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8444932 |
D-dimer, troponin, and NT-proBNP for pulmonary embolism
The present invention relates to a method of diagnosing acute pulmonary embolism (PE) in a subject including a) determining the amount of fibrin-fibrinogen degradation products, in particular...
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8440464 |
Method for evaluation or selection of adiponectin secretion regulator
Provided is a method for conveniently and rapidly evaluating or selecting an adiponectin secretion regulator. The method for evaluating or selecting an adiponectin secretion regulator includes the...
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8442776 |
Structure of compstatin-C3 complex and use for rational drug design
The structure of C3c in complex with the complement inhibitor, compstatin, and use of this information for rational design or identification of complement-inhibiting drugs are disclosed.
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8440465 |
Methods and apparatus for fractionation-based chemical analyses
A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios,...
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8440463 |
Predicting renal failure in diabetes patients based on placental growth factor and soluble FLT-1
Disclosed is a method for predicting the risk of developing renal failure or mortality for a subject suffering from diabetes mellitus. More specifically, a method is disclosed for predicting the...
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8431405 |
Hyperglycosylated hCG detection device
The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a...
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8426214 |
System and method for magnetically concentrating and detecting biomarkers
System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a...
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8426207 |
Methods, systems and devices for analyzing a biological fluid sample following ion exchange
Devices, methods and systems effective to evaluate a physical or chemical property of an ion exchange resin-treated biological fluid sample are provided.
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8426220 |
Utilization of shield effect for dopamine detection and reagent development
The present invention relates to fusion proteins of monoamine oxidase B (MAO B)-green fluorescent protein (GFP) and utilizes “shield effect” to detect the dopamine under physiological con...
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8420780 |
Mutated netrin 4, fragments thereof and uses thereof as drugs
Proteins having the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, or fragments of said sequences are provided. The protein fragments are represented by the sequences of SEQ ID NO: 2q, q...
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8420333 |
G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
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8420321 |
Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-Ile347 polymorphism
The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit...
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8415107 |
Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer
The invention relates to thrombospondin fragments found in plasma, their use or use of portions thereof in diagnostic methods, as method calibrators, method indicators, and as immunogens, and as...
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8415163 |
Method of diagnosing renal dysfunction in a cat based on non-cauxin protein levels
Disclosed is a method of diagnosing renal dysfunction in a cat by removing cauxin from cat urine and detecting a protein in the cat urine sample from which cauxin has been removed. Cauxin is...
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8410252 |
ULBP2 polypeptides
The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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8409870 |
Matrix for real-time aerosol mass spectrometry of atmospheric aerosols and real-time aerosol MALDI MS method
The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass...
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8404458 |
Histone modifications as binary switches controlling gene expression
The present invention relates to a method of modulating a chromatin binding protein or complex which binds to a functional group on an amino acid of a histone. This method involves phosphorylating...
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8399260 |
Method for concentration of low-molecular-weight proteins and peptides in body fluid sample
A method for extracting low-molecular-weight proteins/peptides contained in a body fluid sample, particularly, in serum or plasma. The method includes the steps of (a) to (e): (a) adding reagent 1...
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8399383 |
Protein chips for high throughput screening of protein activity
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of...
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8399186 |
Simultaneous detection of metabolic enzyme activity and metabolite levels
Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) a metabolically indicative enzyme and...
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8394640 |
Study of polymer molecules and conformations with a nanopore
The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or...
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8394641 |
Method of hydrolyzing an enzymatic substrate
The invention is directed to droplet actuator devices and assay methods. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate...
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8394639 |
Biomarkers for renal disease
The invention provides methods and kits for diagnosing a renal disease in a patient or for predicting the risk of a patient for developing a renal disease. In one embodiment, the invention provides...
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8389684 |
Tumor biomarker
The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence or metastasis of cancer by detecting plasma Hsp90α having the amino ...
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8384021 |
Method of forming mass image
An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level. The present invention provides a method of...
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8383089 |
Use of IMP3 as a prognostic marker for cancer
Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a...
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8383415 |
Hydrogel composition to enhance fluorescence
A composition comprising a hydrogel particle and a fluorophore; wherein said composition produces an enhanced fluorescent signal when excited by an energy source capable of exciting the fluorophore.
