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8143071 |
Method and device for extracting an analyte
The invention provides columns and methods for the purification and concentration of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample...
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8138167 |
Methods for treating lung cancers
The present invention provided methods for treating lung cancers using therapeutic agents for lung cancers comprising erbB receptor inhibitors as active ingredients. Methods for examining the...
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8105533 |
Apparatus for measuring corrosion loss
The present invention provides a corrosion loss measuring apparatus which enables to quantitatively determine corrosion loss characteristics of ceramic materials and heat-resistant metallic...
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8088912 |
pRNA chimera
A polyvalent multimeric complex formed from a plurality of circularly permuted chimeric pRNA molecules, each carrying a stabilized biologically active moiety.
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8022198 |
siRNA targeting histamine receptor H1
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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8012756 |
Charge perturbation detection system for DNA and other molecules
Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions...
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8014955 |
Method of identifying unique target sequence
Described are methods and systems for designing target-specific oligonucleotides of L-length. The method comprises a) parsing a polynucleotide target into overlapping sequences of N-length...
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7981677 |
Identifying a high oil phenotype in maize by detecting a marker locus genetically linked with a QTL6 region
Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6...
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7955853 |
Method and device for creating and analyzing an at temerature and pressure oxidation-reduction potential signature in hot water systems for preventing corrosion
Disclosed is a method of creating a real-time oxidation-reduction potential signature in a hot water system to detect REDOX stress and inhibit corrosion in the hot water system. The method includes...
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7955848 |
MicroRNA biomarkers for human breast and lung cancer
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
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7951596 |
Nucleic acid nanotube liquid crystals and use for NMR structure determination of membrane proteins
Compositions and methods for preparing nucleic acid nanotubes using DNA origami techniques are described, which provide for nanotubes of predictable and uniform length. The nucleic acid nanotubes...
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7932229 |
Compositions and methods for the control of mammary cell number
The present invention provides new methods and uses of peptides in effecting a reduction in mammary cell number. The discovery that these peptides reduce mammary cell number further enables the use...
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7871820 |
High frequency of neurexin 1β signal peptide structural variants in patients with autism
The three β-neurexins have similar roles in synaptogenesis and interact with the neuroligins. Mutations located within the gene encoding neurexin 1 have been identified as molecular markers ...
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7871763 |
Hepatocellular carcinoma-related genes and polypeptides, and method for detecting hepatocellular carcinomas
Genes up-regulated in hepatocellular carcinomas and polypeptides encoded by these genes are provided. Vectors, transformants and methods for producing the recombinant polypeptides are also...
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7853410 |
Method for making polynucleotides having desired characteristics
In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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7846734 |
Polynucleotides for use as tags and tag complements, manufacture and use thereof
A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described.
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7807465 |
Methods for identifying an individual at increased risk of developing coronary artery disease
The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more...
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7807816 |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
Antisense molecules capable of binding to a selected target site in the dystrophin gene to induce exon skipping are described.
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7790877 |
Antisense oligonucleotides with increased RNase sensitivity
Combinatorial libraries comprise first oligonucleotide analogs and second oligonucleotide analogs which are coupled together to form antisense molecules capable of binding target polynucleotides...
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7780913 |
Paint for detection of corrosion and warning of chemical and radiological attack
A system for warning of corrosion, chemical, or radiological substances. The system comprises painting a surface with a paint or coating that includes an indicator material and monitoring the...
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7776606 |
Processes to create discrete corrosion defects on substrates and establish corrosion NDI test standards
Methods and apparatuses are provided for creation of discrete corrosion defects with a wide range of diameter to depth aspect ratios for painted test standards. Also provided are methods for use of...
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7718628 |
Antisense modulation of kinesin-like 1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7709262 |
Method for detecting and quantifying rare mutations/polymorphisms
The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The...
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7700359 |
Gene products differentially expressed in cancerous cells
The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of...
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7670840 |
Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors
The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic...
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7613574 |
System and method for automating scientific and engineering experimentation for deriving surrogate response data
The present invention provides a system and method for automatically deriving unique surrogate response data from experiment results in which inherent data loss occurs in a sufficient number of the...
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7612195 |
Retroviral vectors for delivery of interfering RNA
Provided herein are retroviral vectors for delivering interfering RNA into cells.
