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5561070 |
Methods for preparing phospholipid coated particles and for eliciting or isolating antiphospholid antibodies and the particles
The invention provides phospholipid coated particles capable of specifically binding antiphospholipid antibodies and a method for preparing such particles. Methods are also provided for determining...
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5552268 |
Method for measuring total body tissue iron stores
A non-invasive method to measure total body tissue iron stores comprising recovering iron released from total ferritin contained in a body fluid sample derived from a host, measuring the...
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5541117 |
Immunological method for the determination of a haemoglobin derivative
The invention concerns a method for the determination of the content of a particular haemoglobin derivative in a blood sample. In particular, the invention concerns a method for the determination...
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5525525 |
Immuno-latex chromatographic procedure for detection of ciguatoxin, and related polyether marine toxins
An antibody test suitable for the rapid detection of ciguatoxin and other related low molecular weight polyether marine lipid toxins in fish tissue in the field or laboratory is disclosed. The test...
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5521102 |
Controlled sensitivity immunochromatographic assay
An improved one-step immunochromatographic assay which involves the binding of a predetermined amount of analyte to an antibody, enabling the control of the assay sensitivity, is disclosed. The...
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5518887 |
Immunoassays empolying generic anti-hapten antibodies and materials for use therein
The present invention relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of generic anti-hapten antibodies. Also disclosed are multi-analyte...
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5501949 |
Particle bound binding component immunoassay
An immunoassay method for the detection or quantitation of an analyte suspected of being in a solution comprising: (a) combining said specimen, a first binding component, insoluble particles, and...
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5494830 |
Methods for performing determinations of immune reactants in biological fluids
Apparatus for performing determinations of immune reactants (e.g., antigens, antibodies) in bodily fluids includes multiple test units having respective elongated rods with transversely-expanded...
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5489537 |
Agglutination assays and kits employing colloidal dyes
The present invention provides methods and kits for determining the presence or amount of a substance by detection of a colloidal dye associated with agglutinated particles. The disclosure of the...
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5486479 |
Buffer for immunoassay, kit including same and immunoassay method using said buffer
The invention relates to immunoassay reagents that are both sensitive and specific and which require no sample pretreatment. The invention reagents are particularly useful for assaying digoxin...
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5484894 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** Macromolecular microparticles and method of production
A macromolecular microparticle composition formed by dehydrating an aqueous macromolecule solution and crosslinking the dehydrated macromolecules with a crosslinking agent while in a liquid phase...
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5462991 |
Immobilization of pH-sensitive dyes to solid supports
Disclosed are pH dyes containing a suitable compatible substituent which permits binding of the dye to a solid support. Also disclosed are methods for synthesizing such dyes prior to their coupling...
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5460979 |
Indirect fluorescent assay of blood samples
A patient's health is diagnosed by centrifuging blood samples in a transparent tube, which tube contains one or more groups of particles such as lyposomes or plastic beads of different densities...
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5451505 |
Methods for tagging and tracing materials with nucleic acids
The present invention provides methods for tagging and tracing materials using nucleic acids as taggants. The process of tagging involves altering a substance in a manner that allows for the...
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5451504 |
Method and device for detecting the presence of analyte in a sample
An assay provides for detecting the presence of an analyte in a sample. Sample is applied to move through three zones. A mobilizeable receptor capable of binding to the analyte is present in the...
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5447837 |
Multi-immunoassay diagnostic system for antigens or antibodies or both
The present invention provides a test strip for detecting, in a sample from a human subject, the presence of an antigenic substance which comprises a solid support, an antibody directed against the...
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5439830 |
Method of performing at immunoassay using photothermal deflection spectroscopy
In an immunoassay for determining the amount of a target substance in a sample using photothermal deflection spectroscopy to determine the amount of bound label, a sandwich procedure is used which...
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5429925 |
Method for immunodiagnostic detection of dioxins at low concentrations
A method is described for the use of monoclonal antibodies in a sensitive immunoassay for halogenated dioxins and dibenzofurans in industrial samples which contain impurities. Appropriate sample...
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5405784 |
Agglutination method for the determination of multiple ligands
The invention provides a method capable of determining the presence or absence of each of a plurality of different ligands in a specimen. The specimen is contacted with a predetermined number of...
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5397695 |
Attachment of compounds to polymeric particles using carbamoylonium compounds and a kit containing same
Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl...
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5395754 |
Membrane-based immunoassay method
The present invention is directed to a membrane-based immunoassay method for an analyte of interest having at least two sterically separate antigenic sites. The method comprises providing a...
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5374531 |
Immunoassay for determination of cells
Methods and test kits are provided for the quantitative or qualitative determination of selected analytes, e.g., cell subsets in a mixed cell population, using a particulate separation reagent and...
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5372948 |
Assay and reaction vessel with a compartmentalized solubilization chamber
Disclosed are a method and device for performing sequential analytical reactions involving a first dry reagent and a second dry reagent comprised of two or more components having different rates of...
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5369036 |
Enhancement of signal in immunoassays using microparticles which contain different detectable substances
A process for assaying at least one analyte uses a tracer which includes multiple detectable substances. A tracer composition includes at least one ligand labeled with a particulate label, the...
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5369037 |
Simultaneous multiple assays
A particle agglutination-based, stable kinetic method for simultaneously determining the concentrations of multiple analytes in a single fluid sample with the addition of a single reagent, that...
