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7615381 |
Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device
Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is...
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7611908 |
Method and apparatus for therapeutic drug monitoring using an acoustic device
Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the...
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7611907 |
Nano-sized optical fluorescence labels and uses thereof
A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and...
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7611905 |
Apparatus and method of assay in utilizing attenuated total reflection
A surface plasmon resonance (SPR) assay apparatus has an assay stage, which is loadable with a sensor unit. The sensor unit has a prism, thin film, flow cell and flow channel for flow of sample. A...
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7611849 |
Enhanced cellular assay method for use in flow cytometry or similar instruments using optically resonant particles
This invention relates to the field of biological assays where cells can be classified and enumerated using flow cytometry optical instrumentation. The invention combines information from...
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7604956 |
Supersensitive immunoassays
An assay exhibiting improved sensitivity for achieving a factor of ten times (10×) better sensitivity than current sensitivity levels achieved by prior-art immunoassays, as exemplified by ELISA....
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7598092 |
Methods, devices, systems and computer program products for stochastic, competitive, force-based analyte detection
A cantilever array can be positioned adjacent a surface in the presence of a sample. The cantilever array includes a plurality of cantilevers having one member of a specific binding pair thereon....
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7579184 |
Methods to increase dynamic range and improve quantitative analysis in rapid biosensors
Conductimetric assay devices that have both low end and high end sensitivity are described. The geometric shape and/or arrangement of the capture zones make it possible for the assay devices to...
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7572643 |
Nanoparticle composite-coated glass microspheres for use in bioassays
A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of...
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7569396 |
Caffeine detection using internally referenced competitive assays
Methods, compositions, and apparatus for detecting the presence of caffeine in a liquid sample are provided. In certain embodiments, an internally referenced competitive assay allows a very precise...
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7563624 |
Measurement method using biosensor
It is an object of the present invention to provide a method for carrying out on a same biosensor both of the measurement of the amount of a physiologically active substance immobilized on a...
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7563623 |
Biosensor
It is an object of the present invention to provide a biosensor on which a large amount of protein can be immobilized and nonspecific adsorption is less likely to occur with the use of a SAM...
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7553676 |
Specific coupling reaction measuring method
A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the...
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7534624 |
Method and apparatus for assay in utilizing attenuated total reflection, and sample immobilizing device
A sensor unit for assay in utilizing surface plasmon resonance (SPR) includes a dielectric prism. Metal film has a light entrance surface fitted on the prism, and a sensing surface reverse to the...
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7534578 |
Self-referencing biodetection method and patterned bioassays
The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The...
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7524630 |
Functionalized nanoparticles and methods of use
Silica-coated nanoparticles functionalized with biologically active molecules such as antibodies and nucleotides are used to label cells, to detect and isolate nucleic acid molecules having...
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7524625 |
Real time binding analysis of antigens on a biosensor surface
The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors.
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7517700 |
Core-shell particles
Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as...
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7513983 |
Insulator electrode devices
Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base...
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7510882 |
Method and biosensor for analysis
In a method for analysis biomolecules ( 3 ) attached to a solid surface of a substrate ( 1 ) are used for detecting the presence of analytes ( 4 ) in a sample by binding of the analytes to the...
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7510881 |
Method and kit for the quantitative and/or qualitative detection of components in a sample
A method and kit for quantitatively and/or qualitatively detecting one or more components in samples, including the use of metal-particle labelled reagents and an antibody conjugate are disclosed....
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7507588 |
Multiplex microparticle system
Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein...
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7507550 |
Analytical sandwich test for determining NT-proBNP
The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal...
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7498177 |
Quantum dots and their uses
Quantum dots having ligands that comprise tiopronin capping groups are disclosed, along with a method for their preparation. The biocompatibility of these quantum dots is also demonstrated. The...
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7498145 |
Concentration measuring method, concentration measuring kit, and sensor chip for use in the method
The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical...
