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7598385 |
Asymmetric cyanine fluorescent dyes
The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R 1 , R 2 , R 3 , R 4 , R 5 and Y − are as defined in the specification. The present...
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7501093 |
Vial for test strips
A diagnostic test strip vial has a container, a lid, and a plurality of diagnostic test strips. The container has a generally annular wall terminating at a base and at an open mouth. The lid has a...
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7393692 |
SERS method for rapid pharmacokinetic analysis of drugs in saliva
The method and apparatus rapidly separate drugs and their metabolites from saliva and, in a continuous sequence of steps, rapidly detect, identify and quantify them through surface-enhanced Raman...
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7393691 |
SERS method and apparatus for rapid extraction and analysis of drugs in saliva
The method and apparatus rapidly separate drugs and their metabolites from saliva and, in a continuous sequence of steps, rapidly detect, identify and quantify them through surface-enhanced Raman...
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7384754 |
Enrichment and tagging of glycosylated proteins
A method useful in the analysis of glycosylated proteins, in which a mixture containing glycosylated proteins and unglycosylated proteins is contacted with a resin that includes a nucleophile bound...
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7255835 |
Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity
Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a...
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7238532 |
Isothiazolone monitoring in aqueous systems
A method for measuring the concentration of isothiazolones in aqueous systems including removing sample interferences by lowering the pH of a sample collected from the aqueous system containing...
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7204125 |
Pressure activated sampling system
Screening of items for the presence of contaminants, such as explosives residue, is accomplished by subjecting an item loaded into a pressure chamber to a pressure substantially in excess of...
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7198955 |
Method and apparatus for measurement of blood substitutes
A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method...
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7022846 |
Metabolites of prinomastat and their synthesis
Metabolites of a matrix metalloproteinase inhibitor prinomastat and their synthesis. These metabolites are:...
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6825045 |
System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels
A system and method for desorption and ionization of analytes in an ablation medium. In one embodiment, the method includes the steps of preparing a sample having analytes in a medium including at...
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6790668 |
Monitoring patient compliance and bioavailability of drugs by deproteinizing body fluids
The present invention is a method for drug level detection by using a simplified and effective deproteinizing step from body fluids, such as plasma, blood, urine, saliva, tear fluid, followed by...
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6716640 |
Stabilization and amplification of electrochemiluminescence signals
The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
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6620624 |
Mass spectrometry interface, a mass spectrometer and a mass spectrometry
With rotating and translating a rotation-translation drum installed in a vacuum chamber of a mass spectrometry interface to constitute a mass spectro-meter, a liquid sample incorporating a...
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6558956 |
Method and apparatus for detection of a controlled substance
Techniques and devices for detecting and analyzing controlled substances and the like are discussed including highly reactive sensor molecules which are coated on a spectroscopic sample surface ( 4...
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6416762 |
Anti-picornaviral ligands via a combinatorial computational and synthetic approach
The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can...
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6376649 |
Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
Methods for the synthesis of α-hydroxy-β-amino acid and amide derivatives and α-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a...
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6303384 |
Reagent and method for detecting an adulterant in an aqueous sample
This invention relates to a reagent and use of that reagent for detecting adulterants in aqueous samples, particularly in biological specimens such as urine samples using a diazo dye precursor such...
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6288048 |
Cholesterol and hedgehog signaling
The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol...
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6265220 |
Assay for homocysteine
A non-immunochemical method is disclosed for determining homocysteine in a sample. A combination of the sample and a first compound that comprises a cis-1,4-dioxo-2-butene moiety or hydrolytically...
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6245521 |
Assay for evaluating the affinity of compounds to the glutamate GluR5 receptor
A hippocampal GluR5 receptor modulator, 2-amino-3-(3 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid (ATPA) is useful in methods of measuring the binding affinity of chemical...
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6133040 |
Process and test kit for cocaine detection
Test kit and method for discriminating cocaine and its salts from substances that falsely give a positive color reaction with Scott's thiocyanate reagent. As all Scott false positive substances...
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6057161 |
Method for determination of drugs of abuse in biological samples
A high purity styrene-divinyl benzene resin is used for rapid solid phase extraction of drugs of abuse from body fluid samples. Simple extraction procedures are described which provide high...
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6004536 |
Lipophilic cyanine dyes with enchanced aqueous solubilty
The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or...
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5994143 |
Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye...
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5981286 |
Hydrophilic metal complexes
The present invention concerns new hydrophilic metal complexes and their use as luminescent marker groups in immunoassays.
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5916815 |
Assaying system for illicit substances using intentional false positives to initially preserve anonymity
An assaying system for determining the presence of particular illicit substances in human physiological fluid, consisting of a collection cup, a collection cup lid, and a test card with assaying...
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5888757 |
Cell wall assay
Disclosed are methods that can be used to (1) measure the level of polysaccharide in a sample; (2) measure the ability of a compound to degrade a polysaccharide; (3) measure the ability of a...
