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7618792 |
Multiplexed detection of anti-red cell alloantibodies
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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7611909 |
Near infrared chemiluminescent acridinium compounds and uses thereof
A method for the detection or quantitation of unlabeled target analyte in a biological sample, the method comprising labeling a target analyte for a biological sample suspected of containing...
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7604952 |
Detection and determination of the stages of coronary artery disease
A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing...
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7604946 |
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in...
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7598093 |
Nanoparticle and microparticle based detection of cellular products
Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic...
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7597960 |
Functional infrared fluorescent particle
An infrared fluorescent particle comprising a functional group or a substance that is capable of binding to an analyte, wherein fluorescence at infrared wavelength is emitted from the particle upon...
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7595202 |
Analysis method using reporter (label) intermolecular interaction
The present invention provides a method for controlling the spatial arrangement of an energy donor and an energy acceptor in a reaction complex in order to carry out the measurement with good...
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7588905 |
Identification and monitoring of systemic lupus erythematosus
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
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7585640 |
Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
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7566549 |
Immunoassay for LSD and 2-oxo-3-hydroxy-LSD
The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the...
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7563584 |
Methods and compositions for detecting the activation state of multiple proteins in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7560287 |
Long wavelength engineered fluorescent proteins
Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7556967 |
Foldable polymers as probes
Disclosed herein are novel probes, which can be used to detect and identify target molecules of interest in a sample. The disclosed probes can be used to monitor conformational changes induced by...
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7547506 |
Peptide-based fluorescence polarization assay for detection of antibodies to Mycobacterium bovis
The present invention provides an assay for detection of M. bovis -infected animals. A tracer, comprising a peptide of M. bovis protein MPB70 conjugated to a fluorophore, is added to a serum...
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7517701 |
Luminescent lanthanide complexes
Systems, including compositions, kits, and methods, particularly for photoluminescence applications. The systems may include, among others, (1) organic chelators, (2) complexes between the...
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7507588 |
Multiplex microparticle system
Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein...
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7494820 |
Electrochemiluminescence of rare earth metal chelates
Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are...
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7491502 |
In vivo flow cytometry system and method
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe...
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7470379 |
Inorganic particle conjugates
The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.
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7455985 |
Detection and quantification of intracellular pathogens
The present invention provides methods and compositions for detecting bacteria of the Chlamydiaceae family in a biological sample. Methods include, for example, contacting a biological sample with...
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7442558 |
Phthalamide-lanthanide complexes for use as luminescent markers
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also...
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7435603 |
Labeling proteins with dyes that are insoluble or only sparingly soluble in water
The proteins in a biological sample that is sought to be analyzed for its protein composition by an electrophoretic or chromatographic procedure are coupled to a dye in an unusually efficient...
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7432105 |
Self-calibration system for a magnetic binding assay
A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay...
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7422908 |
Chemiluminescent 1,2-dioxetanes
A method of generating light through chemiluminescence involves providing a stable 1,2-dioxetane of the formula:
Wherein (a) R 1 and R 2 are each, individually, a chemical reactive site or...
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7404912 |
Salicylamide-lanthanide complexes for use as luminescent markers
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also...
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7402677 |
Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives
A TBET cassette including at least one xanthine- or pyronin-based compound as a donor or acceptor is disclosed. Also, a method of TBET cassette design in which four criteria may be used is...
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7402398 |
Measuring receptor homodimerization
The invention provides methods and kits for detecting and/or measuring receptor homodimers on a cell surface membrane. In one aspect, the methods employ pairs of probes comprising binding compounds...
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7402397 |
Detecting and profiling molecular complexes
Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first...
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7393656 |
Methods and compositions for risk stratification
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of...
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7390670 |
Signalling compounds and methods for detecting hydrogen peroxide
Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula:
is reacted with peroxide. Sig is a non-polymeric organic...
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7390631 |
Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma
Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d...
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7387880 |
Method for monitoring resting and activated platelets in unfixed blood samples
The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the...
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7381572 |
Reagents and procedures for multi-label high-specificity labeling
A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material;...
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7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7376256 |
Method for analyzing chemical and or biological samples by means of particle images
A method for analyzing chemical and/or biological samples comprises the production of a particle image ( 42 ) of at least one particle included in the sample. Subsequently, a particle surface ( 10...
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7371829 |
Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites
The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as,...
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7371524 |
Substituted azaporphyrins as fluorescence labels
The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According...
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7368296 |
Solid phases optimized for chemiluminescent detection
Solid supports for chemiluminescent assays are provided. The solid support includes a plurality of probes covalently or physically attached to the support surface and a chemiluminescent enhancing...
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7358052 |
Catalytic amplification of multiplexed assay signals
Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a...
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7354773 |
Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry
A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such...
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7348157 |
Immunoassay
A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two...
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7338805 |
Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
The present invention relates to a temperature-stable labeling reagent of formula:
in which
R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable...
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7335515 |
(1→3)-β-D-glucan binding domain protein, measuring method using the substance and assay kit
A (1→3)-β-D-glucan binding protein, a fluorescence-labeled (1→3)-β-D-glucan binding domain protein, a (1→3)-β-D-glucan measuring agent comprising the same, a method for measuring...
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7332567 |
Fret protease assays for clostridial toxins
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus...
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7332356 |
Fluorescent dye binding peptides
The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving...
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations....
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7332354 |
Compounds for chemiluminescense procedures
The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and...
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7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
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7319041 |
Applications of acridinium compounds and derivatives in homogeneous assays
Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent...
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