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8409568 |
Mutant antibody Fc domains and fusion proteins thereof
The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention...
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8404820 |
Human monoclonal antibodies against Bacillus anthracis protective antigen
Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable...
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8383350 |
Assay for detection of IL-10 antibodies
Provided are assays to measure the presence and quantity of an antibody of interest in a patient's bloodstream or other biological sample. ECL and ELISA methods, and kits for such assays, as well...
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8367356 |
Gelsolin binding agent compositions and uses of same
The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination,...
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8349611 |
Resonant sensors and methods of use thereof for the determination of analytes
Resonant sensors, preferably having floating bilayer symmetry, and their methods of use is determining the presence, amount or binding kinetics of an analyte of interest in a test sample are...
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8329475 |
Wash process for removing undesired components in samples being analyzed
A method for removing undesired component(s) from bound desired component(s) in an analysis including: (a) providing a container having a desired component bound thereto and an undesired component;...
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8293716 |
Method of treating cancer by modulation of mortalin
A method of treating cancer in a subject in need thereof is disclosed. The method comprises administering to the subject a siRNA molecule capable of inducing degradation of an mRNA encoding a...
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8293542 |
Real time binding analysis of antigens on a biosensor surface
The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors.
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8277808 |
Mucosal vascular addressins and uses thereof
The present invention relates to isolated antibodies and antigen-binding fragments thereof that bind naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM comprises a...
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8268637 |
Label-free biosensors based upon distributed feedback laser
A biosensor based upon a vertically emitting, distributed feedback (DFB) laser is disclosed. In one configuration, the DFB laser comprises a replica-molded, one- or two-dimensional dielectric...
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8263356 |
Antibodies and methods for predicting dental caries
The present invention relates to antibodies, binding portions thereof, or probes that bind specifically to glucosyltransferase enzymes, and uses of these agents for detecting glucosyltransferase...
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8247188 |
FAS binding antibodies
The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices...
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8241883 |
High throughput mobility shift
The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the...
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8183056 |
Assay
A method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin metabolism, comprising (a) determining the level of...
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8183059 |
Device for detection of target molecules and uses thereof
Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
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8182855 |
Fish food containing fermented soyfood
The present invention relates to an enriched fish food product comprising a binder resin and a fermented soy nutraceutical. Optionally the nutraceutical may contain enzymes or coenzymes. Also, the...
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8178358 |
Serpine2 as a biomarker for IgA nephropathy
The present invention provides a method for diagnosis or prognosis of IgA nephropathy in a subject based on detection of the expression level of one or more biomarker genes selected from the group...
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8173372 |
Methods of donor specific crossmatching
The detection of endothelial cell antibodies has been proven clinically important for successful organ transplantation. Disclosed are methods of isolating Tie-2+ and CD34− precursor endothelial c...
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8173130 |
Antibodies against flagellin and uses thereof
The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including,...
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8148170 |
Immunosensors: scFv-linker design for surface immobilization
An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged...
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8114617 |
Method for quantifying phosphokinase activity on proteins
The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those...
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8114967 |
Constructs and libraries comprising antibody surrogate light chain sequences
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally...
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8093010 |
Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these...
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8093012 |
Multiplex in situ immunohistochemical analysis
A method of in situ immunohistochemical analysis of a biological sample is provided. The method allows for the multiplex and simultaneous detection of multiple antigens, including multiple nuclear...
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8084272 |
Amelioration of heterophile antibody immunosensor interference
The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the...
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8053226 |
Device and method for simultaneously identifying blood group antigens
The invention relates to a device for simultaneously, qualitatively or quantitatively identifying a number of analytes in a liquid sample. The device comprises a membrane with: a charging zone for...
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8048414 |
Antivenom composition containing Fab fragments
F(ab) fragments are isolated from an antibody containing source by contacting the antibody containing source with a papain-polyacrylamide matrix to produce F(ab) and F(c) fragments which are then...
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8039273 |
β-glucuronide-linker drug conjugates
Ligand Drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided.
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8012762 |
Test device, and related methods
Test device for detection and visual indication of a specific analyte in a liquid sample such as a body fluid. The device includes a biodegradable housing, a test strip and a lid. The device is...
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8012770 |
Device for detection of antigens and uses thereof
Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.
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7993865 |
Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen
The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA...
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7994291 |
Human E3α ubiquitin ligase family
The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, ...
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7993867 |
Diagnosis, prevention and treatment of crohn's disease using the OmpC antigen
The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA...
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7993866 |
Diagnosis, prevention and treatment of crohn's disease using the OmpC antigen
The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA...
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7968283 |
Gene expressed in prostate cancer
A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety...
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7939282 |
Methods for detecting sepsis
Compositions and methods for detecting sepsis by contacting a subject-derived sample with a ligand that binds to GRK and determining the concentration of GRK in the sample. An increase in the...
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7935520 |
Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7932048 |
Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody
The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, ...
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7919255 |
Assessment of skeletal growth using measurements of NT-CNP peptides
A means of measuring and monitoring skeletal growth rate using a plasma analyte, amino-terminal C-type natriuretic peptide (NT-CNP). Plasma NT-CNP concentrations reflect the potential for further...
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7910381 |
Immuno gold lateral flow assay
A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with...
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7888050 |
Method for quantifying phosphokinase activity on proteins
The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those...
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7888134 |
Immunosensors: scFv-linker design for surface immobilization
An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged...
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7879612 |
Organic non-sugar compounds for protection of biologically active molecules and conjugate labels and methods of use thereof
Provided are methods comprising the use of non-sugar organic compatible solutes for protection and preservation of the activity of biologically active molecules and conjugate labels. The methods...
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7875434 |
Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional...
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7858760 |
Antibodies to protein expressed in prostate cancer
A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on...
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7846744 |
Methods of identifying anti-inflammatory compounds
A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing IVIG-related reversal of inflammation associated with various immune...
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7833731 |
Gold-binding protein and use thereof
A protein utilizing an anti-gold antibody and a gold-binding side which is a part of the anti-gold antibody is constructed. This protein is capable of specifically binding to gold. This protein or...
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7829347 |
Diagnostic test kits with improved detection accuracy
A diagnostic test kit that provides an integrated system for accurately detecting a test analyte over a broad range of possible concentrations is provided. One feature of the integrated system is...
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7803554 |
Detection of binding factors with fluorescence polarization
This invention relates to a simple and quick method for the detection, identification and/or quantitation of binding factors using fluorescence techniques. A fluorescent probe is incubated with a...
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7794970 |
Method for generating F(ab′)2 antibody fragments
Methods for generating F(ab′)2 fragments from antibodies using thermolysin as well as F(ab′)2 fragments and compositions comprising F(ab′)2 fragments generated by the method are described.
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