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7622046 |
Magnetic transfer method, a device for transferring microparticles and a reactor unit
A magnetic transfer method for sorting, collecting, transferring or dosing microparticles ( 22 ) or magnetic particles either in the same liquid ( 23 ) or from one liquid ( 23 a ) into another ( 23...
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7615382 |
Magnetic sifter
The present invention provides a magnetic sifter that is small in scale, enables three-dimensional flow in a direction normal to the substrate, allows relatively higher capture rates and higher...
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7615381 |
Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device
Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is...
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7611908 |
Method and apparatus for therapeutic drug monitoring using an acoustic device
Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the...
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7608465 |
Multi-analyte diagnostic test for thyroid disorders
Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and...
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7604956 |
Supersensitive immunoassays
An assay exhibiting improved sensitivity for achieving a factor of ten times (10×) better sensitivity than current sensitivity levels achieved by prior-art immunoassays, as exemplified by ELISA....
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7601831 |
Methods, kits and assay system for detecting drug-resistant mycobacterium tuberculosis
The present invention relates to methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis of suspected patient. The system of the present invention largely reduces...
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7598094 |
Methods and apparatus for detecting cardiac injury markers using an acoustic device
Methods for detecting cardiac injury by detecting one or more cardiac markers are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for a cardiac...
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7585682 |
Magnetic in situ dilution
The invention involves methods, assays, and components for the detection and analysis of binding between biological or chemical species, and can specifically be used for drug discovery. In an...
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7575862 |
Assay systems, kits and methods for detecting microorganisms
The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis ) of suspected patient. The present invention also relates to an...
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7569399 |
Multiplex flow assays preferably with magnetic particles as solid phase
Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the...
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7569398 |
Methods and devices for transporting and concentrating an analyte present in a sample
The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these...
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7560289 |
Methods of quantitatively measuring biomolecules
The present invention is directed to methods for quantitatively measuring biomolecules by using magnetic nanoparticles. Through the use of the magnetic nanoparticles and the bioprobes coated to the...
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7553676 |
Specific coupling reaction measuring method
A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the...
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7553625 |
Method and apparatus for in vivo collection of circulating biological components
The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a...
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7537938 |
Biomarker detection in circulating cells
A method is provided for detecting biomarkers in rare circulating cells by forming an enriched population of cells immunomagnetically followed by biomarker detection using binding compounds having...
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7537907 |
Products and methods for single parameter and multiparameter phenotyping of cells
A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are...
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7531366 |
Bead based assays using a liquid crystal reporter
The present invention relates to the field of detection of analytes, and in particular to detection of viruses, cells, bacteria, lipid-membrane containing organisms, proteins, nucleic acids,...
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7527980 |
Indirect detection of cardiac markers for assessing acute myocardial infarction
Assay systems and methods are provided for detecting a target antigen in a physiological fluid (e.g., blood, serum, or urine). The method includes linking via a first antibody a magnetic...
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7527979 |
Devices and methods for rapid detection of pathogens
Assay systems and methods are provided for detecting a target pathogen, such as a microorganism (e.g., bacterium, bacterial toxin) which may be present in a fluid or other location. The method can...
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7527978 |
Flow cytometry based micronucleus assays and kits
The invention is a method for analyzing immature reticulocytes for the presence of micronuclei. The method includes reticulocyte enrichment, fluorescent labeling, micronuclei staining, and analysis...
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7524630 |
Functionalized nanoparticles and methods of use
Silica-coated nanoparticles functionalized with biologically active molecules such as antibodies and nucleotides are used to label cells, to detect and isolate nucleic acid molecules having...
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7514270 |
Immunoassay probe
An analytical instrument for the immobilization of antigens to be detected in an immunoassay using mangetizable beads. The instrument includes a probe containing magnetizable particles and a...
