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9040251 Biomolecule fixing board and method of manufacturing the same  
This invention provides a biomolecule modifying substrate comprising biomolecules selectively fixed to given regions thereon. The biomolecule modifying substrate comprises: a substrate at least...
9034659 Biosensors  
A chemiresistive biosensor for detecting an analyte can include a high specific surface area substrate conformally coated with a conductive polymer, and a binding reagent immobilized on the...
9029132 Sensor for biomolecules  
A sensor for biomolecules includes a silicon fin comprising undoped silicon; a source region adjacent to the silicon fin, the source region comprising heavily doped silicon; a drain region...
9023659 Silica nanoparticle embedding quantum dots, preparation method thereof and biosubstance labeling agent by use thereof  
Disclosed is a quantum dot-embedded silica nanoparticle having plural quantum dots embedded within the silica nanoparticle, wherein the number of quantum dots existing in a concentric area within...
9012204 Activation and monitoring of cellular transmembrane potentials  
The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed.
9012207 Biosensors including metallic nanocavities  
A biomolecular assay includes a substrate with a metallic layer on at least one surface thereof. The metallic film includes nanocavities. The nanocavities are configured to enhance signals that...
9005995 Self-assembled, micropatterned, and radio frequency (RF) shielded biocontainers and their uses for remote spatially controlled chemical delivery  
The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and...
9005994 Methods for biomolecule and biomolecule complex (BMC) detection and analysis and the use of such for research and medical diagnosis  
The present application pertains to improved methods of detecting biomolecules in a biological sample (or system), In particular, embodiments discussed herein allow for the detection of...
8999264 Hydrophilic coating for nonporous surfaces and microfluidic devices including same  
A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion,...
8993236 Electromagnetic molecular sensors and methods of using same  
Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors,...
8993349 Method for enhancing transport of semiconductor nanocrystals across biological membranes  
Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of...
8987003 Biosensor device and method of detecting biological particles  
A biosensor device (100) for detecting biological particles, the biosensor device (100) comprising an electromagnetic radiation transmitting member (102) adapted for transmitting electromagnetic...
8987004 Nanostructures for polarized imaging and receptor/ligan quantization: breaking the diffraction limit for imaging  
The present invention relates to affinity biosensing using polarization of light scattering of aggregated noble metallic nanostructures to determine concentration of an analyte in a test sample....
8974749 Assay device and method  
There is disclosed an analysis device for the analysis of a liquid sample, said device comprising a substrate, said substrate at least partly having projections substantially vertical to the...
8961898 Method for producing bilayer membrane and planar bilayer membrane  
The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a...
8962260 Method and device for combined detection of viral and bacterial infections  
A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for...
8962341 Cell-based detection of APF through its interaction with CKAP4 for diagnosis of interstitial cystitis  
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in...
8945943 Personal glucose meters for detection and quantification of a broad range of analytes  
A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal...
8945944 Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules  
A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte...
8947516 High-resolution 3D imaging of single semiconductor nanocrystals  
A method of imaging microscopic objects includes determining the relative depths of two or more semiconductor nanocrystals by analyzing images of the semiconductor nanocrystals at varying...
8945913 Kits, compositions and methods for detecting a biological condition  
The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one...
8940548 Sensor for biomolecules  
A method for sensing biomolecules in an electrolyte includes exposing a gate dielectric surface of a sensor comprising a silicon fin to the electrolyte, wherein the gate dielectric surface...
8940538 Apparatus and method for quantifying binding and dissociation kinetics of molecular interactions  
The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without...
8932880 Method for the direct measure of molecular interactions by detection of light reflected from multilayered functionalized dielectrics  
Method and apparatus for the quantitative determination of molecular interactions between ligands in solution and receptors immobilized on the surface of a solid transparent material coated by one...
8932877 Fluorescent carbon nanoparticles  
Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be,...