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7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
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7488607 |
Electronically readable microarray with electronic addressing function
Methods and apparatus for electronically addressing and interrogating microarrays are disclosed. The described microarrays include a plurality of features disposed on a substrate. Each of the...
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7485855 |
On-probe sample cleanup system and method for MALDI analysis
A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least...
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7485471 |
Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy
Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the nucleic acid and/or protein-containing analytes in a body fluid are...
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7470550 |
Method of evaluating cell activity
The invention provides a method for evaluating the physiological activity of an external stimulus on living cells by means of a surface plasma resonance analyzer, which comprises evaluating the...
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7470549 |
Measurement method using biosensor
It is an object of the present invention to provide a method for simultaneously carrying out the detection or measurement of a substance interacting with a physiologically active substance...
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7465588 |
Apparatus and method of assay in utilizing attenuated total reflection
An assay apparatus is loaded with a sensor unit as surface plasmon resonance (SPR) biosensor, which includes a transparent dielectric medium and thin film. A first surface of the thin film is a...
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7462496 |
Plasmon-enhanced marking of fragile materials and other applications thereof
The methods and applications of a surface plasmon resonance-enhanced marking technique are disclosed. The technique uses surface plasmon resonance (SPR) excited nanoparticles and a surface plasmon...
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7449343 |
Method for measuring surface plasmon resonance
It is an object of the present invention to provide a measurement method which can suppress noise when a specific binding reaction between a physiologically active substance and a test substance is...
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7442498 |
Method of examining specimen and specimen container to be used in the examination method
A method of immunologically examining a specimen which comprises attaching a cap having a filter impregnated with a labeled antibody enclosed therein to a container body containing a diluted liquid...
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7439078 |
Method for measuring dissociation rate coefficient by surface plasmon resonance analysis
An object of the present invention is to provide a method for measuring the dissociation rate coefficient (Kd) by surface plasmon resonance analysis without measuring the theoretical maximum amount...
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7435384 |
Diagnostic instrument with movable electrode mounting member and methods for detecting analytes
An instrument (A) detects in a sample the presence of an analyte. The sample includes electrically readable particles ( 126 ) with an agent attached thereto that binds with the analyte or is an...
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7429492 |
Multiwell plates with integrated biosensors and membranes
The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane.
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7427512 |
Light-controlled electrokinetic assembly of particles near surfaces
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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7425454 |
Biosensor
It is an object of the present invention to provide a detection surface used for biosensors, in which non-specific adsorption is suppressed and the generation of pinholes is also suppressed. The...
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7413911 |
Method for measuring reaction rate coefficient by surface plasmon resonance analysis
An object of the present invention is to provide a method for measuring a rate coefficient by surface plasmon resonance analysis with excellent accuracy, reliability, and cost performance that can...
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7413607 |
Templated semiconductor particles and methods of making
Composite particles of a semiconductor particle such as a metal chalcogenide within a crosslinked, cored dendrimer are described. Additionally, methods of making the composite particles and...
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7410811 |
Analytical method and device utilizing magnetic materials
The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable...
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7410808 |
Method and assay for detection of residues
Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple...
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7407817 |
Surface plasmon resonance sensors and method for detecting samples using the same
Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by...
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7405054 |
Signal amplification method for surface plasmon resonance-based chemical detection
The present invention provides methods and compositions for amplifying the detection signal in surface plasmon resonance (SPR)-based flow systems. The signal amplification methods comprise the use...
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7404928 |
Thiol terminated monodisperse ethylene oxide oligomer capped gold nanoclusters
A thiol terminated ethylene oxide oligomer and the method of substituting the oligomer onto a gold nanocluster surface using a thiol-exchange reaction to form a charge-neutral, non-ionizable, water...
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7402381 |
Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method
Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption...
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7396676 |
Evanescent wave sensor with attached ligand
The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a NCYX linker moiety, as defined herein. Methods of making the...
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7396675 |
Kit and method for determining a plurality of analytes
The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising
a sensor platform...
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