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7591953 |
Methods and apparatus for continuous large-scale radiolabeling of proteins
Disclosed are improved methods and apparatus for radiolabeling, particularly methods and apparatus for large scale in-line radiolabeling of products, such as proteins and antibodies.
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7357915 |
Method of imaging cell death in vivo
A method of imaging apoptosis in vivo, using radiolabeled annexin, is described.
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7342091 |
Soluble cyclic analogues of β amyloid peptide
The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations....
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7291714 |
Glycoprotein VI and uses thereof
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The...
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7291476 |
O-acetyltranferases
A post-translational modification of a predetermined protein expressed by a cell is detected by specifically detecting an O-acetylation of a serine, threonine or tyrosine residue of the protein as...
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7235370 |
Site-specific aminoglycoside derivatives for use in immunodiagnostic assays
A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group...
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7229782 |
Antibodies specific to multiple beta blockers and methods for their use
The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies.
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7205162 |
Artificial antibodies, method of producing the same and use thereof
Artificial antibodies or antibody mimics are described. They consist of polymers that carry specific binding sites mimicking the properties of antibodies. There is also described a method for...
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7195882 |
Monoclonal antibodies specific for buprenorphine and metabolites thereof
The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine...
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7186518 |
Method and composition useful for determining FK 506
New derivatives of FK 506 are disclosed. These new derivatives and other derivatives that are useful for determining the levels of FK 506 in a sample are also provided as are assay procedures and...
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7169907 |
Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies...
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7132513 |
Bifunctional chelating agent
The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO 2 , —NH 2 , —NCS, —NHCOCH 2 -Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH 2 -Q, or...
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7132269 |
Coupling agents, the active intermediates and the conjugates thereof and the use of said conjugates in diagnostic methods
The present invention concerns coupling agents having the following general formula:
activated intermediates consisting of a coupling agent such as defined above with either a molecule having...
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7115718 |
Haptens, immunogens, antibodies and conjugates to 2-oxo-3-hydroxy-LSD
The invention provides a hapten derivatized with a crosslinker at the nitrogen of the 8β-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned...
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7109310 |
Method and kit for detecting, or determining the quantity of, metabolites of fentanyl and metabolites of fentanyl analogs
The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as...
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7108985 |
Methods and kits useful for the simplification of complex peptide mixtures
Methods and reagents for obtaining simplified mixtures of peptides from a sample containing a number of peptides are disclosed. The simplified sample can be easier to analyze than the original...
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7101980 |
Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes
Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies...
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7101719 |
Support and method for cell based assays
Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The...
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7101549 |
Glycoprotein VI and uses thereof
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The...
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7078495 |
Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus
An IgG 1 λ monoclonal antibody to the immunosuppressive drug tacrolimus has improved properties. In particular, this monoclonal antibody, designated 1H6, has reduced cross-reactivity to several...
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
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7052915 |
Selective labeling and isolation of phosphopeptides and applications to proteome analysis
A method for selective labeling of phosphate groups in natural and synthetic oligomers and polymers in the presence of chemically related groups such as carboxylic acid groups. The method is...
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7045606 |
Bifunctional chelating agent for actinium
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z,...
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7045310 |
Redox reversible bipyridyl-osmium complex conjugates
Novel bipyridyl-osmium complex conjugates and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials...
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7045309 |
9-substituted adenine derivatives as prodrug regulators of cell and tissue function
The present invention relates to 9-substituted adenine derivatives represented by formula (I)
wherein W is selected from the group consisting of H, halogen, azido and amino group; X is...
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6964872 |
Immunoassay method
When insoluble magnetic carrier particles are used in immunoassay, a method is provided which is suitable for saving labor and for treating a large number of samples within a short time while...
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6946547 |
Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class...
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6921669 |
Linker system for activating surfaces for bioconjugation
The present invention relates to a linker system for activating surfaces for bioconjugation, and particularly to a linker system having a novel hydrophilic spacer group. The inventive linker system...
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6913936 |
Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances
A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of...
