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7629172 |
Entrapped binding protein as biosensors
The invention is directed to entrapped mutated binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte...
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7625759 |
Method for using BOC/CDO to modulate hedgehog signaling
The present invention provides for a method of using BOC/CDO hedgehog antagonists to inhibit hedgehog signaling, as well as treating and diagnosing disorders relating to hedgehog signaling or...
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7625758 |
Coumarin-based cyanine dyes for non-specific protein binding
Protein dyes whose molecular structure is that of a coumarin moiety coupled to a quaternary ammonium heterocycle through a vinyl or polyvinyl linkage demonstrate the ability to associate with...
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7622263 |
Kit for immobilizing organic substance, organic substance-immobilized structure, and manufacturing methods therefor
To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic...
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7618827 |
Thyroid hormone analysis by mass spectrometry
Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation...
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7615380 |
Methods for modulating an immune response by modulating KRC activity
This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation,...
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7613574 |
System and method for automating scientific and engineering experimentation for deriving surrogate response data
The present invention provides a system and method for automatically deriving unique surrogate response data from experiment results in which inherent data loss occurs in a sufficient number of the...
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7611853 |
Assay to screen for anti-malarials
Malarial parasite Plasmodium falciparum is responsible for the most severe form of malaria in humans, causing about 2 million deaths every year. Lack of effective vaccines and emergence of...
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7608462 |
Drying SPE cartridges
A method for spectrometric investigation of a plurality of samples dissolved in a solvent comprises: (a) guiding a first solvent with a sample through an SPE cartridge for concentrating the sample...
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7608458 |
Identifying patients at risk for life threatening arrhythmias
The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated...
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7605246 |
Genes differentially expressed in breast cancer
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of...
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7601542 |
Analytical method for protein mapping using hydrogen/deuterium exchange
Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide...
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7601540 |
Gamma secretase notch biomarkers
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity...
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7598087 |
Protein imprinted polymers with integrated emission sites
This invention provides protein or polypeptide imprinted polymers with integrated emission sites (PIPIES) for detecting the presence of a protein or polypeptide analyte comprising templated sites...
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7592180 |
Method for evaluating insulin resistance
A method for evaluating insulin resistance in a simple and highly reliable manner is provided. This method includes measuring a fasting insulin value in blood, a fasting blood sugar value, and an...
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7591953 |
Methods and apparatus for continuous large-scale radiolabeling of proteins
Disclosed are improved methods and apparatus for radiolabeling, particularly methods and apparatus for large scale in-line radiolabeling of products, such as proteins and antibodies.
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7582282 |
Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics
The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the...
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7575929 |
Diagnosis of multiple sclerosis with diketopiperazines
The present invention relates to the diagnosis and monitoring of diseases and conditions by quantifying markers, including degradation products of disease-associated proteins, such as...
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7575927 |
Methods for diagnosing a gastrointestinal disorder in an individual
Methods for measuring at least one mucosally released neuroendocrine gut system component in an individual and methods for diagnosing a gastrointestinal disorder in an individual based on the...
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7575876 |
Biomarkers for neurodegenerative disorders
The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene...
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7566544 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7560285 |
Micelle-controlled nanoparticle synthesis for SERS
The methods and apparatus disclosed herein concern nanoparticle layers uniformly distributed on a surface or substrate. In certain embodiments of the invention, the nanoparticle layers are of use...
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7560258 |
Glass-immobilized, protein-acrylamide copolymer and method of making thereof
Disclosed are a polyacrylamide-based method of fabricating surface-bound peptide and protein arrays, the arrays themselves, and a method of using the arrays to detect proteins and to measure their...
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7560242 |
Metadherin polypeptides, encoding nucleic acids and methods of use
Metadherin, a protein that controls metastasis, and variants of metadherin are described. DNA sequences encoding the same and methods of production are described. Therapies involving the...
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7556969 |
Intensified neutral loss tags and use thereof in mass spectrometry
Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a...
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7550716 |
Mass spectrometer
The present invention provides a mass spectrometer capable of breaking even a sample molecule having a large molecular weight by a CID process. In an embodiment of the present invention, the mass...
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7550301 |
MALDI analysis based on derivatized matrices forming covalent bonds with analyte molecules
Methods and compounds are provided to improve the desorption and ionization of analyte for mass spectrometry analysis. More specifically, it is for laser desorption/ionization mass spectrometry....
