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7629138 |
Estrogen receptor genes and utilization thereof
An estrogen receptor gene and utilization of the estrogen receptor gene. The estrogen receptor gene contains a nucleotide sequence coding for any of the following amino acid sequences: (a) the...
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7618791 |
Methods of detecting cancer with antibodies to cytokine receptor ZCYTOR19
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used...
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7611853 |
Assay to screen for anti-malarials
Malarial parasite Plasmodium falciparum is responsible for the most severe form of malaria in humans, causing about 2 million deaths every year. Lack of effective vaccines and emergence of...
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7608414 |
Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease
Disclosed are methods for diagnosing and prognosing Inflammatory Bowel disease or Crohn's disease (CD) by measuring levels of antibodies to glycans in a biological sample.
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7608412 |
P62 as a diagnostic tool for alzheimer's disease
The p62 protein has been analyzed and identified as the significant contributor to several metabolic pathways that lead to metabolic syndrome, Alzheimer's Disease, and other related diseases. The...
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7604948 |
Biomarkers for diagnosing an autism spectrum disorder
The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using...
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7598050 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a chloride intracellular channel 1 protein
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7595168 |
Method of screening for substances useful for transdifferentiation of microglia into neurons
According to the present invention, there is provided a method of screening for a substance useful for transdifferentiation of microglia into neurons, a method of producing neurons, and a method of...
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7592150 |
Method for diagnosing diseases based on levels of anti-glycan antibodies
Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample.
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7569675 |
High affinity monoclonal antibody for recognizing the progesterone receptor (PR) and method for creating the antibody
A lagomorph derived monoclonal antibody for recognizing the progesterone receptor (PR) (clone SP2) with immunohistochemistry and methods for creating such an antibody are disclosed. No need of...
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7565251 |
Systems and methods for evaluating the significance of differences in biological measurements
A method for fluorophore bias removal in microarray experiments in which the fluorophores used in microarray experiment pairs are reversed. Further, a method for calculating the individual errors...
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7547515 |
Methods for detection of the Ob receptor and the diagnosis of body weight disorders, including obesity and cachexia
The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight...
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7534579 |
14273 receptor, a novel G-protein coupled receptor
The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The...
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7524639 |
Assay for screening antipsychotic drugs
A novel assay method suitable for screening of novel antipsychotics wherein the drugs may be selected based on the differential internalization of the 5-HT2A receptor in neuronal and non-neuronal...
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7517908 |
Method for augmenting the effects of serotonin reuptake inhibitors
A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an...
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7517663 |
Rabbit monoclonal antibody against Id1 protein
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
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7517648 |
NPHP nucleic acids and proteins
The present invention relates to Nephronophthisis, in particular to the NPHP5 protein (nephrocystin-5) and nucleic acids encoding the NPHP5 protein. The present invention also provides assays for...
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7510824 |
Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
A method of screening peptides which bind to at least one PDZ domain and comprise a cell-membrane transduction domain for use in treating traumatic injury to the brain or spinal cord by deforming...
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7491499 |
Method for diagnosing or predicting susceptibility to psychiatric disorders
The present invention provides a method for diagnosing or predicting susceptibility to a psychiatric disorder in an individual, which comprises confirming molecular diversity and/or subcellular...
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7456027 |
Proteolytic biomarkers for traumatic injury to the nervous system
The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic...
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7452681 |
Diagnostic methods for the detection of autism spectrum disorder
The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of...
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7445905 |
Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic...
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7442516 |
Antibody specific to central nervous system tau protein
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable...
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7429448 |
Therapeutic use of the SMR1 protein and active derivatives thereof
The present invention pertains to the use of a peptide molecule consisting in a maturation product of SMR1 (Submandibular rat protein 1) of structural formula QHNPR, as well as the biologically...
