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7618792 |
Multiplexed detection of anti-red cell alloantibodies
Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events...
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7611849 |
Enhanced cellular assay method for use in flow cytometry or similar instruments using optically resonant particles
This invention relates to the field of biological assays where cells can be classified and enumerated using flow cytometry optical instrumentation. The invention combines information from...
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7588905 |
Identification and monitoring of systemic lupus erythematosus
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
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7585640 |
Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
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7584019 |
Systems and methods for the automated pre-treatment and processing of biological samples
Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus. In some embodiments, the actions of a...
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7547557 |
Directed-flow assay device
A diagnostic assay device that directs an applied sample to the analytical membrane of a directed flow device. The device has a sample receiving port defined by layers of built-up material on one...
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7449329 |
Blood test kit
A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to...
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7390631 |
Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma
Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d...
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7300804 |
Method and apparatus for controlling the uniform smearing of a biological liquid over a substrate
A method and apparatus for controlling the processing of a liquid sample, e.g., a blood sample, based on a measurement related to the sample's ability to coat a surface against which the sample is...
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7247501 |
Imaging and targeting tumors using sickle cells
According to the present invention, there is provided a delivery vehicle including sickle red blood cells carrying a moiety. The moiety can be any type of diagnostic or therapeutic agent. The...
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7160686 |
Method for producing a specific antiserum against the universal tumorous antigen and method for diagnosing malignant tumours using said antiserum
The present invention pertains to the field of medicine and may be used for producing a specific antiserum as well as for carrying out immunological diagnoses of malignant tumours. This method for...
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7060453 |
Method and kit for the determination of analyte concentration in blood
A method is provided for determining the level of an analyte in the blood of an individual based on determination of the level of the same analyte in non-blood sample (e.g. urine, saliva and hair)...
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7022529 |
Particles for diagnostic and therapeutic use
Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the...
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6955889 |
Simultaneous determination of forward and reverse ABO blood group
Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be...
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6878811 |
Substance with antithrombotic activity and method for detecting glycokallidin
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a...
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6858439 |
Compositions and methods for separation of moieties on chips
The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable,...
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6830895 |
Method and kit for typing feline blood
The present invention relates to a kit for determining feline blood type, wherein the kit includes a mixture comprised of a first monoclonal antibody and a second monoclonal antibody, wherein both...
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6825000 |
Immunoassay reagent and immunoassay method
An immunoassay reagent is obtained whereby a microscale substance such as an antigen or antibody can be assayed at a high sensitivity, and whereby a need to separate a reacted substance, e.g., an...
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6821790 |
Methods and apparatus for separation of biological fluids
A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte...
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6686158 |
Electronically-indexed solid-phase assay for biomolecules
Disclosed are materials and methods for detecting biomolecules in samples employing transponders associated with the bead(s) used as the solid phase in the assay, and information pertinent to the...
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6677123 |
Process for detecting increased risk of fetal chromosomal abnormality
An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating α-fetoproteins present in the body fluid of a pregnant woman,...
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6673629 |
Neutralization of polycations in a chromatographic device for whole blood use
A chromatography assay device and method for use with whole blood samples utilizing a red blood cell separating agent to aggregate red blood cells and permit plasma or serum to flow by capillary...
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6627404 |
Methods for improving the recovery of troponin I and T in membranes, filters and vessels
A method to facilitate recovery troponin I and/or troponin T from a sample comprising addition of troponin C to the sample or to a surface from which the troponin I and/or troponin T are recovered.
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6544751 |
Methods of harvesting rare cells from blood products
The present invention provides methods of harvesting rare cells from blood products and/or obtaining products of the rare cells. The method includes contacting a blood product containing rare cells...
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6534279 |
Reagent and method for the permeabilization and identification of erythrocytes
A process for permeabilizing erythrocytes in which the erythrocytes are subjected successively to the action of (a) a fixing agent containing an aliphatic aldehyde and oligosaccharide, (b) a...
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6475748 |
Method for differentiating human peripheral blood granulocytes
Disclosed is a method for differentiating human peripheral blood granulocytes which comprises cultivating the granulocytes in the presence of an interferon and acting an immune complex on said...
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6331395 |
Prenatal diagnostic methods
A method of identifying embryonic or fetal red blood cells in a sample containiing maternal blood cells and embryonic or fetal red blood cells or both, the method comprising determining which cell...
