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7417135 Plasmidic gene, ways of acquiring this gene, the amylolytic enzyme it encodes and its application  
The object of the invention is a novel plasmidic gene encoding an amylolytic enzyme which after introduction into a microbial strain, favorably bacterial, especially Lactococcus lactis , enables...
7413906 Quantitative, high-throughput screening method for protein stability  
In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for...
7411042 Tumor associated nucleic acids and uses therefor  
The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments...
7407810 Methods and apparatus for characterizing polymeric mixtures  
The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental...
7407626 Composition and method of use of medical test kit  
A medical test kit includes a glucose testing composition, a protein testing composition, a bilirubin testing composition, a bilinogen testing composition, an amylase testing composition, a blood...
7402402 P38 MAPK pathway predicts endocrine-resistant growth of human breast cancer and provides a novel diagnostic and treatment target  
Acquired and de novo endocrine resistance are major clinical problems in the management of breast cancer patients. Though the antiestrogen tamoxifen prolongs disease-free and overall survival in...
7399638 Prediction method for lipidosis  
The present invention provides a prediction method for lipidosis caused by a compound, which includes detecting (a) phenylacetylglycine and/or phenylacetylglutamine, or an optionally chosen...
7397026 Efficient electron transfer dissociation for mass spectrometry  
The present invention relates to, inter alia, methods and apparatuses for electron transfer dissociation (ETD) that vary the internal energy of precursor ions for ETD. The methods and apparatuses...
7393692 SERS method for rapid pharmacokinetic analysis of drugs in saliva  
The method and apparatus rapidly separate drugs and their metabolites from saliva and, in a continuous sequence of steps, rapidly detect, identify and quantify them through surface-enhanced Raman...
7393691 SERS method and apparatus for rapid extraction and analysis of drugs in saliva  
The method and apparatus rapidly separate drugs and their metabolites from saliva and, in a continuous sequence of steps, rapidly detect, identify and quantify them through surface-enhanced Raman...
7390465 System and method for contamination detection within sealed containers  
A system and a method to detect biological and chemical agents in a sealed contained at, for example, a mail-processing center. The system includes filtration and vacuum subsystems cooperatively...
7385185 Molecular activation for tandem mass spectroscopy  
In a tandem mass spectrometer means are provided for molecular activation of ions prior to fragmentation. An embodiment of a tandem mass spectrometer comprises a first collision cell receiving...
7384790 Method of analyzing peptide for determining C-terminal amino acid sequence  
The present invention provides a method for analyzing the C-terminal amino acid sequence of a peptide by applying reaction technique for successively releasing the C-terminal amino acids therefrom,...
7381567 Dissociative fluorescence enhancement assay  
The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein...
7374944 Device and bioanalytical method utilizing asymmetric biofunctionalized membrane  
Bioanalytical device that includes a biofunctional component and an optional sensor component. The device includes arrays of addressable, durable, asymmetric biofunctional membranes containing...
7371579 Nickel-based reagents for detecting DNA and DNA-protein contacts  
The invention relates to a compound comprising a labeled nickel complex (FIG. 1 ) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base...
7368293 Liver enriched transcription factor  
HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the transthyretin (TTR) and apolipoprotein CIII (apoCIII) genes...
7368290 Structural determination of intact proteins using mass spectrometry  
The present invention relates to novel methods of determining the sequence and structure of proteins. Specifically, the present invention allows for the analysis of intact proteins within a mass...
7368288 Detection and recognition of analytes based on their crystallization patterns  
The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets...
7366617 Mass determination for biopolymers  
A method for determining the masses of ions of a sample that contains a known class of biopolymers and is measured with a mass spectrometer having a statistical or pseudo-statistical error...
7364911 Methods for isolating and labeling sample molecules  
The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more...
7361484 GSK3 polypeptides  
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also...
7354769 Crystallization of IGF-1  
Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising...
7351588 Optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERS  
An optical sensor and method for use with a visible-light laser excitation beam and a Raman spectroscopy detector, for detecting the presence chemical groups in an analyte applied to the sensor are...