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7550299 |
Method for predicting onset/risk of atrial fibrillation (AF)
A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a...
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7547553 |
In vitro method for the diagnosis of neurodegenerative diseases
An in vitro method for the detection, determination of severity and monitoring and prognosis of neurodegenerative diseases is disclosed. The presence and/or concentration of the physiologically...
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7547552 |
Indication composition for surgical instrument cleaning evaluation
The present invention provides an indicator composition for evaluating cleaning of a medical instrument that includes an extracellular matrix component and hemoglobin, as a contamination model...
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7547441 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
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7544518 |
Rapid quantitative analysis of proteins or protein function in complex mixtures
Analytical reagents and mass spectrometry-based methods using these reagents for the rapid, and quantitative analysis of proteins or protein function in mixtures of proteins. The methods employ...
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7541140 |
Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
The present invention relates to identifying the risk of a subject developing renal stones utilizing an assessment of PTH agonist, antagonist and/or total PTH levels, optionally together with an...
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7537704 |
Method for determining the concentration of asymmetric dimethylarginine (ADMA)
The invention relates to a method for determining the concentration of asymmetric dimethylarginine (ADMA) simultaneously with arginine and with symmetric dimethylarginine (SDMA) in biological...
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7531358 |
Method of quantifying surfactant
A method of quantifying an ethylene oxide based nonionic surfactant in a sample containing a physiologically active protein, characterized in that quantitation is performed by colorimetry, in...
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7527932 |
Method of using physiological markers to estimate cardiovascular risk
An individual's risk profile for developing a cardiovascular disorder or for experiencing a cardiovascular event is determined by 1) measuring levels of certain stress-evoked proteins including...
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7524941 |
Methods for the preparation of chemically misaminoacylated tRNA via protective groups
The present invention relates to methods for the preparation of chemically aminoacylated tRNAs for the purpose of introduction of markers into nascent proteins. The present invention also relates...
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7524681 |
Rapid assay for biological substances using FTIR
The present invention relates to a method for determining the condition of a biological fluid by recording the IR spectrum of a sample of the biological fluid. To this end, the biological fluid can...
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7523026 |
Proteome analysis method and proteome analysis system
A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain...
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7521250 |
Fluorescent sensor for phosphate ion and phosphorylated peptide
Disclosed is a fluorescent sensor for phosphate ion and phosphorylated peptide, which comprises a phosphate anion-selective fluorescent compound expressed by the following general formula (1). In...
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7521244 |
Standard reference solutions
Standard reference materials and related methods are described for quality testing and calibration of instruments used for the qualitative and quantitative determination of hemoglobin and glycated...
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7514082 |
Anti-viral VSF protein and hybridoma producing the same
Disclosed are a novel virus suppressing factor (VSF) protein having antiviral activity against a variety of viruses and a hybridoma secreting such a VSF protein. In addition, the present invention...
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7510841 |
Methods of making and using composite arrays for the detection of a plurality of target analytes
The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods...
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7507584 |
Method for the diagnosis of chronic stress and related disorders
Methods for diagnosing chronic stress in patients by first determining the level of one or more analytes in a patient sample and establishing the significance of the one or more analyte levels.
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7485466 |
Protein detection system
A system for detecting protein in mammalian urine is disclosed herein. Phloxine B buffered between pH 2-2.5 undergoes a color change from colorless to red in the presence of protein. Disclosed...
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7485435 |
Simultaneous detection of metabolic enzyme activity and metabolite levels
Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) one or more metabolically indicative...
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7470542 |
Proteins in type 2 diabetes
The present invention relates to the use of naturally occurring compounds and derivatives thereof as markers for predisposition of diabetes related diseases. The invention also relates to a...
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7470540 |
Method and device for the integrated synthesis and analysis of analytes on a support
A method for preparing receptor-coated particles is described which comprises the following steps:
a) providing a support body, b) conducting a liquid containing particles into or onto the support...
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7465585 |
Compositions and methods for inhibiting cell migration
The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and...
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7462489 |
Methods for identifying and analyzing biomarkers from plasma-derived microparticles
The present invention provides methods for identifying candidate biomarkers in the plasma microparticle proteome. It also provides methods for isolating, identifying, and analyzing microparticles...
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