|
Match
|
Document |
Document Title |
|
|
7592187 |
Method of calibrating ligand specificity
A method to determine specificity of ligand binding includes comparing a solid phase carrier first extract obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a...
|
|
|
7563622 |
Molybdenum complex and test kit to enhance accuracy of analysis of endogenous analytes in biological fluids
Methods for enhancement in accuracy of immunochemical analysis of heterogeneous biological fluids containing exogenous substances that can interfere in immunochemical analysis for endogenous...
|
|
|
7563587 |
Method and kit for cell analyte assay
The present invention relates to a method for analysing a cell sample for cell surface-bound or intracellularly bound analytes by providing an array of immobilised specific binding agents for a set...
|
|
|
7547554 |
Method and device for the detection of very small quantities of particles
The invention relates to a method and a device for detecting very small quantities of particles. The inventive method is based on a detection of antigen-antibody reaction products and provides a...
|
|
|
7332344 |
Luminescence assays
A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor...
|
|
|
7241578 |
Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit
The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an...
|
|
|
7144709 |
Diagnostics based on tetrazolium compounds
A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises a flavin-dependent enzyme that has...
|
|
|
7029856 |
Methods for determination of an analyte
The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be...
|
|
|
7026166 |
Fluorogenic dyes
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
|
|
|
7011955 |
Quantitative determination of analytes in a heterogeneous system
The invention concerns a method for quantitative or qualitative determination of an analyte or its interaction or reaction kinetics in a system with at least two different phases, comprising the...
|
|
|
7011954 |
Diagnostics based on tetrazolium compounds
A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises a flavin-dependent enzyme that has...
|
|
|
6991939 |
Optical array device and methods of use thereof for screening, analysis and manipulation of particles
Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A multi-channel device parcels a light source...
|
|
|
6913935 |
Multiple assay method
A method for the assay of N samples each containing a compound to be tested, comprises providing N reaction vessels each containing a population of carrier beads and other reagents for performing...
|
|
|
6908769 |
Dye pair for fluorescence resonance energy transfer (FRET) measurements
The present invention concerns new fluorescent dye systems especially for fluorescence resonance energy transfer determinations for example combined with the time-resolved measurement of the...
|
|
|
6887712 |
Methods and compositions to lower plasma cholesterol levels
A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol. The method provided includes assessing the...
|
|
|
6841392 |
Method and apparatus for selective biological material detection
The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for...
|
|
|
6753156 |
Homogeneous method for detecting and/or determining phosphorylating activity in a biological material
The invention relates to a novel homogeneous method of detecting and/or determining the phosphorylating activity of a biological material towards a substrate containing tyrosine and/or serine...
|
|
|
6723567 |
Screening method for apoptosis and necrosis
The present invention relates to a method for the determination of non-, anti-, or pro-apoptotic and necrotic conditions of cells, newly designed vectors coding for marker proteins, cell lines...
|
|
|
6716640 |
Stabilization and amplification of electrochemiluminescence signals
The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
|
|
|
6682898 |
High-throughput screening assays for modulators of STAT4 activity
This invention provides receptor peptides that have a high affinity for STAT4 and STAT6 polypeptides. Also provided are assays that are useful for identifying compounds that modulate the...
|
|
|
6667179 |
Semiconductor luminescence quenchers for detecting proximal molecular binding events
The invention provides methods and compositions for detecting binding or unbinding of a molecule to a substrate. The molecule comprises a luminophore and the substrate comprises a semiconductor...
|
|
|
6660532 |
Modular assembly for reagentless affinity separation and detection of analyte
The invention provides a reagentless assay kit for analyte in a sample comprising a modular affinity assembly including at least one sensor unit comprising a ligand having binding affinity for the...
|
|
|
6645733 |
Fluorescent intensity method for assaying binding between proteins or peptides
A method for assaying specific binding between a fluorophore-labeled probe and an unlabeled target is provided. The method includes detecting a quenching effect on fluorescence emitted by the...
|
|
|
6623982 |
Increased separation efficiency via controlled aggregation of magnetic nanoparticles
Compositions and methods are disclosed which enhance the microscopic observation and analysis of biological entities such as cells, bacteria and viruses by eliminating interfering magnetic clusters...
|
|
|
6596546 |
Detection of antibodies to bacterial antigens by fluorescence polarization
In a homogeneous immunoassay, fluorophore-conjugated lipopolysaccharide derived bacterial antigens are reacted with antibodies specific for the antigens. Quantitative detection of the formation of...
|
|
|
6582907 |
Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
The present invention provides a method for identifying a test compound that binds to a target species. The method includes: incubating at least one test mixture under isothermal denaturing...
|
|
|
6544751 |
Methods of harvesting rare cells from blood products
The present invention provides methods of harvesting rare cells from blood products and/or obtaining products of the rare cells. The method includes contacting a blood product containing rare cells...
|
|
|
6489131 |
Interference reduction by rheumatoid factors
The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid...
