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7632686 |
High sensitivity quantitation of peptides by mass spectrometry
The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent...
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7569398 |
Methods and devices for transporting and concentrating an analyte present in a sample
The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these...
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7524641 |
Method of separating cells from a sample
Rare cells are separated from a sample fluid by a positive selection or negative selection antibody by centrifuging in a tube containing a harvesting float. The harvesting float has an axial...
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7517699 |
Positive detection lateral-flow apparatus and method for small and large analytes
Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the...
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7488606 |
Collection device for lateral flow chromatography
A device for collecting oral liquids includes a lateral flow chromatography strip having a collection member. The collection member is separated from the remainder of the chromatography strip by a...
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7473563 |
Environmental sampling and testing device
Provided is sampling and testing device for the detection of specific molds, allergens, viruses, bacteria, fungi, and other protein containing substances. Embodiments of the device include a...
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7452731 |
Assay
A method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin metabolism, comprising (a) determining the level of...
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7449329 |
Blood test kit
A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to...
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7445941 |
Diagnostic devices and apparatus for the controlled movement of reagents without membranes
The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of...
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7374936 |
Method and means for site directed therapy
The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates...
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7361480 |
Method and means for detecting gluten-induced diseases
The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies...
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7354776 |
Method of processing and testing powdered samples using immunochromatographic strip tests
A method and kit for processing and testing powdered samples are provided herein. The powdered sample is combined with a fluid to produce a slurry or liquid suspension, and the slurry is contacted...
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7348185 |
Method and apparatus for capturing target substance
A method for capturing a target substance in a sample, comprising the steps of preparing particles capable of capturing the target substance in a dispersed state in a fluid, aggregating the...
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7312028 |
Highly cost-effective analytical device for performing immunoassays with ultra high sensitivity
A simple easy to manufacture analytical device capable of performing membrane based immunoassays on batch of samples within 3 to 10 minutes wherein the method permits focused application of...
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7250308 |
Capture assay utilising a particulate analyte
Device ( 1 ) for assaying a particulate analyte, comprising (a) a receptacle ( 2 ) for receiving a suspension ( 5 ) of particulate analyte, and containing label ( 3 ) for the particulate analyte,...
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7241626 |
Isolation and confirmation of analytes from test devices
Methods, articles, and kits for obtaining elevated concentrations of a substance from a sample that has become bound, for example by providing a positive test result in an immunoassay or other...
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7241628 |
Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a...
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7232690 |
Method and device for detecting and isolating pharmacological compounds being contained in substance mixtures
A process for isolating and/or identifying at least one active chemical substance from a mixture of active and inactive chemical substances, is characterized by the steps:
a) adding a target...
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7192784 |
Method of measurement in chromatography
A substantial amount of a marker reagent associated with a measurement is measured in a marker reagent measurement area, and the substantial amount of the marker reagent is reflected by a result...
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7176036 |
Electroactive microspheres and methods
Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair...
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7169618 |
Magnetic particles and methods of producing coated magnetic particles
An improved method for separating materials is provided, using colloidal, magnetizable aggregates, optionally silanized, and coated with a one or more layers of novel polysaccharide derivatives....
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7087389 |
Highly cost-effective analytical device for performing immunoassays with ultra high sensitivity
A simple easy to manufacture analytical device capable of performing membrane based immunoassays on batch of samples within 3 to 10 minutes wherein the method permits focused application of...
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7071005 |
Method and device for concentrating selected groups of microorganisms
A method and device are described to concentrate target organisms from a mixture of organisms. Beads ( 1 ) made of material such as nylon, polystyrene or glass are coated with antibodies of...
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
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7060505 |
Assay device
An assay device and method are provided which allow the determination of the presence or absence of at least one analyte in a test sample, while providing specific identification of the test...
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7045342 |
Diagnostic detection device and method
The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a...
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6998246 |
Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a...
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6969616 |
Enterotoxin adsorbent, method of adsorptive removal, and adsorption apparatus
The present invention is directed to an enterotoxin adsorbent comprising a compound having a log P (P denotes a partition coefficient in an octanol-water system) value of not less than 2.50 as...
