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7622081 |
Integrated active flux microfluidic devices and methods
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
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7618821 |
Simulated blood components and methods
A control and a cellular fraction for use therein and methods for making the same, including a first cellular component including a plurality of a first group of processed animal red blood cells...
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7615380 |
Methods for modulating an immune response by modulating KRC activity
This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation,...
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7615376 |
Masking background fluorescence and luminescence in the optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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7615358 |
Method for determining the concentration of vital epithelial tumor cells in a body fluid
A method for determining the concentration of vital epithelial tumor cells in a body fluid is disclosed. The method comprises obtaining from the body fluid of a test subject a test specimen,...
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7611902 |
Diagnostic method for myopathy
This invention provides a diagnostic method for determining statin induced myopathy. The method is especially applicable for determining warnings, early signs and also symptomatic myopathy. The...
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7611861 |
Method and apparatus for patch-clamp measurements on cells
The invention shows a method for patch-clamp experiments on cells or similar structures, where at least one cell is inserted into the lumen of a capillary and is positioned inside the capillary so,...
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7609369 |
Methods of detection of iron deficiency and hemochromatosis
New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608457 |
Blood collection and testing improvements
Improvements in blood collection and testing. In one aspect, an improved method of manufacturing a blood collection tube, particularly illustrated for use in sedimentation rate testing, including...
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7601540 |
Gamma secretase notch biomarkers
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity...
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7598089 |
Methods and compositions for separating cells
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover rare...
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7598051 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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7598047 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7592181 |
Occult blood testing device
A self-contained system for testing for the presence of occult blood in a specimen has been provided. The system includes a housing holding a test element and a container for releasing a developing...
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7592180 |
Method for evaluating insulin resistance
A method for evaluating insulin resistance in a simple and highly reliable manner is provided. This method includes measuring a fasting insulin value in blood, a fasting blood sugar value, and an...
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7592179 |
Five-part differential white blood cell control and method for preparation of the same
The present invention provides a method for preparing a five-part differential white blood cell control and a white blood cell control prepared thereby. The white blood cell control obtained by the...
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7588942 |
Standard/reference/control for blood coagulation testing
A whole-blood-based substitute composition that is useful in coagulation assays as a standard, reference, control, calibrator, linearity verifier, or training material is prepared by combining a...
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7588905 |
Identification and monitoring of systemic lupus erythematosus
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
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7585640 |
Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
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7585617 |
Method and device for thermal conditioning of a cell
The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and...
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7582483 |
Method of detecting viable cells
A method of detecting and quantifying viable cells in a sample. The method includes fluorescently staining the cells by adding a fluorescent dye into the sample or putting the sample in contact...
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7579823 |
Thin film sensor
An electrically operated, particle detecting, or characterizing, sensor structured as a thin film multilayer sandwich. Three or more electrodes are deposited onto thin layers of film, and stacked...
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7575939 |
Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7575933 |
Modification of selectivity for sensing for nanostructure device arrays
An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are...
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7575927 |
Methods for diagnosing a gastrointestinal disorder in an individual
Methods for measuring at least one mucosally released neuroendocrine gut system component in an individual and methods for diagnosing a gastrointestinal disorder in an individual based on the...
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7575856 |
Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
The present invention describes devices, solutions, and methods for the ex-vivo assessment, resuscitation, triage, and maintenance of human candidate cadaveric hearts.
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7566544 |
Difference detection methods using matched multiple dyes
A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for...
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7565251 |
Systems and methods for evaluating the significance of differences in biological measurements
A method for fluorophore bias removal in microarray experiments in which the fluorophores used in microarray experiment pairs are reversed. Further, a method for calculating the individual errors...
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7563620 |
Cell aggregate correction method
An apparatus for correcting for cell aggregates in a cell suspension from patients. The apparatus includes a laser cytometry scanning mechanism for scanning cells of a sample of a cell suspension...
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7563584 |
Methods and compositions for detecting the activation state of multiple proteins in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7560290 |
Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-Ile347 polymorphism
The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7560243 |
White blood cell functional assay
A method of rapidly assaying nucleotide receptor P2X 7 pore activity in white blood cells contained within a blood sample. A method according to the invention includes the steps of: (a) labeling...
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7560240 |
Method for monitoring gastrointestinal inflammation in persons with inflammatory bowel disease(IBD)
A method for aiding in differentiating irritable bowel syndrome from inflammatory bowel disease by determining the level of total endogenous human lactoferrin in clinical specimens, such as feces,...
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7560070 |
Cantilever sensors and transducers
Sensor system ( 70 ) for detecting a target substance in a reference liquid, comprising a measurement cantilever ( 71 ) being functionalized by application of a first coating to one of the...
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7556777 |
Specimen vial cap handler and slide labeler
A composite modular system for handling biological sample vials and slides comprises a vial scanner configured to read indicia on the sample vials, a slide labeler configured to mark the slides, a...
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7556776 |
Microfluidic manipulation of fluids and reactions
The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including microreactors for manipulating fluids and reactions. In...
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7556769 |
Fecal occult test packaging
A specimen testing device having a folding top having a top inside and a top outside; a back portion having at least one flap opening, the back portion in folding communication with the folding...
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RE40835 |
Enhancement of immunochemical staining in aldehyde-fixed tissue
A method for restoring immunoreactivity of a tissue, particularly decalcified tissue, fixed width an aldehyde fixative agent and embedded in an embedding medium, usually comprising celloidin, the...
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7553674 |
Methods of identifying compounds useful for modulating intraflagellar transport
The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety of...
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7553453 |
Assay implementation in a microfluidic format
An assay implementation in a microfluidic format in a cartridge relating to a point-of-care instrument platform for monitoring and diagnosing infectious diseases (e.g., AIDS and malaria). The...
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7550299 |
Method for predicting onset/risk of atrial fibrillation (AF)
A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a...
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7550298 |
Automated immunohistochemical and in situ hybridization assay formulations
Provided herein are reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for...
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7544514 |
Method and system for determining platelet-mediated clot formation
The present subject matter concerns methods for determining platelet medicated clot formation. Specifically, the subject matter provides a method for determining platelet-medicated clot formation...
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7538861 |
Cytological imaging system and method
The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological...
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7534619 |
Method for determining metabolic type
A method for determining a person's metabolic typing. The method includes the steps of taking a baseline reading to determine a person's blood pH, administering a substance challenge to a person to...
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7531357 |
Preparation of platelet analogs
Erythrocytes from a vertebrate animal other than a human that have been size reduced and treated with a fixing agent by conventional methods to resemble human platelets are further treated to...
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7527978 |
Flow cytometry based micronucleus assays and kits
The invention is a method for analyzing immature reticulocytes for the presence of micronuclei. The method includes reticulocyte enrichment, fluorescent labeling, micronuclei staining, and analysis...
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7527938 |
Methods for diagnosis and treatment of chronic immune diseases
Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to...
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