|
Match
|
Document |
Document Title |
|
|
8143385 |
Nucleic acids coding for antibodies against human IL-21 receptor and uses therefor
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The antibodies can act as antagonists...
|
|
|
8137991 |
Methods of reducing angiogenesis of age-related macular degeneration (AMD) or choroidal neovascularization by an anti-carboxyetheylpyrrole (CFP) antibody
The present invention pertains to methods of inhibiting angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits one or more CEP protein...
|
|
|
8133744 |
Production of antibodies and to medical uses involving antibodies
A method of making antibodies to a selected part P of an immunoglobulin molecule ZP, Z comprising the non-selected part of ZP, P being the selected part of ZP which comprises a hidden epitope of...
|
|
|
8110663 |
Monoclonal antibodies for cartillage oligomeric matrix protein
The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic...
|
|
|
8067247 |
Use of anti-CD100 antibodies for the treatment of inflammatory disorders affecting the central or peripheral nervous system
The invention relates to the use a BD16 and/or BB18 anti-CD100 antibody or of a chimeric or humanized or human form thereof, or a fragment thereof, for the therapy or diagnosis of a central nervous...
|
|
|
8062881 |
Method for making a polymer blend for reducing protein binding to surfaces
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having...
|
|
|
8034338 |
Immunogenic recombinant antibody
The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian...
|
|
|
7989219 |
Bispecific capturing molecule
A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the...
|
|
|
7977104 |
Methods for predicting pregnancy outcome in a subject by hCG assay
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
|
|
|
7939282 |
Methods for detecting sepsis
Compositions and methods for detecting sepsis by contacting a subject-derived sample with a ligand that binds to GRK and determining the concentration of GRK in the sample. An increase in the...
|
|
|
7939344 |
Use of particulate labels in bioanalyte detection methods
New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular...
|
|
|
7919257 |
Method for selecting a single cell expressing a heterogeneous combination of antibodies
The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being...
|
|
|
7919255 |
Assessment of skeletal growth using measurements of NT-CNP peptides
A means of measuring and monitoring skeletal growth rate using a plasma analyte, amino-terminal C-type natriuretic peptide (NT-CNP). Plasma NT-CNP concentrations reflect the potential for further...
|
|
|
7906297 |
Reagents for the detection of phosphorylated ATR kinase (Ser 428) and uses thereof
The invention discloses two novel phosphorylation sites in human ATR kinase, serine 428 (Ser428) and serine 2317 (Ser2317) respectively, and provides reagents, including antibodies and AQUA...
|
|
|
7893220 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in ...
|
|
|
7875465 |
Target substance capturing molecule
A capturing molecule having not less than two domains specifically binding to different sites of a target substance, wherein the not less than two domains comprise (1) a first domain having a...
|
|
|
7858751 |
Peptide fragment of LYVE-1 and antibody against the same
It is intended to provide a specific peptide fragment of LYVE-1 which can serve as an epitope of a lymphatic vessel-specific antibody, and an antibody recognizing the above peptide fragment. A...
|
|
|
7858757 |
Monoclonal antibodies with specificity for fetal erythroid cells
The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a...
|
|
|
7838245 |
Use of precursors of tachykinins and/or their fragments in medical diagnostic
The present invention relates to the use of protachykinin and/or fragments thereof that can be isolated from body fluids, tissues or other bioiological samples and therefore, serves as a marker...
|
|
|
7833731 |
Gold-binding protein and use thereof
A protein utilizing an anti-gold antibody and a gold-binding side which is a part of the anti-gold antibody is constructed. This protein is capable of specifically binding to gold. This protein or...
|
|
|
7811832 |
Methods for preserving the viability of photoreceptor cells by anti-FAS-ligand/anti-FAS-receptor antibodies
Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an...
|
|
|
7790861 |
Prostate cancer-related compositions, methods, and kits based on DNA macroarray proteomics platforms
The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including,...
