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8444932 D-dimer, troponin, and NT-proBNP for pulmonary embolism  
The present invention relates to a method of diagnosing acute pulmonary embolism (PE) in a subject including a) determining the amount of fibrin-fibrinogen degradation products, in particular...
8440464 Method for evaluation or selection of adiponectin secretion regulator  
Provided is a method for conveniently and rapidly evaluating or selecting an adiponectin secretion regulator. The method for evaluating or selecting an adiponectin secretion regulator includes the...
8442776 Structure of compstatin-C3 complex and use for rational drug design  
The structure of C3c in complex with the complement inhibitor, compstatin, and use of this information for rational design or identification of complement-inhibiting drugs are disclosed.
8440465 Methods and apparatus for fractionation-based chemical analyses  
A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios,...
8440463 Predicting renal failure in diabetes patients based on placental growth factor and soluble FLT-1  
Disclosed is a method for predicting the risk of developing renal failure or mortality for a subject suffering from diabetes mellitus. More specifically, a method is disclosed for predicting the...
8431405 Hyperglycosylated hCG detection device  
The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a...
8426214 System and method for magnetically concentrating and detecting biomarkers  
System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a...
8426207 Methods, systems and devices for analyzing a biological fluid sample following ion exchange  
Devices, methods and systems effective to evaluate a physical or chemical property of an ion exchange resin-treated biological fluid sample are provided.
8426220 Utilization of shield effect for dopamine detection and reagent development  
The present invention relates to fusion proteins of monoamine oxidase B (MAO B)-green fluorescent protein (GFP) and utilizes “shield effect” to detect the dopamine under physiological con...
8420780 Mutated netrin 4, fragments thereof and uses thereof as drugs  
Proteins having the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, or fragments of said sequences are provided. The protein fragments are represented by the sequences of SEQ ID NO: 2q, q...
8420333 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8420321 Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-Ile347 polymorphism  
The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit...
8415107 Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer  
The invention relates to thrombospondin fragments found in plasma, their use or use of portions thereof in diagnostic methods, as method calibrators, method indicators, and as immunogens, and as...
8415163 Method of diagnosing renal dysfunction in a cat based on non-cauxin protein levels  
Disclosed is a method of diagnosing renal dysfunction in a cat by removing cauxin from cat urine and detecting a protein in the cat urine sample from which cauxin has been removed. Cauxin is...
8410252 ULBP2 polypeptides  
The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
8409870 Matrix for real-time aerosol mass spectrometry of atmospheric aerosols and real-time aerosol MALDI MS method  
The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass...
8404458 Histone modifications as binary switches controlling gene expression  
The present invention relates to a method of modulating a chromatin binding protein or complex which binds to a functional group on an amino acid of a histone. This method involves phosphorylating...
8399260 Method for concentration of low-molecular-weight proteins and peptides in body fluid sample  
A method for extracting low-molecular-weight proteins/peptides contained in a body fluid sample, particularly, in serum or plasma. The method includes the steps of (a) to (e): (a) adding reagent 1...
8399383 Protein chips for high throughput screening of protein activity  
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of...
8399186 Simultaneous detection of metabolic enzyme activity and metabolite levels  
Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) a metabolically indicative enzyme and...
8394640 Study of polymer molecules and conformations with a nanopore  
The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or...
8394641 Method of hydrolyzing an enzymatic substrate  
The invention is directed to droplet actuator devices and assay methods. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate...
8394639 Biomarkers for renal disease  
The invention provides methods and kits for diagnosing a renal disease in a patient or for predicting the risk of a patient for developing a renal disease. In one embodiment, the invention provides...
8389684 Tumor biomarker  
The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence or metastasis of cancer by detecting plasma Hsp90α having the amino ...
8384021 Method of forming mass image  
An object of the present invention is to provide a method of comprehensively visualizing a constituent in tumor tissue or the like at a cellular level. The present invention provides a method of...
8383089 Use of IMP3 as a prognostic marker for cancer  
Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a...
8383415 Hydrogel composition to enhance fluorescence  
A composition comprising a hydrogel particle and a fluorophore; wherein said composition produces an enhanced fluorescent signal when excited by an energy source capable of exciting the fluorophore.