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5356782 |
Analytical test apparatus with on board negative and positive control
The invention is an apparatus useful in carrying out an analytical assay. The apparatus has a positive and negative control, as well as a site for determining the presence, amount, or lack of an...
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5342790 |
Apparatus for indirect fluorescent assay of blood samples
A patient's health is diagnosed by centrifuging blood samples in a transparent tube, which tube contains one or more groups of particles such as lyposomes or plastic beads of different densities...
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5330891 |
Method for detection of a nucleic acid using particulate reagent having polyoxyalkylene side chains
Biologically active reagents are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are...
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5294370 |
Selenium or tellurium elemental hydrosols and their preparation
The invention relates to a process for the preparation of a sol of a metallic or a non-metallic element, such as selenium, tellurium, gold and silver, wherein said process comprises the reduction...
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5290707 |
Method for detection of microorganisms
A microorganism detection system provides initial warning, confirmation of dentity, and recognition of pathogenic factors in microorganisms from environmental samples. The method and apparatus of...
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5284948 |
Drug hapten analogues for immunoassays
The invention is directed to new drug hapten analogues comprising: (A) an active ester group; (B) a drug hapten nucleus selected from a hydantoin nucleus or a barbiturate nucleus and (C) a...
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5270166 |
Immunoassays employing generic anti-hapten antibodies and materials for use therein
The present invention relates to immunoassay methods for detecting and measuring the amount of an analyte in a sample by means of generic anti-hapten antibodies. Also disclosed are multi-analyte...
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5242804 |
Simultaneous dual analyte assay
A simultaneous dual analyte assay for determining the fertile period of the human menstrual cycle. The assay utilizes a capture reaction component consisting of P-3-G immobilized on a microporous...
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5238652 |
Analytical test devices for competition assay for drugs of non-protein antigens using immunochromatographic techniques
An analytical test device for competition assay for particular non-protein antigens, such as antigens representing drugs of abuse, is disclosed. The analytical test device is a test kit housing...
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5236849 |
Method of high sensitivity immunoassay
A method of high sensitivity immunoassay characterized by inclusion of processes (A), (B), (C) and (D) described below. Process (A): A process of binding of a solid carrier and a complex...
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5231035 |
Latex agglutination assay
Methods for determining the presence of a first ligand, preferably a hapten, in a sample suspected to contain the first ligand are provided, along with reagent systems and apparatus suitable for...
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5229268 |
Method for diagnostic immunoassay by solid phase separation
A method for performing a diagnostic immunoassay by a solid phase separation. To a reaction mixture of a test sample and labeled antibody, which forms a complex of any analyte present in the test...
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5206086 |
Particle-stabilized epitopes for standardization and control of immunoassays
The invention relates to a process for preparing standards and controls for immunoassays employing monoclonal antibodies. Monoclonal antibodies are used to isolate a restricted portion of an...
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5202269 |
Method for immunochemical determination of hapten
A method for immunochemical determination of a hapten in a sample is disclosed, in which (A) a high-molecular compound to which the hapten is bound (reagent A), (B) insoluble carrier...
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5200315 |
Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent
Biologically active reactive are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are...
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5196349 |
Immunoassays for thyroid hormones using thyroglobulin
Immunoassays for measuring thyroid hormones such as thyroxine(T 4 ) and triiodothyronine(T 3 ) are carried out by incubating a serum sample with either (a) unlabeled thyroglobulin and a labeled...
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5162863 |
Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
In a method and an apparatus wherein carriers sensitized by an antibody or an antigen are caused to react to a specimen sample and the condensation of the carriers caused by the antigen-antibody...
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5162237 |
Reaction cassette for preforming sequential analytical assays by noncentrifugal and noncapillary manipulations
Analytical reaction cassette and method for performing sequential analytical assay procedures to determine the amount of an analyte in a liquid test mixture. The reaction cassette can be in the...
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5154887 |
Phenalenimine fluorescent dyes and their use in analytical compositions, elements and methods
Certain phenalenimine fluorescent compounds represented by the structure ##STR1## wherein R' and R" are independently hydrogen, alkyl, cycloalkyl, aryl or a heterocycle, or R' comprises the carbon...
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5145784 |
Double capture assay method employing a capillary flow device
A capillary flow device useful in double capture assays, such as double capture immunoassays, and a double capture assay. The capillary flow device comprises a capillary track, a sample receptacle,...
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5132206 |
Fluorescent pigments for tagging biological molecules
A general method of assay for biological molecules using daylight fluorescent particles. The method described is applicable to assays involving immunological reagents, nucleic acids, hormones and...
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5106963 |
Phospholipid conjugates and their preparation
Phospholipid conjugate compounds derived from cardiac glycosides and sters useful in liposome immunoassays are disclosed as well as their method of preparation.
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5102788 |
Immunoassay including lyophilized reactant mixture
A lyophilized mixture of reactants for an immunoassay includes antibody-gold sol particle conjugates, antibody latex particle conjugates, polyethylene glycol, a polyethylene glycol p-isooctylphenyl...
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5075215 |
Use of daylight fluorescent pigments for tagging biological molecules
A general method of assay for biological molecules using daylight fluorescent particles. The method described is applicable to assays involving immunological reagents, nucleic acids, hormones and...
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5071774 |
Multiparameter particle analysis
A method for determining the presence of a specific binding member bound to first particles in a liquid medium is disclosed. The method comprises providing in combination (1) a liquid medium...
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