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7622303 |
Methods for identifying patients at risk for life threatening arrhythmias
In general, the invention is directed to systems and techniques for assessing a risk of ventricular tachyarrhythmia in a patient by measuring one or more biochemical markers that reflect the health...
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7618792 |
Multiplexed detection of anti-red cell alloantibodies
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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7615376 |
Masking background fluorescence and luminescence in the optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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7611909 |
Near infrared chemiluminescent acridinium compounds and uses thereof
A method for the detection or quantitation of unlabeled target analyte in a biological sample, the method comprising labeling a target analyte for a biological sample suspected of containing...
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7591953 |
Methods and apparatus for continuous large-scale radiolabeling of proteins
Disclosed are improved methods and apparatus for radiolabeling, particularly methods and apparatus for large scale in-line radiolabeling of products, such as proteins and antibodies.
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7588943 |
Method for quantitative monitoring of a gas injected in a reservoir in particular in a natural environment
A method for quantitative monitoring of a gas injected into a reservoir and likely to react chemically with the injection medium includes injecting into a reservoir a mixture of the potentially...
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7572642 |
Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a...
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7569390 |
Selection of intracellular immunoglobulins
A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This...
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7566549 |
Immunoassay for LSD and 2-oxo-3-hydroxy-LSD
The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the...
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7560243 |
White blood cell functional assay
A method of rapidly assaying nucleotide receptor P2X 7 pore activity in white blood cells contained within a blood sample. A method according to the invention includes the steps of: (a) labeling...
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7553673 |
Quality control of a functional fluid
The present invention describes use of use of a metal compound to control the quality of a functional fluid. Additionally, the present invention concerns a method for controlling the quality of a...
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7531134 |
Method and apparatus for automated analysis and characterization of chemical constituents of process solutions
A method of directed automated analysis of a plurality of analytes of a process solution includes providing a sample of the process solution containing a plurality of the analytes, admixing an...
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7517701 |
Luminescent lanthanide complexes
Systems, including compositions, kits, and methods, particularly for photoluminescence applications. The systems may include, among others, (1) organic chelators, (2) complexes between the...
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7507582 |
Method and device for multicolour 2-photon fluorescence coincidence analysis
A method of fluorescence measurement on analytes, marked with different fluorescent markers, which have spectrally different fluorescence emissions, in a sample is described, having the following...
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7494820 |
Electrochemiluminescence of rare earth metal chelates
Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are...
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7491502 |
In vivo flow cytometry system and method
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe...
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7452727 |
Method for increasing clinical specificity when detecting tumors and their precursor stages by simultaneously measuring at least two different molecular markers
The present invention relates to an automatable method for the improved diagnosis of pathologically altered cells by simultaneously staining at least two different molecular markers, which exhibit...
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7427506 |
High throughput property testing of olefin copolymers using rheological determinations
A high throughput method to determine an amount of a comonomer in a copolymer sample of a copolymer system comprises the steps of providing a plurality of copolymer samples; creating an array of...
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7423131 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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7413868 |
Use of particulate labels in bioanalyte detection methods
New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular...
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7410805 |
Aerosol detection system using optical and mass discrimination
A system to detect and identify various aerosol agents, such as biological agents which have been aerosolized, is disclosed. The system generally includes a mechanism to collect a selected sample...
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7402800 |
Method and device for the continuous determination of damage to systems used for the post-treatment of heat engine exhaust gases
The invention relates to a method for the continuous determination of the damage to at least one system ( 7 ) used for the post-treatment of exhaust gases from an internal combustion engine ( 2 ),...
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7393656 |
Methods and compositions for risk stratification
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of...
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7391040 |
Thermal image beacons
A heat emitting beacon having a rotating parabolic mirror to concentrate the heat from a gas heat source, said mirror back being coated with a passive cold emission material comprised of a...
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7390666 |
Methods and devices for measuring total polar compounds in degrading oils
This invention relates to methods for determining whether or not to discard a sample of oil based on the presence of polar compounds in the oil and devices to be used therewith. In a preferred...
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7389706 |
Method to detect and characterize contaminants in pipes and ducts with interactive tracers
A method and an apparatus for detecting, locating, and quantifying contamination in a fluid flow system like a pipe or duct. This characterization technique uses a conservative and one or more...
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7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7371829 |
Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites
The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as,...
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7364908 |
Separation of fluorous compounds
A method of separating at least a first non-fluorous compound from a mixture of compounds including at least the first non-fluorous compound and a second fluorous compound includes: charging the of...
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7364089 |
Apparatus for electronically determining whether a tax for a product has been paid
An apparatus for electronically determining whether a tax or duty has been paid for the contents of that container. A radio frequency identification (RFID) tag is placed on the container which...
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7344895 |
Production and use of in situ-modified nanoparticles
A process for synthesizing nanoparticles, in particular metal salt nanoparticles. To the synthesis mixture is added a modifying reagent which binds, by means of a first functional group, to the...
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7338805 |
Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
The present invention relates to a temperature-stable labeling reagent of formula:
in which
R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable...
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7332344 |
Luminescence assays
A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor...
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7332295 |
Multidimensional leukocyte differential analysis
This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells,...
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7331248 |
Method and apparatus for detecting and locating explosives, biological, and chemical substances in ducts and structures using tracers
A method and an apparatus for detecting, locating, and quantifying explosive materials and devices, and naturally occurring and man-made dangerous or hazardous biological and chemical materials and...
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7323341 |
Stable isotopic identification and method for identifying products by isotopic concentration
A stable isotopic identification comprising a mathematical array of concentrations of isotopes found in a product, said mathematical array being presented in a machine readable form and comparable...
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7309608 |
Method of analysis of aldehyde and ketone by mass spectrometry
A method of identification and quantitative analysis of aldehydes and/or ketones in a sample by mass spectrometry using stable isotope labeled oxime internal standards or stable isotope labeled...
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7291836 |
Method and device for continuous determination of lubricating oil consumption of an internal combustion engine
The invention relates to a method and device for the continuous determination of the lubricating oil consumption of an internal combustion engine. The inventive method consists in: placing a...
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7282370 |
System and apparatus for sequential processing of analytes
An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte...
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7282339 |
Competitive immunoassay
The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding...
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7279340 |
Synthesis and application of procainamide analogs for use in an immunoassay
The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the...
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7279338 |
Methods for determining cellular response to stimuli
The present invention provides a method for determining cellular response to stimuli. The cells to be tested, for example, may be contained in a section of taste-bud containing lingual epithelium.
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7256047 |
Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjunction with nuclear magnetic resonance spectroscopy, provide a...
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7247274 |
Prevention of precipitate blockage in microfluidic channels
The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular the devices and methods...
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7241580 |
Immunoaffinity chromatography using epitope tags to polyol-responsive monoclonal antibodies
Disclosed is a method of isolating, purifying, or concentrating a target compound. The method includes the steps of onjugating the target compound to an epitope for a polyol-responsive monoclonal...
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7241381 |
Method and apparatus for detecting chemical binding
The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit...
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7235370 |
Site-specific aminoglycoside derivatives for use in immunodiagnostic assays
A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group...
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7232659 |
Multiplex analysis for high throughput discrimination of GPCR agonists and antagonists
The present invention relates generally to molecular assemblies, more particularly to an assay for the detection of G-protein coupled receptor (GPCR) molecular assemblies and bead-based detection...
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7230088 |
Compounds for dual photodiagnosis and therapy
The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates...
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7229842 |
Metal chelate containing compositions for use in chemiluminescent assays
Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a...
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