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7622108 |
Multi-lineage progenitor cells
Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described.
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7618587 |
Analyzers and methods of analyzing blood
Analyzers and methods of analysis are described for performing blood cell counting and immunoassay on a whole blood specimen in one measurement section. An assay sample is prepared by blending...
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7615381 |
Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device
Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is...
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7611908 |
Method and apparatus for therapeutic drug monitoring using an acoustic device
Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the...
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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7611849 |
Enhanced cellular assay method for use in flow cytometry or similar instruments using optically resonant particles
This invention relates to the field of biological assays where cells can be classified and enumerated using flow cytometry optical instrumentation. The invention combines information from...
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7604946 |
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in...
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7598093 |
Nanoparticle and microparticle based detection of cellular products
Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic...
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7597960 |
Functional infrared fluorescent particle
An infrared fluorescent particle comprising a functional group or a substance that is capable of binding to an analyte, wherein fluorescence at infrared wavelength is emitted from the particle upon...
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7592186 |
Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin A complexes in a blood sample
The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs...
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7585641 |
Immunoassay and method of use
A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The...
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7579195 |
Simple membrane assay method and kit
The present invention is to provide a simple membrane assay method for detecting or quantitating an analyte in a specimen sample using an assay device equipped with a membrane bound with a...
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7569399 |
Multiplex flow assays preferably with magnetic particles as solid phase
Heterogeneous assays for different analytes in a single biological sample are performed simultaneously in a multiplexed assay that combines flow cytometry with the use of magnetic particles as the...
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7569398 |
Methods and devices for transporting and concentrating an analyte present in a sample
The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these...
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7569358 |
Doxorubicin immunoassay
Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are...
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7547557 |
Directed-flow assay device
A diagnostic assay device that directs an applied sample to the analytical membrane of a directed flow device. The device has a sample receiving port defined by layers of built-up material on one...
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7507588 |
Multiplex microparticle system
Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein...
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7494824 |
Interactive system for presenting and eliminating substances
An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance...
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7491553 |
Homogeneous immunoassays for multiple allergens
A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling...
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7491552 |
Fluid based analysis of multiple analytes by a sensor array
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
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7488608 |
Reduction of non-specific binding in assays
Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding...
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7459281 |
Docetaxel immunoassay
Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in...
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7455980 |
Method for characterizing autoimmune disorders
The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is...
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7438854 |
Biomolecule substrate, and test and diagnosis methods and apparatuses using the same
A test apparatus is for testing a DNA substrate on which a plurality of DNA fragments for testing are arranged, wherein absolute precision is not required. A substrate is provided on which a...
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7432105 |
Self-calibration system for a magnetic binding assay
A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay...
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7432046 |
Methods for the determination of antibody IgG avidity
The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay...
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7399644 |
Immunoassay, reagent for immunoassay, and production method of the same
An assay method for determining presence of a target antibody or antigen in a specimen qualitatively or quantitatively by mixing the specimen with an antigen or antibody immunologically reactive...
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7393697 |
Diagnostic test for analytes in a sample
Diagnostic devices and methods are provided. The diagnostic devices preferably comprise a test strip with a test area. The sample to be analyzed contacts the test area, which comprises a specific...
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7358097 |
Making a matrix of random encoded arrays
Disclosed is an apparatus and method of maintaining chips or arrays of particles, or arrays of particles deposited on chip surfaces, in a designated area on a substrate surface. This is...
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7344895 |
Production and use of in situ-modified nanoparticles
A process for synthesizing nanoparticles, in particular metal salt nanoparticles. To the synthesis mixture is added a modifying reagent which binds, by means of a first functional group, to the...
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7338812 |
Biochemical labeling materials and manufacturing method thereof
A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular...
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7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
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7332344 |
Luminescence assays
A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor...
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7326579 |
Immunoassay method for lyzed whole blood
The present invention provides an immunoassay method in which blood can be measured even without pretreatment by means of a centrifuge etc. In the present invention, antibodies or antigens in a...
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7316932 |
Method for separating cells
The present invention is related to a method for separating a first population of cells from a second population of cells in a sample by discontinuous density gradient separation using dense...
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7297554 |
Immunoassay system
A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay...
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7279340 |
Synthesis and application of procainamide analogs for use in an immunoassay
The present invention relates to immobilized procainamide analogs, as well as to a method of making immobilized procainamide analogs. These immobilized analogs are prepared by activating the...
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7279339 |
Reagent for an immunoassay
The present invention relates to (1) A reagent for an immunoassay of a target substance existing in a free form and a bound form in a specimen, comprising a latex 1 which is immobilized with a...
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7247489 |
Ion-detecting microspheres and methods of use thereof
This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In...
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7241630 |
Paramagnetic particle detection
A method of determining the number of magnetic particles within a sample using a tuned circuit having a capacitor and a coil. The method comprises:
a. determining the difference in the...
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7235361 |
Biological applications of quantum dots
The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein...
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7232691 |
Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the...
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7229842 |
Metal chelate containing compositions for use in chemiluminescent assays
Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a...
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7217561 |
Method for the controlled transport of magnetic beads
The present invention is related to a method for controlled transport of magnetic beads between a position X and different position Y, such that the magnetic beads are manipulated or transported by...
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7217518 |
Fluorescence polarization assay
The present invention relates to methods for detecting the presence of one or more analytes of interest in a sample by measuring changes in fluorescence anisotropy as a result of binding of the...
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7192786 |
Biospecific assay method
This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled...
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7175993 |
Taxol immunoassay
Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for...
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7172804 |
Film-immobilized capture particles
The present invention relates to film-immobilized capture particles, and substrates coated with film-immobilized capture particles. In particular, the present invention provides microarrays for...
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7160723 |
Cell separation compositions and methods
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even...
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7153681 |
Assay reagents and devices
A reagent useful in immunoassays, comprising a direct particulate level co-sensitised with a specific binding agent having specificity for an analyte or analyte analogue and with a non-specific...
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