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7608706 |
siRNA targeting ras-related nuclear protein
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7604996 |
Compositions and methods for preparing oligonucleotide solutions
The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in...
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7601538 |
Method for analyzing impurity
This method for analyzing impurity includes: a step of immersing each of sets of two evaluation silicon wafers into a washing solution, thereby contaminating the evaluation silicon wafers to be in...
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7598085 |
Test kit for measuring the level of carboxylate anion in engine coolant
The invention includes, in one embodiment, a method for determining the presence or absence of a corrosion-inhibitory level of carboxylate anion in used engine coolant which includes: obtaining a...
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7588890 |
Device for extracting biological molecules from tissue specimens and methods for preparing the same
The present invention provides a non-destructive macromolecules extraction (NDME) device for extracting high quantity of biological molecules (including, but not limited to, proteins, DNA, and/or...
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7588941 |
Dispersion of carbon nanotubes by nucleic acids
Nucleic acid molecules in a stabilized solution such as single stranded DNA and RNA were able to disperse high concentration of bundled carbon nanotubes into aqueous solution.
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7585677 |
Method of evaluating corrosion resistance of material under ammonium bisulfide environment
It is an object to establish a test method that enables a high-concentration ammonium bisulfide environment to be reproduced at a laboratory level, and enables the corrosivity of a material to be...
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7582747 |
siRNA targeting inner centromere protein antigens (INCENP)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7569392 |
Multiplex spatial profiling of gene expression
The present invention provides mass tag complexes that permit simultaneously obtaining information of a plurality of biological molecules. The biological molecules may be RNA or protein, and the...
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7566569 |
Method for measuring surface temperature
The present invention relates to a method for measuring a surface temperature using is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of...
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7553449 |
Method of determination of corrosion rate
The corrosion rate of a metal immersed in a fluid medium is measured by transmission of a beam of radiation normally in the visible or near infra-red portion of the spectrum, through a thin film of...
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7521249 |
Method and composition for the preparation of a sample for analysis
The present invention relates to the preparation of a sample. Preferably, the sample is a sample to be analyzed, for example for ingredient content, etc. Preferred samples include foods, cosmetics,...
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7498316 |
Methods and compositions for treating gain-of-function disorders using RNA interference
The present invention relates to novel methods for treating dominant gain-of-function diseases. The invention provides methods for targeting regions of the copper zinc superoxide dismutase (SOD1),...
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7459311 |
Method of sequencing DNA
The present invention provides a method of identifying a base at a target position in a sample nucleic acid sequence, said method comprising: subjecting a primer hybridised to said sample nucleic...
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7456022 |
Solid support having ligand immobilized thereon by using photocleavable linker
The present invention provides a method of analyzing the interaction between a ligand and a target molecule, which uses a solid support wherein the ligand is immobilized via a linker cleavable by...
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7371833 |
Nucleic acid molecules with specific recognition of native PrPSc, production and use
The invention relates to a method for isolating nucleic acid molecules which are capable of specific interaction with native PrPSc and can differentiate between native PrPc and native PrPSc. The...
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7364904 |
Methods and composition for diagnosing and treating Pseudoxanthoma elasticum and related conditions
Methods and compositions are provided for diagnosing and treating Pseudoxanthoma elasticum (PXE) patients and PXE carriers. Methods and compositions are based on the discovery that PXE mutations...
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7343249 |
Vectorization of sequence alignment computation using distance matrix reshaping
A method for comparing data sequences includes accepting first and second data sequences of data elements. A distance matrix is computed. The matrix includes rows and columns of matrix elements,...
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7253435 |
Particles with light-polarizing codes
Systems using coded particles for multiplexed analysis of biological samples or reagents, in which the codes on the particles are at least partially defined by light-polarizing materials.
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7246516 |
Device for coupling thermogravimetric analyses and acoustic emission measurements
The present invention relates to a device comprising a thermobalance equipped with a detector (5) for measuring acoustic signals emitted by a sample (6) hanging from the balance beam and a...
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7244500 |
Smart coating system
An active coating system capable of collecting, analyzing, managing and adapting to data and/or its environment in real time. An exemplary embodiment of our inventive active coating system is...
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7238795 |
Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds,...
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7238530 |
Isolation and amplification of nucleic acid materials
The invention relates to methods for easily separating single stranded nucleic acid material from double stranded nucleic acid material in a sample containing both. By the right choice of at lease...
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