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5658531 |
Assay device
A disposable assay device for assaying a sample has a body (10) including a reaction chamber (12) which contains or is adapted to receive an assay reagent sensitive to a component (e.g. nicotine...
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5648047 |
Device for colorimetric detection of explosives and narcotics
A hand-held device for rapid colorimertic detection of explosives, narcotics, and other chemicals which can be accurately operated by non-skilled personnel and perform numerous tests in a quick...
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5587323 |
Meconium assay procedure
A improved method for preparing a concentrated meconium extract containing basic and acid-neutral target analytes present in a meconium sample suspected of containing the target analytes is...
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5554542 |
Immunoassay for isothiazolones
Immunoassay for isothiazolones based on monoclonal antibodies that react with isothiazolones, particularly, 5-chloro-2-methyl-3-isothiazolone, hybridomas that produce such antibodies, especially...
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5550062 |
Method and apparatus for chemical detection by pyrolysis
This invention relates to a method and apparatus for detecting and identifying a non-volatile chemical substance, in which the chemical substance (when in a sample) is pyrolyzed into its gaseous...
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5532131 |
Forensically-acceptable determinations of gestational fetal exposure to drugs and other chemical agents
New and improved methods for collecting neonatal meconium samples, preparing meconium specimens for testing and for chemically analyzing neonatal meconium samples to determine their chemical...
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5504091 |
Biotin esters of rapamycin
A compound of the structure ##STR1## R 1 and R 2 are each, independently, hydrogen or ##STR2## X is ##STR3## Y is ##STR4## Z is --CH 2 --, --S--S--, or ##STR5## R 3 is hydrogen, alkyl,...
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5501957 |
Method for measuring glycosyltransferase activity
A method of assaying for glycosyltransferase activity in a sample. In a first step, a sample is reacted with a first sugar donor and an acceptor substrate to produce a transferase product. The...
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5476794 |
Detection method for checking surfaces for nitrogen-containing explosives or drugs
Disclosed is a method of rapidly checking surfaces for the presence of traces of specific compounds such as certain explosives and drugs. A hand-covering such as a cotton glove is used to wipe...
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5457054 |
Unit test kit and method for qualitative identification of an illicit drug
A self-contained unit test for qualitative identification of suspect substances including cocaine, heroin and cannabis, includes a visualization reagent having a compound which undergoes a visible...
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5432093 |
Sequential degradation of proteins and peptides from the N-terminus
A novel method for the sequential degradation from the N-terminus of small samples of proteins or peptides. The released amino acids may be detected by mass spectrometry.
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5424185 |
Human high-affinity neurotransmitter uptake system
Non-primate or primate cells are provided comprising a functional human transporter for neurotransmitter uptake. The cells allow for dissection of the mechanism of neurotransmitter transport, as...
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5420275 |
Pyridopyridazine compounds and their use
An assay method which comprises utilizing chemiluminescence of a pyridopyridazine compound of the formula ##STR1## wherein R 1 is a hydrocarbon group or a heterocyclic group each of which may be...
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5322680 |
Substituted 2-thiazolyl tetrazolium salt indicators
2-Thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for...
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5290702 |
Method of detecting and mapping organic solvent-containing materials on a surface
Chromogenic solvent detectors are used to detect and map the presence of organic solvent-containing materials on a surface. The detector need only be applied to the surface to be tested. When...
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5278074 |
Method of monitoring and controlling corrosion inhibitor dosage in aqueous systems
The concentration of an aromatic azole corrosion inhibitor in the water of an aqueous system is monitored by a fluorometric method which is based upon the measurement of the fluorescence intensity...
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5246865 |
Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection
A protein microsequencing method for use in conjunction with the thiobenzoylation degradation of polypeptides and proteins is disclosed. The process involves reaction of the N-terminal amino acid...
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5187265 |
Chromogenic thiol indicating benzoisothiazolone compounds
The present invention relates to a chromogenic benzoisothiazolone polymer derivative for measuring the presence or appearance of thiols in an aqueous system.
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5185267 |
Method for detecting maternally transferred drug metabolites in newborn infants
An improved method for detecting the presence of durg metabolites in the meconium of newborn infants is described. The method involves a single step extraction of the drug metabolites from meconium...
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5128267 |
Naphthotriazolium salts
Naphthotriazolium salts which are chromogenic indicators for reducing substrate, such as NADH or NADPH.
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5094957 |
Quantitative method for determining concentration of 3-isothiazolone
A method for determining the concentration of isothiazolones in an aqueous system comprising: (a) mixing a known volume of solution to be analyzed with a volume containing a known quantity of...
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5051369 |
Detection method for amino acid derivative
A method for detecting amino acid derivatives in which 2-anilino-5-thiazolinone derivatives of amino acids are reacted with an amino compound of fluorescein or rhodamine derivative amino compounds...
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