 70) for use in detecting the presence of sugars and other analytes (target molecules). The sensor is composed of a metal complex that binds to the target molecule and releases a...
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6054322 |
Use of sialic acid determination for determining alcohol consumption
A method for the determination of an individual's alcohol consumption, characterized in comprising the steps: i) determining the level of sialic acid in a body fluid sample from the individual; ii)...
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6020205 |
Determination of intracellular antioxidant levels
A method of determining intracellular levels of water-soluble and fat-soluble antioxidants. Peripheral blood mononuclear cell lysates are prepared from an individual and analyzed by HPLC, either...
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6008054 |
Method of measuring a β-glucan
For the purpose of improving the accuracy and reproducibility of the measurement of β-glucan by flow injection method using calcofluor, the present invention provides a method in which a gel...
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6004536 |
Lipophilic cyanine dyes with enchanced aqueous solubilty
The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or...
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5962334 |
Process for extracting 2,3,7,8-tetrachlorodibenzo-p-dioxin
A process for the extraction and purification of TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) from a sample matrix. The process of the present invention overcomes a problem of prior art processes for...
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5958785 |
Detection of a carbohydrate biomarker directly associated with chronic alcoholism
Chronic or long-term alcohol consumption is detected and diagnosed by determining the levels of an alcohol-specific ethanol glycoconjugate biomarker, identified as ethyl β-glucuronide, in body...
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