8383417 Assay for monitoring parathyroid hormone (PTH) variants by tandem mass spectrometry  
Methods are described for monitoring the amounts of PTH variants in a biological sample by digesting the sample to produce surrogate peptides specific to the targeted PTH variants, and detecting...
8377701 Specific ligands to sortilin  
The present invention provides a Sortilin crystal and methods for growing said crystal. The invention furthermore provide methods for design of specific ligands based on the crystal structure of...
8377699 Detection and quantification system of biological, matter constituted by one or more optical sensors and one or more light sources, associated process and related applications  
The present invention relates to a system and process for detection and/or qualitative and quantitative identification of the biological material, such as specific sequences of nucleic acids or...
8377696 Highly sensitive method for detecting protein in food  
A method for accurate and precise measurement of target proteins such as food allergen proteins in the specific foods is provided. The method is a method for immunological measurement of a food...
8377702 Detection apparatus for biological materials and methods of making and using the same  
Method that includes providing plurality of test sites each having first and second layers respectively including inorganic first and second surface sites forming parts of interior of a well, the...
8377700 Systems and methods using photoluminescent nanostructure based hydrogels  
Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or...
8377717 Site selectively tagged and templated molecularly imprinted polymers for sensor applications  
This invention provides molecularly imprinted polymers (MIPs) for the detection of analytes, methods for forming the MIPs and detecting the analyte using the MIPs. The MIP comprises templated sites...
8367412 Protein crystallizing agent and method of crystallizing protein therewith  
The present invention provides a technique for crystallizing a desired protein at a high probability; namely, a protein crystallizing agent and a method of crystallizing protein. The present...
8368882 Systems and methods for detecting a signal and applying thermal energy to a signal transmission element  
A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to...
8361734 Xanthurenic acid derivative pharmaceutical compositions and methods related thereto  
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt...
8361800 Diagnostic means and methods using troponin T and NT-proBNP  
The present invention relates to diagnostic means and methods. Specifically, the present invention encompasses a method of diagnosing the cause of cardiac necrosis in a subject comprising...
8361806 Open channel solid phase extraction systems and methods  
The invention provides, inter alia, methods, devices and reagents for the preparation of native and non-denatured biomolecules using solid-phase extraction channels. The invention is particularly...
8349610 Methods, systems and devices for analyzing a surfactant-treated biological fluid sample  
Devices, methods and systems effective to evaluate a physical or chemical property of a surfactant-treated biological fluid sample are provided.
8349617 Optical sensor comprising diffraction gratings with functionalized pores and method of detecting analytes using the sensor  
Diffraction gratings comprising a substrate with protrusions extending therefrom. In one embodiment, the protrusions are made of a porous material, for example porous silicon with a porosity of...
8349611 Resonant sensors and methods of use thereof for the determination of analytes  
Resonant sensors, preferably having floating bilayer symmetry, and their methods of use is determining the presence, amount or binding kinetics of an analyte of interest in a test sample are...
8343772 Specimen processing device, specimen conveyance device, and specimen conveyance method  
A specimen processing device comprising: a specimen processing unit for processing specimens; a first conveyance mechanism for conveying specimens from a carry-in side towards a carry-out side on...
8338185 Methods of determining potency of chemically-synthesized oligonucleotides  
Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or...
8323983 Mass spectrometric analysis method  
Methods of using mass spectrometry and in particular matrix assisted laser desorption-ionization (MALDI) mass spectrometry to analyze, or otherwise detect the presence of or determine the identity...
8323979 Method for the determination of an analyte comprising a primary amino group, and kit for labeling said analyte  
The invention provides a method for labeling an analyte comprising a primary amino group, the method comprising: a. a labeling process comprising reacting the analyte with a dialdehyde in the...
8318498 Luminescent protein staining  
The present invention relates to the use of cyclometalated iridium complexes for detecting poly(amino acids) including peptides, polypeptides, and proteins. Poly(amino acids) are detected in...
8318417 Simultaneous detection of metabolic enzyme activity and metabolite levels  
Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) a metabolically indicative enzyme and...
8313950 Hepcidins as biomarkers for impending lupus nephritis flare  
Biomarkers for determining a kidney flare episode in systemic lupus erythematosus are described.
8313919 Diagnostic test for renal injury  
A method is provided of diagnosing and monitoring acute renal injury leading to acute renal failure in a human or mammalian subject by determining the ratio of the concentration of neutrophil...