|
|
|
6482655 |
Immunoassay procedure utilizing fluorogenic tracer antigens
Disclosed are fluorescent energy transfer dyes which are capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit...
|
|
|
6482601 |
Fluorescence polarization-based homogeneous assay for fumonisin determination in grains
A homogeneous assay for determining the fumonisin content in grains uses the technique of fluorescence polarization. A grain extract is prepared by shaking a crushed grain sample with a solvent. A...
|
|
|
6472227 |
Barbiturate assay, tracers, immunogens, antibodies and kit
The present invention is directed to a fluorescence polarization immunoassay for barbiturates, to the various components needed for preparing and carrying out such an assay, and to methods of...
|
|
|
6432723 |
Biosensors utilizing ligand induced conformation changes
A method for detecting the presence of a target analyte comprising binding a target analyte to a binding ligand comprising at least a first electron donor moiety and a second electron acceptor...
|
|
|
6350579 |
Extended dynamic range assays
A method and compositions for the detection and/or quantification of an analyte through the use of a plurality of labeled probes, with two or more said probes targeted to different regions of said...
|
|
|
6350574 |
Fluorescence polarization—based diagnostic assay for equine infectious anemia virus
A fluorescence polarization assay for Equine Infectious Anemia Virus utilizes a short peptide reagent probe derived from a conserved immunodominant region of gp45. The probe is N-terminally...
|
|
|
6344331 |
Water immiscible solvent based binding systems
A biphase immunoassay method is provided in which a water immiscible liquid is qualitatively or quantitatively measured by mixing a sample of the water immiscible liquid with an aqueous solution...
|
|
|
6326159 |
Receptors for immune complexes
Receptors are disclosed that are antibodies that exhibit a binding affinity for an immune complex of a monoepitopic antigen and an antibody for such antigen that is substantially greater than the...
|
|
|
6303325 |
Method for detecting analytes
The invention relates to methods of determining the presence or amount of an analyte in a sample suspected of containing the analyte, said method comprising the steps of: (a) bringing together in...
|
|
|
6300123 |
Sensor employing impedance measurements
A sensor uses an immobilized affinity component capable of interacting with analyte species and being associated with a conducting polymer such that the interaction of the affinity component and...
|
|
|
6287785 |
Homogenous enzyme immunoassay process
An improved homogeneous enzyme immunoassay process for quantitatively analyzing an antigen by determining the change in the enzymatic activity caused by a reaction between the antigen and an...
|
|
|
6258551 |
Method for carrying out an immunoassay in a multiphase system
The present invention relates to a method of carrying out an immunoassay in a multiphase system. A sample containing an analyte is brought into contact with a receptor A and a tracer. The analyte...
|
|
|
6251615 |
Cell analysis methods
A method of analyzing cells in a carrier solution comprises the following steps: (a) Introducing the carrier solution into a conduit having a surface portion (preferably a substantially flat...
|
|
|
6248544 |
Method of measuring bone resorption rate
Tartrate-resistant acid phosphatase (TRAP) has been used as a marker for bone resorption. However, there are two forms of said enzyme in the body: TRAP 5a and TRAP 5b, of which TRAP 5b is a much...
|
|
|
6243980 |
Protease inhibitor assay
Heterogenous and homogenous assays are provided for the detection of protease inhibitory activity in a sample or target compound, taking advantage of the chemiluminescent characteristics of...
|
|
|
6221625 |
Enzyme-labeled immunoassay and device therefor
An enzyme-labeled immunoassay is performed by the steps of allowing a test sample to react with an enzyme-labeled reagent, allowing a substrate to react with the enzyme to form a signal, and...
|
|
|
6218135 |
1,2-dioxetane derivative
The present invention has its objects to provide a compound not only which is easy to handle, thermally stable, and high in emission efficiency, but also which can show high emission efficiency...
|
|
|
6214628 |
Method of conducting an assay of a sample containing an analyte of interest
In accordance with the present invention, a method of conducting an assay of a sample containing an analyte of interest includes the step of forming a mixture so as to bring a metal-ligand complex...
|
|
|
6197594 |
White trigger preparations for improving the signal detection in bioluminescent and chemiluminescent reactions
The present invention concerns a method for the detection of an analyte in a sample liquid by luminescence measurement according to the principle of a ligand-receptor assay, e.g. an immunoassay or...
|
|
|
6190921 |
Ouabain immunoassay and kit and ouabain labeled with 125I or fluorescent label
The invention deals with the use of a reactive compound in immunological analyses. The compound is ouabain or its analog to which another compound, labeled by radioiodine or by a fluorogen, is...
|
|
|
6180411 |
Light-triggered indicators that memorize analyte concentrations
A new class of optical indicators which are capable of memorizing and preserving the spatial localization of intracellular analytes in a time resolved manner is described. The compounds comprise a...
|
|
|
6159750 |
Fluorescence polarization immunoassay diagnostic method
A method for fluorescence polarization immunoassay (FPIA) involves adding to a fluid container one or more reagents and a sample whose analyte is to be detected and measured, and then taking a...
|