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6303390 |
Method for antigen and antibody determination in bloodgroup serology
Method and test kit for assaying in a sample an analyte which is a bloodgroup antigen present on erythrocytes or an antibody binding to such a bloodgroup antigen. To that end, the sample is treated...
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6291249 |
Method using an apparatus for separation of biological fluids
A cell containing sample is separated into a cell containing portion and a substantially cell depleted portion, by mixing the sample with particles to produce a cell containing network, and...
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6284459 |
Solid support matrices with memories and combinatorial libraries therefrom
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
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6258607 |
Indirect agglutination immunoassay and apparatus therefor
An indirect agglutination immunoassay includes the steps of providing, in a container, an immunoassay system comprising a test sample containing a desired analyte, and a reagent composed of...
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6219584 |
Method and system for determining an effective amount of light energy to delivery to fluids having targets for the light energy
Systems and methods for determining an effective amount of light energy to deliver to fluids, particularly fluids having target and non-target materials. The systems and methods specifically relate...
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6204068 |
Biospecific assay method
This invention is thus related to a biospecific multiparameter assay employing single molecule detection. In particular, this invention is related to a new method for determination of several...
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6184011 |
Method of releasing solid matrix affinity adsorbed particulates
A method of releasing particulates from a solid matrix is provided. The method is effected adding to the solid matrix a degrading enzyme capable of degrading the solid matrix, to thereby release...
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6143575 |
Heterogeneous immunoassay using a precipitable solid phase
The invention relates to a method for carrying out heterogeneous immunoassays, in particular to a method for separating a coated solid phase from a liquid phase by means of precipitation and...
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6132981 |
Method for detecting a mammal's prior exposure to radiation or radiomimetic agents
The present invention is directed to a method for detecting a mammal's prior exposure to radiation or radiomimetic agents. Labeled antibodies are employed to determine the quantity of transferrin...
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6114179 |
Method and test kit for detecting antigens and/or antibodies
A suspension of inert particles is prepared in an aqueous solution, to which an antibody or an antigen and a carrier-bound antigen or antibody, respectively, are added in any desired order. After...
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6046003 |
Method of determining the sequence of nucleic acids employing solid-phase particles carrying transponders
A method is described for determining the sequence of nucleic acids. The method employs small solid phase particles having transponders, with a primary layer of an oligonucleotide of known sequence...
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6001579 |
Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of...
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5968736 |
Methods for recording the reaction history of a solid support
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of...
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5863802 |
Method and test kit detecting antigens and/or antibodies
A suspension of inert particles is prepared in an aqueous solution, to which an antibody or an antigen and a carrier-bound antigen or antibody, respectively, are needed in any desired order. After...
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5856113 |
Antigen and method for measuring anti-erythrocyte antibody
Fragments of cell membrane of erythrocyte are used as an antigen for insolubilization in enzyme immunoassay to provide a highly sensitive, excellent quantitative method for measuring...
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5846748 |
Method for diagnosing visceral leishmaniasis in a patient by identification of a new key marker namely 9-O-acetylated sialoglycoconjugate
This invention relates to identification of a new key marker namely 9-O-Acetylated sialoglycoconjugate with the help of a known 9-O acetylsialic acid binding lectin, Achatinin-H useful for the...
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5840588 |
Agglutination inhibition assay methods and reagents for psychoactive substances
Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these...
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5800983 |
Peptides for HIV-1 detection
HIV-1 peptides having at least one point mutation between position 593 and 611 of the HIV-1 gp160 amino acid sequence. The point mutation either is at position 604 or 610, or both positions....
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5798276 |
Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
The invention describes reactive dyes having an alkyl spacer attached via a sulfonamide bond to a sulforhodamine 101 fluorophore, and a variety of useful conjugates prepared therefrom. The...
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5773222 |
Solid phase immunological assay
A solid phase method of detection or assay of the presence or amount in a serum or plasma sample of a target antibody specific to a cell surface antigen. The sample is contacted with an immobilised...
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5770460 |
One-step lateral flow nonbibulous assay
A particularly efficient design for a nonbibulous lateral flow one step assay for an analyte in a biological sample is disclosed. In the improved device of the invention, three zones which are in...
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5764792 |
Method and apparatus for processing images
A method and apparatus for detecting rare cells in a biological sample is disclosed. A color image of the sample is generated and the color image is decomposed into its color components. A first...
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5723293 |
Diagnostic method and kit for determining Rh blood group genotype
The invention provides a diagnostic method of determining Rh genotypes by the identification of the molecular basis of Rh polymorphisms. Specifically, the invention provides a method for directly...
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