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7625765 |
Directed assembly of functional heterostructures
The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric...
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7618784 |
Assay for phospholipid transfer protein (PLTP) activity
Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the...
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7615369 |
Reconfigurable protein patterning using electrowetting microelectrodes
A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called...
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7615376 |
Masking background fluorescence and luminescence in the optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7582488 |
Gel-shell beads with adsorbed or bound biomolecules
Disclosed are gel-coated beads (including Hydrogel™-coated beads), which are capable of adsorbing, or absorbing, proteins and other biomolecules onto or into the gel coating. The gel-coated beads...
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7572642 |
Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a...
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7569398 |
Methods and devices for transporting and concentrating an analyte present in a sample
The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these...
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7537907 |
Products and methods for single parameter and multiparameter phenotyping of cells
A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are...
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7494824 |
Interactive system for presenting and eliminating substances
An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance...
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7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
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7485472 |
Simple method for quantitative measuring the adhesion of platelets ex vivo
The invention relates to measuring of the adhesion of platelets ex vivo. In this method, monodisperse polymer particles are added to blood, and the number of platelets in the blood are measured...
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7449329 |
Blood test kit
A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to...
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7442553 |
Method for determining the amount of the maleimidyl groups of a particle
A method for quantitatively determining the amount of maleimidyl groups on a polymer fine particle containing at least maleimidyl groups, by allowing a fluorescent material having an SH group to...
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7390677 |
Immunoassay and immunoassay apparatus
An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b)...
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7338813 |
Carrier particle latex for assay reagent and assay reagent
An objective of the invention is to provide a carrier particle latex for an assay reagent capable of assaying a biological sample at a wide range of the concentration in an immunoserological test...
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7309723 |
Redox polymer nanoparticles
The invention provides nanoparticles comprising one or more redox-active species, methods of making such nanoparticles, and methods for using such nanoparticles, for example, as diagnostic agents...
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7297554 |
Immunoassay system
A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay...
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7262063 |
Directed assembly of functional heterostructures
The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric...
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7229835 |
Amine detection method and materials
A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula:
is disclosed. In particular, the...
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7205162 |
Artificial antibodies, method of producing the same and use thereof
Artificial antibodies or antibody mimics are described. They consist of polymers that carry specific binding sites mimicking the properties of antibodies. There is also described a method for...
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7202092 |
Indinavir derivatives useful in immunoassay
Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the...
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7192724 |
Method for differentiating irritable bowel syndrome from inflammatory bowel disease (IBD) and for monitoring persons with IBD using total endogenous lactoferrin as a marker
A method for aiding in differentiating irritable bowel syndrome from inflammatory bowel disease by determining the level of total endogenous human lactoferrin in clinical specimens, such as feces,...
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7192786 |
Biospecific assay method
This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled...
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7179660 |
Carriers coated with polysaccharides, their preparation and use
A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and,...
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7176036 |
Electroactive microspheres and methods
Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair...
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7166477 |
Muscle sample prepared for prion assay
A method of preparing a sample of muscle tissue and of assaying the prepared sample to determine the presence of prions in the sample is disclosed. The muscle tissue is homogenized and mixed with a...
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7148024 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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7144742 |
Quantitative lateral flow assays and devices
This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention...
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7144119 |
System and method for programmable illumination pattern generation
An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus...
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7141431 |
Microparticles with multiple fluorescent signals and methods of using same
This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with...
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7109042 |
Assays
An analytical test device useful for example in pregnancy testing, comprises a hollow casing ( 500 ) constructed of moisture-impervious solid material, such as plastics materials, containing a dry...
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7063952 |
Masking background flourescence and luminescence in optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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7060505 |
Assay device
An assay device and method are provided which allow the determination of the presence or absence of at least one analyte in a test sample, while providing specific identification of the test...
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7056657 |
Apparatus and methods for magnetic separation
Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium. Test medium within a reaction chamber is caused to flow past a collecting surface,...
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7045363 |
Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide
A nucleic acid-bound polypeptide produced by binding a nucleic acid to a polypeptide, a method of producing the nucleic acid-bound polypeptide, and applications of the nucleic acid-bound...
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7029867 |
Method of assaying antilaminin-1 antibody and application thereof
By allowing serum or plasma samples collected from humans to react with laminin-1 or a fragment thereof, and then determining whether or not anti-laminin-1 antibody, an auto-antibody against...
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7026166 |
Fluorogenic dyes
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
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7022529 |
Particles for diagnostic and therapeutic use
Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the...
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7005271 |
Method for the determination of the prethrombotic state
The present invention relates to determining the prethrombotic state, in particular determining an amount or presence of circulating microparticles and/or stimulated procoagulant cells.
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7005292 |
Device and method for the detection of an analyte utilizing mesoscale flow systems
Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow...
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6969605 |
Miniature immuno-optical rapid analyte sensor platform
A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an...
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6960478 |
Multiplex flow assays with magnetic particles as solid phase
Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the...
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6958245 |
Array cytometry
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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6951716 |
Anti-platelet immunoglobulin bead positive control
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one...
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6946547 |
Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class...
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6939681 |
Method of detecting an antibody in a liquid sample
The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an...
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6936477 |
Complex combinatorial chemical libraries encoded with tags
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of...
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6933106 |
Platelet immunoglobulin bead suspension and flow cytometry
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one...
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6927071 |
Method for reducing non-specific aggregation of latex microparticles in the presence of serum or plasma
A particle-enhanced assay for determining an analyte in a test sample in which an additive for reducing non-specific particle aggregation is added in an amount to substantially reduce non-specific...
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