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7642060 |
Rapid resuscitation, growth, capture and detection of microorganisms
A method and system for the detection and identification of a target pathogen in a sample is disclosed. The method and system involve the use of a capture matrix throughout resuscitation, growth,...
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7625765 |
Directed assembly of functional heterostructures
The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric...
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7625748 |
Flow cell device, sensor unit and assay apparatus
A flow cell device is incorporated in the sensor unit for surface plasmon resonance (SPR) assay. A box shaped flow cell body has a lower surface, and is disposed in contact of the lower surface...
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7618829 |
Method of detecting multiple analytes
The invention relates to a a microtiter plate and its use in a method of the invention, which microtiter plate comprises a plurality of containers, wherein the bottom of each container comprises a...
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7611853 |
Assay to screen for anti-malarials
Malarial parasite Plasmodium falciparum is responsible for the most severe form of malaria in humans, causing about 2 million deaths every year. Lack of effective vaccines and emergence of...
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7608463 |
Enhanced waveguide and method
An optical assay apparatus having an optical filter, an optical sensor with a light ray redirection portion and an assay sensing portion, and a filter to block certain wavelengths of excitation...
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7597960 |
Functional infrared fluorescent particle
An infrared fluorescent particle comprising a functional group or a substance that is capable of binding to an analyte, wherein fluorescence at infrared wavelength is emitted from the particle upon...
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7575939 |
Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7572643 |
Nanoparticle composite-coated glass microspheres for use in bioassays
A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of...
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7572642 |
Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
The invention provides a particle comprising a surface, wherein a portion of the surface is capable of emitting electromagnetic radiation and another portion of the surface is capable of emitting a...
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7566531 |
Selective whole cell quartz crystal microbalance biosensors
Selective whole cell QCM biosensors are disclosed. Also disclosed are methods of making and using such whole cell QCM biosensors, e.g., to screen drugs and diagnose diseases.
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7544504 |
Diagnostic methods
The present invention relates to novel methods for the diagnosis of Helicobacter pylori infection. Specifically, the present invention relates to novel non-invasive methods for the detection of...
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7541167 |
Porous glass composite material
A porous glass composite material comprising at least one alkoxodisilane (precursor) having the general formula (or 1 ) 3 Si-spacer-Si(OR 2 ) 3 ,wherein R 1 and R 2 are the same or different and...
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7534578 |
Self-referencing biodetection method and patterned bioassays
The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The...
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7524630 |
Functionalized nanoparticles and methods of use
Silica-coated nanoparticles functionalized with biologically active molecules such as antibodies and nucleotides are used to label cells, to detect and isolate nucleic acid molecules having...
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7524625 |
Real time binding analysis of antigens on a biosensor surface
The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors.
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7521262 |
Functionalized silicon surfaces
The present invention is directed to a silicon substrate having a monolayer formed by an electrochemically-induced reaction between silicon hydride moieties on the silicon surface and optionally...
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7517660 |
Optoelectronic sensor
A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where...
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7510882 |
Method and biosensor for analysis
In a method for analysis biomolecules ( 3 ) attached to a solid surface of a substrate ( 1 ) are used for detecting the presence of analytes ( 4 ) in a sample by binding of the analytes to the...
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7507588 |
Multiplex microparticle system
Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein...
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7498145 |
Concentration measuring method, concentration measuring kit, and sensor chip for use in the method
The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical...
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7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
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7488607 |
Electronically readable microarray with electronic addressing function
Methods and apparatus for electronically addressing and interrogating microarrays are disclosed. The described microarrays include a plurality of features disposed on a substrate. Each of the...
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7485472 |
Simple method for quantitative measuring the adhesion of platelets ex vivo
The invention relates to measuring of the adhesion of platelets ex vivo. In this method, monodisperse polymer particles are added to blood, and the number of platelets in the blood are measured...
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7485470 |
Method for attachment of silylated molecules to glass surfaces
A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are...
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7473551 |
Nano-mechanic microsensors and methods for detecting target analytes
The present invention relates generally to methods and compositions for analyzing test samples containing target analytes including proteins and nucleic acids. The invention uses a surface acoustic...
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7470549 |
Measurement method using biosensor
It is an object of the present invention to provide a method for simultaneously carrying out the detection or measurement of a substance interacting with a physiologically active substance...
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7459315 |
Miniaturized assembly and method of filling assembly
A miniaturized assembly is provided whereby a fluid sample can be divided into a plurality of sample portions in retaining wells and the sample fluid can be displaced from open ends of the wells...
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7449329 |
Blood test kit
A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to...
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7445938 |
System and method for detecting presence of analytes using gratings
The present invention is directed to an optical grating sensor configured to detect a phase change in light passing though the system due to a binding event caused by an analyte. The grating sensor...
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7438854 |
Biomolecule substrate, and test and diagnosis methods and apparatuses using the same
A test apparatus is for testing a DNA substrate on which a plurality of DNA fragments for testing are arranged, wherein absolute precision is not required. A substrate is provided on which a...
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7432046 |
Methods for the determination of antibody IgG avidity
The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay...
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7425454 |
Biosensor
It is an object of the present invention to provide a detection surface used for biosensors, in which non-specific adsorption is suppressed and the generation of pinholes is also suppressed. The...
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7422891 |
Label-free high-throughput optical technique for detecting biomolecular interactions
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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H002223 |
Patterned, micrometer-sized antibody features
A biosensor has a micrometer sized antibody substrate surface which may include patterned single or multiple antibody substrates. The substrate is capable of detecting multiple chemical species...
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7413852 |
Multiplexed diagnostic and therapeutics
A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also...
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7410811 |
Analytical method and device utilizing magnetic materials
The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable...
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7407815 |
Liquid crystal cassette
A functional cassette for the detection of ligands comprises a first inner housing, a second middle housing and a third outer housing and each housing is at least partially rotatable relative to an...
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7402441 |
Method of detecting an analyte in a fluid
A method for the detection of an analyte in a fluid, comprising contacting the fluid with a holographic element comprising a medium and a hologram disposed throughout the volume of the medium,...
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7402381 |
Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption...
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7396676 |
Evanescent wave sensor with attached ligand
The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a NCYX linker moiety, as defined herein. Methods of making the...
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7390676 |
System and method for programmable illumination pattern generation
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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7390649 |
Sensor chips with multiple layers of polysiloxane
The invention relates to sensor chips with multiple layers of polysiloxane with improve homogeneity.
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7385022 |
Polythiocarbonate polythiol
Disclosed is a polythiocarbonate polythiol including repeating units represented by the chemical formula (I):
in which formula (I), R represents a divalent hydrocarbon group, which hydrocarbon...
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7384797 |
Resonant optical cavities for high-sensitivity high-throughput biological sensors and methods
Biosensors including resonant optical cavities. The resonant optical cavities are shaped so as to generate whispering gallery modes, which increase the quality factors of the cavities and...
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7368281 |
Label-free evanescent-field detection of biological and chemical agents
An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The...
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7364919 |
Nanoparticles
Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or...
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7348147 |
Method and system for nucleic acid detection
The present invention relates to a method of detecting nucleic acids comprising suspending at least one recognizable target nucleic acid in a suspending solution containing polymeric particles...
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7341692 |
Detection apparatus for biological materials and methods of making and using the same
Apparatus comprising a surface site layer having a distal site end, wherein the distal site end includes a substantially inorganic surface having a chemical composition selected from a group...
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7332351 |
Method of making nanoparticles
Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved...
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