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7608681 |
Methods and compositions for prolonging elimination half-times of bioactive compounds
Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may...
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7205382 |
Peptides, the production and use thereof for binding immunoglobulins
Peptides having the following amino acid sequence as well as peptides or proteins which contain this amino acid sequence:
R 1...
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6951716 |
Anti-platelet immunoglobulin bead positive control
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one...
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6933106 |
Platelet immunoglobulin bead suspension and flow cytometry
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one...
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6890720 |
Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis
The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of...
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6858438 |
Peptides immunoreactive with autoantibodies from patients with rheumatoid arthritis
The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The...
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6638723 |
Method for diagnosing autoimmune diseases
A method of diagnosing an autoimmune disease is disclosed which involves determining whether autoantibodies from a body fluid react with a microtubule organizing center (MTOC). This diagnostic...
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6489129 |
Antigen-specific IgM detection
The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in...
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6372715 |
Use of erythropoientin and iron preparations for producing pharmaceutical combination preparations for treating rheumatic diseases
The present invention is concerned with the use of individual administration forms of an erythropoietin preparation and a physiologically compatible iron preparation corresponding to an equivalent...
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6303325 |
Method for detecting analytes
The invention relates to methods of determining the presence or amount of an analyte in a sample suspected of containing the analyte, said method comprising the steps of: (a) bringing together in...
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6225442 |
Method of detecting autoantibody present in the serum of rheumatic
A reagent for immunologically detecting rheumatism containing as an antigen at least one mammalian protein selected from among ezrin, radixin and moesin and/or a peptide composed of at least nine...
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6159748 |
Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and labelled antibodies, to simultaneously detect the presence and amount of several antigens...
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6100098 |
Anti-AGE IgG and uses thereof for the diagnosis of severe disease
The present invention relates to the diagnosis of severe diseases based on the determination of the presence of AGE-IgG autoantibodies in patients and to a method of treatment thereof. More...
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5989922 |
Method for determining rheumatoid factors and agents for carrying out the method
The invention relates to an immunochemical method for the detection and determination of rheumatoid factors using immune complexes as specific binding partners as well as to the preparation of...
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5965378 |
Antibody class-specific interference eliminating reagent
The invention concerns a composition composed of several different antibodies or/and antibody fragments which is suitable as a reagent to reduce interferences in an immunological method for the...
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5888833 |
Antigens recognized by antibodies to rheumatoid arthritis, their preparation and their applications
The present invention relates to antigens extracted from mammalian malpighian epithelia, in particular rat esophageal epithelium or human epidermis, which are specifically recognized by the...
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5846532 |
Method and composition for the treatment of disorders involving immunological dysfunction
A method and composition are provided for treatment of disorders involving immunological dysfunction. The invention comprises the administration of a low level of ribonucleotide polymerase protein...
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5834215 |
Method for detecting antipolymer antibodies and diagnosing silicone related disease (SRD) fibromyalgia and chronic fatigue syndrome (CFS)
The present invention provides for a method of detecting antipolymer antibodies, and a method for detecting silicone related disease, fibromyalgia, and chronic fatigue syndrome.
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5831037 |
Method for clinical examination based on the structures of immunoglobin G-linked oligosaccharides
The present invention relates to a novel clinical examination method which comprises analyzing the alteration in the amount of a specific component in oligosaccharides of immunogloblin G. Human...
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5804391 |
Elimination of rheumatoid factor interference using anti-FD antibodies
The invention concerns the use of a composition which is composed of several different antibodies or/and antibody fragments which serves as a reagent to eliminate rheumatoid factor interference in...
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5786154 |
Human phospholipase activating protein and methods for diagnosis of rheumatoid arthritis
The invention provides methods for detecting elevated levels of phospholipase A 2 activating protein in persons suspected of having rheumatoid arthritis to thereby indicate the presence of...
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5776708 |
Method for identifying T cells involved in autoimmune disease
The invention relates to a method for identifying T cell populations involved in autoimmune diseases. This involves determining levels of a Vβ element in a body fluid sample of a patient and...
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5747266 |
Assay and method for determining newborn risk for sudden infant death syndrome
An assay and method for screening newborns to determine risk of Sudden Infant Syndrome is described. The assay and method is based on the detection of elevated IgM-anti-IgG (MAG) levels in...
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5698393 |
Method for elimination of rheumatoid factor interference in diagnostic assays
A method for treating biological samples, e.g., human sera or plasma, suspected of containing rheumatoid factors to eliminate cross-reactivity and false positive assay results in IgM immunoassays...
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5620859 |
Method to aid in the diagnosis of silicone related disease
A process to aid in the diagnosis of silicone related disease in which a correlation between silicone related disease and the presence of antibodies that bind to partially polymerized acrylamide is...
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5556745 |
Method for the detection and quantitative determination of antigen in a test sample containing immune complexes of antigen bound to antibodies and to rheumatoid factors
The invention is a simple and rapid method for immune complex dissociation and destruction of rheumatoid factors. It permits the quantitative measurement of the total, i.e., free and immune...