7348140 Clinical indications for genotyping polymorphic variants of G-protein coupled receptors  
The invention provides compositions and methods for screening individuals for the presence of G-protein coupled receptor (GPCR) variants. The compositions and methods are useful for determining...
7344870 3-phosphoinositide-dependent protein kinase  
The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase.
7344849 Assay  
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
7338807 Screening assays for compounds that cause apoptosis  
This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition,...
7338769 Methods for identifying agonists of cypin  
Disclosed are novel materials and screening methods for diagnosing and monitoring cognitive disorders, as well as for identifying compounds for treating such disorders.
7335478 Reactivation-based molecular interaction sensors  
This invention provides methods and systems for linking the functional activation of a responder molecule to the interaction of two or more binding ensemble members of interest either in vitro or...
7335467 Breast cancer antigens  
The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses...
7332343 Determining enantiomeric excess using indicator-displacement assays  
The invention includes an enantioselective indicator-displacement assay useful to determine enantiomeric excess (ee) enantiomeric samples calorimetrically. Determination may be by inspection of...
7329529 Ubiqutin proteases  
The invention provides isolated nucleic acids molecules that encode novel ubiquitin protease polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression...
7329501 Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance  
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
7326837 Clinical applications of crystalline diamond particles  
A method for profiling proteins in a biological sample by mixing the sample and a diamond-based composition. The diamond-based composition includes a diamond crystallite having a surface that...
7326574 Compositions and methods for detecting stress-inducible proteins  
Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various...
7320894 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor  
The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a...
7319134 Regulation of transcription factor, NF-IL6/LAP  
An alteration in phosphorylation of serine 105, within the activation domain of NF-IL6/LAP, alters its transcriptional efficacy. Polypeptides, polynucleotides and methods of use for modified...
7315767 Impedance spectroscopy based systems and methods  
One aspect of the invention provides a device that non-invasively determines the concentration of a substance in a target. The device includes a first electrode, a measuring circuit, and a data...
7307142 Leptin antagonists  
The invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39 - 42 of a leptin polypeptide...
7306950 Composition and use of substances for stabilising amino acids containing sulphur  
The invention relates to a composition for the stabilization of sulphur-containing amino acids and/or for the inhibition of the continuous formation of sulphur-containing amino acids in withdrawn...
7306949 Combination of CRP and D-dimer for in vitro diagnosis of deep venous thrombosis (DVT)  
The present invention relates to an in vitro diagnostic method for patients with suspected deep venous thrombosis wherein by combined testing of patients' samples for D-dimer and CRP both the...
7303922 Reagentless analysis of biological samples by applying mathematical algorithms to smoothed spectra  
Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly...
7303885 Screening method for candidate drugs  
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
7300798 Chemical arrays  
A method and apparatus for using arrays of polymers each having a pattern of features over a corresponding array region on a surface of a flexible elongated web. In this method each array region...
7297760 Cancer associated protein  
The present invention relates to a novel polypeptide (BCMP 101) compositions comprising the polypeptide, including vaccines, and antibodies that are immunospecific for the polypeptide. The use of...
7294514 Diagnostic method for alzheimer's disease based on holo-transcobalamin II  
The invention provides a diagnostic or prognostic assay method for Alzheimer's Disease by assaying a body fluid sample or a test sample derived therefrom for holo-trancobalamin II.
7294513 Method and apparatus for characterizing solutions of small particles  
A method and apparatus is described by which means molecules in suspension may be characterized in terms of the size and mass distributions present. As a sample solution is separated by centrifugal...
7288404 Microcantilevers for biological and chemical assays and methods of making and using thereof  
Disclosed herein are microcantilevers having structural shapes that are less sensitive to turbulence and drift effects yet provide greater deflections due to analyte concentration. The structural...
7288372 Methods for the preparation of chemically misaminoacylated tRNA via protective groups  
The present invention relates to methods for the preparation of chemically aminoacylated tRNAs for the purpose of introduction of markers into nascent proteins. The present invention also relates...
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