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8383417 |
Assay for monitoring parathyroid hormone (PTH) variants by tandem mass spectrometry
Methods are described for monitoring the amounts of PTH variants in a biological sample by digesting the sample to produce surrogate peptides specific to the targeted PTH variants, and detecting...
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8377701 |
Specific ligands to sortilin
The present invention provides a Sortilin crystal and methods for growing said crystal. The invention furthermore provide methods for design of specific ligands based on the crystal structure of...
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8377699 |
Detection and quantification system of biological, matter constituted by one or more optical sensors and one or more light sources, associated process and related applications
The present invention relates to a system and process for detection and/or qualitative and quantitative identification of the biological material, such as specific sequences of nucleic acids or...
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8377696 |
Highly sensitive method for detecting protein in food
A method for accurate and precise measurement of target proteins such as food allergen proteins in the specific foods is provided. The method is a method for immunological measurement of a food...
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8377702 |
Detection apparatus for biological materials and methods of making and using the same
Method that includes providing plurality of test sites each having first and second layers respectively including inorganic first and second surface sites forming parts of interior of a well, the...
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8377700 |
Systems and methods using photoluminescent nanostructure based hydrogels
Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or...
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8377717 |
Site selectively tagged and templated molecularly imprinted polymers for sensor applications
This invention provides molecularly imprinted polymers (MIPs) for the detection of analytes, methods for forming the MIPs and detecting the analyte using the MIPs. The MIP comprises templated sites...
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8367412 |
Protein crystallizing agent and method of crystallizing protein therewith
The present invention provides a technique for crystallizing a desired protein at a high probability; namely, a protein crystallizing agent and a method of crystallizing protein. The present...
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8368882 |
Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to...
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8361734 |
Xanthurenic acid derivative pharmaceutical compositions and methods related thereto
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt...
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8361800 |
Diagnostic means and methods using troponin T and NT-proBNP
The present invention relates to diagnostic means and methods. Specifically, the present invention encompasses a method of diagnosing the cause of cardiac necrosis in a subject comprising...
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8361806 |
Open channel solid phase extraction systems and methods
The invention provides, inter alia, methods, devices and reagents for the preparation of native and non-denatured biomolecules using solid-phase extraction channels. The invention is particularly...
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8349610 |
Methods, systems and devices for analyzing a surfactant-treated biological fluid sample
Devices, methods and systems effective to evaluate a physical or chemical property of a surfactant-treated biological fluid sample are provided.
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8349617 |
Optical sensor comprising diffraction gratings with functionalized pores and method of detecting analytes using the sensor
Diffraction gratings comprising a substrate with protrusions extending therefrom. In one embodiment, the protrusions are made of a porous material, for example porous silicon with a porosity of...
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8349611 |
Resonant sensors and methods of use thereof for the determination of analytes
Resonant sensors, preferably having floating bilayer symmetry, and their methods of use is determining the presence, amount or binding kinetics of an analyte of interest in a test sample are...
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8343772 |
Specimen processing device, specimen conveyance device, and specimen conveyance method
A specimen processing device comprising: a specimen processing unit for processing specimens; a first conveyance mechanism for conveying specimens from a carry-in side towards a carry-out side on...
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8338185 |
Methods of determining potency of chemically-synthesized oligonucleotides
Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or...
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8323983 |
Mass spectrometric analysis method
Methods of using mass spectrometry and in particular matrix assisted laser desorption-ionization (MALDI) mass spectrometry to analyze, or otherwise detect the presence of or determine the identity...
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8323979 |
Method for the determination of an analyte comprising a primary amino group, and kit for labeling said analyte
The invention provides a method for labeling an analyte comprising a primary amino group, the method comprising: a. a labeling process comprising reacting the analyte with a dialdehyde in the...
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8318498 |
Luminescent protein staining
The present invention relates to the use of cyclometalated iridium complexes for detecting poly(amino acids) including peptides, polypeptides, and proteins. Poly(amino acids) are detected in...
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8318417 |
Simultaneous detection of metabolic enzyme activity and metabolite levels
Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) a metabolically indicative enzyme and...
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8313950 |
Hepcidins as biomarkers for impending lupus nephritis flare
Biomarkers for determining a kidney flare episode in systemic lupus erythematosus are described.
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8313919 |
Diagnostic test for renal injury
A method is provided of diagnosing and monitoring acute renal injury leading to acute renal failure in a human or mammalian subject by determining the ratio of the concentration of neutrophil...
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