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8124743 |
Purification of a bivalently active antibody using a non-chromatographic method
The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a...
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7943368 |
Reducing time to result for blood bank diagnostic testing
Methods for reducing time to result in blood bank diagnostic testing with an agitation device and a low ionic strength solution are disclosed. Specifically provided are methods for reducing...
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7919266 |
Method of detecting red cell antigen-antibody reactions
A process for the detection of antibodies in a test sample by preparing a suspension of erythrocytes with a test serum or plasma by mixing a test serum or plasma with erythrocytes; incubating the...
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7767436 |
Reducing time to result for blood bank diagnostic testing
Methods for reducing time to result in blood bank diagnostic testing with an agitation device and a low ionic strength solution are disclosed. Specifically provided are methods for reducing...
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7732158 |
Method of high-speed detection for biological analyte
This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an...
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7709212 |
Particle based binding assay
The present invention provides a method for detecting the presence or amount of an analyte in a sample, said method comprising: a porous surface to which particles having attached thereto a binding...
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7659125 |
Latex reagent for adiponectin analysis and method of adiponectin analysis
A latex reagent for analyzing adiponectin, comprising a suspension of latex particles carrying a substance which specifically binds to adiponectin, is disclosed. Further, a method for analyzing...
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7429458 |
Methods of using bioelastomers
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of...
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7361480 |
Method and means for detecting gluten-induced diseases
The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7320893 |
Lipoprotein fingerprinting methods using metal ion chelate salts
Methods are disclosed which separate and identify lipoproteins in biological samples. An ultracentrifuge density gradient is used to separate lipoprotein fractions. The fractions are visualized,...
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7241578 |
Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit
The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an...
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7232690 |
Method and device for detecting and isolating pharmacological compounds being contained in substance mixtures
A process for isolating and/or identifying at least one active chemical substance from a mixture of active and inactive chemical substances, is characterized by the steps: a) adding a target to...
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7166477 |
Muscle sample prepared for prion assay
A method of preparing a sample of muscle tissue and of assaying the prepared sample to determine the presence of prions in the sample is disclosed. The muscle tissue is homogenized and mixed with a...
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7166476 |
Highly reproducible agglutination immunoassay method and reagents
The present invention provides an agglutination immunoassay, wherein the agglutination of insoluble carrier particles such as latex are stabilized and uniformized to give good reproducibility, and...
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7151000 |
Method of concentrating proteins from serum
A sample is prepared from blood in a manner which makes it possible to further analyze proteins in the sample, e.g. to detect prions in the sample. Blood is extracted, allowed to clot and subjected...
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7018805 |
α-Amylase assay and uses thereof
This invention relates to methods and kits for measuring α-amylase activity in grain and plant products such as flour or stock.
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6989240 |
Method for detecting hemolysis
This invention provides a method for determining the presence of hemolyzed erythrocytes in blood by detecting erythrocyte adenylate kinase in a serum sample from the blood. This invention also...
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6887672 |
Anti-equine Fc epsilon receptor alpha chain antibodies and methods to detect IgE
The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and...
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6828158 |
Microparticle enhanced light scattering agglutination assay
Reagents and the use of the reagents in a microparticle light scattering agglutination assay are disclosed. The reagents comprise a mixture of particles having relatively stronger light scattering...
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6773928 |
Compositions and methods for enhancing bioassay performance
Compositions of matter and methods for enhancing bioassay performance are disclosed. More particularly, the composition of matter comprises a molecularly compact polymer-ligand conjugate capable of...
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6770488 |
Practical method and apparatus for analyte detection with colloidal particles
A colloidal system for detection of a variety of analytes involves techniques which permit reconstitution of a desiccated substance such as for surface enhanced Raman spectroscopic analysis and...
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6753185 |
Lipoprotein fingerprinting method
Methods are disclosed which separate and identify lipoproteins in biological samples. An ultracentrifuge density gradient is used to separate lipoprotein fractions. The fractions are visualized,...
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6723524 |
Immunoassay method and kit
An immunoassay, e.g. ELISA, method and kit for determining (preferably quantitatively) an analyte adsorbed at a surface or present in a liquid sample, comprising binding the analyte to a solid...
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6689615 |
Methods and devices for processing blood samples
Approaches are described for separating plasma from whole blood samples and include the use of magnetically attractable particles associated with an agglutinating agent. The magnetically...
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6632603 |
Non-captive substrate liquid phase immunoassay
An immunoassay of a liquid biological specimen for a specific analyte is conducted by forming a test sample by contacting the specimen with: (1) a binding substance of a ligand, antiligand or...
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6589755 |
Assay for quantifying arthritic conditions
The present invention is drawn to a novel and newly discovered low molecular weight protein fragments that are degradation products of COMP and have a molecular weight of about 14-33 kilodaltons...