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5496520 |
Rotary fluid manipulator
A rotary fluid manipulator utilizable as a diagnostic device includes a porous body having fluid passages defined therein by fluid blocking means in the porosities of the body such as openings or...
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5486452 |
Devices and kits for immunological analysis
New devices and kits for solid-phase immuno-assays comprising a solid porous support, preferably in the form of a sheet, where antigens or immuno-globulins or both of them are bound by direct...
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5472849 |
Method for detecting inflammation
A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of...
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5466611 |
Method for the determination of antigens or antibodies in the presence of an immune complex
The invention relates to a latex agglutination method for the detection or determination of one partner of an antigen-antibody reaction, wherein, in order to suppress non-specific reactions, to,...
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5378637 |
Method for measuring hyaluronic acid
A method for measuring hyaluronic acid in a biological sample which comprises (a) coating a solid support with hyaluronic acid; (b) incubating the sample with cartilage proteoglycan; (c) exposing...
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5354691 |
Polypeptides and derivatives thereof as well as their use in pharmaceutical and diagnostic compositions
A polypeptide having amino acid sequence 172-192 of a Mycobacterium bovis BCG 64 kD polypeptide, said sequence having the formula ##STR1## as well as polypeptides derived therefrom, in the amino...
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5340720 |
Methods of diagnosing and monitoring rheumatic diseases
Assays which aid in diagnosing systemic lupus erythematosus and rheumatoid arthritis are disclosed. One assay tests urine samples for the presence or absence of an RNA polymerase I antibody which...
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5298396 |
Method for identifying T cells disease involved in autoimmune disease
The invention relates to a method for identifying T cell populations involved in autoimmune diseases. This involves determining levels of a Vβ element in a body fluid sample of a patient and...
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5284750 |
Serum proteins related to autoimmune disease
A method for diagnosing a patient with an autoimmune disease using monoclonal antibodies to quantitate the amount of 680 kd, 54 kd, 44 kd or 14 kd present, wherein an elevated amount of protein...
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5258312 |
Serum proteins used to detect autoimmune disease
A method for diagnosing a patient with an autoimmune disease comprising assaying a blood sample from a patient for increased levels of the carbohydrate moieties of one or more proteins, said...
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5252461 |
Mixed immunoglobulins for detection of rheumatoid factors
Assays are provided for detecting the existence of active rheumatoid arthritis by detecting rheumatoid factor as a blood component which cross-links human IgG with sheep IgG. Particularly, an...
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5250442 |
Method of treating rheumatoid arthritis using tetracycline
A method of treating rheumatoid arthritis which includes first, taking a blood test to determine a rate of erythrocyte sedimentation and a rheumatoid factor, and then fasting for a 12-hour period...
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5223396 |
Method for detecting organ transplant rejection
A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of...
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5221628 |
Binding of aggregated immunoglobulin or immune complexes by serum amyloid P component
A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with serum amyloid P component ("SAP"). The invention also comprises methods of using SAP to detect or...
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5164374 |
Use of oligosaccharides for treatment of arthritis
A method for the treatment of arthritis or a related autoimmune disease that exhibits immune complexes in serum or synovial fluid is provided which comprises exposure of the serum or synovial fluid...
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5140103 |
Peptide fragments containing HP and LP cross-links
A method of determining collagen degradation in vivo, including quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a...
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5124250 |
Element for assaying rheumatoid factor quantitatively and method of assaying the same
An element for assaying a rheumatoid factor quantitatively in biosamples, comprising a polyalkyl methacrylate solid carrier and serum albumin immobilized thereon, the serum albumin being...
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5116766 |
Immune complex isolation
To diagnose diseases in patients, a protein complex, RhC, is prepared from horse serum by precipitating a white powder from the serum at a pH of 5.5 and processing to remove lipids at a pH of 8.2...
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5068177 |
Anti-idiotype antibodies induced by synthetic polypeptides
Chemically synthesized polypeptides containing about 6 to 40 amino acid residues and having amino acid residue sequences that substantially correspond to the primary amino acid residue sequences of...
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5061619 |
Immunoassay using antibody-antigen conjugates
A novel immunoassay techniques is provided which is useful in the detection and determination of antibodies to antigens. Antibodies of all classes to a given antigen or the specific subclass of...
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4925788 |
Immunoassay system and procedure based on precipitin-like interaction between immune complex and Clq or other non-immunospecific factor
A test system and procedure for quantitatively assaying biological material for a target immunological substance by means of immunochemical binding of immune complexes, comprising the target...
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4914041 |
Reagent and method for detecting rheumatoid factor
A reagent for use in immunoassays for rheumatoid factor (RF) is provided. The reagent contains heparin. Use of this reagent suppresses interference from the component Glq found in some test...
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4886743 |
Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof
This invention provides a reagent capable of binding to T cells and having specificity for a unique sequence within the variable region of the β chain of the T cell receptor, the presence of...
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4863850 |
Method for diagnosis of rheumatoid arthritis
A substantially pure rheumatoid arthritis specific protein (RASP) and an antibody against the rheumatoid arthritis specific protein (anti-RASP antibody) are disclosed. The RASP is found...
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