|
|
|
7776572 |
Method for reducing loss of enzyme activity during storage
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having...
|
|
|
7759466 |
Monoclonal antibodies to alpha-amylase
Monoclonal antibody that specifically binds to alpha-amylase and is useful for detecting weather damage (i.e. pre-harvest sprouting) in cereal grain.
|
|
|
7749772 |
Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol
Antibodies having specific binding for the parent THC (Δ9-THC) and its major metabolites are provided which present a significant increase in sensitivity of immunoassays such as lateral flow ...
|
|
|
7745230 |
Estrogen receptors and methods of use
The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-α36 activity. The invention further ...
|
|
|
7741443 |
Binding molecules for the treatment of myeloid cell malignancies
The present invention provides a human C-type lectin, binding molecules that specifically bind to the human C-type lectin, nucleic acid molecules encoding the binding molecules or the human C-type...
|
|
|
7732156 |
Sandwich immunoassay and monoclonal antibodies for COMP, Cartillage Oligomeric Matrix Protein
The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic...
|
|
|
7700299 |
Method for predicting the response to a treatment
The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers...
|
|
|
7670855 |
Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia
The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In...
|
|
|
7662642 |
Method for detection of specific antibodies using ubiquitin fusion proteins
Disclosed are epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising...
|
|
|
7662928 |
Anti-FcRn antibodies for treatment of auto/allo immune conditions
Antibodies to heavy chain of human FcRn are provided which function as non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or...
|
|
|
7615383 |
Methods for treating neuropathy by agonist anti-trk-C monoclonal antibodies
The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such...
|
|
|
7601506 |
Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies
The invention provides a simple method for diagnosing a non-symptomatic or symptomatic human or animal with transmissible spongiform encephalopathy.
|
|
|
7598351 |
Antibody and use thereof
The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2...
|
|
|
7579157 |
Antibody selection method against IGF-IR
Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing the antibodies, and uses for the antibodies are disclosed....
|
|
|
7575873 |
Reagents for diagnosing, imaging and treating atherosclerotic disease
The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL...
|
|
|
7527939 |
Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP
A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are...
|
|
|
7511123 |
Immuno-interactive fragments of the alpha-C subunit of inhibin
Novels immuno-interactive fragments of the (alpha)C portion of a mammalian inhibin alpha subunit are disclosed, together with their variants and derivatives for producing antigen-binding molecules...
|
|
|
7511142 |
Mediator-modified redox biomolecules for use in electrochemical determination of analyte
Compositions and methods for electrochemical detection of an analyte comprising a transition metal compound wherein M is a metallic element that can form a coordinate bond to nitrogen; R and R′ a...
|
|
|
7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
|
|
|
7485438 |
Method of producing polyvalent antigens
Embodiments of the invention generally provide methods and compositions for producing polyvalent antigens. In one aspect, the invention provides a method for producing a cross-linked antigen. In...
|
|
|
7476551 |
Diagnosing atherosclerosis risk by measuring carbamylated low density lipoprotein levels
The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of: measuring the level of carbamylated LDL in a sample obtained...
|
|
|
7473564 |
Kit and method for detecting the ESM-1 protein
The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising: a) a first antibody specifically binding to the N-terminal region of protein ESM-1 contained between the...
|
|
|
7452676 |
Monoclonal antibodies to RNA binding protein GW182
The present invention includes antibodies to human GW182 protein and the use of those antibodies in clinical and diagnostic assays.
|
|
|
7442516 |
Antibody specific to central nervous system tau protein
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable...
|
|
|
7439025 |
Antibodies binding a gamma carboxyglutamic acid displaying epitope
Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while ...
|
|
|
7410771 |
Reagent and method for detecting a Cryptosporidium parvum sporozoite antigen
A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay in...
|
|
|
7410768 |
Test methods and devices
A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses a pair of...
|
|
|
7399636 |
Diagnostic kit for predicting pregnancy outcome
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
|