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7608681 |
Methods and compositions for prolonging elimination half-times of bioactive compounds
Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may...
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7598093 |
Nanoparticle and microparticle based detection of cellular products
Embodiments of the present invention relate to devices and methods for detecting cellular products using detection particles having product-specific detection reagents and having a characteristic...
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7592186 |
Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin A complexes in a blood sample
The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs...
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7588905 |
Identification and monitoring of systemic lupus erythematosus
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
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7585640 |
Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
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7462495 |
Methods and compositions for use in diagnosing and characterizing chronic immune disease
Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to...
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7410802 |
Methods for simultaneously detecting both members of a binding pair
Methods and kits for simultaneously measuring both members of a binding pair are described.
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7402403 |
Tumour markers
A method of determining the immune response of a mammal to circulating tumour marker proteins is described in which a sample of bodily fluid, for example plasma or serum, is contacted with a panel...
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7390631 |
Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma
Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d...
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7361480 |
Method and means for detecting gluten-induced diseases
The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies...
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7361479 |
Assay
The present invention provides a method of determining the presence or amount of newly synthesized antibody in a sample in response to an immunogen by detecting the released antibodies or parts...
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7358058 |
Method and agents for the diagnosis and therapy of chronic inflammatory intestinal disease
Methods for diagnosis, early diagnosis, differential diagnosis, assessment of the severity and therapy-accompanying monitoring and prognosis of chronically inflammatory intestinal diseases (Crohn's...
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7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
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7291473 |
Screening process for atopic dermatitis
The present invention provides a process of screening patients for atopic dermatitis. The process includes the step of determining, in sera of the patient, the presence of antibodies against...
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7285242 |
Biochemical analysis unit and biochemical analyzing method using the same
A biochemical analysis unit includes a substrate made of a material capable of attenuating radiation energy and/or light energy and formed with a plurality of holes, and a plurality of absorptive...
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7258994 |
Saliva immunoassay for detection of antibodies for cardiovascular disease
A method for diagnosing the likelihood and severity of cardiovascular disease in a patient is disclosed. The method determines the levels of antibodies against autoantigens, including myosin,...
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7252961 |
Competitive immunoassay using complexed analyte derivatives
The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for...
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7205382 |
Peptides, the production and use thereof for binding immunoglobulins
Peptides having the following amino acid sequence as well as peptides or proteins which contain this amino acid sequence:
R 1...
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7195881 |
Method and kit for following neurodegenerative diseases
The invention relates to a method for detecting and supervising neurodegenerative diseases, which consists in detecting the presence of antibodies of the A-isotype and/or M-isotype which are...
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7179612 |
Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality
A method for diagnosing a condition of a patient involves the steps of (a) adding one or more reagents to a test sample from a patient, the test samples comprising at least part of a blood sample...
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7176035 |
Protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction
The invention relates to protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction. Using overlapping hexapeptides that...
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7175989 |
Antibodies to trisulfated heparin disaccharide in painful sensory axonal neuropathy
Methods aiding in the diagnosis of certain painful, predominantly sensory, polyneuropathies are disclosed, in which the amount of antibodies to trisulfated disaccharide is assessed in a test...
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7157234 |
Detection of very low quantities of analyte bound to a solid phase
A microscale binding assay, analyte binding array, and kits are disclosed, which exploit the mass action law to harvest analyte from a liquid sample. This is achieved by fabrication of sorbent...
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7122380 |
Pharmaceutical compositions containing antigen-antibody complexes and uses therefor
A pharmaceutical composition suitable for administration to human beings in the prevention or treatment of immunologic disorders includes:
an immune complex of an antigen and a purified...
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7026132 |
Method of monitoring the effect of Cathepsin S inhibitors
The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant...
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6951763 |
Detection of antibodies to glycosphingolipids using solid-phase reactants coated with carbonyl groups
Methods of detecting antibodies to one or more glycosphingolipid(s) of interest in a sample are disclosed which comprise using a solid-phase reactant having carbonyl groups attached theron, and the...
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6951716 |
Anti-platelet immunoglobulin bead positive control
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one...
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6933106 |
Platelet immunoglobulin bead suspension and flow cytometry
Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one...
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6887672 |
Anti-equine Fc epsilon receptor alpha chain antibodies and methods to detect IgE
The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and...