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6905886 |
Preservative solutions
This invention relates to preservative solutions for peptides, for example, parathyroid hormone, insulin-like growth factor binding protein 3 (IGFBP3), adrenocorticotropic hormone (ACTH) and...
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6878811 |
Substance with antithrombotic activity and method for detecting glycokallidin
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a...
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6844166 |
Recombinant reduced valency carbohydrate binding ligands
The invention is based on the discovery of reduced valency carbohydrate binding ligands (CBLs) that can be used to to detect or quantitate (i.e., evaluate) carbohydrates in a sample. CBLs can be...
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6844162 |
Assays for TSH receptor autoantibodies
A method and kit for monitoring autoantibodies to thyroid stimulating hormone (TSH) receptor in a sample of body fluid, which employs the steps of:
(i) incubating TSH receptor with a sample...
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6787325 |
Complexes containing crosslinked avidin, analytical method with the use of crosslinked avidin and analytical reagents and kits
Provided are novel complexes containing a crosslinked avidin, an analyzing method and analyzing reagents and kits whereby a compound to be analyzed can be quickly, conveniently and accurately...
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6773928 |
Compositions and methods for enhancing bioassay performance
Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of...
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6756233 |
Method for measuring free ligands in biological fluids, and assay kits for measuring same
A method for measuring free ligands in biological fluids in the presence of bound ligand and endogenous binding proteins, without disturbing the equilibrium between the free ligand and the...
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6743591 |
Method for counting leukocytes and leukocyte counter
A method for counting leukocytes which comprises liberating elastase from granulocytes contained in a specimen, adding an anti-granulocyte elastase antibody to the thus liberated elastase,...
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6720192 |
Screening for analytes using labeled receptors
A method for assaying an analyte in a sample. The method comprising the steps of a) contacting the sample with material comprising a receptor which is present in a liposome and which liposome...
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6706490 |
Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen
A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the...
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6689568 |
Capture arrays using polypeptide capture agents
A method of evaluating for the presence of a polypeptide in an analyte, using an addressable array of capture agents linked to a substrate. The analyte is exposed to the array and a set of fixed...
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6686209 |
Reagents for detecting cannabinoids
In this disclosure, novel caanabinol-based tracers suitable for use in immunoassays that detect cannabinoids in a biological sample are disclosed. These cannabinol-based tracers are particularly...
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6664071 |
Photodetector and the use of the same
A device for the detection of electromagnetic radiation, wherein the device has (i) a photoactive layer of a semiconductor having a band gap of greater than 2.5 eV, (ii) a dye applied to the...
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6653153 |
Methods for encoding combinatorial libraries
A combinatorial library comprises a plurality of ligand-bearing support units, where the ligand-bearing support units comprise (a) a solid carrier, (b) one or more ligands covalently bound to the...
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6653066 |
Device and method for detecting polyvalent substances
Disclosed is a device and method of use for detecting polyvalent analytes such as antibody to the AIDS virus, utilizing an inverse sandwich method. The test device comprises a first substance...
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6649418 |
Internally referenced competitive assays
The present invention provides internally calibrated competitive assays for use on a solid support. Additionally, the invention provides a method of using such assays.
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6645733 |
Fluorescent intensity method for assaying binding between proteins or peptides
A method for assaying specific binding between a fluorophore-labeled probe and an unlabeled target is provided. The method includes detecting a quenching effect on fluorescence emitted by the...
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6548645 |
Immunoassay for 2-oxo-3-hydroxy LSD
To improve the detection of LSD, and LSD metabolites in biological samples, antibodies are raised to 2-oxo-3-hydroxy-LSD conjugated to a protein carrier. Selected antibodies are matched with an...
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6534325 |
Immunoassay for the detection of amphetamines, methamphetamines and methylenedioxy designer amphetamines
The present invention provides an immunoassay method for the highly sensitive detection of amphetamines, methamphetamines, and methylenedioxy designer amphetamines in urine samples. Commercially...
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6534276 |
Methods for detecting human tissue factor inhibitor
Molecules, such as antibodies, with binding specificity for Tissue factor Inhibitor (TFI) or for polypeptides comprising one or more Kunitz domains of TFI can be used in methods to detect TFI or...
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