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7510839 |
Method for the combined isolation of magnet-beads from a liquid sample and subsequent thermocyclisation for the polymerase chain reaction (PCR) and associated arrangement
Embodiments generally relate to a PCR wherein a magnetic field is focused in a localized area and also to the possibility of a cyclic transfer of heat. According to at least one embodiment of the...
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7507588 |
Multiplex microparticle system
Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein...
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7504262 |
High sensitivity biomolecule detection with magnetic particles
The present invention generally relates to the field of biomolecule detection. More specifically, the present invention relates to compositions, methods and systems for the detection and...
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7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
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7486166 |
High performance hybrid magnetic structure for biotechnology applications
The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined...
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7476313 |
Apparatus for mixing magnetic particles
An apparatus and method for carrying out the affinity separation of a target substance from a liquid test medium by mixing magnetic particles having surface immobilized ligand or receptor within...
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7474184 |
Hybrid magnet devices for molecule manipulation and small scale high gradient-field applications
The present disclosure provides a high performance hybrid magnetic structure made from a combination of permanent magnets and ferromagnetic pole materials which are assembled in a predetermined...
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7470397 |
Disintegratable films for diagnostic devices
The invention provides disintegratable film compositions for diagnostic test devices. The films are prepared with a combination of components that yield films of sufficient film strength and...
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7462322 |
Methods and apparatus for improved luminescence assays
An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a...
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7445895 |
Methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis
The present invention relates to methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis of suspected patient. The system of the present invention largely reduces...
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7432105 |
Self-calibration system for a magnetic binding assay
A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay...
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7432046 |
Methods for the determination of antibody IgG avidity
The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay...
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7431887 |
Microfluidic device and method with trapping of sample in cavities having lids that can be opened or closed
System and method for providing a sample preparing arrangement ( 10 ) submergible in a liquid medium that includes a carrier structure ( 11 ) having at least one cavity ( 12 ) therein and that is...
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7427512 |
Light-controlled electrokinetic assembly of particles near surfaces
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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7425455 |
Biosensor, magnetic molecule measurement device
A biosensor not requiring washing of an unbonded label molecular by analyzing an object to be measured such as an antigen, an antibody, a DNA, and an RNA through magnetic field sensing. The...
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7410811 |
Analytical method and device utilizing magnetic materials
The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable...
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7402381 |
Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption...
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7396690 |
Method for treating magnetic particles and biological analysis device using magnets
A method for treating magnetic particles present in a solution in a container by redispersion, rinsing or displacement, the particles having novel characteristics under the effect of a specific...
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7393698 |
Magnetic fine particles and process for producing the same
The present invention relates to magnetic fine particles having immobilized thereto a polymer having an upper critical solution temperature, and a process for producing the same, a method of...
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7390628 |
Microparticle-based diagnostic methods
The present invention concerns novel materials and methods to detect low frequency surface changes utilizing modified microspheres. Upon exposing the surface to the modified microspheres of the...
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7387901 |
Target substance detecting element, target substance detection apparatus and target substance detection method
Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a...
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7384798 |
Method of detecting analytes in a microfluidic sample and a system for performing the same
A method of detecting analytes in a microfluidic sample includes introducing at least one type of analyte, at least one type of carrier particle, and a fluid into a mixing chamber of a system. The...
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7384561 |
Apparatus and method for separating magnetic particles
An apparatus for separating a predetermined amount of magnetic particles in a fluid, including a fluid conveyance portion having at least a first flow channel for supplying a fluid containing the...
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7384559 |
Device and method for treating magnetic particles
A device for treating magnetizable or magnetically attractable particles which are present in a liquid, comprising a holder for one ore more reaction vessel(s) with the liquid containing the...
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7371830 |
Method for separating biological material from a fluid using magnetic particles
Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles...
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7368295 |
Nanoparticles comprising biologically active TNF which is immobilized on the same
The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in...
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7364921 |
Method and apparatus for separating biological materials and other substances
A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands...
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