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6927068 |
Rapid and non-invasive method to evaluate immunization status of a patient
An assay method and kit for detecting the presence of a predesignated, target IgG antibody in a sample selected from one or more patient bodily fluids. The method comprises the following steps: (a)...
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6858439 |
Compositions and methods for separation of moieties on chips
The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable,...
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RE38688 |
Sheet-like diagnostic device
A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is...
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6841393 |
Selective removal of contaminants from a surface using colored particles and articles having magnets
A system and method for removing contaminants from a surface. The system is designed to use very small particles having means thereon which are capable of selectively binding to a contaminant or...
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6818456 |
Color contrast system for lateral flow immunoassay tests
A lateral flow immunoassay device includes a membrane strip for enabling capillary migration of a sample therealong with a labeled reagent disposed on the membrane. The label reagent is formulated...
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6811969 |
Retentate chromatography—profiling with biospecific interaction adsorbents
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6770488 |
Practical method and apparatus for analyte detection with colloidal particles
A colloidal system for detection of a variety of analytes involves techniques which permit reconstitution of a desiccated substance such as for surface enhanced Raman spectroscopic analysis and...
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6770490 |
Membrane immunobead assay for the detection of ciguatoxin and related polyether marine toxins
An immunological test kit suitable for the rapid detection of ciguatoxin and related low molecular weight lipid polyether marine toxins in fish tissues in the field, home or laboratory. The test...
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6767714 |
Diagnostic detection device and method
The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a...
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6753189 |
Detection apparatus and method for the same
A catcher, having an immunological epitope, is fixed to a detection zone of a spreading layer. A marker, capable of easy detection, has an inmmunological epitope. The marker and bispecific...
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6740485 |
Anti-bacterial methods and materials
Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and provision of...
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6720193 |
Analysis of free analyte fractions by rapid affinity chromatography
The invention is generally directed toward an analytical method to determine the concentration of the free analyte fraction in a sample. More particularly, the method encompasses applying a sample...
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6716640 |
Stabilization and amplification of electrochemiluminescence signals
The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
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6713308 |
System for electrochemical quantitative analysis of analytes within a solid phase
The analytical process utilized in the system of this invention comprises three (3) step distinct steps wherein an analyte of interest in a test sample is initially labeled and subsequently...
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RE38430 |
Solid phase chromatographic immunoassay
A chromatographic test strip comprising a solid support having at least a first portion and a second portion with said portions being in the same plane so as to permit capillary flow communication...
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6689615 |
Methods and devices for processing blood samples
Approaches are described for separating plasma from whole blood samples and include the use of magnetically attractable particles associated with an agglutinating agent. The magnetically...
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6686209 |
Reagents for detecting cannabinoids
In this disclosure, novel caanabinol-based tracers suitable for use in immunoassays that detect cannabinoids in a biological sample are disclosed. These cannabinol-based tracers are particularly...
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6680208 |
Rapid protein identification using antibody mixtures
A method and device is disclosed for rapidly identifying a large number of proteins by placing a protein mixture in a sample chamber of an electrophoresis gel, and performing electrophoresis to...
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6673629 |
Neutralization of polycations in a chromatographic device for whole blood use
A chromatography assay device and method for use with whole blood samples utilizing a red blood cell separating agent to aggregate red blood cells and permit plasma or serum to flow by capillary...
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6653066 |
Device and method for detecting polyvalent substances
Disclosed is a device and method of use for detecting polyvalent analytes such as antibody to the AIDS virus, utilizing an inverse sandwich method. The test device comprises a first substance...
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6649419 |
Method and apparatus for protein manipulation
A method and apparatus for extracting, identifying, and manipulating proteins or peptides from a solution uses paramagnetic beads having a coating with an affinity for the target component. In one...
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6642007 |
Assays for measurement of type II collagen fragments in urine
This invention provides novel methods for monitoring urine for type II collagen fragment using a combination of a capture antibody and a detection antibody, such that type II collagen is...
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