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6514770 |
Immunoassay
Immunoassay methods for measuring the concentration of an analyte in a test specimen are described. The methods use an immunoreagent, where one of the analyte and the immunoreagent is an antigen,...
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6500628 |
Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor
The invention provides isolated nucleic acids molecules, designated Kinase and Phosphatase nucleic acid molecules, which encode novel protein kinase and protein Phosphatase polypeptides. The...
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6416949 |
Method of synthesizing diverse collections of oligomers
A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates...
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6383819 |
Method for determining cholesterol and sensor applicable to the same
The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high...
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6379918 |
Composition, formulae, devices and methods for control of specificity and inclusivity of microorganisms containing closely related antigen epitopes
Compositions, formulae, devices and methods for the detection of target microorganisms, such as by visual immunoprecipitate assay, enzyme linked immunoassay, chemiluminescence, immunoblotting, or...
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6362008 |
Generic signalling mechanism for detection of analytes
A generic signaling assay method comprising an affinity matrix for the detection of low molecular weight compositions is provided. A test sample is mixed with a pre-determined amount of a substance...
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6344336 |
Assay apparatus
The present invention relates to an assay apparatus for detecting a product in a sample. The assay apparatus comprises a fluid pathway with an input of the sample and an input for a reagent with a...
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6300142 |
Device and apparatus for conducting an assay
A apparatus for assaying glycated proteins and other analytes in biological samples such as blood, in which a sample is presented to the apparatus, includes an inlet port between moveable between...
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6210975 |
Process for determining a bindable analyte via immune precipitation and reagent therefor
The invention involves methods for determining analytes, and reagents for use in these methods. The methods and reagents use one or both of a polyvinyl/pyrolidone with a molecular weight of at...
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6203997 |
Quantitation of analytes in whole blood
The invention relates to a method for quantitating the level of a preselected analyte in a sample of blood of a human or animal patient by incubating the test sample with an antibody specific to...
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6166187 |
Method of concentrating prion proteins in blood samples
A sample is prepared from blood in a manner which makes it possible to further analyze proteins in the sample, e.g. to detect prions in the sample. Blood is extracted, allowed to clot and subjected...
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6159683 |
Method of determining stage of sepsis
The invention relates to a method for staging sepsis in a patient by concurrently measuring in a sample of the patient's blood four parameters which are indicative of the stage of sepsis: 1) the...
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6132953 |
Combinatorial synthesis on soluble polyvalent supports having a discrete architecture
The present invention is directed to the use of a soluble polyvalent support for the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in...
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6124139 |
Method and apparatus for indirect agglutination immunoassay
A method of indirect agglutination immunoassay includes, allowing particles of a reagent for immunoassay to precipitate in bottoms of at least one well, inclining the well at a specified angle to...
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6121055 |
Methods and devices for conducting specific binding assays
The invention provides methods for separating bound label from unbound label within an assay mixture, for predispensing assay reactants in self-contained assay vessels, as well as for detecting the...
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6027907 |
Method for immunological determination of hemoglobin derivative and treating reagent for use therein
A hemoglobin derivative-containing sample is treated with a treating reagent containing 2-butanol and then immunologically analyzed to determine the quantity of the hemoglobin derivative. By the...
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6010866 |
Determination of analytes in biological fluids in the presence of substances interfering with assays therefor
A method is provided, in one embodiment, for the determination of an analyte in a biological fluid sample in the presence of a substance interfering with an assay for the analyte. This embodiment...
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6001579 |
Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of...
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5977324 |
Process for concentrating protein with disease-related conformation
A method of concentrating a disease-related conformation of a protein such as the PrPSc in a sample is disclosed. The method comprises liquefying the sample and adding a complexing agent such as...
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5962340 |
Homogeneous immunoassay method utilizing 5-300 mM magnesium
In a method for immunoassay of a trace component in a sample derived from a living body on the basis of a change of turbidity or scattered light intensity caused by antigen-antibody reaction, when...
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5955287 |
Method of determining level of biological substances elevated in the presence of cancer and other neoplasms
A method of performing immunoassay to detect the level of target proteins common to various malignancies including metallopanstimulin or metallopanstimulin-like materials as well as complement...
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5919708 |
Assay for glycated blood proteins
A method of assessing glycated blood protein in a sample which comprises separating glycated and non-glycated protein using a liquid phase precipitation reagent, contacting the sample with a signal...
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5912182 |
Particle aggregation method and apparatus
A sample of liquid with suspended particles is contained in a tube and subjected to a standing wave ultrasound field transverse to the tube, the standing wave exhibiting a progressive change in...
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