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7405051 |
Method of screening antiplatelet agents
A screening tool for an antiplatelet agent wherein the tool is a human ADP receptor P2T AC protein, a variation functionally equivalent thereto, or a homologous protein thereof, and a screening...
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7405049 |
Method for diagnosing inflammatory diseases and infections by the determination of LASP-1 immunoreactivity
Method for early diagnosis and diagnosis, for prognosis and assessment of the severity and for therapy-accompanying monitoring of inflammatory diseases and infections, in particular sepsis-like...
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7396654 |
Neural proteins as biomarkers for traumatic brain injury
The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree...
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7384748 |
Compositions and methods for detecting and treating motor neuron disorders
The present invention relates to the NTE proteins and nucleic acids encoding the NTE proteins. The present invention further provides assays for the detection of NTE polymorphisms and mutations...
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7368253 |
Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies
Markers for TSE that are present prior to formation of detectable pathological prion protein are useful to detect this infection prior to clinical signs. Additional markers are useful to detect the...
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7368251 |
MEGSIN protein
A gene expressed specifically in mesangial cells. A DNA expressed specifically in mesangial cells; a protein encoded by this DNA; an antibody binding to this protein, etc. These substances are...
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7358063 |
Method of detecting PS2V
A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a...
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7354991 |
Peptides for the diagnosis of schizophrenia
Short peptides are provided, which bind to a body fluid sample obtained from a schizophrenic patient at a substantively higher level than to a body fluid sample obtained from a non-schizophrenic...
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7342091 |
Soluble cyclic analogues of β amyloid peptide
The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.
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7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
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7314724 |
Therapeutic applications of laminin and laminin-derived protein fragments
Laminin and specific laminin-derived protein fragments are disclosed as potent inhibitors of Alzheimer's disease type amyloidoses. A specific region is identified within laminin which interacts...
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7303885 |
Screening method for candidate drugs
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
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7294477 |
Allergen and treatment
The present invention is related to novel nucleoli sequences encoding a louse allergen and a methods for diagnosing, treating and preventing lice infestation and associated allergic disease with...
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7285392 |
Methods for identifying active compounds
The present invention relates to methods for identifying agents that modulate the effect of cytokine class I receptor binding compounds, by inhibiting the interaction between the cytokine class I...
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7250265 |
Method of detecting and evaluating angiotensinogen receptor-modulating compounds using placental cells
Disclosed is a method of screening a substance for angiotensinogen receptor-modulatory activity. The method includes the steps of contacting placental-derived cells with labeled angiotensinogen and...
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7238488 |
Therapeutic and diagnostic applications of perlecan domain I splice variants
A method of producing antibodies comprising the step of encoding a peptide sequence from a Domain I perlecan splice variant, wherein the peptide sequence is used to produce anti-peptide antibodies.
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7235375 |
Organic anion transport proteins
The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with...
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7226746 |
Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease
In methods for screening treatments for, and treatment of, neurodegenerative diseases, aggregation in neurons of NACP/α-synuclein is measured and expression of a non-amyloidogenic protein is...
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7176181 |
Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth
The present invention provides compositions that enhance or inhibit the interactions of galectin-8 and galectin-8-like proteins with other extracellular matrix proteins or cell surface receptors,...
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7176035 |
Protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction
The invention relates to protein-protein interactions and methods for identifying interacting proteins and the amino acid sequence at the site of interaction. Using overlapping hexapeptides that...
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7163798 |
Method of preparing cow brain homogenate
An assay method is disclosed which isolates and detects the presence of a disease related conformation of a protein (e.g., PrP Sc ) present in a sample also containing the non-disease related...
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7148332 |
High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody
High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER...
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7148016 |
Immunoassays to detect diseases or disease susceptibility traits
Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels...
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7141434 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing an adenosine kinase
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7122322 |
Endometriosis-specific secretory protein
A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the...
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7067325 |
Removal of embedding media from biological samples and cell conditioning on automated staining instruments
The present invention provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical...
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