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7632929 |
Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be...
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7629133 |
Controlled transport through multiple reversible interaction point membranes
A method for causing a membrane to become permeable to a first chemical species, in which the membrane is contacted with a solution comprising a second chemical species. The membrane comprises a...
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7629016 |
Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surface
The invention relates to a photochemical process for the preparation of an activated polymer surface having an active fluoro group using 1-fluoro-2-nitro-4-azidobenzene to form the activated...
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7625764 |
Stimuli-responsive polymer devices
Conjugates that include polymers that are reversibly self-associative in response to a stimulus and methods for using the conjugates.
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7622259 |
Detection of von-Willebrand factor (vWF) activity
The present invention relates to a method for detecting von-Willebrand factor (vWF) activity comprising assaying a sample in the presence of a soluble form or portion of glycoprotein Ib(α)...
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7618587 |
Analyzers and methods of analyzing blood
Analyzers and methods of analysis are described for performing blood cell counting and immunoassay on a whole blood specimen in one measurement section. An assay sample is prepared by blending...
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7615376 |
Masking background fluorescence and luminescence in the optical analysis of biomedical assays
In a process for the quantitative optical analysis of fluorescently labelled biological cells 5 , a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact...
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7611888 |
Rotaxane compound, rotaxane-bonded solid substrate, and biochip using the same
The present disclosure provides a rotaxane compound that can be used to separate molecules within a linkage layer formed on a solid substrate of a biochip by a predetermined distance. The compound...
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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7604956 |
Supersensitive immunoassays
An assay exhibiting improved sensitivity for achieving a factor of ten times (10×) better sensitivity than current sensitivity levels achieved by prior-art immunoassays, as exemplified by ELISA....
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7598093 |
Nanoparticle and microparticle based detection of cellular products
Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic...
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7598081 |
Materials and procedures for the purification of cells
The subject invention provides new materials and methods for the efficient isolation and purification of stem cells. Specifically, conductive immunopolymers with stem cell specific antibodies can...
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7592187 |
Method of calibrating ligand specificity
A method to determine specificity of ligand binding includes comparing a solid phase carrier first extract obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a...
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7592186 |
Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin A complexes in a blood sample
The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs...
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7572644 |
Hydrogel copolymer, substrate coated with the copolymer, method of producing microarray using the copolymer, and microarray produced by the method
A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the...
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7572642 |
Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a...
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7569399 |
Multiplex flow assays preferably with magnetic particles as solid phase
Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the...
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7550288 |
Reaction method with use of biochemical analysis unit
A biochemical analysis unit has a flow-through area in which plural spot areas are arranged, and probes are spotted onto the spot areas. The biochemical analysis unit is set into a chamber of a...
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7544513 |
Hemoglobin assay for neonatal screening
The present invention provides an assay, suitable for neonatal screening of hemoglobinopathies by quantitatively determining the presence of at least one pair of hemoglobin (Hb) variants,...
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7541160 |
ELISA for VEGF
The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions,...
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7537907 |
Products and methods for single parameter and multiparameter phenotyping of cells
A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are...
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7527939 |
Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP
A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are...
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7527981 |
Bioweapon-detecting fibrous-network products and methods for making same
Methods are disclosed for producing a bioweapon-sensitive fibrous-network product, wherein the subject products exhibit a color change in response to exposure to a biological agent (or portion...
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7510687 |
Simultaneous detection of different antibodies and antigens in clinical alimentary and environmental samples
Method and device to simultaneously detect different antibodies and antigens via immunoenzimatic tests and ELISA (Enzyme Linked ImmunoSorbent Assay) constituted by small absorbent cylinders, on...
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7507588 |
Multiplex microparticle system
Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein...
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7507550 |
Analytical sandwich test for determining NT-proBNP
The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal...
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7504262 |
High sensitivity biomolecule detection with magnetic particles
The present invention generally relates to the field of biomolecule detection. More specifically, the present invention relates to compositions, methods and systems for the detection and...
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7498178 |
Carrier of a diamond fine particle for immobilizing virus
The present invention provides a carrier for immobilizing a bio-derived polymer, and especially, the present invention provides a carrier of diamond fine particle for immobilizing a DNA, RNA,...
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7494824 |
Interactive system for presenting and eliminating substances
An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance...
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7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
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7488608 |
Reduction of non-specific binding in assays
Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding...
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7485430 |
Methods and compositions for evaluation of fertility
The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In...
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7470540 |
Method and device for the integrated synthesis and analysis of analytes on a support
A method for preparing receptor-coated particles is described which comprises the following steps:
a) providing a support body, b) conducting a liquid containing particles into or onto the support...
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7449329 |
Blood test kit
A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to...
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7442553 |
Method for determining the amount of the maleimidyl groups of a particle
A method for quantitatively determining the amount of maleimidyl groups on a polymer fine particle containing at least maleimidyl groups, by allowing a fluorescent material having an SH group to...
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7432046 |
Methods for the determination of antibody IgG avidity
The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay...
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7423131 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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H002223 |
Patterned, micrometer-sized antibody features
A biosensor has a micrometer sized antibody substrate surface which may include patterned single or multiple antibody substrates. The substrate is capable of detecting multiple chemical species...
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7417021 |
Biologically active conjugate of a biopolymer and therapeutic agent
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a...
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7413868 |
Use of particulate labels in bioanalyte detection methods
New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular...
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7407796 |
Interrogation of changes in the contents of a sealed container
A device and method allowing evaluation of the contents of a sealed primary container by means of an integral sensor which is separated from the contents of the sealed primary container yet...
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7407816 |
Isoelectric particles and uses thereof
A plurality of particles of from about 5 nm to 100 μm possessing predetermined isoelectric points in the pH range from about 2.5 to 11 is used in a method of detection of a plurality of analytes,...
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7402381 |
Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption...
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7399636 |
Diagnostic kit for predicting pregnancy outcome
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
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7396691 |
Method for the detection of fluoride or hydrogen fluoride and detection kit
The present invention relates to a method for detecting and/or measuring the concentration of fluoride (F − ) or hydrogen fluoride (HF) in a sample, comprising the steps consisting of bringing...
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7390677 |
Immunoassay and immunoassay apparatus
An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b)...
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7384779 |
Porous substrate plates and the use thereof
A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a...
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7371585 |
Membranes incorporating recognition moieties
The present invention provides a thiosulfonate-activated ionophore comprising an ionophore, a spacer group, and an alkylthiosulfonate moiety. A preferred ionophore is gramicidin A. A preferred...
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7368280 |
Detection of biospecific interactions using amplified differential time domain spectroscopy signal
A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz...
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7368281 |
Label-free evanescent-field detection of biological and chemical agents
An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The...
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