8889424 Device and method for performing a diagnostic test  
A device and method for performing a point of care diagnostic test for detecting and quantifying at least one analyte in a biological sample (e.g., a body fluid). A device may include an...
8883518 Systems and methods of fluidic sample processing  
The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care...
8877518 Multiplexed nanoscale electrochemical sensors for multi-analyte detection  
Provided are nanoscale devices suitable for multiplexed, parallel detection of multiple analytes and methods for fabricating such devices.
8871527 Method and system for measuring a sample to determine the presence of and optionally treat a pathologic condition  
The present invention provides diagnostic in vitro methods as well as kits and devices to be used in the methods of the present invention for diagnosis or prognosis of a pathologic condition...
8859268 Quantitative multiplex detection of pathogen biomarkers  
The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid...
8845981 Biologic fluid analysis cartridge with volumetric sample metering  
A device for volumetric metering a liquid biologic sample is provided. The device includes an initial chamber, a second chamber, a third chamber, a first valve, a second valve and a third valve....
8841119 Sensor for fast detection of E-coli  
A method of fabricating biochip sensor comprising providing a precursor; depositing the precursor on a substrate to form a coating; and rapid melting/quenching treatment of the coating with an...
8841137 Hybrid target analyte responsive polymer sensor with optical amplification  
Disclosed is a product that includes an optical sensor; a target-responsive hydrogel matrix on a surface of the optical sensor (where the hydrogel matrix comprises one or more target-specific...
8835185 Target substance-detecting element  
A substrate of a target substance-detecting element for detecting a target substance in a specimen based on localized surface plasmon resonance comprises a supporting member and a metal nano-dot...
8835182 Immunochromatographic device  
The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex...
8828713 Sensors using high electron mobility transistors  
Embodiments of the invention include sensors comprising high electron mobility transistors (HEMTs) with capture reagents on a gate region of the HEMTs. Example sensors include HEMTs with a thin...
8822168 Assays for detecting small nuclear ribonucleoprotein particle assembly and survival of motor neurons activity  
The present invention includes assays and kits for detecting the assembly of an RNA binding protein-RNA complex and for detecting the activity of an RNA binding protein.
8822231 Assay method and device  
A method for the analysis of at least two analytes in a liquid sample, in which a substrate is provided wherein at least two different types of capturing molecules are immobilized on the substrate...
8808626 Amperometric immunosensor  
An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an...
8809005 Conjugate and its use as a standard in an immunoassay  
A composition comprising a conjugate of an anti-idiotype antibody specifically binding to a CDR region of a parent antibody and method of using polyclonal human serum immunoglobulin of class E, G,...
8802447 Emissive compositions with internal standard and related techniques  
The present invention provides materials, devices, and methods related to determination of an analyte. In some embodiments, an analyte may be determined by monitoring, for example, a change in an...
8802024 Biochip and manufacturing method thereof  
A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first...
8802449 Microchips, kits, and methods for immunoassays  
An objective of the present invention is to provide immunoassay microchips in which microstructures of beads having a sufficient reaction area were constructed within microchannels while...
8796012 Grating-based evanescent field molecular sensor using a thin silicon waveguide layer  
A technique for high sensitivity evanescent field molecular sensing employs a detection scheme that simultaneously couples a polarized beam to a single mode of a waveguide, and couples the...
8796040 System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combination  
A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target...
8790934 Nanoparticles  
Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or...
8784749 Digital microfluidic manipulation device and manipulation method thereof  
This invention provides a digital microfluidic manipulation device and a manipulation method thereof. This device comprises a PDMS membrane having a surface comprising a plurality of hydrophobic...
8765484 Optically encoded particles  
The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film...
8753872 Method and apparatus for assay for multiple analytes  
A method and apparatus for assay of multiple analytes. The method uses a sensing element comprising a substrate upon which is arranged a multiplicity of recognition elements, such that each...
8753893 Multi-dimensional fluid sensors and related detectors and methods  
The present invention provides multi-dimensional sensors with fluidic flow channels for processing fluid samples.