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6878811 |
Substance with antithrombotic activity and method for detecting glycokallidin
A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a...
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6866846 |
Patient-specific immunoadsorbers for the extracorporeal apheresis and methods for their preparation
A process for preparing a patient-specific immunoadsorber, which comprises (i) extracting a body fluid from a patient having an immunopathological condition, the fluid containing immune complexes...
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6864062 |
Purified antigen for Alzheimer's disease and methods of obtaining and using same
The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified...
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6852546 |
Diagnosis of autoimmune disease
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and...
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6835382 |
Ii peptide therapeutics to enhance antigen presentation
Disclosed is a class of compounds referred to herein as effector compounds. Effector compounds are useful in connection with the modulation of an immune response. Modulation refers to the ability...
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6824986 |
Methods for measuring in vivo cytokine production
The present invention involves techniques for evaluating in vivo cytokine production through the in vivo capture of secreting cytokines by labeled cytokine-binding reagents, followed by in vitro...
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6824975 |
Incorporation of selective binding substances in a solid phase assay device
This invention discloses a method and composition for detecting the presence of class specific antibodies reactive with analytes such as bacteria, allergens, autoimmune antigens, viral proteins,...
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6815172 |
Methods and compositions for opsonophagocytic assays
Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides...
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6803196 |
Methods and compositions for detecting signals in binding assays using microparticles
Methods and compounds are provided for detecting target molecules in a sample using specific binding assays. In particular, methods are provided for detecting a nucleic acid target in a sample. In...
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6777193 |
Methods for diagnostic and/or treatment of antiphospholipids antibodies-related diseases, and devices
Methods for detecting anti-lipidic particles antibodies and lipidic particles in cellular membranes for the diagnosis of diseases associated to the antiphospholipid syndrome are disclosed. Kits or...
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6733980 |
Diagnostic method for detection of molecular forms of eosinophilic cationic protein (ISO-ECPS)
Diagnostic methods comprise measuring specifically the level of at least one iso-eosinophilic cationic protein (iso-ECP) in a sample from an individual to be diagnosed, and comparing the measured...
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6727072 |
EGF-r detection kit
A kit containing the reagents necessary for the qualitative or quantitative demonstration of epidermal growth factor receptor (EGFR) in formalin-fixed, paraffin-embedded tissue sections. A...
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6649354 |
Catalytically generated mass labels
The present invention involves a method for assaying a substance. The method of the present invention comprises contacting the substance with an assay agent comprising a catalytic agent to...
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6635469 |
Pressure-mediated binding of biomolecular complexes
The invention relates to ( 1 ) pressure-mediated dissociation of an analyte complexed with an endogenous binding partner to enable detection of a complex formed from the analyte and an exogenous...
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6627458 |
Nuclear envelope protein recognized by atypical p-ANCA in patients with inflammatory bowel disease and autoimmune liver diseases
The present invention is directed to the molecular characterization of the nuclear antigen recognized by atypical p-antineutrophil cytoplasmic antibodies (p-ANCA) in order to better diagnose...
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6558961 |
Immunodiagnostics using particle delivery methods
Methods for assessing immunocompetence, cellular or humoral immunity, antigen exposure, or allergic conditions in an individual by accelerating diagnostic particles into a target skin site in the...
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6514714 |
Method for immunobead flow cytometric detection of anti-HLA panel reactive antibody
The present invention provides an improved method for detection of panel reactive antibodies in serum of a subject against HLA class I antigens, which comprises the steps of adding serum from a...
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6489129 |
Antigen-specific IgM detection
The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in...
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6455244 |
Methods for the detection of antibodies associated with autoimmune disorders and infectious agents employing immunoretroid peptides derived from antigens associated with said disorders and agents
This invention is directed toward methods and kits for the detection of antibodies associated with autoimmune disorders or infectious agents in an individual employing immunoretroid peptides...
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6429024 |
Test method for IgA nephropathy
A test method for IgA nephropathy involves determining antibody, which recognizes the core peptide of the hinge region in IgA1, in specimens. The method is a rapid and sample test method for IgA...
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6416955 |
Eosinophil degranulating conditions
The invention provides methods and materials related to the diagnosis of eosinophil degranulating conditions. Specifically, the invention provides methods and materials that involve visual types of...
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